Gene: BMX

660
ETK|PSCTK2|PSCTK3
BMX non-receptor tyrosine kinase
protein-coding
Xp22.2
Ensembl:ENSG00000102010 MIM:300101 Vega:OTTHUMG00000021180 UniprotKB:P51813
NG_013227.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRABD2B0.925
BMP50.921
IRF60.904
MYOCD0.903
FOXD20.895
TBX180.879
PTGDR0.877
COL8A10.868
GPX80.864
ALX40.862

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.464
FEZF2-0.413
FAM43B-0.413
NDP-0.402
HHATL-0.399
CCDC24-0.392
DBP-0.383
HAGHL-0.381
BDH1-0.378
PURG-0.377

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of BMX mRNA26690555
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of BMX mRNA24449571
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of BMX mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BMX mRNA22228805
C006780bisphenol Abisphenol A results in decreased methylation of BMX promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of BMX mRNA25181051
D002737ChloropreneChloroprene results in increased expression of BMX mRNA23125180
D060729Coal AshCoal Ash results in decreased expression of BMX mRNA19000753
C018021cobaltous chloridecobaltous chloride results in decreased expression of BMX mRNA19320972
D003300Copper[Thiosemicarbazones binds to Copper] which results in increased expression of BMX protein20931265
D019327Copper SulfateCopper Sulfate results in increased expression of BMX mRNA19549813
D016572CyclosporineCyclosporine results in increased methylation of BMX promoter27989131
D004317DoxorubicinBMX protein affects the susceptibility to Doxorubicin21861773
C568507N-(2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide"N-(2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide results in decreased activity of BMX protein"21888390
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of BMX mRNA"15585362
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of BMX mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of BMX mRNA"25554681
D009853OmeprazoleBMX mRNA affects the reaction [Omeprazole results in increased activity of AHR protein]21861773
C545373ponatinibponatinib results in decreased activity of BMX protein19878872
D011441PropylthiouracilPropylthiouracil results in decreased expression of BMX mRNA24780913
D053260SootSoot results in decreased expression of BMX mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BMX mRNA23152189
D013882Thiosemicarbazones[Thiosemicarbazones binds to Copper] which results in increased expression of BMX protein20931265
D014635Valproic AcidValproic Acid results in decreased methylation of BMX gene29154799
D014639VanadiumVanadium results in decreased expression of BMX mRNA19000753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004713protein tyrosine kinase activity-TAS7970727  
GO:0004715non-membrane spanning protein tyrosine kinase activity-IBA21873635  
GO:0004715non-membrane spanning protein tyrosine kinase activity-IDA10688651  11331870  
GO:0004715non-membrane spanning protein tyrosine kinase activity-TAS-  
GO:0005102signaling receptor binding-IBA21873635  
GO:0005515protein binding-IPI10688651  11331870  16186805  25416956  25814554  
GO:0005524ATP binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002250adaptive immune response-IBA21873635  
GO:0006468protein phosphorylation-TAS7970727  
GO:0006661phosphatidylinositol biosynthetic process-TAS-  
GO:0006915apoptotic process-IEA-  
GO:0007155cell adhesion-IEA-  
GO:0007165signal transduction-IDA10688651  11331870  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-IBA21873635  
GO:0007498mesoderm development-TAS9520419  
GO:0030154cell differentiation-IBA21873635  
GO:0035556intracellular signal transduction-IEA-  
GO:0038083peptidyl-tyrosine autophosphorylation-IBA21873635  
GO:0042127regulation of cell proliferation-IBA21873635  
GO:0045087innate immune response-IBA21873635  
GO:0046777protein autophosphorylation-IDA11331870  
GO:0050852T cell receptor signaling pathway-IBA21873635  
GO:0050853B cell receptor signaling pathway-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0031234extrinsic component of cytoplasmic side of plasma membrane-IBA21873635  
GO:0032587ruffle membrane-IDA11331870  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisTAS
R-HSA-111465Apoptotic cleavage of cellular proteinsTAS
R-HSA-1430728MetabolismTAS
R-HSA-1483255PI MetabolismTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-1660499Synthesis of PIPs at the plasma membraneTAS
R-HSA-5357801Programmed Cell DeathTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-75153Apoptotic execution phaseTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27378077Adolescents' ratings of features of parks that encourage park visitation and physical activity. (2016 Jul 4)Veitch JInt J Behav Nutr Phys Act