Gene: SNRPN

6638
HCERN3|PWCR|RT-LI|SM-D|SMN|SNRNP-N|SNURF-SNRPN|sm-N
small nuclear ribonucleoprotein polypeptide N
protein-coding
15q11.2
Ensembl:ENSG00000128739 MIM:182279 Vega:OTTHUMG00000129180 UniprotKB:P63162
NG_012958.1
PubMed
0   ANCO-SNPs
ND
2   
3.171e-1 (AD)  3.063e-1 (ND)   (Frontal_Cortex)
1.386e-1 (AD)  4.546e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg25030262chr15:25092069SNRPNPromoter2.447e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP8A20.934
NMNAT20.932
GLT1D10.931
NBEA0.931
DYNC1I10.927
KRT2220.926
RAB3C0.925
G3BP20.922
REPS20.92
MYCBP20.92

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.538
CSAG1-0.519
REST-0.515
RAB13-0.509
MYL3-0.509
RNF135-0.507
YES1-0.506
ROM1-0.501
CHST14-0.499
TGIF1-0.495

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SNRPN mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] affects the expression of SNRPN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SNRPN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNRPN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] affects the expression of SNRPN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SNRPN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNRPN mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SNRPN gene28458013
C000188alachloralachlor affects the expression of SNRPN mRNA19425180
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SNRPN mRNA16483693
D001262AtenololAtenolol results in increased expression of SNRPN mRNA19915711
C044946benazeprilbenazepril results in decreased expression of SNRPN mRNA14871019
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SNRPN mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of SNRPN mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of SNRPN mRNA23593014
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SNRPN mRNA28628672
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SNRPN mRNA26314618
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SNRPN mRNA17484886
D002857ChromiumChromium results in decreased expression of SNRPN mRNA21437242
C018021cobaltous chloridecobaltous chloride results in decreased expression of SNRPN mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of SNRPN mRNA19549813
D003703DemecolcineDemecolcine results in decreased expression of SNRPN mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SNRPN mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SNRPN mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SNRPN mRNA17361019
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SNRPN mRNA21266533
D004041Dietary FatsDietary Fats results in increased expression of SNRPN mRNA25016146
C007556domiphenSNRPN gene SNP affects the susceptibility to domiphen25622337
C118739entinostatentinostat affects the expression of SNRPN mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] affects the expression of SNRPN mRNA"27188386
D005419FlavonoidsFlavonoids results in increased expression of SNRPN mRNA18035473
D004397FonofosFonofos results in increased methylation of SNRPN promoter22847954
D005557FormaldehydeFormaldehyde results in decreased expression of SNRPN mRNA23649840
C039281furanfuran results in increased methylation of SNRPN gene22079235
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of SNRPN mRNA18951874
C016517indole-3-carbinolindole-3-carbinol affects the expression of SNRPN mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SNRPN mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SNRPN mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SNRPN mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SNRPN mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SNRPN mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SNRPN mRNA24231268
D007854LeadLead affects the expression of SNRPN mRNA28903495
D008731MethoxychlorMethoxychlor results in increased methylation of SNRPN gene21062904
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SNRPN mRNA26272509
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SNRPN mRNA"27188386
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of SNRPN mRNA12634122
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SNRPN protein26558463
C047806monomethylpropionmonomethylpropion results in increased expression of SNRPN mRNA22303338
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SNRPN mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SNRPN mRNA"25620056
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of SNRPN mRNA19074003
D010278ParathionParathion results in increased methylation of SNRPN promoter22847954
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SNRPN mRNA25868421
D010936Plant ExtractsPlant Extracts results in decreased expression of SNRPN mRNA23557933
C005556propionaldehydepropionaldehyde results in increased expression of SNRPN mRNA26079696
C017947sodium arsenitesodium arsenite results in decreased expression of SNRPN mRNA22714537
C012568terbufosterbufos results in increased methylation of SNRPN promoter22847954
C004648testosterone enanthatetestosterone enanthate affects the expression of SNRPN mRNA17440010
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of SNRPN mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SNRPN mRNA23142538
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SNRPN mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of SNRPN mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of SNRPN mRNA23557971
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNRPN mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SNRPN mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SNRPN mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of SNRPN mRNA24935251|2800136
C025643vinclozolinvinclozolin results in increased methylation of SNRPN gene19887539
D014750VincristineVincristine results in decreased expression of SNRPN mRNA23649840
C111237vorinostatvorinostat results in decreased expression of SNRPN mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15105431  18951082  
GO ID GO Term Qualifier Evidence PubMed
GO:0000398mRNA splicing, via spliceosome-IBA21873635  
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0008380RNA splicing-TAS1533223  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005681spliceosomal complex-TAS1533223  
GO:0005682U5 snRNP-IBA21873635  
GO:0005685U1 snRNP-IBA21873635  
GO:0005686U2 snRNP-IBA21873635  
GO:0005687U4 snRNP-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0030532small nuclear ribonucleoprotein complex-TAS7512861  
GO:0046540U4/U6 x U5 tri-snRNP complex-IBA21873635  
GO:0071004U2-type prespliceosome-IBA21873635  
GO:0071013catalytic step 2 spliceosome-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23116464Beckwith Wiedemann imprinting defect found in leucocyte but not buccal DNA in a child born small for gestational age. (2012 Nov 1)Murphy RBMC Med Genet
27247128Abnormal Methylation of Imprinted Genes and Cigarette Smoking: Assessment of Their Association With the Risk of Male Infertility. (2016 May 31)Dong HReprod Sci