Gene: SUMO2

6613
HSMT3|SMT3B|SMT3H2|SUMO3|Smt3A
small ubiquitin-like modifier 2
protein-coding
17q25.1
Ensembl:ENSG00000188612 MIM:603042 Vega:OTTHUMG00000179481 UniprotKB:P61956
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.108e-1 (AD)  3.390e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LAMTOR50.949
PARK70.948
GABARAPL20.947
ERH0.943
UBL50.942
MRFAP10.939
YWHAE0.939
CETN20.939
TXN0.938
BTF30.937

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.902
OR4F29-0.884
MTRNR2L6-0.151
MROH9-0.138
CXCL17-0.135
CPN1-0.135
C8orf74-0.133
FANCD2OS-0.132
TAS2R41-0.132
MTRNR2L9-0.131

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SUMO2 mRNA16483693
C006632arsenic trioxidearsenic trioxide affects the localization of SUMO2 protein20943951
C006632arsenic trioxidearsenic trioxide affects the reaction [SUMO2 protein binds to PML protein]26060329
C006632arsenic trioxide[arsenic trioxide affects the reaction [SUMO2 protein binds to PML protein]] promotes the reaction [SUMO1 protein binds to PML protein]26060329
C006632arsenic trioxide[arsenic trioxide affects the reaction [SUMO2 protein binds to PML protein]] which results in increased ubiquitination of PML protein26060329
C006632arsenic trioxidearsenic trioxide promotes the reaction [RNF4 protein binds to SUMO2 protein]20943951
C006632arsenic trioxidearsenic trioxide promotes the reaction [SUMO2 protein binds to PML protein]20943951
C006632arsenic trioxidearsenic trioxide results in increased expression of SUMO2 mRNA20458559
C006632arsenic trioxidearsenic trioxide results in increased sumoylation of SUMO2 protein28318385
C006632arsenic trioxideRNF4 protein promotes the reaction [arsenic trioxide affects the localization of SUMO2 protein]20943951
C006632arsenic trioxideSENP1 protein promotes the reaction [arsenic trioxide affects the reaction [SUMO2 protein binds to PML protein]]26060329
C006632arsenic trioxideSUMO2 protein mutant form inhibits the reaction [arsenic trioxide affects the reaction [SUMO2 protein binds to PML protein]]26060329
C006632arsenic trioxideSUMO2 protein mutant form inhibits the reaction [arsenic trioxide promotes the reaction [SUMO1 protein binds to PML protein]]26060329
C006632arsenic trioxideSUMO2 protein mutant form inhibits the reaction [arsenic trioxide results in increased ubiquitination of PML protein]26060329
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SUMO2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SUMO2 protein"20416286
C006780bisphenol Abisphenol A affects the expression of SUMO2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of SUMO2 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of SUMO2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SUMO2 mRNA28628672
D019256Cadmium Chloride[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of SUMO2 mRNA19840844
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SUMO2 mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of SUMO2 promoter22457795
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SUMO2 mRNA23650126
C100187chloropicrinchloropicrin results in decreased expression of SUMO2 mRNA28476498
C031180chrysenechrysene results in decreased expression of SUMO2 mRNA26377693
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of SUMO2 mRNA24690739
D019327Copper SulfateCopper Sulfate results in decreased expression of SUMO2 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of SUMO2 mRNA19789285
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SUMO2 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SUMO2 mRNA17361019|2126653
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of SUMO2 mRNA24690739
D005033EthylmaleimideEthylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein]26060329
D005033EthylmaleimideEthylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein]26060329
D005419FlavonoidsFlavonoids results in decreased expression of SUMO2 mRNA18035473
D005485FlutamideFlutamide results in increased expression of SUMO2 mRNA24136188
D005839GentamicinsGentamicins results in increased expression of SUMO2 mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SUMO2 mRNA21179406
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SUMO2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SUMO2 mRNA28628672
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SUMO2 mRNA"18930950
D008748MethylcholanthreneMethylcholanthrene results in increased expression of SUMO2 mRNA18804290
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of SUMO2 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of SUMO2 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SUMO2 mRNA19840844
D009151Mustard GasMustard Gas results in increased expression of SUMO2 mRNA12884408
C012655nimesulidenimesulide results in increased expression of SUMO2 mRNA24136188
D019319Okadaic Acid[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of SUMO2 mRNA19840844
D010578PetroleumPetroleum affects the expression of SUMO2 mRNA25208076
C006253pirinixic acidpirinixic acid results in increased expression of SUMO2 mRNA18301758
D012643SeleniumSelenium results in increased expression of SUMO2 mRNA19244175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SUMO2 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SUMO2 mRNA19840844
D014241TrichloroethyleneTrichloroethylene results in increased methylation of SUMO2 gene27618143
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SUMO2 mRNA"18930950
D014635Valproic AcidValproic Acid results in decreased expression of SUMO2 mRNA19101580|2317975
D014810Vitamin EVitamin E results in increased expression of SUMO2 mRNA19244175
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of SUMO2 mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001222transcription corepressor binding-IPI17081986  
GO:0003723RNA binding-HDA22681889  
GO:0005515protein binding-IPI15383276  16169070  17081986  17099698  17099700  17491593  
20016594  20016603  20802522  21212807  21252943  21326211  
21900206  21965678  21988832  22878415  25416956  
GO:0031386protein tag-IBA21873635  
GO:0031625ubiquitin protein ligase binding-IPI18408734  
GO ID GO Term Qualifier Evidence PubMed
GO:0016925protein sumoylation-IBA21873635  
GO:0016925protein sumoylation-IDA17081986  17696781  21965678  24105744  
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process-IDA18408734  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA21965678  
GO:0005654nucleoplasm-TAS-  
GO:0016605PML body-IDA22406621  
KEGG ID KEGG Term
hsa03013RNA transport
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196791Vitamin D (calciferol) metabolismTAS
R-HSA-2990846SUMOylationIEA
R-HSA-2990846SUMOylationTAS
R-HSA-3065676SUMO is conjugated to E1 (UBA2:SAE1)IEA
R-HSA-3065678SUMO is transferred from E1 to E2 (UBE2I, UBC9)IEA
R-HSA-3065679SUMO is proteolytically processedTAS
R-HSA-3108214SUMOylation of DNA damage response and repair proteinsTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-3215018Processing and activation of SUMOIEA
R-HSA-3215018Processing and activation of SUMOTAS
R-HSA-3232118SUMOylation of transcription factorsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4551638SUMOylation of chromatin organization proteinsTAS
R-HSA-4570464SUMOylation of RNA binding proteinsTAS
R-HSA-4615885SUMOylation of DNA replication proteinsTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-5696395Formation of Incision Complex in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-597592Post-translational protein modificationIEA
R-HSA-597592Post-translational protein modificationTAS
R-HSA-73894DNA RepairTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27181202SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer. (2016 Nov 10)Zhou ZOncogene