Gene: ZSCAN18

65982
ZNF447
zinc finger and SCAN domain containing 18
protein-coding
19q13.43
Ensembl:ENSG00000121413 Vega:OTTHUMG00000183451 UniprotKB:Q8TBC5
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
2.121e-1 (AD)  4.038e-1 (ND)   (Frontal_Cortex)
5.544e-1 (AD)  2.594e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ERAL10.946
KDM1A0.936
CCAR20.935
PSMD30.933
POLR2C0.932
SRP680.93
TMUB20.928
NCAPH20.928
TERF2IP0.927
THYN10.927

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.695
OR4F29-0.655
MTRNR2L9-0.372
MTRNR2L6-0.372
KLRB1-0.358
MTRNR2L10-0.354
TTLL10-0.329
C9orf153-0.315
MTRNR2L2-0.313
KCNJ15-0.313

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of ZSCAN18 mRNA"19095052
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZSCAN18 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZSCAN18 mRNA"27188386
C015001arsenitearsenite results in decreased expression of ZSCAN18 mRNA23974009
C015001arsenitearsenite results in increased methylation of ZSCAN18 promoter23974009
C006780bisphenol Abisphenol A affects the expression of ZSCAN18 mRNA25181051
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ZSCAN18 mRNA21266533
D005472FluorouracilZSCAN18 protein affects the susceptibility to Fluorouracil16217747
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ZSCAN18 mRNA25613284
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ZSCAN18 mRNA28001369
D008942MitoxantroneZSCAN18 protein affects the susceptibility to Mitoxantrone16217747
C558013NSC 689534NSC 689534 results in increased expression of ZSCAN18 mRNA20971185
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of ZSCAN18 mRNA19095052
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ZSCAN18 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of ZSCAN18 mRNA20813756
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of ZSCAN18 mRNA21334430
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of ZSCAN18 mRNA22714537
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ZSCAN18 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of ZSCAN18 mRNA23411599
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZSCAN18 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of ZSCAN18 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of ZSCAN18 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19472401The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers. (2009 Aug 1)Oka DCancer