Gene: LYNX1

66004
-
Ly6/neurotoxin 1
protein-coding
8q24.3
Ensembl:ENSG00000180155 MIM:606110 Vega:OTTHUMG00000164694 UniprotKB:P0DP58
NC_000008.11
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.520e-1 (AD)  8.624e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYNGR10.956
RNF1570.955
CLSTN10.951
KNDC10.95
NDRG40.948
ATP13A20.948
RAB3A0.948
CAMTA20.947
SCAMP50.946
TOLLIP0.944

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.603
TFPI2-0.571
OR4F29-0.561
WWTR1-0.514
CLEC2B-0.51
KCNJ15-0.507
C1orf87-0.505
IL18RAP-0.504
REST-0.501
BEST3-0.498

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LYNX1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LYNX1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LYNX1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LYNX1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LYNX1 mRNA"25510870
D000109AcetylcholineLYNX1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]19619141
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LYNX1 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of LYNX1 mRNA21298039
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LYNX1 mRNA22228805
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of LYNX1 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of LYNX1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of LYNX1 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of LYNX1 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LYNX1 mRNA20938992
D003471CuprizoneCuprizone results in decreased expression of LYNX1 mRNA26577399
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of LYNX1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of LYNX1 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of LYNX1 mRNA18042831
C082748epibatidineLYNX1 protein promotes the reaction [epibatidine binds to and results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]19619141
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LYNX1 mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LYNX1 mRNA20938992
C069837fullerene C60fullerene C60 results in decreased expression of LYNX1 mRNA19167457
C039281furanfuran results in decreased expression of LYNX1 mRNA27387713
D017313FenretinideFenretinide results in decreased expression of LYNX1 mRNA28973697
C082359imidaclopridLYNX1 protein promotes the reaction [imidacloprid results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]19619141
C016517indole-3-carbinolindole-3-carbinol affects the expression of LYNX1 mRNA21396975
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of LYNX1 mRNA27392435
D008344Maneb[Paraquat co-treated with Maneb] results in decreased expression of LYNX1 mRNA18386188
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LYNX1 mRNA20938992
C028007nickel monoxidenickel monoxide results in decreased expression of LYNX1 mRNA19167457
D009538NicotineNicotine results in increased expression of LYNX1 mRNA15778850
D009538NicotineNicotine results in increased expression of LYNX1 protein15778850
D009602NitrosaminesNitrosamines results in decreased expression of LYNX1 mRNA17280689
D000073878Palm OilPalm Oil results in increased expression of LYNX1 mRNA18042831
D010269Paraquat[Paraquat co-treated with Maneb] results in decreased expression of LYNX1 mRNA18386188
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LYNX1 mRNA"25510870
D011441PropylthiouracilPropylthiouracil results in decreased expression of LYNX1 mRNA24780913
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of LYNX1 mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of LYNX1 mRNA25895662
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of LYNX1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LYNX1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LYNX1 mRNA17942748
D013853ThioacetamideThioacetamide results in decreased expression of LYNX1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of LYNX1 mRNA23557971
C046488trimethyltintrimethyltin results in decreased expression of LYNX1 mRNA24002884
D014635Valproic AcidValproic Acid results in increased methylation of LYNX1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of LYNX1 mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008200ion channel inhibitor activity-IEA-  
GO:0030548acetylcholine receptor regulator activity-IDA21252236  
GO:0030550acetylcholine receptor inhibitor activity-IEA-  
GO:0033130acetylcholine receptor binding-IDA21252236  
GO ID GO Term Qualifier Evidence PubMed
GO:0007271synaptic transmission, cholinergic-IEA-  
GO:0099601regulation of neurotransmitter receptor activity-IDA21252236  
GO:2000272negative regulation of signaling receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IEA-  
GO:0005886plasma membrane-IEA-  
GO:0030425dendrite-IEA-  
GO:0031225anchored component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
14764638Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells. (2004 May)Proskocil BJEndocrinology
15778850Expression of lynx1 in developing lung and its modulation by prenatal nicotine exposure. (2005 May)Sekhon HSCell Tissue Res
26586467The prototoxin LYPD6B modulates heteromeric alpha3beta4-containing nicotinic acetylcholine receptors, but not alpha7 homomers. (2016 Mar)Ochoa VFASEB J
22923641The ly-6 protein, lynx1, is an endogenous inhibitor of nicotinic signaling in airway epithelium. (2012 Oct 15)Fu XWAm J Physiol Lung Cell Mol Physiol