Gene info: ID 6611

Gene: SMS

GENE ID: 6611

Synonyms: MRSR|SPMSY|SRS|SpS

Description: spermine synthase

Gene type: protein-coding

Location: Xp22.11

dbXrefs: Ensembl:ENSG00000102172 MIM:300105 Vega:OTTHUMG00000021239 UniprotKB:P52788

RefSeq: NG_009228.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 9

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DNAJA2	0.95
RAB1A	0.946
VDAC2	0.943
RAN	0.941
TERF2IP	0.941
EIF1B	0.939
ISCU	0.938
RRAGA	0.938
VDAC1	0.938
UBE2Q1	0.938

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.762
OR4F29	-0.704
KLRB1	-0.35
VNN3	-0.343
FCRL1	-0.324
IL18RAP	-0.319
CXCR2	-0.317
TFPI2	-0.315
KCNJ15	-0.314
FZD10	-0.313

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00127	Spermine	Small Molecule	71-44-3	Approved\|Nutraceutical	Target

ID	Drug Name	Action	PubMed
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of SMS mRNA"	18648102
D000082	Acetaminophen	Acetaminophen affects the expression of SMS mRNA	17562736
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of SMS mRNA	18007998
C006632	arsenic trioxide	arsenic trioxide results in increased expression of SMS mRNA	22521957
D001280	Atrazine	Atrazine results in increased expression of SMS mRNA	22378314
D001379	Azathioprine	Azathioprine results in decreased expression of SMS mRNA	19192274
C547126	AZM551248	AZM551248 results in decreased expression of SMS mRNA	22323515
C006780	bisphenol A	bisphenol A results in increased expression of SMS mRNA	15223131\|1800799
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SMS mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of SMS mRNA	21786754
C584509	C646 compound	C646 compound results in decreased expression of SMS mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of SMS protein	24527689
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of SMS mRNA	23741332
C100187	chloropicrin	chloropicrin affects the expression of SMS mRNA	26352163
C100187	chloropicrin	chloropicrin results in decreased expression of SMS mRNA	28476498
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SMS mRNA	28628672
D004041	Dietary Fats	Dietary Fats results in decreased expression of SMS mRNA	18042831
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of SMS mRNA	19850644
D004051	Diethylhexyl Phthalate	PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of SMS mRNA]	19850644
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of SMS mRNA	19638242
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in increased expression of SMS mRNA	27638505
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of SMS mRNA	20227414
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of SMS mRNA	17606305
D005472	Fluorouracil	Fluorouracil results in increased expression of SMS mRNA	15152939
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in decreased expression of SMS mRNA]	15016801
C039281	furan	furan results in increased expression of SMS mRNA	27387713
D005947	Glucose	[INS protein co-treated with Glucose] results in decreased expression of SMS mRNA	22634610
D006052	Gold Sodium Thiomalate	Gold Sodium Thiomalate results in decreased expression of SMS mRNA	19192274
C492448	ICG 001	ICG 001 results in decreased expression of SMS mRNA	26191083
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SMS mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SMS mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SMS mRNA	28628672
D008727	Methotrexate	Methotrexate results in decreased expression of SMS mRNA	19192274
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of SMS mRNA	23649840
D008775	Methylprednisolone	Methylprednisolone results in decreased expression of SMS mRNA	19192274
D015741	Metribolone	Metribolone results in increased expression of SMS protein	17152098
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of SMS mRNA"	25554681
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of SMS mRNA	25729387
D000073878	Palm Oil	Palm Oil results in decreased expression of SMS mRNA	18042831
C006253	pirinixic acid	pirinixic acid results in increased expression of SMS mRNA	18301758\|2381119
D010894	Piroxicam	Piroxicam results in decreased expression of SMS mRNA	19192274
D011239	Prednisolone	Prednisolone results in decreased expression of SMS mRNA	19192274
C045950	propiconazole	propiconazole results in increased expression of SMS mRNA	21278054
D011441	Propylthiouracil	Propylthiouracil results in increased expression of SMS mRNA	24780913
C009277	sodium arsenate	sodium arsenate results in increased expression of SMS mRNA	16882884
C017947	sodium arsenite	sodium arsenite affects the methylation of SMS gene	28589171
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SMS mRNA	24680724
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SMS mRNA	25613284
C014215	tetrahydropalmatine	tetrahydropalmatine results in decreased expression of SMS protein	20109541
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of SMS mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution analog results in decreased expression of SMS mRNA	26489853
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of SMS mRNA	25729387
D014635	Valproic Acid	Valproic Acid results in increased expression of SMS mRNA	26272509
D014640	Vancomycin	Vancomycin results in increased expression of SMS mRNA	18930951
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of SMS mRNA	26682919

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0016768	spermine synthase activity	-	IBA	21873635
GO:0016768	spermine synthase activity	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006555	methionine metabolic process	-	TAS	7546290
GO:0006595	polyamine metabolic process	-	TAS	-
GO:0006597	spermine biosynthetic process	-	IBA	21873635
GO:0006597	spermine biosynthetic process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term
hsa00270	Cysteine and methionine metabolism
hsa00330	Arginine and proline metabolism
hsa00410	beta-Alanine metabolism
hsa00480	Glutathione metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-351202	Metabolism of polyamines	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28350250	Proactive outreach smoking cessation program for Chinese employees in China. (2018 Mar 4)	Wang MP	Arch Environ Occup Health
28978498	A Mobile Phone-Based Life Skills Training Program for Substance Use Prevention Among Adolescents: Pre-Post Study on the Acceptance and Potential Effectiveness of the Program, Ready4life. (2017 Oct 4)	Haug S	JMIR Mhealth Uhealth
28838887	The Use of Mobile Apps and SMS Messaging as Physical and Mental Health Interventions: Systematic Review. (2017 Aug 24)	Rathbone AL	J Med Internet Res
28428157	Texting and Mobile Phone App Interventions for Improving Adherence to Preventive Behavior in Adolescents: A Systematic Review. (2017 Apr 19)	Badawy SM	JMIR Mhealth Uhealth
19279561	Association of nicotine metabolite ratio and CYP2A6 genotype with smoking cessation treatment in African-American light smokers. (2009 Jun)	Ho MK	Clin Pharmacol Ther
27349898	The SmokefreeTXT (SFTXT) Study: Web and Mobile Data Collection to Evaluate Smoking Cessation for Young Adults. (2016 Jun 27)	Squiers L	JMIR Res Protoc
29343463	The Impact of mHealth Interventions: Systematic Review of Systematic Reviews. (2018 Jan 17)	Marcolino MS	JMIR Mhealth Uhealth
26116584	A block randomized controlled trial of a brief smoking cessation counselling and advice through short message service on participants who joined the Quit to Win Contest in Hong Kong. (2015 Aug)	Chan SS	Health Educ Res
28974483	Assessing the National Cancer Institute's SmokefreeMOM Text-Messaging Program for Pregnant Smokers: Pilot Randomized Trial. (2017 Oct 3)	Abroms LC	J Med Internet Res