Gene: SMARCD1

6602
BAF60A|CRACD1|Rsc6p
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
protein-coding
12q13.12
Ensembl:ENSG00000066117 MIM:601735 Vega:OTTHUMG00000150194 UniprotKB:Q96GM5
NC_000012.12
PubMed|SNP Mapped
1   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.591e-1 (AD)  1.996e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3782323chr12:50089138 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CPSF70.928
GTF3C20.919
DNAJB120.916
NAT100.913
PI4KB0.909
XPO60.902
DDX560.902
PIP5K1A0.9
TMEM2140.899
SEC24C0.898

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.728
OR4F29-0.68
KLRC2-0.273
MTRNR2L9-0.205
MTRNR2L6-0.198
IFNG-0.186
IAPP-0.177
OR6C74-0.174
TRDN-0.169
C9orf153-0.167

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SMARCD1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SMARCD1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SMARCD1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SMARCD1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SMARCD1 mRNA"25510870
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SMARCD1 mRNA"18648102
C044887beta-methylcholinebeta-methylcholine affects the expression of SMARCD1 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of SMARCD1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of SMARCD1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SMARCD1 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SMARCD1 mRNA28628672
C018475butyraldehydebutyraldehyde results in decreased expression of SMARCD1 mRNA26079696
D002330CarmustineCarmustine results in increased expression of SMARCD1 mRNA15980968
D004390ChlorpyrifosChlorpyrifos results in decreased expression of SMARCD1 mRNA18668222
D002994ClofibrateClofibrate results in increased expression of SMARCD1 mRNA17585979
D060729Coal AshCoal Ash results in decreased expression of SMARCD1 mRNA19000753
C018021cobaltous chloridecobaltous chloride results in decreased expression of SMARCD1 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of SMARCD1 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of SMARCD1 mRNA19789285
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SMARCD1 mRNA28628672
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMARCD1 mRNA17942748
C492448ICG 001ICG 001 results in decreased expression of SMARCD1 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SMARCD1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SMARCD1 mRNA28628672
D007854LeadLead affects the expression of SMARCD1 mRNA28903495
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SMARCD1 mRNA"25510870
C045950propiconazolepropiconazole results in increased expression of SMARCD1 mRNA21278054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SMARCD1 mRNA11489354
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SMARCD1 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMARCD1 mRNA17942748
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of SMARCD1 mRNA28973375
D013853ThioacetamideThioacetamide results in increased expression of SMARCD1 mRNA23411599
D014635Valproic AcidValproic Acid results in decreased expression of SMARCD1 mRNA23179753
D014639VanadiumVanadium results in decreased expression of SMARCD1 mRNA19000753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IEA-  
GO:0003713transcription coactivator activity-NAS8804307  
GO:0005102signaling receptor binding-IEA-  
GO:0005515protein binding-IPI12917342  15985610  16189514  18303029  21516116  24421395  
24434208  25416956  
GO:0032947protein-containing complex scaffold activity-IDA12917342  
GO ID GO Term Qualifier Evidence PubMed
GO:0006337nucleosome disassembly-IDA8895581  
GO:0006338chromatin remodeling-IDA11726552  
GO:0006338chromatin remodeling-IMP12917342  
GO:0006357regulation of transcription by RNA polymerase II-NAS8804307  
GO:0007399nervous system development-IEA-  
GO:0048096chromatin-mediated maintenance of transcription-IMP12917342  
GO:0071398cellular response to fatty acid-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0016514SWI/SNF complex-IDA8804307  11078522  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0071564npBAF complex-ISS-  
GO:0071565nBAF complex-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3214858RMTs methylate histone argininesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939243RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28981154Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations. (2017 Dec)Mathies LDAlcohol Clin Exp Res