Gene: DDRGK1

65992
C20orf116|SEMDSH|UFBP1|dJ1187M17.3
DDRGK domain containing 1
protein-coding
20p13
Ensembl:ENSG00000198171 MIM:616177 Vega:OTTHUMG00000031732 UniprotKB:Q96HY6
NC_000020.11
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.119e-1 (AD)  1.186e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAP7D10.941
LONP10.933
EGLN20.933
MRPS50.927
SAFB0.924
ATG4B0.921
NDUFV10.92
STK250.917
U2AF20.917
WIPI20.915

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.744
OR4F29-0.721
KCNJ15-0.354
IL18RAP-0.344
CXCR2-0.335
CEACAM3-0.334
HBD-0.331
FCGR3B-0.328
CXCR1-0.326
MTRNR2L6-0.324

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D020106AcrylamideAcrylamide results in decreased expression of DDRGK1 mRNA28959563
D001280AtrazineAtrazine results in decreased expression of DDRGK1 mRNA25929836
C006780bisphenol Abisphenol A affects the expression of DDRGK1 mRNA21786754
D019833GenisteinESR2 promotes the reaction [Genistein results in decreased expression of DDRGK1 protein]20884965
D019833GenisteinGenistein results in decreased expression of DDRGK1 protein20884965
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DDRGK1 mRNA25613284
D007657Ketone BodiesKetone Bodies results in decreased expression of DDRGK1 mRNA16807920
C045463leflunomideleflunomide results in increased expression of DDRGK1 mRNA24136188
C029938nickel sulfatenickel sulfate results in decreased expression of DDRGK1 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in increased expression of DDRGK1 protein23718831
C045950propiconazolepropiconazole results in decreased expression of DDRGK1 mRNA21278054
C009277sodium arsenatesodium arsenate results in decreased expression of DDRGK1 mRNA23922661
C017947sodium arsenitesodium arsenite results in decreased expression of DDRGK1 mRNA22714537
D018038Sodium SeleniteSodium Selenite results in increased expression of DDRGK1 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DDRGK1 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DDRGK1 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of DDRGK1 mRNA28065790
D014635Valproic AcidValproic Acid affects the expression of DDRGK1 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DDRGK1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001103RNA polymerase II repressing transcription factor binding-IDA23675531  
GO:0005515protein binding-IPI20018847  20228063  23675531  25219498  
GO:0044389ubiquitin-like protein ligase binding-IPI25219498  
GO ID GO Term Qualifier Evidence PubMed
GO:0008284positive regulation of cell proliferation-IMP23675531  
GO:0010628positive regulation of gene expression-IMP23675531  
GO:0010629negative regulation of gene expression-IMP23675531  
GO:0030335positive regulation of cell migration-IMP23675531  
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process-IMP23675531  
GO:0033146regulation of intracellular estrogen receptor signaling pathway-IDA25219498  
GO:0034976response to endoplasmic reticulum stress-ISS-  
GO:0043066negative regulation of apoptotic process-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP23675531  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IMP23675531  
GO:1901800positive regulation of proteasomal protein catabolic process-IMP23675531  
GO:1902808positive regulation of cell cycle G1/S phase transition-IC23675531  
GO:1903721positive regulation of I-kappaB phosphorylation-IMP23675531  
GO:1905050positive regulation of metallopeptidase activity-IMP23675531  
GO:1905552positive regulation of protein localization to endoplasmic reticulum-ISS-  
GO:1905636positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding-IMP23675531  
GO:1990592protein K69-linked ufmylation-IDA25219498  
GO ID GO Term Qualifier Evidence PubMed
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-TAS23675531  
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005783endoplasmic reticulum-IDA20018847  
GO:0005789endoplasmic reticulum membrane-IDA20228063  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28104585RCAD/BiP pathway is necessary for the proper synthesis of digestive enzymes and secretory function of the exocrine pancreas. (2017 Mar 1)Miller CAm J Physiol Gastrointest Liver Physiol