Gene: SNAI2

6591
SLUG|SLUGH|SLUGH1|SNAIL2|WS2D
snail family transcriptional repressor 2
protein-coding
8q11.21
Ensembl:ENSG00000019549 MIM:602150 Vega:OTTHUMG00000149912 UniprotKB:O43623
NG_012130.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.412e-1 (AD)  3.733e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GAS10.632
GPX80.59
SLC25A240.586
AHR0.582
TNFRSF190.581
PTGER40.577
DSG20.576
CAV10.575
CCDC71L0.574
CAV20.574

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NXNL1-0.274
RLBP1-0.247
ZNF98-0.242
CABLES1-0.235
LDHD-0.232
OR4F5-0.223
EPHB1-0.221
GPT-0.218
OR4F29-0.216
IZUMO4-0.215

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of SNAI2 mRNA28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of SNAI2 mRNA19933214
C5259212-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine"2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine results in decreased expression of SNAI2 mRNA"29108245
C5259212-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine"TLN1 protein inhibits the reaction [2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine results in decreased expression of SNAI2 mRNA]"29108245
C1214792,4-dihydroxybenzophenone"2,4-dihydroxybenzophenone results in increased expression of SNAI2 protein"27145024
C1214792,4-dihydroxybenzophenone"fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of SNAI2 protein]"27145024
C5191322-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride"2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of SNAI2 protein]"22869556
C0163923,3'-diindolylmethane"3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of SNAI2 protein]"28844962
C0163923,3'-diindolylmethane"3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of SNAI2 protein]"28844962
C0163923,3'-diindolylmethane"3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of SNAI2 protein]"28844962
C0414773-hydroxyflavone3-hydroxyflavone results in decreased expression of SNAI2 protein27600294
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SNAI2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAI2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAI2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAI2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAI2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAI2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAI2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAI2 mRNA"27188386
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of SNAI2 protein27145024
C1052604-tert-octylphenolfulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of SNAI2 protein]27145024
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAI2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAI2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAI2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAI2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAI2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAI2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAI2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of SNAI2 mRNA21420995|2906747
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SNAI2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SNAI2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SNAI2 mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of SNAI2 mRNA28522335
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of SNAI2 mRNA16541421
D000968Antimycin AAntimycin A results in increased expression of SNAI2 mRNA19304788
D016718Arachidonic AcidArachidonic Acid results in increased expression of SNAI2 mRNA16704987
C006632arsenic trioxidearsenic trioxide results in decreased expression of SNAI2 mRNA25258189
C006632arsenic trioxidearsenic trioxide results in decreased expression of SNAI2 protein24680928
C006632arsenic trioxideMIR491 mRNA affects the reaction [arsenic trioxide results in decreased expression of SNAI2 protein]24680928
C015001arsenite[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of SNAI2 mRNA15894712
C015001arsenitearsenite results in decreased expression of SNAI2 mRNA15894712
C547126AZM551248AZM551248 results in increased expression of SNAI2 mRNA22323515
C487081belinostatbelinostat results in increased expression of SNAI2 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAI2 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SNAI2 mRNA27221058
D001564Benzo(a)pyrene[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of SNAI2 mRNA15894712
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SNAI2 mRNA15894712|1977048
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SNAI2 mRNA"20018196|2038263
D004958EstradiolEstradiol affects the expression of SNAI2 mRNA23557687
D004958Estradiol"3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of SNAI2 protein]"28844962
D004958EstradiolEstradiol affects the expression of SNAI2 mRNA22574217
D004958EstradiolEstradiol results in decreased expression of SNAI2 protein15955695
D004958EstradiolEstradiol results in increased expression of SNAI2 mRNA25690688
D004958EstradiolEstradiol results in increased expression of SNAI2 protein28844962
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of SNAI2 mRNA]25690688
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of SNAI2 protein]28844962
D004958EstradiolJM 3100 inhibits the reaction [Estradiol results in increased expression of SNAI2 protein]28844962
C006780bisphenol Abisphenol A affects the expression of SNAI2 mRNA21786754|2355768
C006780bisphenol A"3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of SNAI2 protein]"28844962
C006780bisphenol Abisphenol A results in increased expression of SNAI2 mRNA25690688|2927551
C006780bisphenol Abisphenol A results in increased expression of SNAI2 protein28844962
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI2 mRNA]25690688
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI2 protein]28844962
C006780bisphenol AJM 3100 inhibits the reaction [bisphenol A results in increased expression of SNAI2 protein]28844962
C006780bisphenol Abisphenol A results in decreased expression of SNAI2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SNAI2 mRNA28628672
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SNAI2 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of SNAI2 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of SNAI2 mRNA25979313
C100187chloropicrinchloropicrin affects the expression of SNAI2 mRNA26352163
C100187chloropicrinchloropicrin results in decreased expression of SNAI2 mRNA28476498
D002737ChloropreneChloroprene results in decreased expression of SNAI2 mRNA23125180
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of SNAI2 mRNA23518002
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of SNAI2 protein23518002
C031180chrysenechrysene results in increased expression of SNAI2 mRNA26377693
D002939CiprofloxacinCiprofloxacin results in decreased expression of SNAI2 protein26947806
D003474CurcuminCurcumin results in decreased expression of SNAI2 protein19573523
D016572CyclosporineCyclosporine results in decreased expression of SNAI2 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of SNAI2 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of SNAI2 mRNA22416070
D016572CyclosporineCyclosporine results in increased expression of SNAI2 protein22416070
D003561CytarabineCytarabine results in decreased expression of SNAI2 mRNA21198554
C040424destruxin Bdestruxin B promotes the reaction [sorafenib results in decreased expression of SNAI2 protein]24434019
C040424destruxin Bdestruxin B results in decreased expression of SNAI2 protein24434019
C040424destruxin Bsorafenib promotes the reaction [destruxin B results in decreased expression of SNAI2 protein]24434019
D003907DexamethasoneDexamethasone results in decreased expression of SNAI2 mRNA28453788
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SNAI2 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SNAI2 mRNA21266533
D002945CisplatinCisplatin results in increased expression of SNAI2 mRNA19561079|2161858
D002945CisplatinU 0126 inhibits the reaction [Cisplatin results in increased expression of SNAI2 mRNA]21618587
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SNAI2 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of SNAI2 mRNA18042831
D002117CalcitriolCalcitriol results in increased expression of SNAI2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of SNAI2 mRNA21592394
C010945embelinembelin results in decreased expression of SNAI2 protein24694877
D004726EndosulfanEndosulfan affects the localization of SNAI2 protein22677888
D004726EndosulfanEndosulfan results in increased expression of SNAI2 mRNA22677888
D000431EthanolEthanol results in decreased expression of SNAI2 mRNA28919490
D015025ZearalenoneZearalenone results in decreased expression of SNAI2 mRNA28965971
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of SNAI2 mRNA28329830
D005472FluorouracilFluorouracil results in increased expression of SNAI2 protein26310874
D005472Fluorouracilresveratrol inhibits the reaction [Fluorouracil results in increased expression of SNAI2 protein]26310874
D005557FormaldehydeFormaldehyde results in decreased expression of SNAI2 mRNA28937961
C070081fulvestrant"fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of SNAI2 protein]"27145024
C070081fulvestrantfulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of SNAI2 protein]27145024
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI2 mRNA]25690688
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI2 protein]28844962
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of SNAI2 mRNA]25690688
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of SNAI2 protein]28844962
C070081fulvestrantfulvestrant inhibits the reaction [nonylphenol results in increased expression of SNAI2 mRNA]25690688
C070081fulvestrantfulvestrant inhibits the reaction [Triclosan results in increased expression of SNAI2 protein]28844962
C419708gefitinibSNAI2 protein affects the susceptibility to gefitinib21037017
D006820Hyaluronic AcidHyaluronic Acid analog results in increased expression of SNAI2 mRNA20159036
D006820Hyaluronic AcidHyaluronic Acid analog results in increased expression of SNAI2 protein20159036
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of SNAI2 protein22580338
D007213IndomethacinIndomethacin results in increased expression of SNAI2 mRNA16984733
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SNAI2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SNAI2 mRNA28628672
C544151jinfukangjinfukang results in increased expression of SNAI2 mRNA27392435
C088327JM 3100JM 3100 inhibits the reaction [bisphenol A results in increased expression of SNAI2 protein]28844962
C088327JM 3100JM 3100 inhibits the reaction [Estradiol results in increased expression of SNAI2 protein]28844962
C088327JM 3100JM 3100 inhibits the reaction [Triclosan results in increased expression of SNAI2 protein]28844962
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SNAI2 mRNA24796395
C045463leflunomideleflunomide results in increased expression of SNAI2 mRNA28988120
D001556LindaneLindane affects the expression of SNAI2 mRNA17785943
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SNAI2 mRNA26378955
C013592mangiferinmangiferin results in decreased expression of SNAI2 protein23707762
C042720mercuric bromidemercuric bromide results in increased expression of SNAI2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAI2 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SNAI2 mRNA26272509|2800136
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SNAI2 mRNA26011545
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of SNAI2 mRNA27221058
D008770Methylnitrosourea[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI2 mRNA25164625
D008770MethylnitrosoureaQuercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI2 mRNA]25164625
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SNAI2 mRNA24810058
C008493methylselenic acidmethylselenic acid results in increased expression of SNAI2 mRNA18548127
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of SNAI2 mRNA24128854
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SNAI2 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SNAI2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SNAI2 mRNA"25554681
C022838nickel chloridenickel chloride promotes the reaction [SNAI2 protein binds to CDH1 promoter]22648416
C022838nickel chloridenickel chloride results in increased expression of SNAI2 protein22648416
D009534NiclosamideNiclosamide results in decreased expression of SNAI2 protein25174399
D009534NiclosamideWNT7A protein affects the reaction [Niclosamide results in increased expression of SNAI2 protein]25174399
D009538NicotineNicotine results in increased expression of SNAI2 mRNA23219715
D009538NicotineNicotine results in decreased expression of SNAI2 mRNA20339300
C025256nonylphenolfulvestrant inhibits the reaction [nonylphenol results in increased expression of SNAI2 mRNA]25690688
C025256nonylphenolnonylphenol results in increased expression of SNAI2 mRNA25690688
C570897NSC668394NSC668394 results in increased expression of SNAI2 mRNA27137931
C500026palbociclib"2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of SNAI2 protein]"22869556
C500026palbociclibpalbociclib results in increased expression of SNAI2 protein22869556
D000073878Palm OilPalm Oil results in increased expression of SNAI2 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAI2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of SNAI2 mRNA26272509
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of SNAI2 mRNA18593933
D010416PentachlorophenolPentachlorophenol results in increased expression of SNAI2 mRNA24642059
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in decreased expression of SNAI2 mRNA28973697
D010634PhenobarbitalPhenobarbital affects the expression of SNAI2 mRNA19159669
D010634PhenobarbitalPhenobarbital results in decreased expression of SNAI2 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAI2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SNAI2 mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of SNAI2 mRNA23557933
D011374ProgesteroneProgesterone results in decreased expression of SNAI2 mRNA23012394|2301818
D011794QuercetinQuercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI2 mRNA]25164625
C012526quercitrinquercitrin affects the expression of SNAI2 mRNA25193878
C059514resveratrolresveratrol inhibits the reaction [Fluorouracil results in increased expression of SNAI2 protein]26310874
C059514resveratrolresveratrol inhibits the reaction [TGFB1 protein results in increased expression of SNAI2 mRNA]23146760
C059514resveratrolresveratrol inhibits the reaction [TGFB1 protein results in increased expression of SNAI2 protein]23146760|2588490
C059514resveratrolresveratrol results in decreased expression of SNAI2 mRNA21304978|2269295
C059514resveratrolresveratrol results in decreased expression of SNAI2 protein22692956|2631087
C009166retinol acetateretinol acetate results in increased expression of SNAI2 mRNA16772331
D012402RotenoneRotenone results in increased expression of SNAI2 mRNA19304788
D012715Sesame OilSesame Oil results in increased expression of SNAI2 mRNA29191790
C017947sodium arsenitesodium arsenite deficiency inhibits the reaction [sodium arsenite results in increased expression of SNAI2 protein]28336213
C017947sodium arsenitesodium arsenite results in increased expression of SNAI2 protein28336213
C471405sorafenibdestruxin B promotes the reaction [sorafenib results in decreased expression of SNAI2 protein]24434019
C471405sorafenibsorafenib promotes the reaction [destruxin B results in decreased expression of SNAI2 protein]24434019
C471405sorafenibsorafenib results in decreased expression of SNAI2 protein24434019
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SNAI2 mRNA26378955
D016559TacrolimusTacrolimus results in increased expression of SNAI2 mRNA22416070
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of SNAI2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of SNAI2 mRNA21592394
D013739Testosterone[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI2 mRNA25164625
D013739TestosteroneQuercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI2 mRNA]25164625
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SNAI2 mRNA16443690
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of SNAI2 mRNA]26971374
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of SNAI2 protein]26971374
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SNAI2 promoter]24154488|2697137
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SNAI2 protein]26971374
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SNAI2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SNAI2 protein24154488|2697137
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SNAI2 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SNAI2 mRNA19770486|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SNAI2 mRNA17586704|2415448
D013853ThioacetamideThioacetamide results in decreased expression of SNAI2 mRNA23411599
D013893ThiramThiram results in increased expression of SNAI2 mRNA20530235
C009495titanium dioxidetitanium dioxide results in decreased expression of SNAI2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SNAI2 protein27087172
D014212TretinoinTretinoin results in decreased expression of SNAI2 mRNA20530235
D014212TretinoinTretinoin results in decreased expression of SNAI2 mRNA21934132
D014212TretinoinTretinoin results in increased expression of SNAI2 mRNA23724009
D014212TretinoinTretinoin results in increased expression of SNAI2 mRNA17038669
C034613triacsin Ctriacsin C results in increased expression of SNAI2 mRNA16704987
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAI2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SNAI2 mRNA24935251|2627250
D014260Triclosan"3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of SNAI2 protein]"28844962
D014260Triclosanfulvestrant inhibits the reaction [Triclosan results in increased expression of SNAI2 protein]28844962
D014260TriclosanJM 3100 inhibits the reaction [Triclosan results in increased expression of SNAI2 protein]28844962
D014260TriclosanTriclosan results in increased expression of SNAI2 protein28844962
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SNAI2 mRNA"26743178
C057693troglitazonetroglitazone results in decreased expression of SNAI2 mRNA28973697
C113580U 0126U 0126 inhibits the reaction [Cisplatin results in increased expression of SNAI2 mRNA]21618587
D014520UrethaneUrethane results in increased expression of SNAI2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAI2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SNAI2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SNAI2 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of SNAI2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of SNAI2 mRNA24896083
D014638VanadatesVanadates results in increased expression of SNAI2 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SNAI2 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of SNAI2 mRNA21126777
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAI2 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of SNAI2 mRNA26272509
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of SNAI2 mRNA18593933
D015032ZincZinc binds to SNAI2 protein18761175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA10866665  11912130  16707493  18663143  
GO:0003677DNA binding-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0005515protein binding-IPI25416956  
GO:0043565sequence-specific DNA binding-IDA10518215  10866665  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA10866665  11912130  
GO:0000122negative regulation of transcription by RNA polymerase II-IMP18663143  
GO:0001649osteoblast differentiation-IEP20128911  
GO:0001837epithelial to mesenchymal transition-IMP9182671  17984306  
GO:0003198epithelial to mesenchymal transition involved in endocardial cushion formation-ISS-  
GO:0003198epithelial to mesenchymal transition involved in endocardial cushion formation-TAS20951801  
GO:0003273cell migration involved in endocardial cushion formation-ISS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0007219Notch signaling pathway-IMP18663143  
GO:0007605sensory perception of sound-IMP12444107  
GO:0010839negative regulation of keratinocyte proliferation-IDA16707493  
GO:0010957negative regulation of vitamin D biosynthetic process-IDA18485278  19502595  
GO:0014032neural crest cell development-IMP12444107  
GO:0030335positive regulation of cell migration-IMP15314165  
GO:0032331negative regulation of chondrocyte differentiation-IMP19756381  
GO:0032642regulation of chemokine production-IMP21182836  
GO:0033629negative regulation of cell adhesion mediated by integrin-IC16707493  
GO:0035921desmosome disassembly-IMP9182671  
GO:0043473pigmentation-IMP12444107  
GO:0043518negative regulation of DNA damage response, signal transduction by p53 class mediator-IMP15314165  
GO:0045667regulation of osteoblast differentiation-IMP19756381  21182836  
GO:0060070canonical Wnt signaling pathway-IMP20128911  
GO:0060429epithelium development-ISS18716062  
GO:0070563negative regulation of vitamin D receptor signaling pathway-IDA19502595  
GO:0071364cellular response to epidermal growth factor stimulus-IDA18716062  
GO:0090090negative regulation of canonical Wnt signaling pathway-IDA19502595  
GO:0090090negative regulation of canonical Wnt signaling pathway-IMP19756381  
GO:1900387negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter-IMP15737616  16707493  17984306  
GO:1902230negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage-IMP15314165  
GO:2000810regulation of bicellular tight junction assembly-IMP15314165  
GO:2000811negative regulation of anoikis-IMP17984306  
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand-ISS10518215  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA19756381  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA10866665  25893292  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04520Adherens junction
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1257604PIP3 activates AKT signalingIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-6807070PTEN RegulationTAS
R-HSA-6807070PTEN RegulationIEA
R-HSA-8943724Regulation of PTEN gene transcriptionTAS
R-HSA-8943724Regulation of PTEN gene transcriptionIEA
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006925Intracellular signaling by second messengersIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26081431Fibroblast-epithelial cell interactions drive epithelial-mesenchymal transition differently in cells from normal and COPD patients. (2015 Jun 18)Nishioka MRespir Res