Gene: SNAP25

6616
CMS18|RIC-4|RIC4|SEC9|SNAP|SNAP-25|SUP|bA416N4.2|dJ1068F16.2
synaptosome associated protein 25
protein-coding
20p12.2
Ensembl:ENSG00000132639 MIM:600322 Vega:OTTHUMG00000031863 UniprotKB:P60880
NG_029626.1
PubMed
0   ANCO-SNPs
CD|ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.440e-1 (AD)  3.049e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VSNL10.986
BASP10.979
ATP6V1G20.976
YWHAH0.976
ATP1B10.976
PPP3R10.975
NAPB0.974
PFN20.974
RTN10.973
CHN10.972

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.654
OR4F29-0.627
CNN2-0.407
ARHGEF5-0.407
CSAG1-0.405
RUNX3-0.404
KCNJ15-0.396
TFPI2-0.396
CXCR2-0.393
WDR38-0.39

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00083Botulinum Toxin Type ABiotechDrug93384-43-1Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of SNAP25 protein"21673325
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SNAP25 mRNA"21394737
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in increased expression of SNAP25 mRNA"19114083
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of SNAP25 mRNA"20206263
C0179063-dinitrobenzene3-dinitrobenzene results in increased oxidation of SNAP25 protein25716674
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA"27188386
C0159298-((4-chlorophenyl)thio)cyclic-3',5'-AMP"8-((4-chlorophenyl)thio)cyclic-3',5'-AMP affects the splicing of SNAP25 exon"22684629
C0159298-((4-chlorophenyl)thio)cyclic-3',5'-AMP"N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP affects the splicing of SNAP25 exon]"22684629
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SNAP25 mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of SNAP25 protein16483693
C015001arsenitearsenite results in decreased degradation of SNAP25 protein18597805
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of SNAP25 mRNA"18687144|2363490
D001280AtrazineAtrazine results in decreased expression of SNAP25 mRNA22378314
C487081belinostatbelinostat results in increased expression of SNAP25 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SNAP25 mRNA28412278
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SNAP25 protein28412278
D001564Benzo(a)pyreneSNAP25 protein affects the reaction [Benzo(a)pyrene results in decreased expression of GRIA1 mRNA]28412278
D001564Benzo(a)pyreneSNAP25 protein affects the reaction [Benzo(a)pyrene results in decreased expression of GRIA1 protein]28412278
D001564Benzo(a)pyreneSNAP25 protein affects the reaction [Benzo(a)pyrene results in decreased expression of GRIA2 mRNA]28412278
D001564Benzo(a)pyreneSNAP25 protein affects the reaction [Benzo(a)pyrene results in decreased expression of GRIA2 protein]28412278
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SNAP25 mRNA21839799
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SNAP25 protein28412278
C044887beta-methylcholinebeta-methylcholine affects the expression of SNAP25 mRNA21179406
C053541bicalutamidebicalutamide results in increased expression of SNAP25 mRNA15790403
C006780bisphenol Abisphenol A results in decreased expression of SNAP25 mRNA22946080|2518105
D019274Botulinum Toxins, Type A"Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein"22223483|2661502
D019274Botulinum Toxins, Type A"Botulinum Toxins, Type A results in increased cleavage of and results in decreased expression of SNAP25 protein"11181932
D019274Botulinum Toxins, Type A"Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein"26615023
D019274Botulinum Toxins, Type A"methylamine inhibits the reaction [Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein]"11181932
D019274Botulinum Toxins, Type A"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein]"11181932
D019274Botulinum Toxins, Type A"Zinc affects the reaction [Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein]"11181932
D019274Botulinum Toxins, Type A"[Botulinum Toxins, Type A co-treated with botulinum toxin type E] results in increased cleavage of SNAP25 protein"10978741
D019274Botulinum Toxins, Type A"Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein"10978741|1138471
C096324botulinum toxin type Cbotulinum toxin type C results in increased cleavage of SNAP25 protein26615023
C096324botulinum toxin type Cbotulinum toxin type C results in increased cleavage of SNAP25 protein17666428
C096324botulinum toxin type Cbotulinum toxin type C results in increased cleavage of SNAP25 protein26615023
C096326botulinum toxin type Ebotulinum toxin type E results in increased cleavage of SNAP25 protein26615023
C096326botulinum toxin type E"[Botulinum Toxins, Type A co-treated with botulinum toxin type E] results in increased cleavage of SNAP25 protein"10978741
C096326botulinum toxin type Ebotulinum toxin type E results in increased cleavage of SNAP25 protein10978741
C096326botulinum toxin type Ebotulinum toxin type E results in increased cleavage of SNAP25 protein26615023
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of SNAP25 mRNA18636392
D003024ClozapineSNAP25 gene SNP affects the susceptibility to Clozapine15823421
D003024ClozapineClozapine results in increased expression of SNAP25 mRNA15860345
C018021cobaltous chloridecobaltous chloride results in decreased expression of SNAP25 mRNA19376846
D005576ColforsinColforsin affects the splicing of SNAP25 exon22684629
D005576ColforsinColforsin promotes the reaction [HNRNPK protein binds to SNAP25 exon]22684629
D005576ColforsinHNRNPA1 mutant form inhibits the reaction [Colforsin affects the splicing of SNAP25 exon]22684629
D005576ColforsinN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin affects the splicing of SNAP25 exon]22684629
C009160cyclonitecyclonite results in increased expression of SNAP25 mRNA19417177
D016572CyclosporineCyclosporine results in decreased expression of SNAP25 mRNA27989131
C017160cypermethrincypermethrin results in decreased expression of SNAP25 protein21561882
C017160cypermethrinMinocycline inhibits the reaction [cypermethrin results in decreased expression of SNAP25 protein]21561882
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of SNAP25 mRNA28104350
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of SNAP25 protein28104350
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SNAP25 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SNAP25 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SNAP25 mRNA23558232
D002945Cisplatintrichostatin A inhibits the reaction [Cisplatin results in decreased expression of SNAP25 mRNA]23558232
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SNAP25 mRNA26924002
D004026DieldrinDieldrin results in decreased expression of SNAP25 protein20584760
C024629dimethyl phthalatedimethyl phthalate affects the expression of SNAP25 mRNA26924002
C061132diphenyldiselenidediphenyldiselenide results in decreased expression of SNAP25 protein19926633
D000431EthanolEthanol results in decreased expression of SNAP25 mRNA20655511
D000431Ethanol"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of SNAP25 mRNA]"20655511
D005419FlavonoidsFlavonoids results in increased expression of SNAP25 mRNA18035473
C069837fullerene C60fullerene C60 results in decreased expression of SNAP25 mRNA19167457
D005947GlucoseGlucose results in decreased expression of SNAP25 protein23776493
D006220HaloperidolSNAP25 gene SNP affects the susceptibility to Haloperidol15823421
D006220HaloperidolHaloperidol affects the expression of SNAP25 mRNA15860345
D003932HeroinHeroin results in decreased expression of SNAP25 mRNA16710320
D006834HydrazinesHydrazines results in decreased expression of SNAP25 mRNA21647536
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SNAP25 protein21179406
C518329isopropyl-9H-thioxanthen-9-oneisopropyl-9H-thioxanthen-9-one results in decreased expression of SNAP25 mRNA20558275
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SNAP25 mRNA27392435
C057416KT 5720KT 5720 inhibits the reaction [PRKACA protein results in increased phosphorylation of SNAP25 protein]14766180
D007840LatexLatex analog results in increased expression of SNAP25 mRNA24768652
D007854LeadSNAP25 gene SNP affects the susceptibility to [lead acetate results in increased abundance of Lead]26859824
D007854LeadLead affects the splicing of SNAP25 mRNA28903495
C008261lead acetateSNAP25 gene SNP affects the susceptibility to [lead acetate results in increased abundance of Lead]26859824
C008261lead acetatelead acetate results in decreased expression of SNAP25 mRNA21126476
C008261lead acetatelead acetate results in decreased expression of SNAP25 protein21126476
C008261lead acetatelead acetate results in decreased expression of SNAP25 mRNA27984133
C008261lead acetatelead acetate results in decreased expression of SNAP25 protein27492863|2798413
D008070LipopolysaccharidesLipopolysaccharides affects the expression of SNAP25 mRNA28070326
D008070LipopolysaccharidesPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of SNAP25 mRNA]28070326
C027451methylamine"methylamine inhibits the reaction [Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein]"11181932
C004925methylmercuric chloridemethylmercuric chloride affects the expression of SNAP25 protein27012723
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SNAP25 protein25809596
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SNAP25 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of SNAP25 protein26965727
D008774MethylphenidateSNAP25 gene polymorphism affects the susceptibility to Methylphenidate17023870
C008493methylselenic acidmethylselenic acid results in increased expression of SNAP25 mRNA18548127
D008911MinocyclineMinocycline inhibits the reaction [cypermethrin results in decreased expression of SNAP25 protein]21561882
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SNAP25 mRNA26924002
C523799MRK 003SNAP25 results in decreased susceptibility to MRK 00319903844
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide"N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP affects the splicing of SNAP25 exon]"22684629
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin affects the splicing of SNAP25 exon]22684629
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SNAP25 mRNA"23634900
C520612N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of SNAP25 mRNA]"20655511
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein]"11181932
C025256nonylphenolnonylphenol results in decreased expression of SNAP25 mRNA22946080
C474055octylphenoloctylphenol results in decreased expression of SNAP25 mRNA22946080
C076029olanzapineSNAP25 gene SNP affects the susceptibility to olanzapine15823421
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of SNAP25 mRNA18636392
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of SNAP25 mRNA26272509
D052638Particulate MatterParticulate Matter results in decreased expression of SNAP25 mRNA22178795
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in decreased expression of SNAP25 mRNA18593933
D010634PhenobarbitalPhenobarbital results in decreased expression of SNAP25 mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA"27188386
D010936Plant ExtractsPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of SNAP25 mRNA]28070326
D011189Potassium ChloridePotassium Chloride affects the splicing of SNAP25 exon22684629
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SNAP25 mRNA23608068
D017035Pravastatin[LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of SNAP25 protein26875785
D015742PropofolSNAP25 protein affects the reaction [Propofol affects the localization of STX1A protein]29320738
D011441PropylthiouracilPropylthiouracil results in decreased expression of SNAP25 mRNA24780913
D018967RisperidoneSNAP25 gene SNP affects the susceptibility to Risperidone15823421
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of SNAP25 mRNA19244175
D012643SeleniumSelenium results in decreased expression of SNAP25 mRNA19244175
D012834SilverSilver analog results in decreased expression of SNAP25 mRNA27693314
D012834SilverSilver analog results in increased expression of SNAP25 protein27693314
D012834SilverSilver results in decreased expression of SNAP25 mRNA27693314
C017947sodium arsenitesodium arsenite results in increased expression of SNAP25 mRNA25879800
D013739Testosterone[FSHB protein co-treated with Testosterone] results in increased expression of SNAP25 mRNA18535249
D013739Testosterone[PRKACA protein mutant form co-treated with Testosterone] results in increased expression of SNAP25 mRNA18535249
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of SNAP25 mRNA27693314
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of SNAP25 protein27693314
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in decreased expression of SNAP25 protein"25852303
D013792ThalidomideThalidomide results in increased expression of SNAP25 mRNA27693314
D013792ThalidomideThalidomide results in increased expression of SNAP25 protein27693314
D013849ThimerosalThimerosal results in decreased expression of SNAP25 protein27693314
D014212TretinoinTretinoin promotes the reaction [ZMYND8 protein binds to SNAP25 gene]26655721
D014212TretinoinTretinoin promotes the reaction [ZMYND8 protein binds to SNAP25 promoter]26655721
D014212TretinoinTretinoin results in increased expression of SNAP25 mRNA21934132|2665572
D014212TretinoinZMYND8 protein affects the reaction [Tretinoin results in increased expression of SNAP25 mRNA]26655721
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SNAP25 mRNA24935251|2627250
C012589trichostatin Atrichostatin A inhibits the reaction [Cisplatin results in decreased expression of SNAP25 mRNA]23558232
D014266TrientineTrientine results in increased expression of SNAP25 protein23541064
D014415TunicamycinTunicamycin results in decreased expression of SNAP25 mRNA22378314
D017974Uranium CompoundsUranium Compounds results in increased expression of SNAP25 mRNA19654044
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SNAP25 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SNAP25 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of SNAP25 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of SNAP25 mRNA21427059
D014635Valproic AcidValproic Acid results in decreased expression of SNAP25 mRNA27693314
D014635Valproic AcidValproic Acid results in decreased expression of SNAP25 protein27693314
D014638VanadatesVanadates results in increased expression of SNAP25 mRNA22714537
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of SNAP25 mRNA19244175
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of SNAP25 mRNA26272509
D015032Zinc[PCI 5002 co-treated with Zinc] results in decreased expression of SNAP25 mRNA18593933
D015032Zinc"Zinc affects the reaction [Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein]"11181932
D015034Zinc OxideZinc Oxide analog results in decreased expression of SNAP25 mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of SNAP25 mRNA27215404
C088658zoledronic acidzoledronic acid results in increased expression of SNAP25 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005484SNAP receptor activity-IBA21873635  
GO:0005515protein binding-IPI8692999  11438518  15603740  
GO:0017075syntaxin-1 binding-IBA21873635  
GO:0017075syntaxin-1 binding-IPI12730201  
GO:0019905syntaxin binding-IBA21873635  
GO:0048306calcium-dependent protein binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001504neurotransmitter uptake-NAS8760387  
GO:0006887exocytosis-IBA21873635  
GO:0006906vesicle fusion-IBA21873635  
GO:0007268chemical synaptic transmission-NAS8760387  
GO:0007626locomotory behavior-IEA-  
GO:0008306associative learning-IEA-  
GO:0010975regulation of neuron projection development-IEA-  
GO:0016079synaptic vesicle exocytosis-TAS15217342  
GO:0016081synaptic vesicle docking-NAS8760387  
GO:0016082synaptic vesicle priming-IBA21873635  
GO:0031629synaptic vesicle fusion to presynaptic active zone membrane-IBA21873635  
GO:0031915positive regulation of synaptic plasticity-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO:0050796regulation of insulin secretion-TAS15537656  
GO:0060291long-term synaptic potentiation-IEA-  
GO:0098967exocytic insertion of neurotransmitter receptor to postsynaptic membrane-IEA-  
GO:0099590neurotransmitter receptor internalization-IEA-  
GO:1990926short-term synaptic potentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA24327345  
GO:0005737cytoplasm-ISS-  
GO:0005802trans-Golgi network-IEA-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IDA24327345  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0008021synaptic vesicle-IEA-  
GO:0008076voltage-gated potassium channel complexcolocalizes_withISS-  
GO:0016020membrane-ISS-  
GO:0030054cell junction-IEA-  
GO:0030426growth cone-ISS-  
GO:0031083BLOC-1 complexcolocalizes_withIDA19546860  
GO:0031201SNARE complex-IBA21873635  
GO:0031201SNARE complex-IDA12130530  12730201  
GO:0031201SNARE complex-ISS-  
GO:0031201SNARE complex-TAS15217342  
GO:0031234extrinsic component of cytoplasmic side of plasma membrane-IEA-  
GO:0031982vesiclecolocalizes_withIDA15459722  
GO:0035579specific granule membrane-TAS-  
GO:0036477somatodendritic compartment-IEA-  
GO:0042734presynaptic membrane-TAS15217342  
GO:0043005neuron projection-ISS-  
GO:0043209myelin sheath-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0070032synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex-IBA21873635  
GO:0070821tertiary granule membrane-TAS-  
GO:0098794postsynapse-IEA-  
KEGG ID KEGG Term
hsa04130SNARE interactions in vesicular transport
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1430728MetabolismIEA
R-HSA-163685Integration of energy metabolismIEA
R-HSA-1643685DiseaseTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168799Neurotoxicity of clostridium toxinsTAS
R-HSA-181429Serotonin Neurotransmitter Release CycleTAS
R-HSA-181430Norepinephrine Neurotransmitter Release CycleTAS
R-HSA-210500Glutamate Neurotransmitter Release CycleTAS
R-HSA-212676Dopamine Neurotransmitter Release CycleTAS
R-HSA-264642Acetylcholine Neurotransmitter Release CycleTAS
R-HSA-422356Regulation of insulin secretionIEA
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449836Other interleukin signalingTAS
R-HSA-5250968Toxicity of botulinum toxin type A (BoNT/A)TAS
R-HSA-5250971Toxicity of botulinum toxin type C (BoNT/C)TAS
R-HSA-5250992Toxicity of botulinum toxin type E (BoNT/E)TAS
R-HSA-5339562Uptake and actions of bacterial toxinsTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-888590GABA synthesis, release, reuptake and degradationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23939223Gene-environment interactions affect long-term depression (LTD) through changes in dopamine receptor affinity in Snap25 deficient mice. (2013 Sep 26)Baca MBrain Res
22028400Cigarette experimentation in Mexican origin youth: psychosocial and genetic determinants. (2012 Jan)Wilkinson AVCancer Epidemiol Biomarkers Prev
27559543Evaluation of the Nicotinic Acetylcholine Receptor-Associated Proteome at Baseline and Following Nicotine Exposure in Human and Mouse Cortex. (2016 Jul-Aug)McClure-Begley TDeNeuro
21426264Candidate pathway association study in cocaine dependence: the control of neurotransmitter release. (2012 Feb)Fernandez-Castillo NWorld J Biol Psychiatry