Gene: SNAI1

6615
SLUGH2|SNA|SNAH|SNAIL|SNAIL1|dJ710H13.1
snail family transcriptional repressor 1
protein-coding
20q13.13
Ensembl:ENSG00000124216 MIM:604238 Vega:OTTHUMG00000033048 UniprotKB:O95863
NC_000020.11
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.273e-2 (AD)  4.559e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NFKB20.802
FOSL10.783
ICAM10.777
ZC3H12A0.774
PLAUR0.764
PNP0.755
SERPINH10.753
HSPA60.747
MAP2K30.746
RNF1220.743

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAPLN1-0.432
LHX6-0.425
CNTN6-0.413
KCNS2-0.405
CASC15-0.401
RGS7BP-0.399
CCDC177-0.398
DOK6-0.394
NXPH2-0.394
FAM19A2-0.39

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5326571,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one"1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one analog inhibits the reaction [Asbestos, Serpentine affects the localization of SNAI1 protein]"26685284
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in decreased expression of SNAI1 mRNA25827057
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]25656647
C5259212-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine"2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine results in decreased expression of SNAI1 mRNA"24497940
C1214792,4-dihydroxybenzophenone"2,4-dihydroxybenzophenone results in increased expression of SNAI1 protein"27145024
C1214792,4-dihydroxybenzophenone"fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of SNAI1 protein]"27145024
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 protein]25118938
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]25656647
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of SNAI1 protein23921149
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneSB 216763 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 protein]]25118938
C0281452'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine[2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine results in decreased activity of NOTCH1 protein] which affects the expression of SNAI1 protein20348013
C0163923,3'-diindolylmethane"3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of SNAI1 protein]"28844962
C0163923,3'-diindolylmethane"3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of SNAI1 protein]"28844962
C0163923,3'-diindolylmethane"3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of SNAI1 protein]"28844962
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SNAI1 mRNA"28284859
C0230353,4,5,3',4'-pentachlorobiphenyl"Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SNAI1 mRNA]"28284859
C0230353,4,5,3',4'-pentachlorobiphenyl"AHR mRNA promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SNAI1 mRNA]"28284859
C0230353,4,5,3',4'-pentachlorobiphenyl"fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SNAI1 mRNA]"28284859
C0230353,4,5,3',4'-pentachlorobiphenyl"PKM protein promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SNAI1 mRNA]"28284859
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SNAI1 mRNA"23196670
C4972863,4',5-trimethoxystilbene"3,4',5-trimethoxystilbene promotes the reaction [Tamoxifen results in decreased expression of SNAI1 protein]"23921149
C4972863,4',5-trimethoxystilbene"3,4',5-trimethoxystilbene results in decreased expression of SNAI1 protein"23921149
C4972863,4',5-trimethoxystilbene"Tamoxifen promotes the reaction [3,4',5-trimethoxystilbene results in decreased expression of SNAI1 protein]"23921149
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of SNAI1 mRNA16788091
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]25656647
C4949143,5,3',4',5'-pentamethoxystilbene"3,5,3',4',5'-pentamethoxystilbene results in decreased expression of SNAI1 protein"23921149
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of SNAI1 protein27145024
C1052604-tert-octylphenolfulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of SNAI1 protein]27145024
D000082AcetaminophenAcetaminophen affects the expression of SNAI1 mRNA17562736
D000111Acetylcysteine"Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SNAI1 mRNA]"28284859
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]17596522
D000111AcetylcysteineAcetylcysteine inhibits the reaction [benz(a)anthracene results in increased expression of SNAI1 mRNA]21635667
D000111AcetylcysteineAcetylcysteine inhibits the reaction [benzo(k)fluoranthene results in increased expression of SNAI1 mRNA]21635667
D000111Acetylcysteine"Acetylcysteine inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of SNAI1 mRNA]"21635667
D000450AldosteroneAcetylcysteine inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]17596522
D000450AldosteroneAldosterone results in increased expression of SNAI1 mRNA17596522
D000450Aldosteroneeplerenone inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]17596522
D000450AldosteroneRotenone inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]17596522
D000450AldosteroneU 0126 inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]17596522
C526957alisol B 23-acetatealisol B 23-acetate inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]28578904
C526957alisol B 23-acetatealisol B 23-acetate inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]28578904
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of SNAI1 mRNA16541421
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of SNAI1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SNAI1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SNAI1 mRNA24449571
C545357antroquinonolantroquinonol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]25656647
C006632arsenic trioxidearsenic trioxide results in decreased expression of SNAI1 mRNA25304214
C006632arsenic trioxidearsenic trioxide results in decreased expression of SNAI1 protein24680928
C006632arsenic trioxideMIR491 affects the reaction [arsenic trioxide results in decreased expression of SNAI1 mRNA]25304214
C006632arsenic trioxideMIR491 mRNA affects the reaction [arsenic trioxide results in decreased expression of SNAI1 protein]24680928
C030935benz(a)anthraceneAcetylcysteine inhibits the reaction [benz(a)anthracene results in increased expression of SNAI1 mRNA]21635667
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of SNAI1 mRNA21635667
C030935benz(a)anthraceneSB 203580 inhibits the reaction [benz(a)anthracene results in increased expression of SNAI1 mRNA]21635667
C022921benzo(k)fluorantheneAcetylcysteine inhibits the reaction [benzo(k)fluoranthene results in increased expression of SNAI1 mRNA]21635667
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of SNAI1 mRNA21635667
C022921benzo(k)fluorantheneSB 203580 inhibits the reaction [benzo(k)fluoranthene results in increased expression of SNAI1 mRNA]21635667
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SNAI1 mRNA20064835|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of SNAI1 gene25435355
D004958Estradiol"3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of SNAI1 protein]"28844962
D004958EstradiolEstradiol results in decreased expression of SNAI1 protein15955695
D004958EstradiolEstradiol results in increased expression of SNAI1 mRNA25690688
D004958EstradiolEstradiol results in increased expression of SNAI1 protein25690688|2753925
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of SNAI1 mRNA]25690688
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of SNAI1 protein]25690688|2753925
D004958EstradiolEstradiol results in increased expression of SNAI1 mRNA19484750
C006780bisphenol A"3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of SNAI1 protein]"28844962
C006780bisphenol Abisphenol A results in increased expression of SNAI1 mRNA25690688|2927551
C006780bisphenol Abisphenol A results in increased expression of SNAI1 protein25690688|2884496
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI1 mRNA]25690688
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI1 protein]25690688|2884496
C006780bisphenol Abisphenol A results in increased expression of SNAI1 mRNA27480627
C006780bisphenol Abisphenol A results in increased expression of SNAI1 protein27480627
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI1 mRNA]27480627
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI1 protein]27480627
C006780bisphenol ASNAI1 protein promotes the reaction [bisphenol A results in decreased expression of CDH1 protein]27480627
C006780bisphenol ASNAI1 protein promotes the reaction [bisphenol A results in increased expression of VIM protein]27480627
C006780bisphenol Abisphenol A results in increased expression of SNAI1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SNAI1 gene28505145
C006780bisphenol AESR1 protein promotes the reaction [bisphenol A results in increased expression of SNAI1 mRNA]27480627
C018475butyraldehydebutyraldehyde results in increased expression of SNAI1 mRNA26079696
D019256Cadmium Chloride2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 protein]25118938
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SNAI1 protein25118938
D019256Cadmium ChlorideNOTCH1 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 protein]25118938
D019256Cadmium ChlorideSB 216763 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 protein]]25118938
D019256Cadmium ChlorideSNAI1 mutant form inhibits the reaction [Cadmium Chloride results in decreased expression of CDH1 protein]25118938
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SNAI1 mRNA25827057
D002331CarnitineCarnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of SNAI1 protein]28973641
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of SNAI1 mRNA24763279
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of SNAI1 mRNA27481218
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of SNAI1 protein27481218
D020111Chlorodiphenyl (54% Chlorine)MIR30D mRNA inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of SNAI1 mRNA]27481218
D020111Chlorodiphenyl (54% Chlorine)MIR30D mRNA inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of SNAI1 protein]27481218
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SNAI1 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SNAI1 protein23518002
D002939CiprofloxacinCiprofloxacin results in decreased expression of SNAI1 protein26947806
C018021cobaltous chloridecobaltous chloride results in increased expression of and affects the localization of SNAI1 protein26174737
C018021cobaltous chloridetetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of and affects the localization of SNAI1 protein]26174737
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of SNAI1 mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of SNAI1 mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of SNAI1 mRNA22077320
D003474CurcuminCurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]25656647
C057862cyanoginosin LRcyanoginosin LR results in increased expression of SNAI1 mRNA27856280
C057862cyanoginosin LRcyanoginosin LR results in increased expression of SNAI1 protein27856280
C057862cyanoginosin LRSMAD2 protein affects the reaction [cyanoginosin LR results in increased expression of SNAI1 protein]27856280
D016572CyclosporineCyclosporine results in increased expression of and results in increased stability of SNAI1 protein22416070
D016572Cyclosporine[GSK3A protein co-treated with GSK3B protein] affects the reaction [Cyclosporine results in increased expression of SNAI1 protein]22416070
D016572CyclosporineCyclosporine results in increased expression of SNAI1 protein22416070
D016572CyclosporineSNAI1 protein affects the reaction [Cyclosporine results in decreased expression of CDH1 protein]22416070
D015638Cytochalasin DCytochalasin D affects the localization of SNAI1 protein25756282
C014347decitabinedecitabine results in increased expression of SNAI1 mRNA16367923
C107676deguelindeguelin inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]22986522
C107676deguelindeguelin results in decreased expression of SNAI1 mRNA19861542
C107676deguelindeguelin results in decreased expression of SNAI1 protein22986522
D003907DexamethasoneDexamethasone results in decreased expression of SNAI1 mRNA25047013
C028009diallyl disulfidediallyl disulfide results in decreased expression of SNAI1 mRNA20600798
C028009diallyl disulfidediallyl disulfide results in decreased expression of SNAI1 protein20600798
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of SNAI1 protein27566995
C042577diallyl trisulfideLDHA protein inhibits the reaction [diallyl trisulfide results in decreased expression of SNAI1 protein]27566995
D003976DiazinonDiazinon results in increased methylation of SNAI1 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SNAI1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SNAI1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of SNAI1 mRNA21618587
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SNAI1 mRNA28085963
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of SNAI1 mRNA20146380
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of SNAI1 mRNA28939011
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of SNAI1 mRNA24690739
C010945embelinembelin results in decreased expression of SNAI1 protein24694877
D004726EndosulfanEndosulfan affects the localization of SNAI1 protein22677888
D004726EndosulfanEndosulfan results in increased expression of SNAI1 mRNA22677888
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of SNAI1 mRNA22079256
C414690eplerenoneeplerenone inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]17596522
C015860ergosta-4,6,8(14),22-tetraen-3-one"ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]"28578904
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SNAI1 mRNA17557909
C108339fludioxonilfludioxonil results in increased expression of SNAI1 protein27539251
C108339fludioxonilfulvestrant inhibits the reaction [fludioxonil results in increased expression of SNAI1 protein]27539251
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SNAI1 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of SNAI1 mRNA28937961
C070081fulvestrant"fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of SNAI1 protein]"27145024
C070081fulvestrant"fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SNAI1 mRNA]"28284859
C070081fulvestrantfulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of SNAI1 protein]27145024
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI1 mRNA]25690688
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI1 protein]25690688|2884496
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of SNAI1 mRNA]25690688
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of SNAI1 protein]25690688|2753925
C070081fulvestrantfulvestrant inhibits the reaction [fludioxonil results in increased expression of SNAI1 protein]27539251
C070081fulvestrantfulvestrant inhibits the reaction [nonylphenol results in increased expression of SNAI1 mRNA]25690688
C070081fulvestrantfulvestrant inhibits the reaction [nonylphenol results in increased expression of SNAI1 protein]25690688
C070081fulvestrantfulvestrant inhibits the reaction [Triclosan results in increased expression of SNAI1 protein]28844962
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI1 mRNA]27480627
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI1 protein]27480627
C039281furanfuran results in increased expression of SNAI1 mRNA27387713
C007845gingerolgingerol inhibits the reaction [Glucose results in increased expression of SNAI1 mRNA]21829520
C097367ginsenoside Rg3ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]24793912
C097367ginsenoside Rg3ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]24793912
D005947Glucosegingerol inhibits the reaction [Glucose results in increased expression of SNAI1 mRNA]21829520
D005947GlucoseGlucose results in increased expression of SNAI1 mRNA21829520
D005947GlucoseMAPK14 protein promotes the reaction [Glucose results in increased expression of SNAI1 mRNA]21829520
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of SNAI1 mRNA24763279
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of SNAI1 protein22580338
C492448ICG 001ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]28578904
C492448ICG 001Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]28578904
C492448ICG 001ICG 001 inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]28578904
C041508indeno(1,2,3-cd)pyrene"Acetylcysteine inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of SNAI1 mRNA]"21635667
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in increased expression of SNAI1 mRNA"21635667
C041508indeno(1,2,3-cd)pyrene"SB 203580 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of SNAI1 mRNA]"21635667
C057531jasplakinolidejasplakinolide inhibits the reaction [AHNAK protein affects the localization of SNAI1 protein]20388789
C057531jasplakinolidejasplakinolide inhibits the reaction [EIF4E protein affects the localization of SNAI1 protein]20388789
C057531jasplakinolidejasplakinolide inhibits the reaction [S100A1 protein affects the localization of SNAI1 protein]20388789
C057531jasplakinolidejasplakinolide inhibits the reaction [SEPT9 protein affects the localization of SNAI1 protein]20388789
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SNAI1 mRNA27392435
C490728lapatinib[lapatinib results in decreased susceptibility to lapatinib] which results in increased expression of SNAI1 protein26643609
C490728lapatinibNiclosamide inhibits the reaction [[lapatinib results in decreased susceptibility to lapatinib] which results in increased expression of SNAI1 protein]26643609
C490728lapatinibSNAI1 protein results in decreased susceptibility to lapatinib26643609
C045463leflunomideleflunomide results in increased expression of SNAI1 mRNA28988120
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SNAI1 protein22344225
D018021Lithium ChlorideLithium Chloride results in decreased degradation of SNAI1 protein20348013
D018021Lithium Chloride[Lithium Chloride results in decreased degradation of SNAI1 protein] which affects the expression of CDH1 protein20348013
D018021Lithium Chloride[Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein] which results in decreased expression of SNAI1 protein19440036
D019808LosartanICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]28578904
D019808LosartanLosartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]28578904
D019808LosartanLosartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]28578904
C530108LY2109761LY2109761 inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]25884904
C530108LY2109761LY2109761 inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]25884904
C013592mangiferinmangiferin results in decreased expression of SNAI1 protein23707762
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SNAI1 mRNA20938992
D008770Methylnitrosourea[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI1 mRNA25164625
D008770MethylnitrosoureaQuercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI1 mRNA]25164625
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of SNAI1 mRNA25145660
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SNAI1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SNAI1 mRNA"25554681
C022838nickel chloridenickel chloride promotes the reaction [SNAI1 protein binds to CDH1 promoter]22648416
C022838nickel chloridenickel chloride results in increased expression of SNAI1 protein22648416
C029938nickel sulfatenickel sulfate results in increased expression of SNAI1 mRNA20146380
D009534NiclosamideNiclosamide inhibits the reaction [[lapatinib results in decreased susceptibility to lapatinib] which results in increased expression of SNAI1 protein]26643609
D009538NicotineNicotine results in increased expression of SNAI1 mRNA23219715
D009538NicotineNicotine results in increased expression of SNAI1 protein23219715
D009538NicotineSNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of BMI1 mRNA]23219715
D009538NicotineSNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of NANOG mRNA]23219715
D009538NicotineSNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]23219715
D009538NicotineSNAI1 results in increased susceptibility to Nicotine23219715
C025256nonylphenolfulvestrant inhibits the reaction [nonylphenol results in increased expression of SNAI1 mRNA]25690688
C025256nonylphenolfulvestrant inhibits the reaction [nonylphenol results in increased expression of SNAI1 protein]25690688
C025256nonylphenolnonylphenol results in increased expression of SNAI1 mRNA25690688
C025256nonylphenolnonylphenol results in increased expression of SNAI1 protein25690688
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SNAI1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of SNAI1 mRNA25729387
D010100OxygenHIF1A protein promotes the reaction [Oxygen deficiency results in increased expression of SNAI1 protein]22340517
D010100OxygenOxygen deficiency results in increased expression of SNAI1 protein22340517
C102487pachymic acidpachymic acid analog inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]28578904
C102487pachymic acidpachymic acid analog inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]28578904
D052638Particulate MatterParticulate Matter results in increased expression of SNAI1 mRNA28846189
D052638Particulate MatterParticulate Matter results in increased expression of SNAI1 protein28846189
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of SNAI1 mRNA18593933
C076994perfluorooctane sulfonic acidCarnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of SNAI1 protein]28973641
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of SNAI1 mRNA28973641
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of SNAI1 protein28973641
C121565pifithrinpifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SNAI1 mRNA]20064835
C006253pirinixic acidpirinixic acid results in decreased expression of SNAI1 mRNA20813756
D010938Plant OilsPlant Oils results in increased expression of SNAI1 mRNA23370395
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of SNAI1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SNAI1 mRNA22714537
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of SNAI1 mRNA22079256
D011441PropylthiouracilPropylthiouracil results in decreased expression of SNAI1 mRNA24780913
C107773pterostilbenepterostilbene results in decreased expression of SNAI1 protein23921149
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of SNAI1 protein]27060453
C528580qishen yiqiqishen yiqi inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]27636716
C528580qishen yiqiqishen yiqi inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]27636716
D011794QuercetinQuercetin results in increased expression of SNAI1 mRNA21632981
D011794QuercetinQuercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI1 mRNA]25164625
C059514resveratrolresveratrol inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]23146760|2588490
C059514resveratrolresveratrol inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]23146760|2588490
C059514resveratrolresveratrol results in decreased expression of SNAI1 mRNA21304978
C059514resveratrolresveratrol results in decreased expression of SNAI1 protein23921149
C059514resveratrolresveratrol inhibits the reaction [EGF protein results in increased expression of SNAI1 mRNA]21794976
C009166retinol acetateretinol acetate results in increased expression of SNAI1 mRNA16772331
D012402RotenoneRotenone inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]17596522
C010327salinomycinsalinomycin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of SNAI1 mRNA]26896736
C010327salinomycinsalinomycin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of SNAI1 protein]26896736
C005705sanguinarinesanguinarine results in decreased expression of SNAI1 protein19063874
C093642SB 203580SB 203580 inhibits the reaction [BMP5 protein results in increased expression of SNAI1 mRNA]15242789
C093642SB 203580SB 203580 inhibits the reaction [benz(a)anthracene results in increased expression of SNAI1 mRNA]21635667
C093642SB 203580SB 203580 inhibits the reaction [benzo(k)fluoranthene results in increased expression of SNAI1 mRNA]21635667
C093642SB 203580"SB 203580 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of SNAI1 mRNA]"21635667
C093642SB 203580SB 203580 inhibits the reaction [thymoquinone results in decreased expression of SNAI1 protein]27060453
C417521SB 216763SB 216763 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 protein]]25118938
C417521SB 216763"SB 216763 inhibits the reaction [Asbestos, Serpentine affects the localization of SNAI1 protein]"26685284
C417521SB 216763SB 216763 results in increased expression of SNAI1 protein23921149
D017632Asbestos, Serpentine"1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one analog inhibits the reaction [Asbestos, Serpentine affects the localization of SNAI1 protein]"26685284
D017632Asbestos, Serpentine"Asbestos, Serpentine affects the localization of SNAI1 protein"26685284
D017632Asbestos, Serpentine"SB 216763 inhibits the reaction [Asbestos, Serpentine affects the localization of SNAI1 protein]"26685284
D012834SilverSilver results in increased expression of SNAI1 mRNA26014281
D020123SirolimusSirolimus inhibits the reaction [sodium arsenite results in increased expression of SNAI1 mRNA]28888487
D020123SirolimusSirolimus results in increased expression of SNAI1 protein28888487
C009277sodium arsenatesodium arsenate affects the methylation of SNAI1 promoter20667999
C009277sodium arsenatesodium arsenate results in increased expression of SNAI1 mRNA20667999
C017947sodium arseniteSirolimus inhibits the reaction [sodium arsenite results in increased expression of SNAI1 mRNA]28888487
C017947sodium arseniteSNAI1 protein affects the reaction [sodium arsenite results in decreased expression of CDH1 protein]28888487
C017947sodium arseniteSNAI1 protein affects the reaction [sodium arsenite results in increased expression of VIM protein]28888487
C017947sodium arsenitesodium arsenite promotes the reaction [SQSTM1 protein binds to SNAI1 protein]28888487
C017947sodium arsenite[sodium arsenite results in increased activity of RELA protein] which results in increased expression of SNAI123069812
C017947sodium arsenitesodium arsenite results in increased expression of SNAI123069812
C017947sodium arsenitesodium arsenite results in increased expression of SNAI1 mRNA24068038|2888848
C017947sodium arsenitesodium arsenite results in increased expression of SNAI1 protein28336213|2888848
C017947sodium arseniteSQSTM1 protein affects the reaction [sodium arsenite results in increased expression of SNAI1 protein]28888487
C017947sodium arsenitesodium arsenite results in decreased expression of SNAI1 mRNA23732083
C471405sorafenibsorafenib inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]21360571
C471405sorafenibsorafenib inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]21360571
D016559Tacrolimus[GSK3A protein co-treated with GSK3B protein] affects the reaction [Tacrolimus results in increased expression of SNAI1 protein]22416070
D016559TacrolimusTacrolimus results in increased expression of SNAI1 protein22416070
D016559TacrolimusTacrolimus results in increased expression of SNAI1 protein22416070
D013629Tamoxifen"3,4',5-trimethoxystilbene promotes the reaction [Tamoxifen results in decreased expression of SNAI1 protein]"23921149
D013629Tamoxifen"Tamoxifen promotes the reaction [3,4',5-trimethoxystilbene results in decreased expression of SNAI1 protein]"23921149
D013629TamoxifenTamoxifen results in decreased expression of SNAI1 protein23921149
D013739Testosterone[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI1 mRNA25164625
D013739TestosteroneQuercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI1 mRNA]25164625
D013749Tetrachlorodibenzodioxinpifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SNAI1 mRNA]20064835
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SNAI1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SNAI1 mRNA15591033|1758670
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SNAI1 protein24154488
D013755Tetradecanoylphorbol Acetate2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]25656647
D013755Tetradecanoylphorbol Acetate2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]25656647
D013755Tetradecanoylphorbol Acetate3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]25656647
D013755Tetradecanoylphorbol Acetateantroquinonol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]25656647
D013755Tetradecanoylphorbol AcetateCurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]25656647
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of SNAI1 protein25656647
C034269tetraethylenepentaminetetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of and affects the localization of SNAI1 protein]26174737
C034269tetraethylenepentaminetetraethylenepentamine results in decreased expression of SNAI1 protein26174737
C003466thymoquinonepyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of SNAI1 protein]27060453
C003466thymoquinoneSB 203580 inhibits the reaction [thymoquinone results in decreased expression of SNAI1 protein]27060453
C003466thymoquinonethymoquinone results in decreased expression of SNAI1 protein27060453
C009495titanium dioxidetitanium dioxide results in increased expression of SNAI1 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SNAI1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SNAI1 protein27087172
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SNAI1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of SNAI1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of SNAI1 mRNA23830798
D014212TretinoinTretinoin results in increased expression of SNAI1 mRNA23724009
D014212TretinoinTretinoin results in increased expression of SNAI1 mRNA16604517|1678809
C012589trichostatin Atrichostatin A affects the expression of SNAI1 mRNA28542535
D014260Triclosan"3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of SNAI1 protein]"28844962
D014260Triclosanfulvestrant inhibits the reaction [Triclosan results in increased expression of SNAI1 protein]28844962
D014260TriclosanTriclosan results in increased expression of SNAI1 protein28844962
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SNAI1 mRNA"26179874
C113580U 0126U 0126 inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]17596522
C113580U 0126U 0126 inhibits the reaction [FGF16 protein results in increased expression of SNAI1 mRNA]24253043
D014520UrethaneUrethane results in increased expression of SNAI1 mRNA28818685
D024483Vitamin K 3Vitamin K 3 affects the expression of SNAI1 mRNA20044591
C000588914WJ1376-1WJ1376-1 inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]24727557
C000588914WJ1376-1WJ1376-1 inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]24727557
C000588915WJ1398-1WJ1398-1 inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]24727557
C000588915WJ1398-1WJ1398-1 inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]24727557
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of SNAI1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA11912130  
GO:0005515protein binding-IPI15448698  16096638  18331720  19411070  19955572  20385133  
20389281  20562920  21577210  23644467  24209753  25203322  
25314079  25416956  
GO:0019900kinase binding-IPI15448698  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA11912130  
GO:0000122negative regulation of transcription by RNA polymerase II-IMP15314165  
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0001649osteoblast differentiation-IEP20128911  
GO:0001707mesoderm formation-ISS-  
GO:0001837epithelial to mesenchymal transition-IDA16096638  
GO:0001837epithelial to mesenchymal transition-ISS-  
GO:0003198epithelial to mesenchymal transition involved in endocardial cushion formation-TAS20951801  
GO:0010718positive regulation of epithelial to mesenchymal transition-IMP20018240  23288509  
GO:0010718positive regulation of epithelial to mesenchymal transition-ISS-  
GO:0010718positive regulation of epithelial to mesenchymal transition-TAS17072303  
GO:0010957negative regulation of vitamin D biosynthetic process-IDA19502595  
GO:0016477cell migration-IEA-  
GO:0030335positive regulation of cell migration-IMP15314165  20018240  
GO:0031069hair follicle morphogenesis-IEA-  
GO:0043518negative regulation of DNA damage response, signal transduction by p53 class mediator-IMP15314165  
GO:0045893positive regulation of transcription, DNA-templated-IMP20018240  
GO:0060021roof of mouth development-IEA-  
GO:0060536cartilage morphogenesis-IEA-  
GO:0060707trophoblast giant cell differentiation-IEA-  
GO:0060806negative regulation of cell differentiation involved in embryonic placenta development-IEA-  
GO:0060972left/right pattern formation-IEA-  
GO:0061314Notch signaling involved in heart development-ISS-  
GO:0070828heterochromatin organization-ISS-  
GO:1902230negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage-IMP15314165  
GO:2000810regulation of bicellular tight junction assembly-IMP15314165  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA15448698  19955572  23288509  24209753  25893292  
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-TAS-  
GO:0005721pericentric heterochromatin-IDA24239292  
GO:0005737cytoplasm-IDA15448698  19955572  24209753  
GO:0005737cytoplasm-ISS-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
hsa04520Adherens junction
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1257604PIP3 activates AKT signalingIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-6807070PTEN RegulationTAS
R-HSA-6807070PTEN RegulationIEA
R-HSA-8943724Regulation of PTEN gene transcriptionTAS
R-HSA-8943724Regulation of PTEN gene transcriptionIEA
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006925Intracellular signaling by second messengersIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24354880Effects of a functional variant c.353T>C in snai1 on risk of two contextual diseases. Chronic obstructive pulmonary disease and lung cancer. (2014 Jan 15)Yang LAm J Respir Crit Care Med