Gene: SMARCA4

6597
BAF190|BAF190A|BRG1|CSS4|MRD16|RTPS2|SNF2|SNF2L4|SNF2LB|SWI2|hSNF2b
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
protein-coding
19p13.2
Ensembl:ENSG00000127616 MIM:603254 Vega:OTTHUMG00000169272 UniprotKB:P51532
NG_011556.2
PubMed
0   ANCO-SNPs
OD|ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.360e-1 (AD)  2.193e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TCF250.953
NEURL40.952
AP3D10.948
PPP6R20.945
DBNL0.944
USP50.943
SPTAN10.943
DHX300.943
DNAJC50.941
SPRYD30.938

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.678
OR4F29-0.643
MTRNR2L6-0.368
MTRNR2L9-0.346
MTRNR2L10-0.334
CLEC2B-0.333
SH2D1A-0.318
CXCR2-0.314
KCNJ15-0.307
S100A12-0.306

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMARCA4 mRNA"27188386
C5466076,2',4'-trimethoxyflavone"6,2',4'-trimethoxyflavone inhibits the reaction [SMARCA4 protein binds to IL6 promoter]"21104991
C5466076,2',4'-trimethoxyflavone"SMARCA4 protein promotes the reaction [6,2',4'-trimethoxyflavone results in decreased expression of IL6 mRNA]"21104991
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMARCA4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SMARCA4 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SMARCA4 mRNA19770486
D013196Dihydrotestosterone[Dihydrotestosterone co-treated with bicalutamide] promotes the reaction [AR protein binds to SMARCA4 protein]18487222
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SMARCA4 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SMARCA4 mRNA24449571
D001151ArsenicArsenic affects the methylation of SMARCA4 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of SMARCA4 mRNA20458559
D001280AtrazineAtrazine results in decreased expression of SMARCA4 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of SMARCA4 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SMARCA4 mRNA22228805
D004958EstradiolEstradiol affects the expression of SMARCA4 mRNA18214933
D004958EstradiolEstradiol results in decreased expression of SMARCA4 mRNA16705744|1916744
C053541bicalutamidebicalutamide promotes the reaction [SMARCA4 protein binds to KLK3 promoter]18487222
C053541bicalutamide[Dihydrotestosterone co-treated with bicalutamide] promotes the reaction [AR protein binds to SMARCA4 protein]18487222
C053541bicalutamidePHB protein promotes the reaction [bicalutamide promotes the reaction [SMARCA4 protein binds to KLK3 promoter]]18487222
C006780bisphenol Abisphenol A affects the expression of SMARCA4 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of SMARCA4 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of SMARCA4 mRNA25181051
C084597chlorcyclizinechlorcyclizine results in decreased expression of SMARCA4 mRNA21058326
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SMARCA4 mRNA23650126
D002737ChloropreneChloroprene results in increased expression of SMARCA4 mRNA23125180
D002995Clofibric AcidClofibric Acid affects the expression of SMARCA4 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of SMARCA4 mRNA19320972
D003042CocaineCocaine deficiency promotes the reaction [SMARCA4 protein binds to CTNNB1 promoter]27422367
D003042CocaineCocaine deficiency promotes the reaction [SMARCA4 protein binds to DBN1 promoter]27422367
D003042CocaineCocaine deficiency promotes the reaction [SMARCA4 protein binds to MEF2D promoter]27422367
D003042CocaineCocaine deficiency promotes the reaction [SMARCA4 protein binds to SMAD3 protein]27422367
D003042CocaineCocaine deficiency results in increased expression of SMARCA4 protein27422367
D016572CyclosporineCyclosporine results in decreased expression of SMARCA4 mRNA22147139
D016572CyclosporineCyclosporine results in increased expression of SMARCA4 mRNA25562108
C093628cyproconazolecyproconazole results in decreased expression of SMARCA4 mRNA22334560
C515055darinaparsindarinaparsin inhibits the reaction [[SMARCA4 protein binds to HMOX1 promoter] which results in increased expression of HMOX1 mRNA]23426167
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of SMARCA4 mRNA23640034
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SMARCA4 mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SMARCA4 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SMARCA4 mRNA27392435|2759478
C000944dicrotophosdicrotophos results in increased expression of SMARCA4 mRNA28302478
D004026DieldrinDieldrin results in decreased expression of SMARCA4 mRNA28385952
D011397PromegestoneSMARCA4 protein affects the reaction [Promegestone results in increased expression of FOS mRNA]19609353
D011397PromegestoneSMARCA4 protein affects the reaction [Promegestone results in increased expression of MYC mRNA]19609353
D004147DioxinsDioxins affects the expression of SMARCA4 mRNA20463971
C109476epoxiconazoleepoxiconazole results in decreased expression of SMARCA4 mRNA22334560
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SMARCA4 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMARCA4 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SMARCA4 mRNA23649840
D018120FinasterideFinasteride results in increased expression of SMARCA4 mRNA24136188
D005485FlutamideFlutamide results in increased expression of SMARCA4 mRNA20566332|2413618
C069837fullerene C60fullerene C60 results in increased expression of SMARCA4 mRNA19167457
C070081fulvestrantfulvestrant results in decreased expression of SMARCA4 protein24169358
D019833GenisteinGenistein results in increased expression of SMARCA4 mRNA16705744
D005839GentamicinsGentamicins results in increased expression of SMARCA4 mRNA22061828
C029424hydrazinehydrazine results in increased expression of SMARCA4 mRNA15282401
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SMARCA4 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to SMARCA4 enhancer]23582323
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to SMARCA4 promoter]23582323
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of SMARCA4 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides affects the expression of SMARCA4 mRNA21645290
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SMARCA4 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMARCA4 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride affects the expression of SMARCA4 mRNA20864626
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SMARCA4 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SMARCA4 mRNA"20188158
C008493methylselenic acidmethylselenic acid results in decreased expression of SMARCA4 mRNA18548127
C437683motexafin gadoliniummotexafin gadolinium results in decreased expression of SMARCA4 mRNA16357179
C437683motexafin gadolinium[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SMARCA4 mRNA16357179
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of SMARCA4 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SMARCA4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SMARCA4 mRNA"25554681|2562005
C028007nickel monoxidenickel monoxide results in increased expression of SMARCA4 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SMARCA4 mRNA25729387
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of SMARCA4 mRNA18593933
C000603674PF-06687252PF-06687252 results in decreased activity of SMARCA4 protein27422367
D010634PhenobarbitalPhenobarbital results in decreased expression of SMARCA4 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of SMARCA4 mRNA12082028
C443641poly(propyleneimine)poly(propyleneimine) analog results in decreased expression of SMARCA4 mRNA16308212
C045950propiconazolepropiconazole results in decreased expression of SMARCA4 mRNA22334560
C059514resveratrolresveratrol results in decreased expression of SMARCA4 protein25505154
D012643SeleniumSelenium results in increased expression of SMARCA4 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SMARCA4 mRNA25895662
D013749TetrachlorodibenzodioxinSMARCA4 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]18842620
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [SMARCA4 protein binds to CYP1A1 enhancer]18842620
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [SMARCA4 protein binds to CYP1A1 promoter]18842620
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [SMARCA4 protein binds to CYP1B1 enhancer]18842620
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [SMARCA4 protein binds to CYP1B1 promoter]18842620
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SMARCA4 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMARCA4 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SMARCA4 mRNA18796159
D019284ThapsigarginThapsigargin results in increased expression of SMARCA4 protein24648495
D013893ThiramThiram results in decreased expression of SMARCA4 mRNA20530235
D019772TopotecanSMARCA4 protein affects the susceptibility to Topotecan16217747
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SMARCA4 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of SMARCA4 mRNA24977338
D014415TunicamycinTunicamycin results in decreased expression of SMARCA4 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of SMARCA4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SMARCA4 mRNA28001369|2915479
D014635Valproic AcidValproic Acid results in increased methylation of SMARCA4 gene29154799
C025643vinclozolinvinclozolin affects the expression of SMARCA4 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of SMARCA4 mRNA18042343|2303416
C111237vorinostatvorinostat results in decreased expression of SMARCA4 mRNA27188386
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of SMARCA4 mRNA18593933
D019345Zinc Acetate[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SMARCA4 mRNA16357179
D019345Zinc AcetateZinc Acetate results in decreased expression of SMARCA4 mRNA16357179

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA bindingcontributes_toHDA16217013  
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingcontributes_toHDA16217013  
GO:0001164RNA polymerase I CORE element sequence-specific DNA binding-IDA22368283  
GO:0002039p53 binding-IPI11950834  
GO:0003713transcription coactivator activity-IDA15774904  
GO:0003713transcription coactivator activity-IMP16687403  
GO:0003713transcription coactivator activity-NAS8804307  
GO:0003714transcription corepressor activity-IDA18487222  20418909  
GO:0003723RNA binding-IEA-  
GO:0004386helicase activity-IEA-  
GO:0005515protein binding-IPI10078207  11726552  11780067  11988099  12065415  12192000  
12200431  12368262  12917342  14701856  15985610  16051670  
16687403  17984088  18303029  19149898  19571879  20224553  
20418909  22140357  23022380  23540691  24434208  24550003  
28420882  28649782  
GO:0005524ATP binding-IEA-  
GO:0008094DNA-dependent ATPase activity-IGI8232556  
GO:0008134transcription factor binding-IPI22368283  
GO:0030957Tat protein binding-IPI16687403  
GO:0031492nucleosomal DNA bindingcontributes_toHDA16217013  
GO:0047485protein N-terminus binding-IPI12917342  
GO:0050681androgen receptor binding-IPI18487222  
GO:0070182DNA polymerase binding-IPI19571879  
GO:0070577lysine-acetylated histone binding-IDA17582821  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-TAS17938176  19149898  
GO:0001188RNA polymerase I transcriptional preinitiation complex assembly-IEA-  
GO:0003407neural retina development-IEP18816825  
GO:0006325chromatin organization-TAS-  
GO:0006337nucleosome disassembly-IDA8895581  
GO:0006338chromatin remodeling-IC18816825  
GO:0006338chromatin remodeling-IDA10943845  11726552  
GO:0006338chromatin remodeling-IMP22368283  
GO:0006357regulation of transcription by RNA polymerase II-NAS8804307  
GO:0007399nervous system development-IEA-  
GO:0030177positive regulation of Wnt signaling pathway-IMP19571879  
GO:0030308negative regulation of cell growth-IMP12065415  
GO:0038111interleukin-7-mediated signaling pathway-TAS-  
GO:0043044ATP-dependent chromatin remodeling-HDA16217013  
GO:0043923positive regulation by host of viral transcription-IMP16687403  
GO:0045892negative regulation of transcription, DNA-templated-IDA12065415  
GO:0045892negative regulation of transcription, DNA-templated-IMP18487222  
GO:0045893positive regulation of transcription, DNA-templated-IMP8208605  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA15774904  17938176  
GO:0045944positive regulation of transcription by RNA polymerase II-IGI8232556  
GO:0051091positive regulation of DNA-binding transcription factor activity-IDA11950834  17938176  
GO:0060766negative regulation of androgen receptor signaling pathway-IMP18487222  
GO:1901838positive regulation of transcription of nucleolar large rRNA by RNA polymerase I-IMP22368283  
GO:1902661positive regulation of glucose mediated signaling pathway-IDA22368283  
GO:1902895positive regulation of pri-miRNA transcription by RNA polymerase II-IMP25569094  
GO:1904837beta-catenin-TCF complex assembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-HDA16217013  
GO:0000790nuclear chromatin-IDA12065415  15774904  
GO:0005615extracellular space-HDA22664934  
GO:0005634nucleus-IDA8232556  11726552  20418909  22368283  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA22368283  
GO:0016020membrane-HDA19946888  
GO:0016514SWI/SNF complex-IDA8804307  10943845  11078522  
GO:0032991protein-containing complex-HDA16217013  
GO:0071564npBAF complex-IDA18816825  
GO:0071564npBAF complex-ISS-  
GO:0071565nBAF complex-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266695Interleukin-7 signalingTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-201722Formation of the beta-catenin:TCF transactivating complexTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3214858RMTs methylate histone argininesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939243RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28256572Clinicopathological and molecular characterization of SMARCA4-deficient thoracic sarcomas with comparison to potentially related entities. (2017 Jun)Yoshida AMod Pathol
25278450Genome-wide DNA methylation analysis of lung carcinoma reveals one neuroendocrine and four adenocarcinoma epitypes associated with patient outcome. (2014 Dec 1)Karlsson AClin Cancer Res
22975805The transcriptional landscape and mutational profile of lung adenocarcinoma. (2012 Nov)Seo JSGenome Res
24585446Genetic variants in the SWI/SNF complex and smoking collaborate to modify the risk of pancreatic cancer in a Chinese population. (2015 Sep)Zhu BMol Carcinog
25469260Association of a transcription factor 21 gene polymorphism with hypertension. (2015 Jan)Fujimaki TBiomed Rep
29260792A Novel Role for Oligodendrocyte Precursor Cells (OPCs) and Sox10 in Mediating Cellular and Behavioral Responses to Heroin. (2018 May)Martin JANeuropsychopharmacology