Gene: SNCB

6620
-
synuclein beta
protein-coding
5q35.2
Ensembl:ENSG00000074317 MIM:602569 Vega:OTTHUMG00000130661 UniprotKB:Q16143
NG_012131.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.794e-1 (AD)  9.608e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NRGN0.958
REEP20.952
NAPA0.951
PRKAR1B0.95
CCDC920.948
KLHDC30.947
RUNDC3A0.945
TMEM59L0.944
STMN30.943
SYN10.941

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.733
OR4F29-0.704
ARHGEF5-0.403
TFPI2-0.398
REST-0.374
C1orf87-0.372
GJA3-0.368
PTPN7-0.364
EVA1A-0.362
KCNJ15-0.359

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SNCB mRNA"27291303
D000082AcetaminophenAcetaminophen affects the expression of SNCB mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of SNCB mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SNCB mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of SNCB protein16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in decreased expression of SNCB mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SNCB mRNA24449571
C015001arsenitearsenite results in increased methylation of SNCB promoter23974009
C006780bisphenol Abisphenol A results in decreased expression of SNCB mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SNCB gene28505145
C013418bromfenacoumbromfenacoum results in decreased expression of SNCB protein28903499
C026690cerous chloridecerous chloride results in increased expression of SNCB mRNA23573234
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SNCB gene20938992
D002994ClofibrateClofibrate results in decreased expression of SNCB mRNA17585979
D003042CocaineCocaine affects the expression of SNCB mRNA20187946
D019327Copper SulfateCopper Sulfate results in decreased expression of SNCB mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of SNCB mRNA19789285
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SNCB mRNA23640034
D003976DiazinonDiazinon results in decreased methylation of SNCB gene22964155
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SNCB mRNA27392435
D002945CisplatinCisplatin results in increased expression of SNCB mRNA27392435
D005419FlavonoidsFlavonoids results in increased expression of SNCB mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SNCB gene20938992
D005839GentamicinsGentamicins results in decreased expression of SNCB mRNA22061828
D006820Hyaluronic AcidHyaluronic Acid analog results in decreased expression of SNCB protein23178681
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SNCB protein21179406
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of SNCB protein23178681
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SNCB mRNA27392435
D007854LeadLead affects the expression of SNCB mRNA28903495
D008694MethamphetamineMethamphetamine results in increased expression of SNCB protein19826936
D000432MethanolMethanol results in decreased expression of SNCB protein22257634
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SNCB gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SNCB mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SNCB mRNA24810058
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of SNCB mRNA23602845
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SNCB mRNA19710929
C006253pirinixic acidNCF1 protein promotes the reaction [pirinixic acid results in decreased expression of SNCB mRNA]17950772
C006253pirinixic acidpirinixic acid results in decreased expression of SNCB mRNA17950772
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of SNCB mRNA]17950772
D010936Plant ExtractsPlant Extracts results in increased expression of SNCB mRNA20924750
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SNCB mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of SNCB mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of SNCB mRNA27029645
C080703SK&F 83959SK&F 83959 results in decreased expression of SNCB protein25852303
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SNCB mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SNCB mRNA15328365
D024505TocopherolsTocopherols results in increased expression of SNCB mRNA17654050
D014241TrichloroethyleneTrichloroethylene results in increased methylation of SNCB gene27618143
C012589trichostatin Atrichostatin A results in decreased expression of SNCB mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of SNCB mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of SNCB mRNA25979313
C025643vinclozolinvinclozolin affects the expression of SNCB mRNA19015723
D014801Vitamin AVitamin A results in decreased expression of SNCB protein22274401

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004859phospholipase inhibitor activity-TAS9806846  
GO:0005509calcium ion binding-IDA11312271  
GO:0046914transition metal ion binding-IMP25495902  
GO:1903136cuprous ion binding-IMP25495902  
GO ID GO Term Qualifier Evidence PubMed
GO:0007268chemical synaptic transmission-IEA-  
GO:0010038response to metal ion-TAS-  
GO:0042417dopamine metabolic process-IEA-  
GO:0043086negative regulation of catalytic activity-IEA-  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0050808synapse organization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0016234inclusion body-IDA17222866  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-5660489MTF1 activates gene expressionTAS
R-HSA-5660526Response to metal ionsTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22511924Genetic dissection of acute ethanol responsive gene networks in prefrontal cortex: functional and mechanistic implications. (2012)Wolen ARPLoS One