Gene info: ID 6649

Gene: SOD3

GENE ID: 6649

Synonyms: EC-SOD

Description: superoxide dismutase 3

Gene type: protein-coding

Location: 4p15.2

dbXrefs: Ensembl:ENSG00000109610 MIM:185490 Vega:OTTHUMG00000128565 UniprotKB:P08294

RefSeq: NG_012213.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 13

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.122e-1 (AD) 8.768e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TUBB2B	0.794
PLCD1	0.789
LRP10	0.788
PLTP	0.775
FKBP10	0.774
ALDH1L1	0.773
NFATC1	0.772
RAB34	0.772
PLEKHO2	0.77
TRIP6	0.764

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
XKR4	-0.55
TYRP1	-0.548
ZNF860	-0.541
GABRG3	-0.538
CASC15	-0.537
EPHA5	-0.533
EPHA3	-0.526
GPR61	-0.52
IL12RB2	-0.517
KCNS2	-0.515

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SOD3 mRNA"	21394737
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [AGT protein results in increased expression of SOD3 protein]	10400907
C573693	2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid	2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid results in decreased expression of SOD3 mRNA	22193206
C011269	2,5-hexanedione	"2,5-hexanedione results in increased expression of SOD3 mRNA"	22952946\|2746621
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in decreased expression of SOD3 mRNA"	20406850
C031278	2-chloroethyl ethyl sulfide	2-chloroethyl ethyl sulfide results in decreased activity of SOD3 protein	16788954
C580935	4-((4-hydroxyphenylimino)methyl)benzene-1,2-diol	"4-((4-hydroxyphenylimino)methyl)benzene-1,2-diol results in increased expression of SOD3 mRNA"	28960787
C580935	4-((4-hydroxyphenylimino)methyl)benzene-1,2-diol	"4-((4-hydroxyphenylimino)methyl)benzene-1,2-diol results in increased expression of SOD3 protein"	28960787
C000619336	4-(E)-((p-tolylimino)-methylbenzene-1,2-diol)	"4-(E)-((p-tolylimino)-methylbenzene-1,2-diol) results in increased expression of SOD3 mRNA"	28960787
C000619336	4-(E)-((p-tolylimino)-methylbenzene-1,2-diol)	"4-(E)-((p-tolylimino)-methylbenzene-1,2-diol) results in increased expression of SOD3 protein"	28960787
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [cobaltous chloride results in decreased expression of SOD3 mRNA]	21804221
C075773	4-phenylbutyric acid	4-phenylbutyric acid results in increased expression of SOD3 mRNA	21804221
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [cobaltous chloride results in decreased expression of SOD3 mRNA]"	19031313
D000082	Acetaminophen	SOD3 inhibits the reaction [Acetaminophen results in increased activity of CASP3 protein]	11529661
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of SOD3 mRNA]	21881231
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of SOD3 protein]	21881231
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of SOD3 mRNA]	21804221
C027696	acipimox	acipimox results in increased expression of SOD3 mRNA	25352640
D000171	Acrolein	Acrolein results in increased expression of SOD3 protein	28482051
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of SOD3 mRNA	28522335
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SOD3 mRNA	16483693
D001149	Arsenates	Arsenates results in decreased expression of SOD3 mRNA	19895865
C015001	arsenite	arsenite results in increased methylation of SOD3 promoter	23974009
D001194	Asbestos	Asbestos results in increased secretion of SOD3 protein	21362472
D001194	Asbestos	SOD3 gene polymorphism affects the susceptibility to Asbestos	21362472
D001194	Asbestos	SOD3 gene polymorphism promotes the reaction [Asbestos results in increased secretion of SOD3 protein]	21362472\|2136247
D001194	Asbestos	SOD3 protein affects the susceptibility to Asbestos	16458190
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite affects the expression of and affects the activity of SOD3 protein"	15298984
D017638	Asbestos, Crocidolite	"SOD3 protein affects the susceptibility to Asbestos, Crocidolite"	18165226
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Estradiol results in decreased expression of SOD3 mRNA]	25130429
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Estradiol results in decreased expression of SOD3 protein]	25130429
D001205	Ascorbic Acid	Ascorbic Acid affects the localization of SOD3 protein	23027624
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Estradiol inhibits the reaction [NFE2L2 protein binds to SOD3 promoter]]	23027624
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Estradiol results in decreased activity of SOD3 protein]	23027624
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Estradiol results in decreased expression of SOD3 mRNA]	23027624
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Estradiol results in decreased expression of SOD3 protein]	23027624
D001205	Ascorbic Acid	Ascorbic Acid results in increased activity of SOD3 protein	23027624
D001205	Ascorbic Acid	Ascorbic Acid results in increased expression of SOD3 protein	23027624
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in increased expression of SOD3 protein	19451411
C051597	Bandrowski's base	Bandrowski's base results in increased expression of SOD3 mRNA	20566472
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SOD3 mRNA	15034205
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SOD3 mRNA	14625279
D001564	Benzo(a)pyrene	"[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of SOD3 mRNA"	28987381
D001564	Benzo(a)pyrene	[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of SOD3 mRNA]	14625279
D004958	Estradiol	Ascorbic Acid inhibits the reaction [Estradiol results in decreased expression of SOD3 mRNA]	25130429
D004958	Estradiol	Ascorbic Acid inhibits the reaction [Estradiol results in decreased expression of SOD3 protein]	25130429
D004958	Estradiol	Estradiol results in decreased expression of SOD3 mRNA	25130429\|2896078
D004958	Estradiol	Estradiol results in decreased expression of SOD3 protein	25130429\|2896078
D004958	Estradiol	resveratrol inhibits the reaction [Estradiol results in decreased expression of SOD3 mRNA]	25130429
D004958	Estradiol	resveratrol inhibits the reaction [Estradiol results in decreased expression of SOD3 protein]	25130429
D004958	Estradiol	Estradiol affects the expression of SOD3 mRNA	16195479
D004958	Estradiol	Estradiol inhibits the reaction [Progesterone results in decreased expression of SOD3 mRNA]	16195479
D004958	Estradiol	Ascorbic Acid inhibits the reaction [Estradiol inhibits the reaction [NFE2L2 protein binds to SOD3 promoter]]	23027624
D004958	Estradiol	Ascorbic Acid inhibits the reaction [Estradiol results in decreased activity of SOD3 protein]	23027624
D004958	Estradiol	Ascorbic Acid inhibits the reaction [Estradiol results in decreased expression of SOD3 mRNA]	23027624
D004958	Estradiol	Ascorbic Acid inhibits the reaction [Estradiol results in decreased expression of SOD3 protein]	23027624
D004958	Estradiol	Butylated Hydroxyanisole inhibits the reaction [Estradiol inhibits the reaction [NFE2L2 protein binds to SOD3 promoter]]	23027624
D004958	Estradiol	Butylated Hydroxyanisole inhibits the reaction [Estradiol results in decreased activity of SOD3 protein]	23027624
D004958	Estradiol	Butylated Hydroxyanisole inhibits the reaction [Estradiol results in decreased expression of SOD3 mRNA]	23027624
D004958	Estradiol	Butylated Hydroxyanisole inhibits the reaction [Estradiol results in decreased expression of SOD3 protein]	23027624
D004958	Estradiol	Estradiol inhibits the reaction [NFE2L2 protein binds to SOD3 promoter]	23027624
D004958	Estradiol	Estradiol results in decreased activity of SOD3 protein	23027624
D004958	Estradiol	Estradiol results in decreased expression of SOD3 mRNA	23027624\|2489486
D004958	Estradiol	Estradiol results in decreased expression of SOD3 protein	23027624\|2489486
D004958	Estradiol	Estradiol results in increased expression of and results in increased activity of SOD3 protein	12816884
D004958	Estradiol	Estradiol results in increased expression of SOD3 mRNA	12816884\|1619547
D004958	Estradiol	Estradiol results in increased stability of SOD3 mRNA	12816884
D004958	Estradiol	fulvestrant inhibits the reaction [Estradiol results in increased expression of SOD3 mRNA]	12816884
D004958	Estradiol	Progesterone inhibits the reaction [Estradiol results in increased expression of SOD3 mRNA]	16195479
D004958	Estradiol	resveratrol inhibits the reaction [Estradiol results in decreased expression of SOD3 mRNA]	24894866
D004958	Estradiol	resveratrol inhibits the reaction [Estradiol results in decreased expression of SOD3 protein]	24894866
C006780	bisphenol A	bisphenol A results in decreased expression of SOD3 mRNA	28273538
C006780	bisphenol A	bisphenol A results in decreased expression of SOD3 protein	28273538
C006780	bisphenol A	bisphenol A affects the expression of SOD3 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of SOD3 gene	28505145
D002065	Buspirone	Buspirone results in decreased expression of SOD3 mRNA	24136188
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole inhibits the reaction [Estradiol inhibits the reaction [NFE2L2 protein binds to SOD3 promoter]]	23027624
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole inhibits the reaction [Estradiol results in decreased activity of SOD3 protein]	23027624
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole inhibits the reaction [Estradiol results in decreased expression of SOD3 mRNA]	23027624
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole inhibits the reaction [Estradiol results in decreased expression of SOD3 protein]	23027624
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole results in increased activity of SOD3 protein	23027624
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole results in increased expression of SOD3 mRNA	23027624
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole results in increased expression of SOD3 protein	23027624
D019256	Cadmium Chloride	Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of SOD3 mRNA]	21881231
D019256	Cadmium Chloride	Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of SOD3 protein]	21881231
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of SOD3 mRNA	21881231
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of SOD3 protein	21881231
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of SOD3 mRNA	23545341
C006698	carbendazim	carbendazim results in increased expression of SOD3 mRNA	27466211
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of SOD3 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of SOD3 mRNA	23341968
D002251	Carbon Tetrachloride	Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of SOD3 mRNA]	23341968
D002726	Chlorogenic Acid	Chlorogenic Acid results in decreased expression of SOD3 mRNA	20706672
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of SOD3 mRNA	17452286
D002791	Cholesterol, Dietary	"[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA"	28734741
D002791	Cholesterol, Dietary	"donepezil inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA]"	28734741
D002791	Cholesterol, Dietary	"Probucol inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA]"	28734741
D002791	Cholesterol, Dietary	"Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA]"	28734741
D002791	Cholesterol, Dietary	"thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA]"	28734741
D019826	Cholic Acid	Cholic Acid results in increased expression of SOD3 mRNA	25496033
D019826	Cholic Acid	NR1H4 gene mutant form inhibits the reaction [Cholic Acid results in increased expression of SOD3 mRNA]	25496033
C039671	ciglitazone	ciglitazone results in decreased expression of SOD3 mRNA	22193206
C020722	cinnamyl alcohol	cinnamyl alcohol results in increased expression of SOD3 mRNA	20566472
D002994	Clofibrate	Clofibrate results in decreased expression of SOD3 mRNA	17585979
D002994	Clofibrate	Clofibrate results in increased expression of SOD3 mRNA	11328961
D003024	Clozapine	Clozapine results in increased expression of SOD3 mRNA	15860345
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin inhibits the reaction [Streptozocin results in decreased expression of SOD3 protein]	15821039
C007095	cobaltiprotoporphyrin	tin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Streptozocin results in decreased expression of SOD3 protein]]	15821039
C018021	cobaltous chloride	[cobaltous chloride results in increased expression of and results in increased activity of HMOX1 protein] which results in increased expression of SOD3 protein	19666846
C018021	cobaltous chloride	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [cobaltous chloride results in decreased expression of SOD3 mRNA]"	19031313
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of SOD3 mRNA	19031313
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of SOD3 protein	19031313
C018021	cobaltous chloride	SB 203580 inhibits the reaction [cobaltous chloride results in decreased expression of SOD3 mRNA]	19031313
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of SOD3 mRNA	20594416
C018021	cobaltous chloride	4-phenylbutyric acid inhibits the reaction [cobaltous chloride results in decreased expression of SOD3 mRNA]	21804221
C018021	cobaltous chloride	Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of SOD3 mRNA]	21804221
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of SOD3 mRNA	21804221\|2438626
D003300	Copper	[Copper co-treated with ATOX1 protein] results in increased activity of SOD3 protein	18977292
D003300	Copper	Copper inhibits the reaction [Streptozocin results in decreased activity of SOD3 protein]	23884884
D003300	Copper	Copper promotes the reaction [ATOX1 protein binds to SOD3 promoter]	18977292
D003300	Copper	[Copper promotes the reaction [ATOX1 protein binds to SOD3 promoter]] which results in increased expression of SOD3 mRNA	18977292\|1897729
D003300	Copper	[Copper promotes the reaction [ATOX1 protein binds to SOD3 promoter]] which results in increased expression of SOD3 protein	18977292\|1897729
D003300	Copper	Copper results in increased expression of SOD3 mRNA	16629173\|1897729
D003300	Copper	SOD3 protein inhibits the reaction [[Copper co-treated with Hydrogen Peroxide] results in increased degradation of Hyaluronic Acid]	18165226
C015763	cumene	[cumene co-treated with KRAS gene mutant form] results in decreased expression of SOD3 mRNA	18648096
C017180	decamethrin	SOD3 mRNA results in decreased susceptibility to decamethrin	18179425
D003671	DEET	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of SOD3 mRNA	28659758
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SOD3 mRNA	16054899
D003976	Diazinon	Diazinon results in decreased expression of SOD3 mRNA	17452286
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of SOD3 mRNA	21266533
D002945	Cisplatin	Cisplatin results in increased expression of SOD3 mRNA	25450742
D002945	Cisplatin	SOD3 protein affects the susceptibility to Cisplatin	16217747
D002945	Cisplatin	[Cisplatin co-treated with Lutein] results in decreased expression of SOD3 mRNA	24865317
D002945	Cisplatin	Cisplatin results in decreased expression of SOD3 mRNA	24865317
D002945	Cisplatin	Cisplatin results in increased expression of SOD3 mRNA	21151649
D002945	Cisplatin	Cisplatin results in decreased expression of SOD3 mRNA	23603837
D004041	Dietary Fats	[AGT protein affects the susceptibility to Dietary Fats] which affects the expression of SOD3 mRNA	26704350
D004041	Dietary Fats	Dietary Fats results in decreased expression of SOD3 mRNA	18042831
D004041	Dietary Fats	"[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA"	28734741
D004041	Dietary Fats	"donepezil inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA]"	28734741
D004041	Dietary Fats	"Probucol inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA]"	28734741
D004041	Dietary Fats	"Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA]"	28734741
D004041	Dietary Fats	"thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA]"	28734741
D002117	Calcitriol	Calcitriol results in decreased expression of SOD3 mRNA	26485663
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of SOD3 mRNA	22193206
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of SOD3 mRNA	20566472
D004221	Disulfiram	Disulfiram results in increased expression of SOD3 mRNA	20566472
D004237	Diuron	Diuron results in decreased expression of SOD3 mRNA	25152437
D004237	Diuron	Diuron results in increased expression of SOD3 mRNA	21551480
C076946	donepezil	"donepezil inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA]"	28734741
D004317	Doxorubicin	Doxorubicin promotes the reaction [ABCC1 gene mutant form results in decreased expression of SOD3 mRNA]	26822305
D004317	Doxorubicin	Doxorubicin promotes the reaction [ABCC1 gene mutant form results in decreased expression of SOD3 protein]	26822305
D004317	Doxorubicin	Doxorubicin results in decreased expression of SOD3 mRNA	26822305
D004317	Doxorubicin	Doxorubicin results in decreased expression of SOD3 protein	26822305
D004610	Ellagic Acid	Ellagic Acid results in decreased expression of SOD3 mRNA	12002526
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of SOD3 mRNA	20706672
D004967	Estrogens	Estrogens results in increased expression of SOD3 mRNA	12816884
D004967	Estrogens	Estrogens deficiency results in decreased expression of SOD3 mRNA	12816884
D004967	Estrogens	Estrogens inhibits the reaction [Estrogens deficiency results in decreased expression of SOD3 mRNA]	12816884
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of SOD3 mRNA	17555576
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOD3 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of SOD3 mRNA	17557909\|2909715
D005054	Eugenol	Eugenol results in increased expression of SOD3 mRNA	20566472
D018120	Finasteride	Finasteride affects the expression of SOD3 mRNA	18811921
D018120	Finasteride	Finasteride affects the expression of SOD3 protein	18811921
D005485	Flutamide	Flutamide results in decreased expression of SOD3 mRNA	24136188
D005557	Formaldehyde	Formaldehyde results in increased expression of SOD3 mRNA	28937961
C070081	fulvestrant	fulvestrant inhibits the reaction [Estradiol results in increased expression of SOD3 mRNA]	12816884
D019833	Genistein	Genistein results in decreased expression of SOD3 mRNA	20706672
D005947	Glucose	Glucose results in decreased expression of SOD3 mRNA	21818840
D006034	Glycyrrhetinic Acid	Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of SOD3 mRNA]	23341968
C412815	GW 4064	GW 4064 promotes the reaction [NR1H4 protein binds to SOD3 promoter]	25496033
C412815	GW 4064	GW 4064 results in increased expression of SOD3 mRNA	25496033
C412815	GW 4064	SOD3 promotes the reaction [GW 4064 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]]	25496033
C412815	GW 4064	SOD3 promotes the reaction [GW 4064 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]]	25496033
C412815	GW 4064	GW 4064 results in increased expression of SOD3 mRNA	25496033
C412815	GW 4064	NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of SOD3 mRNA]	25496033
C425931	GW 501516	GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of SOD3 protein]	22886847
D006220	Haloperidol	Haloperidol results in increased expression of SOD3 mRNA	15860345
D006581	Hexachlorobenzene	Hexachlorobenzene affects the expression of SOD3 mRNA	15159207
C080043	hexyl cinnamic aldehyde	hexyl cinnamic aldehyde results in increased expression of SOD3 mRNA	20566472
D017313	Fenretinide	Fenretinide results in decreased expression of SOD3 mRNA	28973697
D006820	Hyaluronic Acid	SOD3 protein binds to Hyaluronic Acid	18165226
D006820	Hyaluronic Acid	SOD3 protein inhibits the reaction [[Copper co-treated with Hydrogen Peroxide] results in increased degradation of Hyaluronic Acid]	18165226
D006861	Hydrogen Peroxide	SOD3 promotes the reaction [GW 4064 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]]	25496033
D006861	Hydrogen Peroxide	SOD3 promotes the reaction [GW 4064 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]]	25496033
D006861	Hydrogen Peroxide	SOD3 protein inhibits the reaction [[Copper co-treated with Hydrogen Peroxide] results in increased degradation of Hyaluronic Acid]	18165226
D007501	Iron	[manganese chloride co-treated with Iron] affects the expression of SOD3 mRNA	12387356
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SOD3 mRNA	16054899
C036643	isoeugenol	isoeugenol results in increased expression of SOD3 mRNA	20566472
D007649	Ketamine	Ketamine results in increased expression of SOD3 mRNA	20080153
D007854	Lead	Lead results in increased expression of SOD3 protein	25596430
C008261	lead acetate	lead acetate affects the expression of SOD3 mRNA	21864555
C029891	lead chloride	lead chloride results in increased expression of SOD3 protein	22030410
C482199	lipopolysaccharide, E coli O55-B5	"[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of SOD3 mRNA"	28987381
D019808	Losartan	Losartan inhibits the reaction [AGT protein results in increased expression of SOD3 protein]	10400907
D014975	Lutein	[Cisplatin co-treated with Lutein] results in decreased expression of SOD3 mRNA	24865317
D014975	Lutein	Lutein results in decreased expression of SOD3 mRNA	24865317
C025340	manganese chloride	[manganese chloride co-treated with Iron] affects the expression of SOD3 mRNA	12387356
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of SOD3 protein	18599595\|2341568
D008727	Methotrexate	Methotrexate results in increased expression of SOD3 mRNA	21678067
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of SOD3 protein	29258870
D008767	Methylmercury Compounds	Methylmercury Compounds affects the expression of SOD3 mRNA	18959803
C043243	methyl tert-butyl ether	methyl tert-butyl ether results in increased activity of SOD3 protein	19150650
D015735	Mifepristone	Mifepristone inhibits the reaction [Progesterone results in decreased expression of SOD3 mRNA]	16195479
C523799	MRK 003	MRK 003 results in decreased expression of SOD3 mRNA	21169257
C568376	MT19c compound	MT19c compound results in decreased expression of SOD3 mRNA	21781307
C029938	nickel sulfate	nickel sulfate results in increased expression of SOD3 mRNA	20566472
C012655	nimesulide	nimesulide results in decreased expression of SOD3 mRNA	24136188
C025589	ochratoxin A	ochratoxin A results in increased expression of SOD3 mRNA	17316727
C485800	osajin	osajin results in decreased expression of SOD3 mRNA	20706672
D010081	Oxazolone	Oxazolone results in decreased expression of SOD3 mRNA	21893156
D010100	Oxygen	Oxygen deficiency results in decreased activity of SOD3 protein	22140445
D010100	Oxygen	Oxygen deficiency results in decreased expression of SOD3 mRNA	20594416
D010126	Ozone	SOD3 protein inhibits the reaction [Ozone results in increased expression of IL6 protein]	11999998
D000073878	Palm Oil	Palm Oil results in decreased expression of SOD3 mRNA	18042831
D010269	Paraquat	Paraquat results in increased expression of SOD3 mRNA	22996356
D010269	Paraquat	[Quercetin co-treated with Paraquat] results in increased expression of SOD3 mRNA	22996356
D010269	Paraquat	APOD protein affects the reaction [Paraquat results in increased expression of SOD3 mRNA]	21688324
D010269	Paraquat	Paraquat results in decreased expression of SOD3 mRNA	17215068\|2610857
D010269	Paraquat	Paraquat results in increased expression of SOD3 mRNA	12732627\|2168832
C084656	paricalcitol	[Phosphorus co-treated with paricalcitol] results in increased expression of SOD3 mRNA	17715259
D052638	Particulate Matter	Particulate Matter analog results in increased expression of SOD3 mRNA	15322212
D052638	Particulate Matter	Particulate Matter results in increased expression of SOD3 mRNA	24216475
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in decreased expression of SOD3 mRNA	23602845
D026023	Permethrin	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of SOD3 mRNA	28659758
D030421	Peroxynitrous Acid	[Streptozocin results in decreased activity of SOD3 protein] which results in increased chemical synthesis of Peroxynitrous Acid	23884884
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of SOD3 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital affects the expression of SOD3 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased expression of SOD3 mRNA	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of SOD3 mRNA	19162173
D010705	Phosgene	Phosgene affects the expression of SOD3 mRNA	16300373
D010758	Phosphorus	[Phosphorus co-treated with paricalcitol] results in increased expression of SOD3 mRNA	17715259
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of SOD3 mRNA	15728792
D059808	Polyphenols	Polyphenols results in decreased expression of SOD3 mRNA	16293270
C474837	pomiferin	pomiferin results in decreased expression of SOD3 mRNA	20706672
C027373	potassium chromate(VI)	[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of SOD3 mRNA]	14625279
D011192	Potassium Dichromate	[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of SOD3 mRNA]	14625279
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of SOD3 mRNA	19162173
D011341	Probucol	"Probucol inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA]"	28734741
D011374	Progesterone	Estradiol inhibits the reaction [Progesterone results in decreased expression of SOD3 mRNA]	16195479
D011374	Progesterone	Progesterone results in decreased expression of SOD3 mRNA	16195479
D011374	Progesterone	Mifepristone inhibits the reaction [Progesterone results in decreased expression of SOD3 mRNA]	16195479
D011374	Progesterone	Progesterone inhibits the reaction [Estradiol results in increased expression of SOD3 mRNA]	16195479
D011374	Progesterone	Progesterone results in decreased activity of SOD3 protein	16195479
D011374	Progesterone	Progesterone results in decreased expression of SOD3 mRNA	16195479
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of SOD3 mRNA	24780913
C033607	puerarin	puerarin results in decreased expression of SOD3 mRNA	20706672
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in decreased expression of SOD3 mRNA	20685819
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of SOD3 mRNA	27029645
D011729	Pyridostigmine Bromide	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of SOD3 mRNA	28659758
D011794	Quercetin	[Quercetin co-treated with Paraquat] results in increased expression of SOD3 mRNA	22996356
D011794	Quercetin	Quercetin results in increased expression of SOD3 mRNA	22996356
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of SOD3 mRNA	15576828
D017382	Reactive Oxygen Species	SOD3 protein affects the abundance of Reactive Oxygen Species	17010595
C059514	resveratrol	resveratrol inhibits the reaction [Estradiol results in decreased expression of SOD3 mRNA]	25130429
C059514	resveratrol	resveratrol inhibits the reaction [Estradiol results in decreased expression of SOD3 protein]	25130429
C059514	resveratrol	resveratrol results in decreased expression of SOD3 mRNA	20706672
C059514	resveratrol	resveratrol results in increased expression of SOD3	20610621
C059514	resveratrol	resveratrol results in increased expression of SOD3 mRNA	28960787
C059514	resveratrol	resveratrol results in increased expression of SOD3 protein	28960787
C059514	resveratrol	resveratrol results in increased expression of SOD3 mRNA	20610621
C059514	resveratrol	resveratrol inhibits the reaction [Estradiol results in decreased expression of SOD3 mRNA]	24894866
C059514	resveratrol	resveratrol inhibits the reaction [Estradiol results in decreased expression of SOD3 protein]	24894866
C059514	resveratrol	resveratrol results in increased expression of SOD3 mRNA	24894866
C059514	resveratrol	resveratrol results in increased expression of SOD3 protein	24894866
C529148	rosavin	rosavin results in decreased expression of SOD3 mRNA	20706672
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SOD3 mRNA	16054899
C093642	SB 203580	SB 203580 inhibits the reaction [cobaltous chloride results in decreased expression of SOD3 mRNA]	19031313
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in decreased expression of SOD3 mRNA"	16251409
D012834	Silver	Silver results in decreased expression of SOD3 mRNA	19429238
D019821	Simvastatin	"Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA]"	28734741
C017947	sodium arsenite	sodium arsenite results in decreased expression of SOD3 mRNA	21396911
C016104	sodium bichromate	sodium bichromate results in increased expression of SOD3 mRNA	12325037
D013311	Streptozocin	Copper inhibits the reaction [Streptozocin results in decreased activity of SOD3 protein]	23884884
D013311	Streptozocin	INS protein inhibits the reaction [Streptozocin results in decreased activity of SOD3 protein]	23884884
D013311	Streptozocin	SOD3 gene mutant form promotes the reaction [Streptozocin results in increased chemical synthesis of Superoxides]	23884884
D013311	Streptozocin	[Streptozocin results in decreased activity of SOD3 protein] which results in increased chemical synthesis of Peroxynitrous Acid	23884884
D013311	Streptozocin	[Streptozocin results in decreased activity of SOD3 protein] which results in increased chemical synthesis of Superoxides	23884884
D013311	Streptozocin	Streptozocin results in increased expression of and results in decreased activity of SOD3 protein	23884884
D013311	Streptozocin	cobaltiprotoporphyrin inhibits the reaction [Streptozocin results in decreased expression of SOD3 protein]	15821039
D013311	Streptozocin	Streptozocin results in decreased expression of SOD3 mRNA	16973718
D013311	Streptozocin	Streptozocin results in decreased expression of SOD3 protein	15821039\|1697371
D013311	Streptozocin	tin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Streptozocin results in decreased expression of SOD3 protein]]	15821039
D013311	Streptozocin	Trientine inhibits the reaction [Streptozocin results in decreased expression of SOD3 mRNA]	16973718
D013311	Streptozocin	Trientine inhibits the reaction [Streptozocin results in decreased expression of SOD3 protein]	16973718
D013481	Superoxides	[ATP7A protein results in increased activity of SOD3 protein] which results in decreased chemical synthesis of Superoxides	23884884
D013481	Superoxides	SOD3 gene mutant form promotes the reaction [Streptozocin results in increased chemical synthesis of Superoxides]	23884884
D013481	Superoxides	SOD3 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]	16864745
D013481	Superoxides	[Streptozocin results in decreased activity of SOD3 protein] which results in increased chemical synthesis of Superoxides	23884884
C061133	tamibarotene	tamibarotene results in decreased expression of SOD3 mRNA	15498508
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SOD3 mRNA	21296121
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SOD3 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOD3 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SOD3 mRNA	15034205\|1566782
D017392	Thiobarbituric Acid Reactive Substances	SOD3 protein results in decreased abundance of Thiobarbituric Acid Reactive Substances	16377630
C003466	thymoquinone	"thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA]"	28734741
C055421	tin mesoporphyrin	tin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Streptozocin results in decreased expression of SOD3 protein]]	15821039
D014118	Toxins, Biological	"Toxins, Biological affects the expression of SOD3 mRNA"	19682533
D014212	Tretinoin	Tretinoin results in decreased expression of SOD3 mRNA	15498508
D014266	Trientine	Trientine inhibits the reaction [Streptozocin results in decreased expression of SOD3 mRNA]	16973718
D014266	Trientine	Trientine inhibits the reaction [Streptozocin results in decreased expression of SOD3 protein]	16973718
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of SOD3 mRNA	21893156
C057693	troglitazone	troglitazone results in decreased expression of SOD3 mRNA	28973697
D014635	Valproic Acid	Valproic Acid results in increased methylation of SOD3 gene	29154799
D014640	Vancomycin	Vancomycin results in increased expression of SOD3 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions analog results in increased expression of SOD3 mRNA	15322212
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of SOD3 mRNA	19165385
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of SOD3 mRNA	24216475
C025643	vinclozolin	vinclozolin results in decreased expression of SOD3 mRNA	23034163
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of SOD3 mRNA	26682919
C088658	zoledronic acid	zoledronic acid results in increased expression of SOD3 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004784	superoxide dismutase activity	-	IBA	21873635
GO:0004784	superoxide dismutase activity	-	TAS	-
GO:0005507	copper ion binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	15528465 25416956
GO:0008201	heparin binding	-	IEA	-
GO:0008270	zinc ion binding	-	IBA	21873635
GO:0016532	superoxide dismutase copper chaperone activity	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001666	response to hypoxia	-	IEA	-
GO:0019430	removal of superoxide radicals	-	IBA	21873635
GO:0019430	removal of superoxide radicals	-	IEA	-
GO:0034599	cellular response to oxidative stress	-	TAS	-
GO:0046688	response to copper ion	-	IEA	-
GO:0055114	oxidation-reduction process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	HDA	27068509
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	HDA	20551380
GO:0005615	extracellular space	-	IBA	21873635
GO:0005634	nucleus	-	IEA	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005796	Golgi lumen	-	TAS	-
GO:0062023	collagen-containing extracellular matrix	-	HDA	27559042
GO:0062023	collagen-containing extracellular matrix	colocalizes_with	HDA	20551380
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-2262752	Cellular responses to stress	IEA
R-HSA-3299685	Detoxification of Reactive Oxygen Species	TAS
R-HSA-3299685	Detoxification of Reactive Oxygen Species	IEA
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-8953897	Cellular responses to external stimuli	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23638916	Genetic variation of superoxide dismutases in patients with primary open-angle glaucoma. (2014 Jun)	Celojevic D	Ophthalmic Genet
19213780	Superoxide dismutases, lung function and bronchial responsiveness in a general population. (2009 May)	Siedlinski M	Eur Respir J
16467073	Functional variants of antioxidant genes in smokers with COPD and in those with normal lung function. (2006 May)	Young RP	Thorax
18566111	Genetic variation and gene expression in antioxidant related enzymes and risk of COPD: a systematic review. (2008 Nov)	Bentley AR	Thorax
25541994	SIRT6 minor allele genotype is associated with >5-year decrease in lifespan in an aged cohort. (2014)	TenNapel MJ	PLoS One
25541553	Adiposity is associated with DNA methylation profile in adipose tissue. (2015 Aug)	Agha G	Int J Epidemiol
23289810	Superoxide dismutase gene polymorphisms in patients with age-related cataract. (2013 Sep)	Celojevic D	Ophthalmic Genet
19108943	Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction. (2009 Feb)	Rosta K	Eur J Obstet Gynecol Reprod Biol
23688726	Genetic variation in antioxidant enzymes, cigarette smoking, and longitudinal change in lung function. (2013 Oct)	Tang W	Free Radic Biol Med
20966810	Superoxide dismutase and nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase polymorphisms and pancreatic cancer risk. (2011 Jan)	Mohelnikova-Duchonova B	Pancreas
26087411	Cigarette Smoke-Induced Hypermethylation of the GCLC Gene Is Associated With COPD. (2016 Feb)	Cheng L	Chest
20673035	Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPD. (2010 Aug)	Sorheim IC	COPD
17903307	Framingham Heart Study genome-wide association: results for pulmonary function measures. (2007 Sep 19)	Wilk JB	BMC Med Genet