Gene: SNCA

6622
NACP|PARK1|PARK4|PD1
synuclein alpha
protein-coding
4q22.1
Ensembl:ENSG00000145335 MIM:163890 Vega:OTTHUMG00000130948 UniprotKB:P37840
NG_011851.1
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
24   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.604e-2 (AD)  4.081e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NAPB0.968
MAPK90.966
AK50.963
MLLT110.959
DYNC1I10.956
CMAS0.955
YWHAG0.95
STMN20.95
SYT10.95
PPP3CB0.95

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF135-0.522
EVC2-0.49
OR4F5-0.489
OR4F29-0.487
CHST14-0.486
CSAG1-0.483
TGIF1-0.473
SYDE1-0.472
ASB4-0.47
RUNX3-0.467

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02709ResveratrolSmall Molecule501-36-0Approved|Experimental|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0849241,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline"1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA mRNA"15114628
C0849241,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline"1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA protein"15114628
C0849241,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline"acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA protein]"15114628
C0849241,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline"Acetylcysteine inhibits the reaction [1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA protein]"15114628
C0849241,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline"coenzyme Q10 inhibits the reaction [1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA protein]"15114628
C0849241,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline"Selegiline inhibits the reaction [1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA protein]"15114628
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of SNCA mRNA"26377693
C0256031,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Rotenone results in increased expression of and results in increased phosphorylation of SNCA protein]"25433145
C0326681-nitropyrene1-nitropyrene results in decreased expression of SNCA mRNA19041380
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of SNCA mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of SNCA mRNA"23829299
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of SNCA mRNA"20406850
C07699627-hydroxycholesterol27-hydroxycholesterol results in increased expression of SNCA mRNA18841091
C07699627-hydroxycholesterol27-hydroxycholesterol results in increased expression of SNCA protein18841091|1901438
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased expression of SNCA protein21898719
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of SNCA mRNA"20206263
C0259463-methyladenine3-methyladenine inhibits the reaction [Rotenone results in decreased expression of SNCA mRNA]27133439
C0259463-methyladenine3-methyladenine inhibits the reaction [Rotenone results in decreased expression of SNCA protein]27133439
C0087454,4'-bisphenol F"4,4'-bisphenol F results in decreased expression of SNCA mRNA"26186136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SNCA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNCA mRNA"27188386
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of SNCA protein]17459145
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [SNCA protein binds to SNCA protein]21372141
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SNCA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNCA mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SNCA mRNA17942131
D000082AcetaminophenAcetaminophen inhibits the reaction [SNCA protein binds to SNCA protein]18164319
C099158acetyl-aspartyl-glutamyl-valyl-aspartal"acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA protein]"15114628
D000108Acetylcarnitine[Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]20414966
D000108AcetylcarnitineAcetylcarnitine inhibits the reaction [Rotenone results in increased expression of SNCA protein]20414966
D000111Acetylcysteine"Acetylcysteine inhibits the reaction [1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA protein]"15114628
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Silicon Dioxide analog results in increased expression of SNCA protein]27613482
D000171AcroleinAcrolein affects the metabolism of SNCA protein17690948
D000171AcroleinAcrolein binds to SNCA protein17690948
D000255Adenosine TriphosphateGW8510 inhibits the reaction [SNCA protein results in decreased abundance of Adenosine Triphosphate]24989254
D000255Adenosine TriphosphateSB 216763 inhibits the reaction [SNCA protein results in decreased abundance of Adenosine Triphosphate]24989254
D000255Adenosine TriphosphateSNCA protein results in decreased abundance of Adenosine Triphosphate24989254
D000438AlcoholsAlcohols results in increased expression of SNCA protein18055133
D000447AldehydesAldehydes results in increased expression of SNCA mRNA25014914
D024502alpha-Tocopherolalpha-Tocopherol inhibits the reaction [Rotenone results in increased expression of SNCA protein]16439141
D000535AluminumSNCA protein affects the susceptibility to Aluminum23106139
C010845aluminum chloridealuminum chloride affects the folding of SNCA protein11553618
C091584aminochrome 1aminochrome 1 promotes the reaction [SNCA protein binds to SNCA protein]25634539
C091584aminochrome 1NQO1 protein inhibits the reaction [aminochrome 1 promotes the reaction [SNCA protein binds to SNCA protein]]25634539
D0150812-Naphthylamine2-Naphthylamine results in increased expression of SNCA mRNA18247414
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of SNCA protein23984410
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of SNCA mRNA16483693
D003913DextroamphetamineDextroamphetamine results in decreased expression of SNCA mRNA12558987
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SNCA mRNA24449571
D047310ApigeninApigenin inhibits the reaction [Rotenone results in increased expression of SNCA protein]28389404
C000228aristolochic acid I[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of SNCA mRNA23912714
C042310aristolochic acid II[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of SNCA mRNA23912714
D001151ArsenicArsenic affects the methylation of SNCA gene25304211
D001151ArsenicArsenic promotes the reaction [SNCA protein binds to SNCA protein]27413109
D001151ArsenicArsenic results in increased expression of SNCA protein27413109
C025657arsenic acidarsenic acid results in decreased expression of SNCA25639566
C006632arsenic trioxidearsenic trioxide results in decreased expression of SNCA mRNA20458559
C015001arsenitearsenite results in increased methylation of SNCA promoter23974009
D001205Ascorbic AcidAscorbic Acid results in increased expression of SNCA mRNA15305145
D001241AspirinAspirin results in decreased expression of SNCA mRNA21353610
D001241AspirinAspirin inhibits the reaction [SNCA protein binds to SNCA protein]18164319
C040929bafilomycin A1[bafilomycin A1 co-treated with Rotenone] results in increased expression of SNCA protein26031332
C040929bafilomycin A1bafilomycin A1 results in increased expression of SNCA protein26031332
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SNCA mRNA18247414
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SNCA mRNA17942131|2156981
C044887beta-methylcholinebeta-methylcholine affects the expression of SNCA mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of SNCA mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of SNCA mRNA25181051|2618613
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of SNCA mRNA17942131
D000069286BortezomibBortezomib results in increased expression of SNCA mRNA17895889
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SNCA mRNA22079614
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of SNCA protein15114628
C018475butyraldehydebutyraldehyde results in increased expression of SNCA mRNA26079696
D002101Cacodylic AcidCacodylic Acid results in decreased expression of SNCA25639566
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SNCA mRNA20061341
C040048caffeic acidcaffeic acid inhibits the reaction [SNCA protein binds to SNCA protein]20150427
D002118Calciumomega-Conotoxin GVIA inhibits the reaction [SNCA protein results in increased uptake of Calcium]17179863
D002118CalciumSNCA protein results in increased uptake of Calcium17179863
C071482calpeptincalpeptin inhibits the reaction [Paraquat results in increased expression of SNCA protein alternative form]24509835
C459604candoxincandoxin results in decreased expression of SNCA mRNA16309724
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SNCA mRNA17805973
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SNCA protein16174552
D004390ChlorpyrifosChlorpyrifos results in increased expression of SNCA mRNA21968025
C018021cobaltous chloridecobaltous chloride affects the folding of SNCA protein11553618
C018021cobaltous chloridecobaltous chloride results in decreased expression of SNCA mRNA19320972
D003042CocaineCocaine affects the expression of SNCA protein19393250
D003042CocaineCocaine results in increased expression of SNCA mRNA12684441
D003042CocaineCocaine results in increased expression of SNCA protein12684441|1611027
C024989coenzyme Q10"coenzyme Q10 inhibits the reaction [1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA protein]"15114628
C024989coenzyme Q10[coenzyme Q10 co-treated with Creatine] results in decreased expression of SNCA protein19476553
C024989coenzyme Q10coenzyme Q10 inhibits the reaction [Dichlorvos promotes the reaction [SNCA protein binds to SNCA protein]]21843543
C011423conduritol epoxide[conduritol epoxide binds to and results in decreased activity of GBA protein] which results in increased expression of SNCA protein19576930
C011423conduritol epoxide[conduritol epoxide binds to and results in decreased activity of GBA protein] which affects the localization of SNCA protein19576930
C011423conduritol epoxide[conduritol epoxide binds to and results in decreased activity of GBA protein] which results in increased expression of SNCA protein19576930
D003300CopperCopper binds to and results in decreased folding of SNCA protein22355530
D003300CopperCopper results in decreased expression of SNCA mRNA22465980
D003300CopperCopper results in increased expression of SNCA mRNA19781568
D003300CopperCopper binds to SNCA protein16839607|2115843
D003300CopperCopper promotes the reaction [SNCA protein binds to SNCA protein]18823621
D003401Creatine[coenzyme Q10 co-treated with Creatine] results in decreased expression of SNCA protein19476553
C029892cupric chloridecupric chloride affects the folding of SNCA protein11553618
C029892cupric chloridecupric chloride promotes the reaction [Hydrogen Peroxide results in increased oxidation of SNCA protein]16839607
D016572CyclosporineCyclosporine results in decreased expression of SNCA mRNA17942131
D016572CyclosporineCyclosporine inhibits the reaction [cypermethrin promotes the reaction [SNCA protein binds to SNCA protein]]25370934
D016572CyclosporineCyclosporine inhibits the reaction [cypermethrin results in increased expression of SNCA protein]25370934
C017160cypermethrincypermethrin results in increased expression of SNCA mRNA27704156
C017160cypermethrinCyclosporine inhibits the reaction [cypermethrin promotes the reaction [SNCA protein binds to SNCA protein]]25370934
C017160cypermethrinCyclosporine inhibits the reaction [cypermethrin results in increased expression of SNCA protein]25370934
C017160cypermethrincypermethrin promotes the reaction [SNCA protein binds to SNCA protein]25370934
C017160cypermethrincypermethrin results in increased expression of SNCA protein25370934
C017160cypermethrin"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [cypermethrin promotes the reaction [SNCA protein binds to SNCA protein]]"25370934
C017160cypermethrin"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [cypermethrin results in increased expression of SNCA protein]"25370934
D003561CytarabineCytarabine promotes the reaction [SNCA protein mutant form results in increased susceptibility to ferrous chloride]14535945
D003561CytarabineCytarabine promotes the reaction [SNCA protein mutant form results in increased susceptibility to Iron]14535945
C014347decitabinedecitabine affects the expression of SNCA mRNA23300844
C014347decitabine[decitabine co-treated with trichostatin A] results in increased expression of SNCA mRNA17891453
C014347decitabinedecitabine results in decreased methylation of SNCA promoter23441691
C014347decitabinedecitabine results in increased expression of SNCA mRNA19151715|2344169
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SNCA mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of SNCA mRNA28962523
D002945CisplatinCisplatin affects the expression of SNCA mRNA23300844
D004006Dichlorvoscoenzyme Q10 inhibits the reaction [Dichlorvos promotes the reaction [SNCA protein binds to SNCA protein]]21843543
D004006DichlorvosDichlorvos affects the localization of SNCA protein21073741
D004006DichlorvosDichlorvos promotes the reaction [SNCA protein binds to SNCA protein]21843543
D004008DiclofenacDiclofenac results in increased expression of SNCA mRNA26934552
D004008DiclofenacDiclofenac inhibits the reaction [SNCA protein binds to SNCA protein]18164319
D004026Dieldrin"Dieldrin promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA protein]"16809432
D004026DieldrinDieldrin results in increased expression of SNCA protein17291500
D004026DieldrinSNCA protein promotes the reaction [Dieldrin results in increased expression of CASP3 protein]15987830
D004026DieldrinDieldrin affects the folding of SNCA protein11445065
D004041Dietary FatsDietary Fats results in increased expression of SNCA mRNA18042831|2501614
C552250diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo(lmn)(3,8)phenanthroline-2,7-diacetate"diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo(lmn)(3,8)phenanthroline-2,7-diacetate inhibits the reaction [1-Methyl-4-phenylpyridinium promotes the reaction [SNCA protein binds to SNCA protein]]"23754278
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of SNCA mRNA17005392
D0151023,4-Dihydroxyphenylacetic Acid"SNCA protein mutant form results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid"18622040
C007517diphenyleneiodonium[N-((3-(aminomethyl)phenyl)methyl)ethanimidamide co-treated with diphenyleneiodonium] inhibits the reaction [SNCA protein mutant form results in increased susceptibility to Lipopolysaccharides]21245015
D004050DitiocarbDitiocarb results in increased expression of SNCA protein22874009
D004050DitiocarbDitiocarb affects the folding of SNCA protein11445065
D004298DopamineSNCA gene mutant form results in increased susceptibility to Dopamine15234109
D004298DopamineSNCA protein affects the abundance of Dopamine17131421|2231945
D004298Dopamine[SNCA protein affects the localization of SLC6A3 protein] which affects the uptake of Dopamine19032594
D004298DopamineSNCA protein affects the uptake of Dopamine19032594
D004298Dopamine[SNCA protein co-treated with Dopamine] results in increased expression of HMOX1 protein21735318
D004298Dopamine[SNCA protein co-treated with Paraquat co-treated with Dopamine] results in increased expression of HMOX1 protein21735318
D004298DopamineTRAP1 protein inhibits the reaction [SNCA protein affects the abundance of Dopamine]22319455
D004298DopamineSNCA affects the susceptibility to Dopamine19409267
D004298DopamineSNCA protein mutant form results in decreased abundance of Dopamine18622040
D004298DopamineSNCA protein promotes the reaction [Rotenone results in decreased abundance of Dopamine]26075822
D004298DopamineSNCA protein results in increased abundance of Dopamine26075822
D004317DoxorubicinDoxorubicin results in decreased expression of SNCA mRNA25896364
C060297echinacosideechinacoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA]27432061
C071192entacaponeentacapone inhibits the reaction [SNCA protein binds to SNCA protein]20150427
C118739entinostatentinostat results in increased expression of SNCA mRNA27188386
D000431EthanolEthanol results in decreased expression of SNCA mRNA17920746
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SNCA mRNA12075121
C436526EUK-189EUK-189 results in decreased susceptibility to [Iron co-treated with Paraquat co-treated with SNCA gene mutant form]21039522
C415144fenpyroximateSNCA protein results in increased susceptibility to fenpyroximate16239214
C029451ferrous chlorideCytarabine promotes the reaction [SNCA protein mutant form results in increased susceptibility to ferrous chloride]14535945
C029451ferrous chlorideferrous chloride affects the folding of SNCA protein11553618
C029451ferrous chlorideHydroxyurea promotes the reaction [SNCA protein mutant form results in increased susceptibility to ferrous chloride]14535945
C029451ferrous chlorideSNCA protein mutant form results in increased susceptibility to ferrous chloride14535945
C020748ferrous sulfateferrous sulfate inhibits the reaction [SNCA protein results in decreased abundance of Glutathione]27424009
C020748ferrous sulfateferrous sulfate inhibits the reaction [SNCA protein results in decreased expression of SOD1 protein]27424009
C020748ferrous sulfateferrous sulfate promotes the reaction [SNCA protein results in decreased activity of SOD1 protein]27424009
C020748ferrous sulfateferrous sulfate promotes the reaction [SNCA protein results in decreased expression of GCLC protein]27424009
C020748ferrous sulfateferrous sulfate promotes the reaction [SNCA protein results in increased abundance of Reactive Oxygen Species]27424009
D005411Flame RetardantsFlame Retardants results in increased expression of SNCA protein16451863|1855017
D005419FlavonoidsFlavonoids results in increased expression of SNCA mRNA18035473
D005480FlurbiprofenFlurbiprofen inhibits the reaction [SNCA protein binds to SNCA protein]18164319
D005707Gallic AcidGallic Acid inhibits the reaction [SNCA protein binds to SNCA protein]20150427
D005978Glutathioneferrous sulfate inhibits the reaction [SNCA protein results in decreased abundance of Glutathione]27424009
D005978GlutathioneSNCA protein results in decreased abundance of Glutathione27424009
D005978GlutathioneGlutathione inhibits the reaction [manganese chloride promotes the reaction [SNCA protein binds to SNCA protein binds to SNCA protein]]23353026
D019803Glutathione DisulfideSNCA protein results in decreased abundance of Glutathione Disulfide27424009
C473027GW 3965GW 3965 results in increased expression of SNCA mRNA18841091
C473027GW 3965GW 3965 results in increased expression of SNCA protein18841091
C500810GW8510GW8510 inhibits the reaction [SNCA protein results in decreased abundance of Adenosine Triphosphate]24989254
C500810GW8510GW8510 inhibits the reaction [SNCA protein results in increased activity of CASP3 protein]24989254
C500810GW8510GW8510 inhibits the reaction [SNCA protein results in increased activity of CASP7 protein]24989254
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of SNCA protein28214749
D017313FenretinideFenretinide results in decreased expression of SNCA mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of SNCA mRNA alternative form19857570
D006861Hydrogen PeroxideSNCA gene mutant form results in increased susceptibility to Hydrogen Peroxide24290359
D006861Hydrogen Peroxide[SNCA gene mutant form results in increased susceptibility to Hydrogen Peroxide] which results in increased metabolism of MEF2C protein24290359
D006861Hydrogen PeroxideSNCA protein affects the susceptibility to Hydrogen Peroxide22319455
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [manganese chloride promotes the reaction [SNCA protein binds to SNCA protein binds to SNCA protein]]23353026
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of SNCA mRNA23353026
D006861Hydrogen Peroxidecupric chloride promotes the reaction [Hydrogen Peroxide results in increased oxidation of SNCA protein]16839607
D0201553-Hydroxybutyric Acid3-Hydroxybutyric Acid inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]16239214
D0201553-Hydroxybutyric Acid3-Hydroxybutyric Acid promotes the reaction [tauroursodeoxycholic acid inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]]16239214
D006918HydroxyureaHydroxyurea promotes the reaction [SNCA protein mutant form results in increased susceptibility to ferrous chloride]14535945
D006918HydroxyureaHydroxyurea promotes the reaction [SNCA protein mutant form results in increased susceptibility to Iron]14535945
D007052IbuprofenIbuprofen inhibits the reaction [SNCA protein binds to SNCA protein]18164319
D007501IronCytarabine promotes the reaction [SNCA protein mutant form results in increased susceptibility to Iron]14535945
D007501IronHydroxyurea promotes the reaction [SNCA protein mutant form results in increased susceptibility to Iron]14535945
D007501IronIron affects the localization of SNCA protein12401952
D007501IronSNCA protein mutant form results in increased susceptibility to Iron14535945
D007501IronSNCA protein mutant form results in increased susceptibility to [Paraquat co-treated with Iron]27324791
D007501IronEUK-189 results in decreased susceptibility to [Iron co-treated with Paraquat co-treated with SNCA gene mutant form]21039522
D007501IronIron promotes the reaction [SNCA protein binds to SNCA protein]18823621
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of SNCA protein15618438
D007660KetoprofenKetoprofen inhibits the reaction [SNCA protein binds to SNCA protein]18164319
C067713lactacystinlactacystin promotes the reaction [SNCA protein mutant form binds to SNCA protein mutant form]16584840
C067713lactacystinlactacystin results in decreased expression of SNCA protein18818210
D007854LeadLead results in decreased expression of SNCA mRNA19921347
C008261lead acetatelead acetate results in increased expression of SNCA protein22811615
C017461lead nitratelead nitrate affects the localization of SNCA protein19542206
C017461lead nitratelead nitrate results in increased expression of SNCA mRNA19542206
C017461lead nitrateMT1 protein promotes the reaction [lead nitrate results in increased expression of SNCA mRNA]19542206
C002385linsidominelinsidomine results in increased expression of SNCA protein12880480
C002385linsidomineSelegiline inhibits the reaction [linsidomine results in increased expression of SNCA protein]12880480
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of SNCA protein"23567316
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with SNCA protein] results in increased expression of IL1B mRNA22122884
D008070LipopolysaccharidesLipopolysaccharides results in increased metabolism of SNCA protein21245015
D008070Lipopolysaccharides[N-((3-(aminomethyl)phenyl)methyl)ethanimidamide co-treated with diphenyleneiodonium] inhibits the reaction [SNCA protein mutant form results in increased susceptibility to Lipopolysaccharides]21245015
D008070LipopolysaccharidesSNCA protein mutant form results in increased susceptibility to Lipopolysaccharides21245015
D008094LithiumLithium inhibits the reaction [Rotenone results in increased expression of and results in increased phosphorylation of SNCA protein]25433145
D018021Lithium ChlorideLithium Chloride results in increased expression of SNCA mRNA23527032
D008344ManebManeb promotes the reaction [Paraquat results in increased expression of SNCA protein]26498265
D008344ManebManeb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]24290359
D008344Maneb[Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]] which results in increased abundance of Nitric Oxide24290359
D008344Maneb[Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]] which results in increased metabolism of MEF2C protein24290359
D008344ManebParaquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]24290359
D008344Maneb[Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]] which results in increased abundance of Nitric Oxide24290359
D008344Maneb[Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]] which results in increased metabolism of MEF2C protein24290359
D008344ManebSNCA gene mutant form results in increased susceptibility to Maneb24290359
D008344ManebSNCA protein mutant form results in increased susceptibility to [Paraquat co-treated with Maneb]27324791
D008344ManebSNCA protein results in increased susceptibility to [Maneb co-treated with Paraquat]23017109
D008344Maneb[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ADORA1 mRNA23017109
D008344Maneb[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of APBB1 mRNA23017109
D008344Maneb[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ASCL1 mRNA23017109
D008344Maneb[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP2 mRNA23017109
D008344Maneb[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA23017109
D008344Maneb[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DLL1 mRNA23017109
D008344Maneb[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD2 mRNA23017109
D008344Maneb[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD5 mRNA23017109
D008344Maneb[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of HEYL mRNA23017109
D008344Maneb[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX5 mRNA23017109
D008344Maneb[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of SEMA4D mRNA23017109
D008344Maneb[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of VEGFA mRNA23017109
D008344ManebSNCA protein inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA]23017109
D008345ManganeseManganese promotes the reaction [SNCA protein binds to SNCA protein]25416158
D008345ManganeseSNCA gene inhibits the reaction [DJR-1.1 mutant form results in increased transport of and results in increased abundance of Manganese]24452053
D008345ManganeseSNCA gene inhibits the reaction [PDR-1 mutant form results in increased transport of and results in increased abundance of Manganese]24452053
D008345ManganeseSNCA protein inhibits the reaction [Manganese affects the localization of CYCS protein]25416158
D008345ManganeseSNCA protein inhibits the reaction [Manganese results in increased activity of CASP3 protein]25416158
D008345ManganeseSNCA protein inhibits the reaction [Manganese results in increased activity of CASP9 protein]25416158
D008345ManganeseSNCA protein inhibits the reaction [Manganese results in increased cleavage of and results in increased activity of PRKCD protein]25416158
D008345ManganeseManganese affects the localization of SNCA protein20188756
D008345ManganeseManganese affects the reaction [P4HB protein binds to SNCA protein]24777576
D008345ManganeseManganese promotes the reaction [SNCA protein binds to and results in increased expression of SNCA protein]24777576
D008345ManganeseManganese results in increased expression of SNCA mRNA19781568
C025340manganese chlorideSNCA gene inhibits the reaction [DJR-1.1 mutant form results in increased susceptibility to manganese chloride]24452053
C025340manganese chloridemanganese chloride affects the folding of SNCA protein11553618
C025340manganese chloride[manganese chloride co-treated with SNCA protein] results in increased expression of IL1B mRNA28539244
C025340manganese chloride[manganese chloride co-treated with SNCA protein] results in increased expression of IL1B protein28539244
C025340manganese chloridemanganese chloride promotes the reaction [SNCA protein binds to SNCA protein]25416158
C025340manganese chloridemanganese chloride promotes the reaction [SNCA protein results in increased expression of CSF2 mRNA]28539244
C025340manganese chloridemanganese chloride promotes the reaction [SNCA protein results in increased expression of [IL12A protein binds to IL12B protein]]28539244
C025340manganese chloridemanganese chloride promotes the reaction [SNCA protein results in increased expression of IL6 mRNA]28539244
C025340manganese chloridemanganese chloride promotes the reaction [SNCA protein results in increased expression of TNF protein]28539244
C025340manganese chloridemanganese chloride results in increased expression of SNCA mRNA28986288
C025340manganese chlorideSNCA gene inhibits the reaction [DJR-1.1 mutant form promotes the reaction [manganese chloride results in increased abundance of Reactive Nitrogen Species]]24452053
C025340manganese chlorideSNCA gene inhibits the reaction [DJR-1.1 mutant form promotes the reaction [manganese chloride results in increased abundance of Reactive Oxygen Species]]24452053
C025340manganese chlorideSNCA gene inhibits the reaction [PDR-1 mutant form promotes the reaction [manganese chloride results in increased abundance of Reactive Nitrogen Species]]24452053
C025340manganese chlorideSNCA gene inhibits the reaction [PDR-1 mutant form promotes the reaction [manganese chloride results in increased abundance of Reactive Oxygen Species]]24452053
C025340manganese chlorideSNCA gene inhibits the reaction [PDR-1 mutant form results in increased susceptibility to manganese chloride]24452053
C025340manganese chlorideSNCA protein inhibits the reaction [manganese chloride affects the localization of CYCS protein]25416158
C025340manganese chlorideSNCA protein inhibits the reaction [manganese chloride results in increased activity of CASP3 protein]25416158
C025340manganese chlorideSNCA protein inhibits the reaction [manganese chloride results in increased activity of CASP9 protein]25416158
C025340manganese chlorideSNCA protein inhibits the reaction [manganese chloride results in increased cleavage of and results in increased activity of PRKCD protein]25416158
C025340manganese chlorideGlutathione inhibits the reaction [manganese chloride promotes the reaction [SNCA protein binds to SNCA protein binds to SNCA protein]]23353026
C025340manganese chlorideHydrogen Peroxide promotes the reaction [manganese chloride promotes the reaction [SNCA protein binds to SNCA protein binds to SNCA protein]]23353026
C025340manganese chloridemanganese chloride promotes the reaction [SNCA protein binds to SNCA protein binds to SNCA protein]23353026
C025340manganese chloridemanganese chloride results in increased expression of SNCA19276553
C025340manganese chloridemanganese chloride results in increased expression of SNCA mRNA23353026
C025340manganese chloridemanganese chloride results in increased expression of SNCA protein23353026
C025340manganese chlorideSNCA protein promotes the reaction [manganese chloride results in increased expression of and results in increased phosphorylation of EIF2AK3 protein]23934647
C025340manganese chlorideSNCA protein promotes the reaction [manganese chloride results in increased expression of and results in increased phosphorylation of EIF2A protein]23934647
C025340manganese chlorideSNCA protein promotes the reaction [manganese chloride results in increased expression of and results in increased splicing of XBP1 mRNA]23934647
C025340manganese chlorideSNCA protein promotes the reaction [manganese chloride results in increased expression of ATF4 mRNA]23934647
C025340manganese chlorideSNCA protein promotes the reaction [manganese chloride results in increased expression of CASP12 protein]23934647
C025340manganese chlorideSNCA protein promotes the reaction [manganese chloride results in increased expression of DDIT3 mRNA]23934647
C025340manganese chlorideSNCA protein promotes the reaction [manganese chloride results in increased expression of DDIT3 protein]23934647
C025340manganese chlorideSNCA protein promotes the reaction [manganese chloride results in increased expression of HSP90B1 mRNA]23934647
C025340manganese chlorideSNCA protein promotes the reaction [manganese chloride results in increased expression of HSP90B1 protein]23934647
C025340manganese chlorideSNCA protein promotes the reaction [manganese chloride results in increased expression of HSPA5 mRNA]23934647
C025340manganese chlorideSNCA protein promotes the reaction [manganese chloride results in increased expression of HSPA5 protein]23934647
C025340manganese chlorideSNCA protein promotes the reaction [manganese chloride results in increased phosphorylation of ERN1 protein]23934647
D008469Meclofenamic AcidMeclofenamic Acid inhibits the reaction [SNCA protein binds to SNCA protein]18164319
D008550MelatoninMelatonin inhibits the reaction [Rotenone results in increased expression of SNCA protein]18289173
D008550MelatoninMelatonin inhibits the reaction [sodium arsenite promotes the reaction [SNCA protein binds to SNCA protein]]17645694
C042720mercuric bromidemercuric bromide results in decreased expression of SNCA mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SNCA mRNA"27188386
D008694MethamphetamineSNCA gene SNP results in increased susceptibility to Methamphetamine15542733
D008694MethamphetamineMethamphetamine results in increased expression of SNCA protein16181420
D008694MethamphetamineSNCA affects the susceptibility to Methamphetamine12732244
D008694MethamphetamineMethamphetamine promotes the reaction [SNCA protein binds to SNCA protein]25090657
D008694MethamphetamineMethamphetamine results in increased expression of SNCA protein17904249|2509065
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SNCA mRNA20061341
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of SNCA mRNA26558463
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of SNCA mRNA26056851
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium promotes the reaction [SNCA protein binds to SNCA protein]23754278
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased methylation of SNCA promoter23441691
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SNCA27432061
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SNCA mRNA16678164
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SNCA protein16678164|1713142
D0156551-Methyl-4-phenylpyridiniumADCYAP1 protein inhibits the reaction [SNCA protein results in increased susceptibility to 1-Methyl-4-phenylpyridinium]15888489
D0156551-Methyl-4-phenylpyridinium"diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo(lmn)(3,8)phenanthroline-2,7-diacetate inhibits the reaction [1-Methyl-4-phenylpyridinium promotes the reaction [SNCA protein binds to SNCA protein]]"23754278
D0156551-Methyl-4-phenylpyridiniumDNAJB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA mRNA]16678164
D0156551-Methyl-4-phenylpyridiniumDNAJB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA protein]16678164
D0156551-Methyl-4-phenylpyridiniumechinacoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA]27432061
D0156551-Methyl-4-phenylpyridiniumGRP protein inhibits the reaction [SNCA protein results in increased susceptibility to 1-Methyl-4-phenylpyridinium]15888489
D0156551-Methyl-4-phenylpyridiniumIGF1 protein inhibits the reaction [SNCA protein results in increased susceptibility to 1-Methyl-4-phenylpyridinium]15888489
D0156551-Methyl-4-phenylpyridiniumKCNJ6 protein promotes the reaction [SNCA protein results in increased susceptibility to 1-Methyl-4-phenylpyridinium]15888489
D0156551-Methyl-4-phenylpyridiniumSNCA mRNA affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]19646423
D0156551-Methyl-4-phenylpyridiniumSNCA mRNA affects the susceptibility to 1-Methyl-4-phenylpyridinium19646423
D0156551-Methyl-4-phenylpyridiniumSNCA protein affects the reaction [SLC6A3 protein results in increased susceptibility to 1-Methyl-4-phenylpyridinium]12151787
D0156551-Methyl-4-phenylpyridiniumSNCA protein affects the susceptibility to 1-Methyl-4-phenylpyridinium17131421|1903259
D0156551-Methyl-4-phenylpyridiniumSNCA protein affects the uptake of 1-Methyl-4-phenylpyridinium19032594
D0156551-Methyl-4-phenylpyridiniumSNCA protein mutant form promotes the reaction [SLC6A3 protein results in increased susceptibility to 1-Methyl-4-phenylpyridinium]12151787
D0156551-Methyl-4-phenylpyridiniumSNCA protein mutant form results in increased susceptibility to 1-Methyl-4-phenylpyridinium16297908
D0156551-Methyl-4-phenylpyridiniumSNCA protein results in increased susceptibility to 1-Methyl-4-phenylpyridinium12151787|1588848
D0156551-Methyl-4-phenylpyridiniumSNCA results in increased susceptibility to 1-Methyl-4-phenylpyridinium24173167
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SNCA mRNA26056851|2655846
D0156551-Methyl-4-phenylpyridiniumSNCA protein affects the susceptibility to 1-Methyl-4-phenylpyridinium20079841
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium promotes the reaction [SNCA protein binds to SNCA protein]19287320
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SNCA protein19287320
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SNCA protein modified form17280646
D0156551-Methyl-4-phenylpyridiniumRifampin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA protein modified form]17280646
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of and affects the localization of SNCA protein alternative form"19857570
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA mRNA alternative form"19857570
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"GPX1 protein inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA mRNA alternative form]"19857570
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA mRNA alternative form]"19857570
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"U 0126 promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA mRNA alternative form]"19857570
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [SNCA protein binds to SNCA protein]"15099020
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [SNCA protein mutant form binds to RAB3A protein]"15099020
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [SNCA protein mutant form binds to RAB5A protein]"15099020
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [SNCA protein mutant form binds to RAB8A protein]"15099020
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA mRNA"19857570|2374757
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA mRNA alternative form"19857570
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA protein"23747572
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Dieldrin promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA protein]"16809432
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"SNCA affects the susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"12732244
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"SNCA protein affects the susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"19032594
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA mRNA]"23747572
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA protein]"23747572
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA mRNA alternative form"19857570
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"U 0126 promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA mRNA alternative form]"19857570
D008777MethyltestosteroneMethyltestosterone results in decreased expression of SNCA mRNA29191790
D052998MicrocystinsMicrocystins results in increased expression of SNCA mRNA22430071
D052998MicrocystinsMicrocystins results in increased expression of SNCA protein22430071
C502230Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [cypermethrin promotes the reaction [SNCA protein binds to SNCA protein]]"25370934
C502230Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [cypermethrin results in increased expression of SNCA protein]"25370934
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of SNCA25639566
D009020MorphineMorphine results in increased expression of SNCA mRNA15183518
C523799MRK 003SNCA results in increased susceptibility to MRK 00319903844
C496401N-((3-(aminomethyl)phenyl)methyl)ethanimidamide[N-((3-(aminomethyl)phenyl)methyl)ethanimidamide co-treated with diphenyleneiodonium] inhibits the reaction [SNCA protein mutant form results in increased susceptibility to Lipopolysaccharides]21245015
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SNCA mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SNCA mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of SNCA mRNA19812364
D009532NickelNickel results in decreased expression of SNCA mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of SNCA mRNA22714537
D009538NicotineNicotine results in increased expression of SNCA mRNA18247414
D009569Nitric Oxide[Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]] which results in increased abundance of Nitric Oxide24290359
D009569Nitric Oxide[Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]] which results in increased abundance of Nitric Oxide24290359
C037740N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid"N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA mRNA alternative form]"19857570
D016627OxidopamineOxidopamine results in increased expression of SNCA mRNA alternative form19857570
D016627OxidopamineSNCA protein mutant form results in increased susceptibility to Oxidopamine16297908
D016627OxidopamineOxidopamine results in increased expression of SNCA protein22016808
D020866omega-Conotoxin GVIAomega-Conotoxin GVIA inhibits the reaction [SNCA protein results in increased uptake of Calcium]17179863
D000073878Palm OilPalm Oil results in increased expression of SNCA mRNA18042831
D010269Paraquatcalpeptin inhibits the reaction [Paraquat results in increased expression of SNCA protein alternative form]24509835
D010269ParaquatManeb promotes the reaction [Paraquat results in increased expression of SNCA protein]26498265
D010269ParaquatManeb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]24290359
D010269Paraquat[Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]] which results in increased abundance of Nitric Oxide24290359
D010269Paraquat[Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]] which results in increased metabolism of MEF2C protein24290359
D010269ParaquatParaquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]24290359
D010269Paraquat[Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]] which results in increased abundance of Nitric Oxide24290359
D010269Paraquat[Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]] which results in increased metabolism of MEF2C protein24290359
D010269ParaquatParaquat results in increased expression of SNCA protein17934957|2353536
D010269ParaquatParaquat results in increased expression of SNCA protein alternative form24509835
D010269ParaquatParaquat results in increased expression of SNCA protein modified form26409479
D010269ParaquatSNCA gene mutant form results in increased susceptibility to Paraquat24290359
D010269ParaquatSNCA protein affects the susceptibility to Paraquat24509835
D010269Paraquat[SNCA protein co-treated with Paraquat co-treated with Dopamine] results in increased expression of HMOX1 protein21735318
D010269ParaquatSNCA protein inhibits the reaction [Paraquat results in decreased activity of ACO2 protein]15234109
D010269ParaquatSNCA protein mutant form results in increased susceptibility to [Paraquat co-treated with Iron]27324791
D010269ParaquatSNCA protein mutant form results in increased susceptibility to [Paraquat co-treated with Maneb]27324791
D010269ParaquatSNCA protein results in decreased susceptibility to Paraquat12716914|1523410
D010269ParaquatSNCA protein results in increased susceptibility to [Maneb co-treated with Paraquat]23017109
D010269ParaquatSNCA protein results in increased susceptibility to Paraquat23934919|2732479
D010269ParaquatEUK-189 results in decreased susceptibility to [Iron co-treated with Paraquat co-treated with SNCA gene mutant form]21039522
D010269ParaquatParaquat promotes the reaction [SNCA protein binds to SNCA protein]17879265
D010269ParaquatParaquat results in increased expression of SNCA protein11707429|2229202
D010269ParaquatSNCA gene affects the susceptibility to Paraquat21039522
D010269Paraquat[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ADORA1 mRNA23017109
D010269Paraquat[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of APBB1 mRNA23017109
D010269Paraquat[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ASCL1 mRNA23017109
D010269Paraquat[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP2 mRNA23017109
D010269Paraquat[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA23017109
D010269Paraquat[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DLL1 mRNA23017109
D010269Paraquat[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD2 mRNA23017109
D010269Paraquat[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD5 mRNA23017109
D010269Paraquat[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of HEYL mRNA23017109
D010269Paraquat[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX5 mRNA23017109
D010269Paraquat[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of SEMA4D mRNA23017109
D010269Paraquat[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of VEGFA mRNA23017109
D010269ParaquatSNCA protein inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA]23017109
D010269ParaquatParaquat affects the folding of SNCA protein11445065
D052638Particulate MatterParticulate Matter results in increased expression of SNCA protein25498254
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of SNCA protein16451863|1855017
C046012pentanalpentanal results in increased expression of SNCA mRNA26079696
D026023PermethrinPermethrin results in increased expression of SNCA protein14575646
D010634PhenobarbitalPhenobarbital affects the expression of SNCA mRNA23091169
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of SNCA mRNA21334430
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SNCA mRNA23608068
D011341ProbucolProbucol inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]16239214
C005556propionaldehydepropionaldehyde results in increased expression of SNCA mRNA26079696
D011441PropylthiouracilPropylthiouracil affects the expression of SNCA mRNA24780913
D011441PropylthiouracilPropylthiouracil results in decreased expression of SNCA mRNA24780913
C428725pyridabenSNCA protein results in increased susceptibility to pyridaben16239214
D011748PyrogallolPyrogallol inhibits the reaction [SNCA protein binds to SNCA protein]20150427
D011794QuercetinQuercetin inhibits the reaction [SNCA protein binds to SNCA protein]20150427
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of SNCA mRNA16079270
D026361Reactive Nitrogen SpeciesSNCA gene inhibits the reaction [DJR-1.1 mutant form promotes the reaction [manganese chloride results in increased abundance of Reactive Nitrogen Species]]24452053
D026361Reactive Nitrogen SpeciesSNCA gene inhibits the reaction [PDR-1 mutant form promotes the reaction [manganese chloride results in increased abundance of Reactive Nitrogen Species]]24452053
D017382Reactive Oxygen Speciesferrous sulfate promotes the reaction [SNCA protein results in increased abundance of Reactive Oxygen Species]27424009
D017382Reactive Oxygen SpeciesSNCA gene inhibits the reaction [DJR-1.1 mutant form promotes the reaction [manganese chloride results in increased abundance of Reactive Oxygen Species]]24452053
D017382Reactive Oxygen SpeciesSNCA gene inhibits the reaction [PDR-1 mutant form promotes the reaction [manganese chloride results in increased abundance of Reactive Oxygen Species]]24452053
D017382Reactive Oxygen SpeciesSNCA protein results in increased abundance of Reactive Oxygen Species27424009
D012110ReserpineSNCA protein mutant form affects the susceptibility to Reserpine18622040
C059514resveratrolBECN1 protein affects the reaction [resveratrol results in increased degradation of SNCA protein]21778691
C059514resveratrolresveratrol binds to [SNCA protein binds to SNCA protein]17597573
C059514resveratrolresveratrol results in increased degradation of SNCA protein21778691
D012293RifampinRifampin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA protein modified form]17280646
D012293RifampinRifampin results in increased sumoylation of SNCA protein28132806
D012293RifampinUBE2I mRNA promotes the reaction [Rifampin results in increased sumoylation of SNCA protein]28132806
D012402Rotenone3-Hydroxybutyric Acid inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]16239214
D012402Rotenone3-Hydroxybutyric Acid promotes the reaction [tauroursodeoxycholic acid inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]]16239214
D012402Rotenone3-methyladenine inhibits the reaction [Rotenone results in decreased expression of SNCA mRNA]27133439
D012402Rotenone3-methyladenine inhibits the reaction [Rotenone results in decreased expression of SNCA protein]27133439
D012402Rotenone[Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]20414966
D012402RotenoneAcetylcarnitine inhibits the reaction [Rotenone results in increased expression of SNCA protein]20414966
D012402Rotenonealpha-Tocopherol inhibits the reaction [Rotenone results in increased expression of SNCA protein]16439141
D012402RotenoneProbucol inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]16239214
D012402RotenoneRotenone affects the localization of SNCA protein19628769
D012402RotenoneRotenone affects the localization of SNCA protein mutant form19628769
D012402RotenoneRotenone promotes the reaction [SNCA protein binds to SNCA protein]23244436
D012402RotenoneRotenone promotes the reaction [SNCA protein binds to YWHAB protein]15280438
D012402RotenoneRotenone results in decreased expression of SNCA mRNA27133439
D012402RotenoneRotenone results in decreased expression of SNCA protein27133439
D012402RotenoneRotenone results in increased expression of SNCA mRNA alternative form19857570
D012402RotenoneRotenone results in increased expression of SNCA protein12177198|1511462
D012402RotenoneSIRT3 protein inhibits the reaction [Rotenone results in increased expression of SNCA protein]27053302
D012402RotenoneSNCA gene mutant form results in increased susceptibility to Rotenone24290359
D012402RotenoneSNCA protein affects the susceptibility to Rotenone22319455|2758556
D012402RotenoneSNCA protein mutant form results in increased susceptibility to Rotenone23153578
D012402RotenoneSNCA protein promotes the reaction [Rotenone results in increased secretion of CASP3 protein]26963176
D012402RotenoneSNCA protein results in decreased susceptibility to Rotenone16239214|1704172
D012402RotenoneSNCA protein results in increased susceptibility to Rotenone12151787|1851441
D012402Rotenone[Staurosporine co-treated with Rotenone] promotes the reaction [SNCA protein binds to SNCA protein]19114014
D012402Rotenonetauroursodeoxycholic acid inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]16239214
D012402RotenoneThioctic Acid inhibits the reaction [Rotenone results in increased expression of SNCA protein]20414966
D012402RotenoneTRAP1 protein inhibits the reaction [SNCA protein affects the susceptibility to Rotenone]22319455
D012402Rotenone4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of SNCA protein]17459145
D012402Rotenone[bafilomycin A1 co-treated with Rotenone] results in increased expression of SNCA protein26031332
D012402RotenoneRotenone affects the localization of SNCA protein20464527
D012402RotenoneRotenone promotes the reaction [SNCA protein binds to SNCA protein]15099020
D012402RotenoneRotenone promotes the reaction [SNCA protein mutant form binds to RAB3A protein]15099020
D012402RotenoneRotenone promotes the reaction [SNCA protein mutant form binds to RAB5A protein]15099020
D012402RotenoneRotenone promotes the reaction [SNCA protein mutant form binds to RAB8A protein]15099020
D012402RotenoneRotenone results in increased expression of SNCA protein17459145|2603133
D012402RotenoneRotenone results in increased secretion of and results in increased uptake of and affects the localization of SNCA protein23205266
D012402RotenoneSESN2 protein inhibits the reaction [Rotenone results in increased expression of SNCA protein]26031332
D012402Rotenone"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Rotenone results in increased expression of and results in increased phosphorylation of SNCA protein]"25433145
D012402RotenoneApigenin inhibits the reaction [Rotenone results in increased expression of SNCA protein]28389404
D012402RotenoneLithium inhibits the reaction [Rotenone results in increased expression of and results in increased phosphorylation of SNCA protein]25433145
D012402RotenoneMelatonin inhibits the reaction [Rotenone results in increased expression of SNCA protein]18289173
D012402RotenoneRotenone affects the localization of SNCA protein11100151|1769072
D012402RotenoneRotenone affects the localization of SNCA protein modified form19626387
D012402RotenoneRotenone promotes the reaction [SNCA protein binds to SNCA protein binds to SNCA protein]25433145
D012402RotenoneRotenone results in decreased degradation of SNCA protein25433145
D012402RotenoneRotenone results in decreased expression of SNCA protein25430725
D012402RotenoneRotenone results in increased expression of SNCA protein16219024|1643914
D012402RotenoneRotenone results in increased phosphorylation of and results in increased expression of SNCA protein25433145
D012402RotenoneRotenone results in increased ubiquitination of SNCA protein19626387
D012402RotenoneSNCA protein promotes the reaction [Rotenone results in decreased abundance of Dopamine]26075822
D012402RotenoneSNCA protein promotes the reaction [Rotenone results in decreased expression of TH protein]26075822
D012402RotenoneSNCA protein results in increased susceptibility to Rotenone26075822
D012402RotenoneValproic Acid inhibits the reaction [Rotenone affects the localization of SNCA protein modified form]19626387
D012402RotenoneValproic Acid inhibits the reaction [Rotenone results in increased ubiquitination of SNCA protein]19626387
D012402RotenoneYWHAE mutant form promotes the reaction [Rotenone results in increased expression of SNCA protein]24002177
D012402RotenoneRotenone affects the folding of SNCA protein11445065
C003402sapropterinSNCA mutant form results in increased abundance of sapropterin24148766
D012524SarinSarin results in decreased expression of SNCA mRNA19522546
D012524SarinSarin results in decreased expression of SNCA protein28973502
C417521SB 216763SB 216763 inhibits the reaction [SNCA protein results in decreased abundance of Adenosine Triphosphate]24989254
D012642Selegiline"Selegiline inhibits the reaction [1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA protein]"15114628
D012642SelegilineSelegiline inhibits the reaction [linsidomine results in increased expression of SNCA protein]12880480
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SNCA mRNA25895662
D012822Silicon DioxideAcetylcysteine inhibits the reaction [Silicon Dioxide analog results in increased expression of SNCA protein]27613482
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SNCA protein27613482
D012834SilverSilver results in increased expression of SNCA mRNA27131904
C017947sodium arsenitesodium arsenite promotes the reaction [SNCA protein binds to SNCA protein]27413109
C017947sodium arsenitesodium arsenite results in increased expression of SNCA mRNA22714537
C017947sodium arsenitesodium arsenite results in increased expression of SNCA protein27413109
C017947sodium arseniteATG7 mutant form inhibits the reaction [sodium arsenite results in decreased expression of SNCA]25639566
C017947sodium arseniteMelatonin inhibits the reaction [sodium arsenite promotes the reaction [SNCA protein binds to SNCA protein]]17645694
C017947sodium arsenitesodium arsenite affects the localization of SNCA protein17681577
C017947sodium arsenitesodium arsenite promotes the reaction [SNCA protein binds to SNCA protein]17645694
C017947sodium arsenitesodium arsenite results in decreased expression of SNCA25639566
D053260SootSoot results in increased expression of SNCA protein25498254
D053260SootSoot results in decreased expression of SNCA mRNA22461453
D019311StaurosporineSNCA protein affects the reaction [Staurosporine results in increased activity of SLC6A3 protein]19032594
D019311Staurosporine[Staurosporine co-treated with Rotenone] promotes the reaction [SNCA protein binds to SNCA protein]19114014
C041573stigmatellinSNCA protein results in increased susceptibility to stigmatellin16239214
C025462sulindac sulfidesulindac sulfide inhibits the reaction [SNCA protein binds to SNCA protein]18164319
D013619TacrineTacrine results in decreased expression of SNCA mRNA12832660
D013629TamoxifenTamoxifen affects the expression of SNCA mRNA14699072
C031655tauroursodeoxycholic acid3-Hydroxybutyric Acid promotes the reaction [tauroursodeoxycholic acid inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]]16239214
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]16239214
C084178telmisartan"telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA mRNA]"23747572
C084178telmisartan"telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA protein]"23747572
C004648testosterone enanthatetestosterone enanthate affects the expression of SNCA mRNA17440010
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of SNCA mRNA28970181
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SNCA mRNA19933214
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of SNCA protein"25852303
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine affects the localization of SNCA protein"25852303
D008063Thioctic Acid[Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]20414966
D008063Thioctic AcidThioctic Acid inhibits the reaction [Rotenone results in increased expression of SNCA protein]20414966
C009495titanium dioxidetitanium dioxide results in increased expression of SNCA mRNA23557971
C423915TO-901317TO-901317 results in increased expression of SNCA mRNA18841091
C423915TO-901317TO-901317 results in increased expression of SNCA protein18841091
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of SNCA mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SNCA mRNA28111298
D024505TocopherolsTocopherols results in increased expression of SNCA mRNA17654050
C066340tolcaponetolcapone inhibits the reaction [SNCA protein binds to SNCA protein]20150427
D019772TopotecanTopotecan results in decreased expression of SNCA mRNA25729387
D014212TretinoinTretinoin results in increased expression of SNCA mRNA21934132
C012589trichostatin A[decitabine co-treated with trichostatin A] results in increased expression of SNCA mRNA17891453
C012589trichostatin Atrichostatin A results in increased expression of SNCA mRNA24935251
C113580U 0126"U 0126 promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA mRNA alternative form]"19857570
C113580U 0126"U 0126 promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA mRNA alternative form]"19857570
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNCA mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SNCA mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SNCA mRNA19101580|2317975
D014635Valproic AcidValproic Acid inhibits the reaction [Rotenone affects the localization of SNCA protein modified form]19626387
D014635Valproic AcidValproic Acid inhibits the reaction [Rotenone results in increased ubiquitination of SNCA protein]19626387
D014638VanadatesVanadates results in increased expression of SNCA mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased expression of SNCA protein25498254
D014801Vitamin AVitamin A results in increased expression of SNCA protein22274401
D015039ZiramZiram results in increased expression of SNCA protein18818210

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IDA11850416  
GO:0003779actin binding-IPI18331289  
GO:0005504fatty acid bindingNOTIDA16687662  
GO:0005507copper ion binding-IDA21319811  21320589  
GO:0005509calcium ion binding-IDA11312271  11850416  
GO:0005515protein binding-IPI10319874  11943812  11956199  12044636  12059041  12958153  
15590652  15671022  16595633  16882008  17156375  18331289  
19549071  19762560  21320589  21798244  21985244  22119730  
22163275  23183827  24412932  
GO:0005543phospholipid binding-IDA17222866  
GO:0008017microtubule binding-IEA-  
GO:0008198ferrous iron binding-IDA11850416  
GO:0008270zinc ion binding-IDA11850416  
GO:0016491oxidoreductase activity-IDA21320589  
GO:0019894kinesin binding-IPI16176937  
GO:0019904protein domain specific binding-IEA-  
GO:0030544Hsp70 protein binding-IPI18975920  
GO:0042393histone binding-IDA16959795  
GO:0042802identical protein binding-IDA24936070  25561023  
GO:0042802identical protein binding-IPI15502874  16330551  16764865  18614564  19745811  19875982  
21443877  22119730  23927048  24374342  24895406  24983211  
25643172  25732184  
GO:0043014alpha-tubulin binding-IPI11698390  
GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process-IDA10818098  
GO:0043274phospholipase binding-IEA-  
GO:0044212transcription regulatory region DNA binding-TAS24252804  
GO:0047485protein N-terminus binding-IEA-  
GO:0048156tau protein binding-IDA17408955  21127069  
GO:0048487beta-tubulin binding-IEA-  
GO:0051219phosphoprotein binding-IDA21127069  
GO:0060961phospholipase D inhibitor activityNOTIDA19146388  
GO:0070840dynein complex binding-IPI16176937  
GO:1903136cuprous ion binding-IMP25495902  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-TAS24252804  
GO:0001774microglial cell activation-TAS24252804  
GO:0001921positive regulation of receptor recycling-IDA18980610  
GO:0001933negative regulation of protein phosphorylation-IEA-  
GO:0001956positive regulation of neurotransmitter secretion-IEA-  
GO:0006631fatty acid metabolic process-IEA-  
GO:0006638neutral lipid metabolic process-IEA-  
GO:0006644phospholipid metabolic process-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process-IDA21050448  
GO:0007006mitochondrial membrane organization-IEA-  
GO:0007568aging-IEA-  
GO:0008344adult locomotory behavior-IEA-  
GO:0010040response to iron(II) ion-IDA11850416  
GO:0010517regulation of phospholipase activity-IDA15641770  
GO:0010642negative regulation of platelet-derived growth factor receptor signaling pathway-IDA12239163  
GO:0014048regulation of glutamate secretion-IEA-  
GO:0014059regulation of dopamine secretion-TAS21320589  
GO:0022898regulation of transmembrane transporter activity-IGI18331289  
GO:0031115negative regulation of microtubule polymerization-IDA21127069  
GO:0031623receptor internalization-IDA18980610  
GO:0031648protein destabilization-IDA21320589  
GO:0032026response to magnesium ion-IDA11850416  
GO:0032410negative regulation of transporter activity-IDA16882008  
GO:0032496response to lipopolysaccharide-IDA12406186  
GO:0032769negative regulation of monooxygenase activity-IDA11943812  
GO:0033138positive regulation of peptidyl-serine phosphorylation-ISS-  
GO:0034341response to interferon-gamma-IDA19157893  
GO:0034599cellular response to oxidative stress-IC23507046  
GO:0035067negative regulation of histone acetylation-IDA16959795  
GO:0040012regulation of locomotion-IEA-  
GO:0042416dopamine biosynthetic process-TAS21320589  
GO:0042775mitochondrial ATP synthesis coupled electron transport-IEA-  
GO:0043030regulation of macrophage activation-IEA-  
GO:0043065positive regulation of apoptotic process-TAS24252804  
GO:0043066negative regulation of apoptotic process-IMP10818098  
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IMP10818098  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0044344cellular response to fibroblast growth factor stimulus-IEA-  
GO:0045807positive regulation of endocytosis-IDA18980610  
GO:0045920negative regulation of exocytosis-IMP12239163  
GO:0045963negative regulation of dopamine metabolic process-IEA-  
GO:0048148behavioral response to cocaine-IEA-  
GO:0048169regulation of long-term neuronal synaptic plasticity-IEA-  
GO:0048488synaptic vesicle endocytosis-ISS-  
GO:0048489synaptic vesicle transport-IEA-  
GO:0050729positive regulation of inflammatory response-IDA25533483  
GO:0050808synapse organization-IEA-  
GO:0050812regulation of acyl-CoA biosynthetic process-IEA-  
GO:0051281positive regulation of release of sequestered calcium ion into cytosol-IDA15641770  
GO:0051583dopamine uptake involved in synaptic transmission-TAS21320589  
GO:0051585negative regulation of dopamine uptake involved in synaptic transmission-IDA12958153  
GO:0051612negative regulation of serotonin uptake-IDA16882008  
GO:0051621regulation of norepinephrine uptake-IGI18331289  
GO:0051622negative regulation of norepinephrine uptake-IDA17156375  
GO:0055074calcium ion homeostasisNOTIDA12239163  
GO:0055114oxidation-reduction process-IDA21320589  
GO:0060079excitatory postsynaptic potential-IEA-  
GO:0060291long-term synaptic potentiation-IEA-  
GO:0060732positive regulation of inositol phosphate biosynthetic process-IDA15641770  
GO:0070495negative regulation of thrombin-activated receptor signaling pathway-IDA12239163  
GO:0070555response to interleukin-1-IDA12406186  
GO:0071280cellular response to copper ion-IDA21320589  
GO:0071872cellular response to epinephrine stimulus-TAS21320589  
GO:0071902positive regulation of protein serine/threonine kinase activity-IDA21127069  
GO:0097435supramolecular fiber organization-TAS21320589  
GO:1901215negative regulation of neuron death-IDA15863497  
GO:1901216positive regulation of neuron death-IDA25533483  
GO:1902957negative regulation of mitochondrial electron transport, NADH to ubiquinone-TAS24252804  
GO:1903284positive regulation of glutathione peroxidase activity-IDA23507046  
GO:1903285positive regulation of hydrogen peroxide catabolic process-IDA23507046  
GO:1903421regulation of synaptic vesicle recycling-TAS23983262  
GO:1903426regulation of reactive oxygen species biosynthetic process-TAS24252804  
GO:1904307response to desipramine-IEA-  
GO:1904715negative regulation of chaperone-mediated autophagy-IMP20697033  
GO:1905606regulation of presynapse assembly-IGI25533483  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IDA15863497  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA24936070  
GO:0005634nucleus-IDA12406186  16959795  17408955  24936070  
GO:0005640nuclear outer membrane-IEA-  
GO:0005737cytoplasm-IDA12406186  12958153  15863497  16959795  17408955  23983262  24403142  25561023  
GO:0005739mitochondrion-TAS24252804  
GO:0005741mitochondrial outer membrane-IEA-  
GO:0005747mitochondrial respiratory chain complex Icolocalizes_withTAS24252804  
GO:0005758mitochondrial intermembrane space-IEA-  
GO:0005759mitochondrial matrix-IEA-  
GO:0005764lysosome-TAS24477431  
GO:0005791rough endoplasmic reticulum-IEA-  
GO:0005794Golgi apparatus-IEA-  
GO:0005829cytosol-IDA8248242  24936070  
GO:0005829cytosol-TAS-  
GO:0005840ribosome-IEA-  
GO:0005886plasma membrane-IDA12958153  15641770  17222866  
GO:0005938cell cortex-IDA19157893  
GO:0008021synaptic vesicle-IEA-  
GO:0015629actin cytoskeleton-IDA17408955  
GO:0016020membrane-IDA24936070  
GO:0016234inclusion body-IDA17222866  20039155  
GO:0030054cell junction-IEA-  
GO:0030424axon-IDA12958153  
GO:0030426growth cone-IDA12958153  
GO:0031092platelet alpha granule membranecolocalizes_withIDA12239163  
GO:0043025neuronal cell body-IEA-  
GO:0043195terminal bouton-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA20039155  
GO:0098794postsynapse-IEA-  
GO:0099512supramolecular fiber-IDA17222866  18346205  23507046  
KEGG ID KEGG Term
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-977225Amyloid fiber formationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22763023An exploratory analysis on gene-environment interactions for Parkinson disease. (2012 Oct)Gao JNeurobiol Aging
28289797[Epidemiology and causes of Parkinson's disease]. (2017 Apr)Lill CMNervenarzt
16961766The genetics of alcoholism: identifying specific genes through family studies. (2006 Sep)Edenberg HJAddict Biol
17374033Linkage disequilibrium and association analysis of alpha-synuclein and alcohol and drug dependence in two American Indian populations. (2007 Apr)Clarimon JAlcohol Clin Exp Res
17374032Association of alcohol craving with alpha-synuclein (SNCA). (2007 Apr)Foroud TAlcohol Clin Exp Res
18210157Exploring gene-environment interactions in Parkinson's disease. (2008 Apr)McCulloch CCHum Genet
26297298Differential expression of alpha-synuclein splice variants in the brain of alcohol misusers: Influence of genotype. (2015 Oct 1)Janeczek PDrug Alcohol Depend
23384371Genetic variation in the alpha synuclein gene (SNCA) is associated with BOLD response to alcohol cues. (2013 Mar)Wilcox CEJ Stud Alcohol Drugs
16762686Peripheral blood alpha-synuclein mRNA levels are elevated in cynomolgus monkeys that chronically self-administer ethanol. (2006 Jan)Walker SJAlcohol
20664293alpha-Synuclein gene may interact with environmental factors in increasing risk of Parkinson's disease. (2010)Gatto NMNeuroepidemiology
21309955Alpha-synuclein and heroin craving in opiate-dependent patients on injectable heroin maintenance. (2012 Sep)Dursteler-MacFarland KMAddict Biol
19630743From QTL to candidate gene: a genetic approach to alcoholism research. (2009 May)Spence JPCurr Drug Abuse Rev
28833174Enhanced motivation to alcohol in transgenic mice expressing human alpha-synuclein. (2017 Nov)Rotermund CJ Neurochem
21513161[Inheritance mechnisam of gene SNCA for alcohol dependence]. (2010 Nov)Yang YQYi Chuan
24844177Genetic risk prediction and neurobiological understanding of alcoholism. (2014 May 20)Levey DFTransl Psychiatry
22974310Reduced expression of alpha-synuclein in alcoholic brain: influence of SNCA-Rep1 genotype. (2014 May)Janeczek PAddict Biol
22425546SNCA polymorphisms, smoking, and sporadic Parkinson's disease in Japanese. (2012 Jun)Miyake YParkinsonism Relat Disord
20876472A comprehensive analysis of deletions, multiplications, and copy number variations in PARK2. (2010 Sep 28)Kay DMNeurology
22839974UCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan. (2012 Jul 28)Miyake YBMC Neurol
22792237Different genes interact with particulate matter and tobacco smoke exposure in affecting lung function decline in the general population. (2012)Curjuric IPLoS One
16459936Drinking trajectories from adolescence to the mid-forties among alcohol dependent males. (2005 Nov)Jacob TJ Stud Alcohol
23055790Environmental-genetic interactions in the pathogenesis of Parkinson's disease. (2012 Sep)Tsuboi YExp Neurobiol
26621272The Key Proteins of Dopaminergic Neurotransmission of Human Peripheral Blood Lymphocytes: Changed mRNA Level in Alcohol Dependence Syndrome. (2015 Dec)Taraskina AEBull Exp Biol Med
28676755Variants in SNCA Gene Are Associated with Parkinson's Disease Risk and Cognitive Symptoms in a Brazilian Sample. (2017)Campelo CLCFront Aging Neurosci