Gene info: ID 664

Gene: BNIP3

GENE ID: 664

Synonyms: NIP3

Description: BCL2 interacting protein 3

Gene type: protein-coding

Location: 10q26.3

dbXrefs: Ensembl:ENSG00000176171 MIM:603293 Vega:OTTHUMG00000019278 UniprotKB:Q12983

RefSeq: NC_000010.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.187e-1 (AD) 3.685e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PGAM1	0.946
OAT	0.942
COPS8	0.942
GHITM	0.937
ARL8B	0.937
PAIP2	0.934
GRSF1	0.926
NARS	0.926
PRNP	0.926
UQCRC2	0.924

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.705
OR4F29	-0.671
MTRNR2L10	-0.401
MTRNR2L6	-0.401
MTRNR2L9	-0.39
CSAG1	-0.378
MTRNR2L3	-0.374
KLRB1	-0.364
KCNJ15	-0.363
MTRNR2L2	-0.356

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of BNIP3 mRNA"	26377693
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of BNIP3 mRNA	25596134
C095284	1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one	"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in decreased expression of BNIP3 mRNA]"	11592958
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in decreased expression of BNIP3 mRNA	28329830
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of BNIP3 mRNA"	20206263
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of BNIP3 mRNA]"	19467301
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BNIP3 mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of BNIP3 mRNA	12419474
C029370	4-toluidine	4-toluidine results in increased expression of BNIP3 mRNA	27638505
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BNIP3 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of BNIP3 mRNA	25704631
D000082	Acetaminophen	Acetaminophen results in increased expression of BNIP3 mRNA	25596134
D000082	Acetaminophen	[Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of BNIP3 mRNA	17093179
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]	19442826
D020106	Acrylamide	Acrylamide results in increased expression of BNIP3 mRNA	28959563
D000638	Amiodarone	Amiodarone affects the expression of BNIP3 mRNA	19483382
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of BNIP3 mRNA	16483693
D000968	Antimycin A	Antimycin A results in increased expression of BNIP3 mRNA	19304788
D000975	Antioxidants	Antioxidants inhibits the reaction [Manganese results in increased expression of BNIP3 protein]	19442826
C006632	arsenic trioxide	[arsenic trioxide co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in decreased expression of BNIP3 mRNA	25446377
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of BNIP3 mRNA]	25446377
C006632	arsenic trioxide	arsenic trioxide results in increased expression of BNIP3 mRNA	15592527\|1753043
C006632	arsenic trioxide	arsenic trioxide results in increased expression of BNIP3 protein	15592527
C006632	arsenic trioxide	BNIP3 protein results in increased susceptibility to arsenic trioxide	15592527
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of BNIP3 mRNA	19730151
D001280	Atrazine	Atrazine results in decreased expression of BNIP3 mRNA	22378314
D001374	Azacitidine	Azacitidine results in increased expression of BNIP3 mRNA	25446377
C040929	bafilomycin A1	bafilomycin A1 results in increased expression of BNIP3 mRNA	25981168
C040929	bafilomycin A1	bafilomycin A1 results in increased expression of BNIP3 protein	25981168
C040929	bafilomycin A1	BNIP3 mutant form promotes the reaction [bafilomycin A1 results in increased cleavage of PARP1 protein]	25981168
C040929	bafilomycin A1	Erlotinib Hydrochloride inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 protein]	25981168
C040929	bafilomycin A1	gefitinib inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 protein]	25981168
C040929	bafilomycin A1	HIF1A mutant form inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 mRNA]	25981168
C040929	bafilomycin A1	lapatinib inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 mRNA]	25981168
D001553	Benzbromarone	Benzbromarone affects the expression of BNIP3 mRNA	19483382
D001554	Benzene	[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of BNIP3 mRNA	17905399
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of BNIP3 mRNA	21569818
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BNIP3 mRNA"	20382639
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	[arsenic trioxide co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in decreased expression of BNIP3 mRNA	25446377
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	arsenic trioxide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of BNIP3 mRNA]	25446377
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Valproic Acid results in increased expression of BNIP3 mRNA]	25446377
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of BNIP3 mRNA	25446377
D001629	Bezafibrate	Bezafibrate results in increased expression of BNIP3 mRNA	17118139
C053541	bicalutamide	bicalutamide results in increased expression of BNIP3 mRNA	15790403
C002791	bismuth tripotassium dicitrate	bismuth tripotassium dicitrate results in increased expression of BNIP3 mRNA	15912405
C006780	bisphenol A	bisphenol A affects the expression of BNIP3 mRNA	23557687
C006780	bisphenol A	bisphenol A results in decreased expression of BNIP3 mRNA	29275510
C006780	bisphenol A	[bisphenol A co-treated with Genistein] results in increased methylation of BNIP3 gene	28505145
C006780	bisphenol A	bisphenol A results in increased expression of BNIP3 mRNA	25181051
D000069286	Bortezomib	Bortezomib results in increased expression of BNIP3 protein	20110775
D002065	Buspirone	Buspirone results in increased expression of BNIP3 mRNA	24136188
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of BNIP3 mRNA	12419474
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of BNIP3 mRNA	15003993
D002104	Cadmium	Cadmium results in increased expression of BNIP3 mRNA	24824807
D002104	Cadmium	Cadmium results in increased expression of BNIP3 protein	24824807
D002104	Cadmium	pyrazolanthrone inhibits the reaction [Cadmium results in increased expression of BNIP3 protein]	24824807
D002104	Cadmium	U 0126 inhibits the reaction [Cadmium results in increased expression of BNIP3 protein]	24824807
D002104	Cadmium	Cadmium results in increased expression of BNIP3 protein	24824807
D002104	Cadmium	Cadmium results in increased expression of BNIP3 protein	24824807
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of BNIP3 mRNA	26472689
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of BNIP3 mRNA	12760830\|2559613
D002110	Caffeine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BNIP3 mRNA"	20230807
D002110	Caffeine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BNIP3 mRNA]"	20230807
C459604	candoxin	candoxin results in decreased expression of BNIP3 mRNA	16309724
D002211	Capsaicin	Capsaicin results in decreased expression of BNIP3 mRNA	19502594
D002220	Carbamazepine	Carbamazepine affects the expression of BNIP3 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of BNIP3 mRNA	17084009
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of BNIP3 mRNA	17484886
D002251	Carbon Tetrachloride	CYP2E1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in decreased expression of BNIP3 mRNA]	17084009
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of BNIP3 mRNA	15963342
C004656	chloroacetaldehyde	chloroacetaldehyde results in increased expression of BNIP3 mRNA	25596134
C100187	chloropicrin	chloropicrin results in increased expression of BNIP3 mRNA	26352163
D002746	Chlorpromazine	Chlorpromazine results in increased expression of BNIP3 mRNA	25596134
D002922	Ciguatoxins	Ciguatoxins affects the expression of BNIP3 mRNA	18353800
D004002	Clodronic Acid	Clodronic Acid results in decreased expression of BNIP3 mRNA	25596134
D002994	Clofibrate	Clofibrate affects the expression of BNIP3 mRNA	19483382
D003035	Cobalt	Cobalt results in increased expression of BNIP3 protein	24824807
D003035	Cobalt	[tungsten carbide binds to Cobalt] which results in increased expression of BNIP3 mRNA	20105288
D003035	Cobalt	[tungsten carbide co-treated with Cobalt] results in increased expression of BNIP3 mRNA	18078969
D003035	Cobalt	Cobalt results in increased expression of BNIP3 protein	24824807
C018021	cobaltous chloride	cobaltous chloride results in increased expression of BNIP3 mRNA	19320972\|1937684
C018021	cobaltous chloride	HIF1A mutant form inhibits the reaction [cobaltous chloride results in increased expression of BNIP3 mRNA]	25100165
C018021	cobaltous chloride	peoniflorin inhibits the reaction [cobaltous chloride results in increased expression of BNIP3 mRNA]	22269387
C018021	cobaltous chloride	tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of BNIP3 mRNA]	25100165
C018021	cobaltous chloride	cobaltous chloride results in increased expression of BNIP3 mRNA	15375294\|1716933
C018021	cobaltous chloride	cobaltous chloride results in increased expression of BNIP3 protein	15375294\|2368455
C018021	cobaltous chloride	cobaltous chloride results in increased expression of BNIP3 mRNA	24386269
C060728	cobalt oxide	cobalt oxide analog results in increased expression of BNIP3 mRNA	24821434
D003042	Cocaine	Cocaine affects the expression of BNIP3 mRNA	15681117
C036978	concanamycin A	concanamycin A results in increased expression of BNIP3 mRNA	25981168
C036978	concanamycin A	lapatinib inhibits the reaction [concanamycin A results in increased expression of BNIP3 mRNA]	25981168
D003300	Copper	[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of BNIP3 mRNA	15467011
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of BNIP3 mRNA	19549813
D003513	Cycloheximide	Cycloheximide inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]	19442826
D016572	Cyclosporine	Cyclosporine results in decreased expression of BNIP3 mRNA	21632981\|2556210
D016572	Cyclosporine	Cyclosporine results in increased expression of BNIP3 mRNA	25596134
D016572	Cyclosporine	Cyclosporine results in increased expression of BNIP3 mRNA	25596134
D003609	Dactinomycin	[Dactinomycin co-treated with TNF protein] results in increased expression of BNIP3 mRNA	11592958
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Ethanol results in increased expression of BNIP3 protein]	24095927
D003609	Dactinomycin	Dactinomycin inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]	19442826
C014347	decitabine	decitabine affects the expression of BNIP3 mRNA	23300844
C014347	decitabine	decitabine results in decreased methylation of BNIP3 promoter	15942716\|1719590
C014347	decitabine	[decitabine results in decreased methylation of BNIP3 promoter] which results in increased expression of BNIP3 mRNA	17195906\|1719590
C014347	decitabine	decitabine results in increased expression of BNIP3 mRNA	15942716\|1636792
C014347	decitabine	decitabine results in increased expression of BNIP3 protein	19732952
C014347	decitabine	[decitabine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of BNIP3 mRNA	15251184
C014347	decitabine	decitabine results in decreased expression of BNIP3 mRNA	15251184
D003703	Demecolcine	Demecolcine results in decreased expression of BNIP3 mRNA	23649840
D003840	Deoxycholic Acid	BNIP3 protein affects the susceptibility to Deoxycholic Acid	12507930
D003907	Dexamethasone	Dexamethasone results in decreased expression of BNIP3 mRNA	25047013
D003907	Dexamethasone	Dexamethasone results in increased expression of BNIP3 mRNA	21041162
D064730	Dexrazoxane	Dexrazoxane results in increased expression of BNIP3 mRNA	26873546
D003976	Diazinon	Diazinon results in increased methylation of BNIP3 gene	22964155
D003976	Diazinon	Diazinon affects the expression of BNIP3 mRNA	22546817
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of BNIP3 mRNA	21266533
D002945	Cisplatin	Cisplatin affects the expression of BNIP3 mRNA	23300844
D002945	Cisplatin	Cisplatin results in increased expression of BNIP3 mRNA	21074548
D002945	Cisplatin	Cisplatin results in increased phosphorylation of BNIP3 protein	22006019
D002945	Cisplatin	Cisplatin results in increased expression of BNIP3 mRNA	21575413
D004026	Dieldrin	Dieldrin affects the expression of BNIP3 mRNA	22546817
D004040	Dietary Carbohydrates	[Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of BNIP3 mRNA	17093179
D004041	Dietary Fats	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of BNIP3 mRNA]"	19467301
D004041	Dietary Fats	Dietary Fats results in increased expression of BNIP3 mRNA	19467301
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of BNIP3 mRNA	21041162
D004298	Dopamine	[Dopamine results in increased expression of HIF1A protein] which results in increased expression of BNIP3 mRNA	19410601
D004298	Dopamine	[Dopamine results in increased expression of HIF1A protein] which results in increased expression of BNIP3 protein	19410601
D004317	Doxorubicin	Doxorubicin results in decreased expression of BNIP3 mRNA	22908232
D004317	Doxorubicin	Doxorubicin results in increased expression of BNIP3 mRNA	19001878\|2589636
D004317	Doxorubicin	PARP1 protein promotes the reaction [Doxorubicin results in increased expression of BNIP3 mRNA]	19001878
D004391	Dust	Dust results in decreased expression of BNIP3 mRNA	17805423
C062669	epicatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein]]	29061316
C062669	epicatechin gallate	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein]	29061316
C045651	epigallocatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein]]	29061316
C045651	epigallocatechin gallate	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein]	29061316
D000069347	Erlotinib Hydrochloride	Erlotinib Hydrochloride inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 protein]	25981168
D000431	Ethanol	Ethanol results in decreased expression of BNIP3 mRNA	28986285
D000431	Ethanol	Dactinomycin inhibits the reaction [Ethanol results in increased expression of BNIP3 protein]	24095927
D000431	Ethanol	Ethanol results in increased expression of BNIP3 mRNA	24095927
D000431	Ethanol	Ethanol results in increased expression of BNIP3 protein	24095927
D000431	Ethanol	FOXO3 gene mutant form inhibits the reaction [Ethanol results in increased expression of BNIP3 mRNA]	24095927
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of BNIP3 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of BNIP3 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of BNIP3 mRNA	17942748
D005001	Ethionine	Ethionine affects the expression of BNIP3 mRNA	19483382
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of BNIP3 mRNA	23649840
C010953	exochelins	exochelins results in increased expression of BNIP3 protein	12460908
C540355	fenamidone	fenamidone results in decreased expression of BNIP3 mRNA	27029645
D011345	Fenofibrate	Fenofibrate results in increased expression of BNIP3 mRNA	25596134
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in decreased expression of BNIP3 mRNA	28329830
D005472	Fluorouracil	BNIP3 affects the susceptibility to Fluorouracil	15067352
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in decreased expression of BNIP3 mRNA]	15016801
D005480	Flurbiprofen	Flurbiprofen results in increased expression of BNIP3 mRNA	16949054
D005492	Folic Acid	Folic Acid affects the expression of BNIP3 mRNA	17320366
D005557	Formaldehyde	Formaldehyde results in decreased expression of BNIP3 mRNA	23649840
D005707	Gallic Acid	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein]]	29061316
D005707	Gallic Acid	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein]	29061316
C057580	gallocatechol	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein]]	29061316
C057580	gallocatechol	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein]	29061316
C419708	gefitinib	gefitinib inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 protein]	25981168
D019833	Genistein	[bisphenol A co-treated with Genistein] results in increased methylation of BNIP3 gene	28505145
D005978	Glutathione	Glutathione inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]	19442826
D006861	Hydrogen Peroxide	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein]]	29061316
D006861	Hydrogen Peroxide	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein]	29061316
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of BNIP3 mRNA	20044591
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of BNIP3 mRNA	12419474
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of BNIP3 protein	29061316
C031927	hydroquinone	hydroquinone results in decreased expression of BNIP3 mRNA	15452088
D007052	Ibuprofen	Ibuprofen results in increased expression of BNIP3 mRNA	25596134
D007069	Ifosfamide	Ifosfamide results in decreased expression of BNIP3 mRNA	25596134
D007501	Iron	Iron deficiency results in increased expression of BNIP3 mRNA	23776592
D007530	Isoflurane	Isoflurane results in increased expression of BNIP3 mRNA	16978161
D007545	Isoproterenol	Isoproterenol results in increased expression of BNIP3 mRNA	20003209
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of BNIP3 mRNA	27292261
D007649	Ketamine	Ketamine results in decreased expression of BNIP3 mRNA	20080153
D007654	Ketoconazole	Ketoconazole results in increased expression of BNIP3 mRNA	25808816
C490728	lapatinib	lapatinib inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 mRNA]	25981168
C490728	lapatinib	lapatinib inhibits the reaction [concanamycin A results in increased expression of BNIP3 mRNA]	25981168
C045463	leflunomide	leflunomide results in increased expression of BNIP3 mRNA	24136188
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of BNIP3 mRNA"	24972896
D008070	Lipopolysaccharides	HIF1A protein promotes the reaction [Lipopolysaccharides results in increased expression of BNIP3 mRNA]	21307008
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of BNIP3 mRNA	21307008
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of BNIP3 protein	21307008
D008070	Lipopolysaccharides	Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of BNIP3 mRNA]	21307008
D008070	Lipopolysaccharides	Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of BNIP3 protein]	21307008
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of BNIP3 mRNA	16401727\|1641532
D008344	Maneb	Maneb results in increased expression of BNIP3 mRNA	18266926
D008344	Maneb	Maneb results in increased expression of BNIP3 protein	18266926
D008345	Manganese	Antioxidants inhibits the reaction [Manganese results in increased expression of BNIP3 protein]	19442826
C025340	manganese chloride	Acetylcysteine inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]	19442826
C025340	manganese chloride	BNIP3 protein affects the reaction [manganese chloride affects the localization of CYCS protein]	19442826
C025340	manganese chloride	BNIP3 protein affects the susceptibility to manganese chloride	19442826
C025340	manganese chloride	Cycloheximide inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]	19442826
C025340	manganese chloride	Dactinomycin inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]	19442826
C025340	manganese chloride	Glutathione inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]	19442826
C025340	manganese chloride	manganese chloride results in increased expression of and affects the localization of BNIP3 protein	19442826
C025340	manganese chloride	[N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]	19442826
D008687	Metformin	Metformin results in increased expression of BNIP3 mRNA	25596134
D008727	Methotrexate	BNIP3 protein affects the susceptibility to Methotrexate	16217747
D008727	Methotrexate	[Methotrexate co-treated with CDKN1A protein] results in decreased expression of BNIP3 mRNA	18483502
D008727	Methotrexate	Methotrexate affects the expression of BNIP3 mRNA	18502557
C005219	methyl cellosolve	methyl cellosolve results in increased expression of BNIP3 mRNA	21061450
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of BNIP3 mRNA	23179753\|2718838
C030957	methylmercury II	[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of BNIP3 mRNA	17905399
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of BNIP3 mRNA	23649840
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of BNIP3 mRNA	18266926
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of BNIP3 mRNA	17475336\|1806909
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of BNIP3 protein	22776087
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BNIP3 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BNIP3 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BNIP3 mRNA]"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BNIP3 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BNIP3 mRNA]"	20230807
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of BNIP3 mRNA	22108045
C437683	motexafin gadolinium	motexafin gadolinium results in increased expression of BNIP3 mRNA	16357179
C437683	motexafin gadolinium	[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BNIP3 mRNA	16357179
D009151	Mustard Gas	Mustard Gas inhibits the reaction [Oxygen deficiency results in increased expression of BNIP3 mRNA]	26082309
D009151	Mustard Gas	Mustard Gas inhibits the reaction [Oxygen deficiency results in increased expression of BNIP3 protein]	26082309
D009151	Mustard Gas	Quinolones inhibits the reaction [Mustard Gas inhibits the reaction [Oxygen deficiency results in increased expression of BNIP3 protein]]	26082309
C455139	myrtucommulone A	myrtucommulone A affects the expression of BNIP3 mRNA	26032814
C104820	N-(3-(aminomethyl)benzyl)acetamidine	[N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]	19442826
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of BNIP3 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of BNIP3 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of BNIP3 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of BNIP3 mRNA"	25620056
C051752	nefazodone	nefazodone results in increased expression of BNIP3 mRNA	24136188
C022838	nickel chloride	HIF1A protein promotes the reaction [nickel chloride results in increased expression of BNIP3 protein]	28552779
C022838	nickel chloride	nickel chloride results in increased expression of BNIP3 mRNA	17312168\|2855277
C022838	nickel chloride	HIF1A affects the reaction [nickel chloride results in increased expression of BNIP3 mRNA]	12426141\|1272925
C022838	nickel chloride	nickel chloride results in increased expression of BNIP3 mRNA	12426141\|1272925
C022838	nickel chloride	nickel chloride affects the expression of BNIP3 mRNA	22110744\|2254681
C017557	nickel subsulfide	nickel subsulfide affects the expression of BNIP3 mRNA	12729255
C029938	nickel sulfate	nickel sulfate results in increased expression of BNIP3 mRNA	17382205
D009538	Nicotine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BNIP3 mRNA"	20230807
D009538	Nicotine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BNIP3 mRNA]"	20230807
C012655	nimesulide	nimesulide results in increased expression of BNIP3 mRNA	24136188
D009569	Nitric Oxide	Nitric Oxide results in decreased expression of BNIP3 mRNA	11592958
D009569	Nitric Oxide	Nitric Oxide results in increased expression of BNIP3 protein	16002567
D009585	Nitrogen Dioxide	Nitrogen Dioxide results in increased expression of BNIP3 mRNA	27206323
D026422	S-Nitrosoglutathione	S-Nitrosoglutathione results in decreased expression of BNIP3 mRNA	11592958
C558013	NSC 689534	NSC 689534 results in increased expression of BNIP3 mRNA	20971185
C025589	ochratoxin A	ochratoxin A results in increased expression of BNIP3 mRNA	19562491
D009853	Omeprazole	Omeprazole affects the expression of BNIP3 mRNA	19483382
C016340	o,p'-DDT	"o,p'-DDT analog results in increased expression of BNIP3 mRNA"	22937105
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of BNIP3 mRNA"	22937105
D008939	Mitotane	Mitotane analog results in increased expression of BNIP3 mRNA	23485034
D008939	Mitotane	Mitotane results in increased expression of BNIP3 mRNA	23485034
C030110	oxaliplatin	oxaliplatin results in decreased expression of BNIP3 mRNA	17762391
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of BNIP3 mRNA	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of BNIP3 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of BNIP3 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	Particulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of BNIP3 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	Vehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of BNIP3 mRNA]	17655762
D010100	Oxygen	Mustard Gas inhibits the reaction [Oxygen deficiency results in increased expression of BNIP3 mRNA]	26082309
D010100	Oxygen	Mustard Gas inhibits the reaction [Oxygen deficiency results in increased expression of BNIP3 protein]	26082309
D010100	Oxygen	Oxygen deficiency results in increased expression of BNIP3 mRNA	17914565\|2004264
D010100	Oxygen	Oxygen deficiency results in increased expression of BNIP3 protein	26082309
D010100	Oxygen	[Quinolones co-treated with Oxygen deficiency] results in increased expression of BNIP3 mRNA	26082309
D010100	Oxygen	Quinolones inhibits the reaction [Mustard Gas inhibits the reaction [Oxygen deficiency results in increased expression of BNIP3 protein]]	26082309
D010100	Oxygen	Oxygen deficiency affects the expression of BNIP3 mRNA	17193925
D010100	Oxygen	Oxygen deficiency results in increased expression of BNIP3 mRNA	20880076\|2362479
D010269	Paraquat	BNIP3 protein affects the susceptibility to Paraquat	18056701
D010269	Paraquat	Paraquat results in decreased expression of BNIP3 mRNA	18836921
D010269	Paraquat	Paraquat results in increased expression of BNIP3 mRNA	18056701\|1826692
D010269	Paraquat	Paraquat results in increased expression of BNIP3 protein	18056701\|1826692
D010269	Paraquat	Paraquat results in increased expression of BNIP3 protein	18056701
D052638	Particulate Matter	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of BNIP3 mRNA]	17655762
D052638	Particulate Matter	Particulate Matter affects the expression of BNIP3 mRNA	17655762
D052638	Particulate Matter	Particulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of BNIP3 mRNA]	17655762
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of BNIP3 mRNA	26705709
D010424	Pentobarbital	Pentobarbital results in increased expression of BNIP3 mRNA	16978161
C015423	peoniflorin	peoniflorin inhibits the reaction [cobaltous chloride results in increased expression of BNIP3 mRNA]	22269387
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in decreased expression of BNIP3 mRNA	23602845
D030421	Peroxynitrous Acid	Peroxynitrous Acid results in increased expression of BNIP3 protein	16002567
D010795	Phthalic Acids	Phthalic Acids results in increased expression of BNIP3 mRNA	21061450
D010862	Pilocarpine	Pilocarpine results in increased expression of BNIP3 mRNA	17971868
C006253	pirinixic acid	pirinixic acid results in increased expression of BNIP3 mRNA	17118139\|1742611
C006253	pirinixic acid	pirinixic acid affects the expression of BNIP3 mRNA	19483382
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of BNIP3 mRNA	28903501
D011374	Progesterone	Progesterone results in decreased expression of BNIP3 mRNA	23018184
D011374	Progesterone	Progesterone results in increased expression of BNIP3 mRNA	23012394
C045950	propiconazole	propiconazole results in decreased expression of BNIP3 mRNA	21278054
D015742	Propofol	Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of BNIP3 mRNA]	21307008
D015742	Propofol	Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of BNIP3 protein]	21307008
D011441	Propylthiouracil	Propylthiouracil affects the expression of BNIP3 mRNA	19483382
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Cadmium results in increased expression of BNIP3 protein]	24824807
C031280	pyrazole	pyrazole results in decreased expression of BNIP3 mRNA	17945193
D011794	Quercetin	Quercetin results in decreased expression of BNIP3 mRNA	21632981
D011794	Quercetin	Quercetin results in increased expression of BNIP3 mRNA	19729006
D011794	Quercetin	Quercetin affects the expression of BNIP3 mRNA	18178720
D015363	Quinolones	[Quinolones co-treated with Oxygen deficiency] results in increased expression of BNIP3 mRNA	26082309
D015363	Quinolones	Quinolones inhibits the reaction [Mustard Gas inhibits the reaction [Oxygen deficiency results in increased expression of BNIP3 protein]]	26082309
D015363	Quinolones	Quinolones results in increased expression of BNIP3 mRNA	26082309
D011899	Ranitidine	[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of BNIP3 mRNA	16401727\|1641532
C089730	rosiglitazone	rosiglitazone results in increased expression of BNIP3 mRNA	25596134
D012402	Rotenone	Rotenone results in increased expression of BNIP3 mRNA	19304788
C078903	seocalcitol	seocalcitol results in increased expression of BNIP3 mRNA	12040012
D019821	Simvastatin	Simvastatin results in increased expression of BNIP3 mRNA	17428261
D020123	Sirolimus	Sirolimus inhibits the reaction [IL2 protein results in increased expression of BNIP3 mRNA]	11355896
C110881	S-nitro-N-acetylpenicillamine	"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in decreased expression of BNIP3 mRNA]"	11592958
C110881	S-nitro-N-acetylpenicillamine	S-nitro-N-acetylpenicillamine results in decreased expression of BNIP3 mRNA	11592958
C110881	S-nitro-N-acetylpenicillamine	S-nitro-N-acetylpenicillamine results in decreased expression of BNIP3 protein	11592958
C017947	sodium arsenite	[CARM1 mutant form co-treated with sodium arsenite] results in increased expression of BNIP3 mRNA	23699174
C017947	sodium arsenite	[PRMT1 mutant form co-treated with sodium arsenite] results in increased expression of BNIP3 mRNA	23699174
C017947	sodium arsenite	sodium arsenite results in decreased expression of BNIP3 mRNA	12760830
C017947	sodium arsenite	sodium arsenite results in increased expression of BNIP3 mRNA	20886546\|2822993
D013629	Tamoxifen	Tamoxifen affects the expression of BNIP3 mRNA	17555576
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of BNIP3 mRNA	20189893
D013749	Tetrachlorodibenzodioxin	[decitabine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of BNIP3 mRNA	15251184
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of BNIP3 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of BNIP3 mRNA	15251184\|1566782
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of BNIP3 mRNA	21041162
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of BNIP3 mRNA	28973375
C034269	tetraethylenepentamine	tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of BNIP3 mRNA]	25100165
D019284	Thapsigargin	Thapsigargin results in decreased expression of BNIP3 mRNA	22378314
D019284	Thapsigargin	Thapsigargin results in decreased expression of BNIP3 protein	24648495
D013849	Thimerosal	Thimerosal results in decreased expression of BNIP3 mRNA	27188386
D013853	Thioacetamide	Thioacetamide affects the expression of BNIP3 mRNA	19483382
C009495	titanium dioxide	titanium dioxide results in decreased expression of BNIP3 mRNA	23557971
D014212	Tretinoin	SOX11 protein promotes the reaction [Tretinoin results in increased expression of BNIP3 mRNA]	17055661
C011559	tributyltin	tributyltin results in decreased expression of BNIP3 mRNA	27614199
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of BNIP3 mRNA	26745549
D014241	Trichloroethylene	PPARA protein inhibits the reaction [Trichloroethylene results in increased expression of BNIP3 protein]	15363585
D014241	Trichloroethylene	Trichloroethylene results in increased expression of BNIP3 mRNA	15363585\|2897337
D014241	Trichloroethylene	[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of BNIP3 mRNA	17905399
C012589	trichostatin A	trichostatin A results in increased expression of BNIP3 mRNA	24935251
C057693	troglitazone	troglitazone results in increased expression of BNIP3 mRNA	25596134
C002802	tungsten carbide	[tungsten carbide binds to Cobalt] which results in increased expression of BNIP3 mRNA	20105288
C002802	tungsten carbide	[tungsten carbide co-treated with Cobalt] results in increased expression of BNIP3 mRNA	18078969
C002802	tungsten carbide	tungsten carbide results in increased expression of BNIP3 mRNA	20105288
D014415	Tunicamycin	Tunicamycin results in decreased expression of BNIP3 mRNA	22378314
C113580	U 0126	U 0126 inhibits the reaction [Cadmium results in increased expression of BNIP3 protein]	24824807
C406224	valdecoxib	valdecoxib results in increased expression of BNIP3 mRNA	24136188
D014635	Valproic Acid	benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Valproic Acid results in increased expression of BNIP3 mRNA]	25446377
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BNIP3 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of BNIP3 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of BNIP3 mRNA	19949822\|2317975
D014635	Valproic Acid	Valproic Acid results in increased expression of and affects the localization of BNIP3 protein	25446377
D014635	Valproic Acid	Valproic Acid results in increased expression of BNIP3 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in increased methylation of BNIP3 gene	29154799
D014635	Valproic Acid	Vincristine affects the reaction [Valproic Acid affects the localization of BNIP3 protein]	25446377
D014635	Valproic Acid	Valproic Acid affects the expression of BNIP3 mRNA	17292431\|1796380
D001335	Vehicle Emissions	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of BNIP3 mRNA]	17655762
D001335	Vehicle Emissions	Vehicle Emissions affects the expression of BNIP3 mRNA	17655762
D001335	Vehicle Emissions	Vehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of BNIP3 mRNA]	17655762
D014750	Vincristine	Vincristine affects the reaction [Valproic Acid affects the localization of BNIP3 protein]	25446377
D014750	Vincristine	Vincristine results in decreased expression of BNIP3 mRNA	23649840
D024483	Vitamin K 3	Vitamin K 3 results in decreased expression of BNIP3 mRNA	25270620
C111237	vorinostat	vorinostat results in decreased expression of BNIP3 mRNA	27188386
D019345	Zinc Acetate	[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BNIP3 mRNA	16357179
D019345	Zinc Acetate	Zinc Acetate results in increased expression of BNIP3 mRNA	16357179
D015034	Zinc Oxide	Zinc Oxide results in increased expression of BNIP3 mRNA	19755143
C088658	zoledronic acid	zoledronic acid results in decreased expression of BNIP3 mRNA	19036117
C088658	zoledronic acid	zoledronic acid results in increased expression of BNIP3 mRNA	25596134

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	7954800 10381623 15868100 16189514 17360363 18371312 19060904 20436456 21516116 22292033 25416956 27107012 27107014
GO:0042802	identical protein binding	-	IPI	10381623 16189514 25416956 27107012
GO:0042803	protein homodimerization activity	-	IDA	9396766 10381623
GO:0042803	protein homodimerization activity	-	NAS	22505714
GO:0046982	protein heterodimerization activity	-	IDA	10381623
GO:0051020	GTPase binding	-	IPI	20436456

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000422	autophagy of mitochondrion	-	NAS	22505714
GO:0001666	response to hypoxia	-	ISS	-
GO:0006915	apoptotic process	-	IPI	7954800
GO:0008219	cell death	-	ISS	-
GO:0008626	granzyme-mediated apoptotic signaling pathway	-	IDA	9396766
GO:0010508	positive regulation of autophagy	-	TAS	18309324
GO:0010637	negative regulation of mitochondrial fusion	-	IDA	20436456
GO:0010659	cardiac muscle cell apoptotic process	-	IEA	-
GO:0010666	positive regulation of cardiac muscle cell apoptotic process	-	IEA	-
GO:0010917	negative regulation of mitochondrial membrane potential	-	IEA	-
GO:0010940	positive regulation of necrotic cell death	-	IEA	-
GO:0016032	viral process	-	IEA	-
GO:0016239	positive regulation of macroautophagy	-	IGI	19273585
GO:0021987	cerebral cortex development	-	IEA	-
GO:0035694	mitochondrial protein catabolic process	-	IMP	22292033
GO:0043065	positive regulation of apoptotic process	-	IDA	9973195 10381623
GO:0043066	negative regulation of apoptotic process	-	TAS	7954800
GO:0043067	regulation of programmed cell death	-	IBA	21873635
GO:0043068	positive regulation of programmed cell death	-	IBA	21873635
GO:0043068	positive regulation of programmed cell death	-	IDA	10891486
GO:0043243	positive regulation of protein complex disassembly	-	IDA	20436456
GO:0043653	mitochondrial fragmentation involved in apoptotic process	-	IDA	20436456
GO:0045837	negative regulation of membrane potential	-	IDA	10891486
GO:0046902	regulation of mitochondrial membrane permeability	-	IDA	10891486
GO:0048102	autophagic cell death	-	IEA	-
GO:0048709	oligodendrocyte differentiation	-	IEA	-
GO:0050873	brown fat cell differentiation	-	IEA	-
GO:0051402	neuron apoptotic process	-	ISS	-
GO:0051561	positive regulation of mitochondrial calcium ion concentration	-	IEA	-
GO:0051607	defense response to virus	-	IDA	9973195
GO:0055093	response to hyperoxia	-	IEA	-
GO:0060548	negative regulation of cell death	-	IGI	19273585
GO:0070301	cellular response to hydrogen peroxide	-	IEA	-
GO:0071260	cellular response to mechanical stimulus	-	IEP	19593445
GO:0071279	cellular response to cobalt ion	-	IMP	20436456
GO:0071456	cellular response to hypoxia	-	IGI	19273585
GO:0071456	cellular response to hypoxia	-	IMP	20436456
GO:0072593	reactive oxygen species metabolic process	-	IDA	10891486
GO:0090141	positive regulation of mitochondrial fission	-	IDA	20436456
GO:0090200	positive regulation of release of cytochrome c from mitochondria	-	IDA	20436456
GO:0097345	mitochondrial outer membrane permeabilization	-	IBA	21873635
GO:0097345	mitochondrial outer membrane permeabilization	-	IDA	18371312
GO:1901998	toxin transport	-	IEA	-
GO:1902109	negative regulation of mitochondrial membrane permeability involved in apoptotic process	-	IEA	-
GO:1903599	positive regulation of autophagy of mitochondrion	-	IEA	-
GO:1903715	regulation of aerobic respiration	-	IEA	-
GO:1990144	intrinsic apoptotic signaling pathway in response to hypoxia	-	IMP	20436456
GO:2000378	negative regulation of reactive oxygen species metabolic process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	ISS	-
GO:0005635	nuclear envelope	-	IBA	21873635
GO:0005635	nuclear envelope	-	IDA	7954800
GO:0005654	nucleoplasm	-	ISS	-
GO:0005737	cytoplasm	-	ISS	-
GO:0005739	mitochondrion	-	IDA	7954800 9396766 18371312
GO:0005739	mitochondrion	-	TAS	9973195
GO:0005741	mitochondrial outer membrane	-	IBA	21873635
GO:0005741	mitochondrial outer membrane	-	IDA	22292033
GO:0005783	endoplasmic reticulum	-	IBA	21873635
GO:0005783	endoplasmic reticulum	-	NAS	22505714
GO:0014069	postsynaptic density	-	IEA	-
GO:0030425	dendrite	-	ISS	-
GO:0031307	integral component of mitochondrial outer membrane	-	IDA	10891486
GO:0031966	mitochondrial membrane	-	IDA	10891486
GO:0031966	mitochondrial membrane	-	IMP	9396766

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22429763	Hypoxia induces apoptosis and autophagic cell death in human periodontal ligament cells through HIF-1alpha pathway. (2012 Jun)	Song ZC	Cell Prolif
25654620	Differentiation of embryonic stem cells into cardiomyocytes used to investigate the cardioprotective effect of salvianolic acid B through BNIP3 involved pathway. (2015)	Huang CY	Cell Transplant