Gene: AACS

65985
ACSF1|SUR-5
acetoacetyl-CoA synthetase
protein-coding
12q24.31
Ensembl:ENSG00000081760 MIM:614364 Vega:OTTHUMG00000168550 UniprotKB:Q86V21
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.145e-1 (AD)  5.337e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MICAL20.957
CLSTN30.956
KCNB10.954
MADD0.953
RTN4RL10.951
ATP2B30.951
MYH100.95
SEMA4F0.95
AP3B20.949
UBE2O0.949

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.629
REST-0.607
HEY2-0.602
WWTR1-0.573
MBNL3-0.57
RAI14-0.569
ASB4-0.566
RNF135-0.565
COPZ2-0.561
MYL3-0.556

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of AACS mRNA"21354444
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of AACS mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of AACS mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of AACS mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of AACS mRNA"23196670
C0502243,5,5-trimethylhexanoylferrocene"3,5,5-trimethylhexanoylferrocene results in increased expression of AACS protein"22649188
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of AACS mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of AACS mRNA25064622
D000082AcetaminophenAcetaminophen results in increased expression of AACS mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of AACS mRNA17562736
C006418adrenocorticotropin zincadrenocorticotropin zinc results in decreased expression of AACS mRNA19920212
D000638AmiodaroneAmiodarone affects the expression of AACS mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AACS mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of AACS mRNA24449571
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of AACS mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AACS mRNA19770486|2171566
D004958EstradiolEstradiol results in decreased expression of AACS mRNA19484750
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid affects the expression of AACS mRNA18192240
C006780bisphenol Abisphenol A affects the expression of AACS mRNA21786754|2355768
C006780bisphenol Abisphenol A affects the methylation of AACS promoter27334623
C006780bisphenol Abisphenol A results in increased expression of AACS mRNA21932408|2527062
C006780bisphenol Abisphenol A results in increased expression of AACS mRNA24988533|2518105
C584509C646 compoundC646 compound results in increased expression of AACS mRNA26191083
D002220CarbamazepineCarbamazepine affects the expression of AACS mRNA25979313
D002746ChlorpromazineChlorpromazine affects the expression of AACS mRNA25064622
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of AACS mRNA28472532
D003042CocaineCocaine affects the expression of AACS mRNA20187946
D003300CopperCopper results in decreased expression of AACS mRNA17205981
D016572CyclosporineCyclosporine affects the expression of AACS mRNA25064622
D016572CyclosporineCyclosporine results in increased expression of AACS mRNA20106945
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of AACS mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of AACS mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of AACS mRNA21266533
D002945CisplatinCisplatin results in increased expression of AACS mRNA27594783
D004008DiclofenacDiclofenac results in decreased expression of AACS mRNA26934552
D004041Dietary FatsDietary Fats affects the expression of AACS mRNA19680557
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of AACS mRNA28433925
D004041Dietary FatsDietary Fats results in decreased expression of AACS mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of AACS mRNA25016146
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of AACS mRNA28433925
D019422Dietary SucroseDietary Sucrose results in increased expression of AACS mRNA26033743
D004317DoxorubicinDoxorubicin affects the methylation of AACS gene28962528
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of AACS mRNA25064622
C007738fluoranthenefluoranthene results in decreased expression of AACS mRNA28329830
C061365flusilazoleflusilazole results in increased expression of AACS mRNA28263823
C039281furanfuran results in decreased methylation of AACS gene27387713
C039281furanfuran results in increased expression of AACS mRNA27387713
D005944GlucosamineGlucosamine results in increased expression of AACS mRNA17178593
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of AACS mRNA22634610
C010176halofuginonehalofuginone results in decreased expression of AACS mRNA17180598
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of AACS mRNA25613284
C005219methyl cellosolvemethyl cellosolve results in increased expression of AACS mRNA21061450
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of AACS mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of AACS mRNA"25620056
D009532NickelNickel results in decreased expression of AACS mRNA25583101
D009538NicotineNicotine results in decreased expression of AACS mRNA26776438
D009538NicotineNicotine results in increased methylation of AACS promoter26776438
D000073878Palm OilPalm Oil affects the expression of AACS mRNA19680557
D000073878Palm OilPalm Oil results in decreased expression of AACS mRNA18042831
D010269ParaquatParaquat affects the expression of AACS mRNA25064622
D010634PhenobarbitalPhenobarbital results in decreased expression of AACS mRNA19270015
D010634PhenobarbitalPhenobarbital results in increased expression of AACS mRNA23091169
D010795Phthalic AcidsPhthalic Acids results in decreased expression of AACS mRNA15728792
D010795Phthalic AcidsPhthalic Acids results in increased expression of AACS mRNA21061450
C006253pirinixic acidpirinixic acid results in decreased expression of AACS mRNA18445702|2381119
C006253pirinixic acidpirinixic acid results in increased expression of AACS mRNA18301758
D011285Pregnenolone CarbonitrileNR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of AACS mRNA]22698814
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of AACS mRNA28903501
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of AACS mRNA22698814
D011441PropylthiouracilPropylthiouracil results in decreased expression of AACS mRNA24780913
C059514resveratrolresveratrol results in increased expression of AACS protein25505154
D015474IsotretinoinIsotretinoin results in decreased expression of AACS mRNA20436886
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of AACS mRNA21427059
D012969Sodium FluorideSodium Fluoride results in decreased expression of AACS protein28918527
C013698tallowtallow affects the expression of AACS mRNA19680557
D013629TamoxifenTamoxifen affects the expression of AACS mRNA20937368
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate promotes the reaction [LEP gene mutant form results in increased expression of AACS mRNA]21079772
D013739TestosteroneTestosterone results in increased expression of AACS mRNA16579987
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AACS mRNA26377647|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AACS mRNA18295293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AACS mRNA21215274
D013752TetracyclineTetracycline affects the expression of AACS mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of AACS mRNA25064622
C009495titanium dioxidetitanium dioxide results in decreased expression of AACS mRNA23557971
C032910triadimefontriadimefon results in increased expression of AACS mRNA17178688
D014520UrethaneUrethane results in increased expression of AACS mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of AACS mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of AACS mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of AACS mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of AACS mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of AACS mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:0005524ATP binding-IEA-  
GO:0030729acetoacetate-CoA ligase activity-TAS-  
GO:0047760butyrate-CoA ligase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001889liver development-IEA-  
GO:0006631fatty acid metabolic process-IEA-  
GO:0007584response to nutrient-IEA-  
GO:0014074response to purine-containing compound-IEA-  
GO:0032024positive regulation of insulin secretion-IEA-  
GO:0034201response to oleic acid-IEA-  
GO:0042594response to starvation-IEA-  
GO:0045471response to ethanol-IEA-  
GO:0046951ketone body biosynthetic process-TAS-  
GO:0050872white fat cell differentiation-IEA-  
GO:0060612adipose tissue development-IEA-  
GO:0071333cellular response to glucose stimulus-IEA-  
GO:0071394cellular response to testosterone stimulus-IEA-  
GO:0071397cellular response to cholesterol-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00650Butanoate metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-74182Ketone body metabolismTAS
R-HSA-77111Synthesis of Ketone BodiesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22561175Quantitative assessment of abdominal aortic calcification and associations with lumbar intervertebral disc height loss: the Framingham Study. (2012 Apr)Suri PSpine J