Gene: SNTB1

6641
59-DAP|A1B|BSYN2|DAPA1B|SNT2|SNT2B1|TIP-43
syntrophin beta 1
protein-coding
8q24.12
Ensembl:ENSG00000172164 MIM:600026 Vega:OTTHUMG00000165041 UniprotKB:Q13884
NC_000008.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.546e-1 (AD)  8.243e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11780390chr8:120637885 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDLIM50.857
GNG120.855
EPS80.85
PRKD30.837
CPNE30.825
ANTXR10.825
PARD3B0.824
MAML20.817
DDR20.814
FERMT20.81

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNB2-0.609
CALHM1-0.585
ABCC12-0.58
HAS1-0.57
OPRD1-0.566
RTP1-0.564
B3GNT4-0.563
CDCA5-0.559
PNPLA5-0.553
FBLN7-0.551

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of SNTB1 mRNA"21920950
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SNTB1 mRNA"18648102
D020106AcrylamideAcrylamide results in decreased expression of SNTB1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SNTB1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SNTB1 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SNTB1 gene27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of SNTB1 mRNA28522335
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of SNTB1 mRNA21298039
D001151ArsenicArsenic affects the methylation of SNTB1 gene25304211
C547126AZM551248AZM551248 results in decreased expression of SNTB1 mRNA22323515
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SNTB1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SNTB1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SNTB1 mRNA20064835|2010694
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SNTB1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SNTB1 mRNA22228805
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of SNTB1 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of SNTB1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of SNTB1 mRNA26496021
C006780bisphenol Abisphenol A results in increased methylation of SNTB1 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of SNTB1 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of SNTB1 mRNA25979313
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SNTB1 mRNA27858113
C031180chrysenechrysene results in decreased expression of SNTB1 mRNA26377693
D019327Copper SulfateCopper Sulfate results in decreased expression of SNTB1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SNTB1 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of SNTB1 mRNA27989131
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SNTB1 mRNA17361019
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SNTB1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SNTB1 mRNA27392435
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of SNTB1 mRNA22129741
D002117CalcitriolCalcitriol results in increased expression of SNTB1 mRNA26485663
D005472FluorouracilFluorouracil results in increased expression of SNTB1 mRNA16510598
C039281furanfuran results in increased expression of SNTB1 mRNA25539665
D017313FenretinideFenretinide results in decreased expression of SNTB1 mRNA28973697
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of SNTB1 mRNA22129741
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SNTB1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of SNTB1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SNTB1 mRNA23086925|2479639
C410337K 7174K 7174 results in increased expression of SNTB1 mRNA24086573
C045463leflunomideleflunomide results in increased expression of SNTB1 mRNA28988120
D008558MelphalanMelphalan results in decreased expression of SNTB1 mRNA22363485
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SNTB1 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SNTB1 mRNA"25554681
D010100OxygenOxygen deficiency results in increased expression of SNTB1 mRNA26516004
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of SNTB1 mRNA26705709
C006253pirinixic acidpirinixic acid results in increased expression of SNTB1 mRNA18301758
D011441PropylthiouracilPropylthiouracil results in increased expression of SNTB1 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of SNTB1 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SNTB1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SNTB1 mRNA23221170
C017947sodium arsenitesodium arsenite results in increased expression of SNTB1 mRNA22714537
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of SNTB1 mRNA25172293
D013853ThioacetamideThioacetamide results in increased expression of SNTB1 mRNA23411599
D014212TretinoinTretinoin results in increased expression of SNTB1 mRNA16054129
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of SNTB1 mRNA]27469509
C012589trichostatin Atrichostatin A results in decreased expression of SNTB1 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SNTB1 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of SNTB1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SNTB1 mRNA24935251|2800136
D014635Valproic AcidValproic Acid results in increased expression of SNTB1 mRNA29154799
D024483Vitamin K 3Vitamin K 3 affects the expression of SNTB1 mRNA20044591
D019287Zinc SulfateZinc Sulfate results in decreased expression of SNTB1 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0005198structural molecule activity-IEA-  
GO:0005515protein binding-IPI7844150  8576247  12477932  16192269  
GO:0005516calmodulin binding-IEA-  
GO:0030165PDZ domain binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006936muscle contraction-TAS8183929  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005856cytoskeleton-IEA-  
GO:0005925focal adhesion-HDA21423176  
GO:0016010dystrophin-associated glycoprotein complex-TAS8119949  
GO:0032991protein-containing complex-IDA18468998  
GO:0042383sarcolemma-IEA-  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal