Gene: CHID1

66005
GL008|SI-CLP|SICLP
chitinase domain containing 1
protein-coding
11p15.5
Ensembl:ENSG00000177830 MIM:615692 Vega:OTTHUMG00000133314 UniprotKB:Q9BWS9
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.251e-1 (AD)  7.926e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11053561chr11:869492CHID13'UTR4.620e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PMM10.925
NDUFV10.921
CDIPT0.92
NDUFC20.916
MANBAL0.915
LRPAP10.913
NCAPH20.913
YIF1B0.911
RUVBL20.911
TIMM500.911

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.673
OR4F29-0.631
MTRNR2L6-0.419
MTRNR2L9-0.408
EBF1-0.401
PABPC4L-0.398
SIX1-0.391
P2RY14-0.39
MTRNR2L10-0.388
IL18RAP-0.385

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CHID1 mRNA"28903501
D000082AcetaminophenAcetaminophen affects the expression of CHID1 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of CHID1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CHID1 mRNA27153756
D001151ArsenicArsenic affects the methylation of CHID1 gene25304211
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CHID1 mRNA28628672
C006780bisphenol Abisphenol A results in increased methylation of CHID1 promoter27312807
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of CHID1 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of CHID1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CHID1 mRNA28628672
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CHID1 mRNA27339419
D003907Dexamethasone[Dexamethasone co-treated with IL4 protein] results in increased expression of CHID1 mRNA16357325
D003907Dexamethasone[Dexamethasone co-treated with IL4 protein] results in increased expression of CHID1 protein16357325
D003907DexamethasoneDexamethasone results in increased expression of CHID1 mRNA16357325
D003907DexamethasoneIFNG protein inhibits the reaction [[Dexamethasone co-treated with IL4 protein] results in increased expression of CHID1 mRNA]16357325
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CHID1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CHID1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CHID1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of CHID1 mRNA27594783
D011345FenofibrateFenofibrate results in decreased expression of CHID1 mRNA11798191
D005897GlafenineGlafenine results in increased expression of CHID1 mRNA24136188
D017313FenretinideFenretinide results in decreased expression of CHID1 mRNA28973697
C016517indole-3-carbinolindole-3-carbinol affects the expression of CHID1 mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CHID1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CHID1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CHID1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CHID1 mRNA28628672
C410337K 7174K 7174 results in decreased expression of CHID1 mRNA24086573
D007854LeadLead affects the splicing of CHID1 mRNA28903495
C008261lead acetatelead acetate results in increased expression of CHID1 mRNA21829687
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CHID1 mRNA23458150
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CHID1 mRNA"20188158
D008774MethylphenidateMethylphenidate results in decreased expression of CHID1 mRNA22470460
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CHID1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CHID1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CHID1 mRNA"25554681
C012655nimesulidenimesulide results in increased expression of CHID1 mRNA24136188
D010634PhenobarbitalPhenobarbital affects the expression of CHID1 mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of CHID1 mRNA11798191
D012715Sesame OilSesame Oil results in increased expression of CHID1 mRNA29191790
C009277sodium arsenatesodium arsenate results in increased expression of CHID1 mRNA23922661
C017947sodium arsenitesodium arsenite affects the expression of CHID1 mRNA20816728
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of CHID1 mRNA26496021
D019284ThapsigarginThapsigargin results in decreased expression of CHID1 protein24648495
C011559tributyltintributyltin results in decreased expression of CHID1 mRNA29191790
D014241TrichloroethyleneTrichloroethylene results in increased methylation of CHID1 gene27618143
C012589trichostatin Atrichostatin A results in increased expression of CHID1 mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of CHID1 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CHID1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004568chitinase activity-IBA21873635  
GO:0005515protein binding-IPI16357325  
GO:0008061chitin binding-IBA21873635  
GO:0070492oligosaccharide binding-IPI20724479  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0005975carbohydrate metabolic process-IEA-  
GO:0006032chitin catabolic process-IBA21873635  
GO:0045087innate immune response-IEA-  
GO:1900016negative regulation of cytokine production involved in inflammatory response-IDA20724479  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IBA21873635  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA16357325  
GO:0005634nucleus-HDA21630459  
GO:0005764lysosome-IDA16357325  
GO:0005770late endosome-IDA16357325  
GO:0005802trans-Golgi network-IDA16357325  
GO:0016020membrane-HDA19946888  
GO:0043202lysosomal lumen-TAS-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25241909Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease. (2014 Sep 21)Lee JHRespir Res