Gene: SON

6651
BASS1|C21orf50|DBP-5|NREBP|SON3|TOKIMS
SON DNA binding protein
protein-coding
21q22.11
Ensembl:ENSG00000159140 MIM:182465 Vega:OTTHUMG00000065806 UniprotKB:P18583
NG_052981.1
PubMed
0   ANCO-SNPs
CD|ND|AD
22   
4.337e-1 (AD)  3.231e-1 (ND)   (Frontal_Cortex)
5.424e-1 (AD)  3.255e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEC24B0.932
CNOT10.928
NCOA10.926
COPB20.924
PRRC2C0.922
AFF40.921
SETX0.919
ADNP0.918
TRIP120.918
SNRNP2000.916

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.709
OR4F29-0.682
NANOGNB-0.202
KLRC2-0.184
APOA4-0.169
C17orf112-0.168
OR4F16-0.163
HMHB1-0.157
KRTAP1-1-0.152
TNFRSF13B-0.146

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of SON mRNA25596134
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SON mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SON mRNA"21346803
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in decreased expression of SON protein26194647
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SON mRNA"18648102
C0005950156,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in decreased expression of SON mRNA"28073004
D000082AcetaminophenAcetaminophen affects the expression of SON mRNA17562736
C109238acylineacyline results in increased expression of SON mRNA17510436
C016601afimoxifeneafimoxifene results in decreased expression of SON mRNA16514628
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SON gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SON mRNA19770486
C006632arsenic trioxideSON protein results in increased susceptibility to arsenic trioxide20707922
D001280AtrazineAtrazine results in increased expression of SON mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of SON mRNA22323515
D001554BenzeneBenzene affects the expression of SON mRNA16188086
D001554BenzeneBenzene results in decreased expression of SON mRNA15878777
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SON mRNA"19150397
D004958EstradiolEstradiol results in increased expression of SON mRNA16514628
C044887beta-methylcholinebeta-methylcholine affects the expression of SON mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of SON mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of SON mRNA17553608
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SON mRNA25596134
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of SON mRNA25596134
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SON mRNA16934159
C059262cidofovircidofovir results in decreased expression of SON mRNA25596134
D004002Clodronic AcidClodronic Acid results in decreased expression of SON mRNA25596134
C018021cobaltous chloridecobaltous chloride results in increased expression of SON mRNA19376846
D003042CocaineCocaine affects the expression of SON mRNA20187946
D016572CyclosporineCyclosporine affects the expression of SON mRNA25596134
C014347decitabinedecitabine results in increased expression of SON mRNA15251184
C014347decitabine[Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of SON mRNA15251184
D003976DiazinonDiazinon affects the expression of SON mRNA22546817
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of SON mRNA"25908611
D002945CisplatinCisplatin results in decreased expression of SON mRNA25596134|2759478
D004026DieldrinDieldrin affects the expression of SON mRNA22546817
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SON protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SON mRNA17557909
D011345FenofibrateFenofibrate results in decreased expression of SON mRNA25596134
C070081fulvestrantfulvestrant results in decreased expression of SON mRNA16514628
D005839GentamicinsGentamicins results in increased expression of SON mRNA22061828
D007069IfosfamideIfosfamide results in decreased expression of SON mRNA25596134
D007213IndomethacinIndomethacin results in decreased expression of SON mRNA16984733
C544151jinfukangjinfukang results in decreased expression of SON mRNA27392435
D008687MetforminMetformin results in decreased expression of SON mRNA25596134
D008777MethyltestosteroneMethyltestosterone results in decreased expression of SON mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SON mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SON mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of SON mRNA18978301
C502362N-butyrylglucosamineN-butyrylglucosamine results in increased expression of SON mRNA16142878
C022838nickel chloridenickel chloride affects the expression of SON mRNA22546817
D010100OxygenOxygen deficiency results in decreased expression of SON mRNA25596134
D010100OxygenOxygen deficiency results in increased expression of SON mRNA24205000
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of SON mRNA28973697
D010634PhenobarbitalPhenobarbital affects the expression of SON mRNA23091169
D010758PhosphorusPhosphorus results in increased expression of SON mRNA17715259
C045950propiconazolepropiconazole results in decreased expression of SON mRNA21278054
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of SON mRNA16514628
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of SON mRNA21427059
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of SON mRNA19244175
D012643SeleniumSelenium results in decreased expression of SON mRNA19244175
D012715Sesame OilSesame Oil results in increased expression of SON mRNA29191790
C009277sodium arsenatesodium arsenate results in increased expression of SON mRNA21795629
C061133tamibarotenetamibarotene affects the expression of SON mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SON mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of SON mRNA15251184
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SON mRNA15251184
D019284ThapsigarginThapsigargin results in increased expression of SON protein24648495
D013849ThimerosalThimerosal results in decreased expression of SON mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SON mRNA28065790
D014212TretinoinTretinoin results in decreased expression of SON mRNA15498508
D014241TrichloroethyleneTrichloroethylene results in increased expression of SON mRNA19448997
C012589trichostatin Atrichostatin A results in decreased expression of SON mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of SON mRNA28973697
D014520UrethaneUrethane results in decreased expression of SON mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of SON mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SON mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in decreased expression of SON mRNA20546886|2142705
C025643vinclozolinvinclozolin results in increased expression of SON mRNA23034163
D014750VincristineVincristine results in decreased expression of SON mRNA23649840
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of SON mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of SON mRNA19244175
C111237vorinostatvorinostat results in decreased expression of SON mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003723RNA binding-IDA21504830  
GO:0005515protein binding-IPI15324660  17353931  21504830  
GO:0050733RS domain binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000226microtubule cytoskeleton organization-IMP21504830  
GO:0000281mitotic cytokinesis-IMP21504830  
GO:0006397mRNA processing-IDA21504830  
GO:0008380RNA splicing-IEA-  
GO:0043066negative regulation of apoptotic process-IDA10509013  
GO:0043484regulation of RNA splicing-IMP27545680  
GO:0048024regulation of mRNA splicing, via spliceosome-IDA21504830  
GO:0051726regulation of cell cycle-IBA21873635  
GO:0051726regulation of cell cycle-IMP21504830  
GO ID GO Term Qualifier Evidence PubMed
GO:0016607nuclear speck-IDA21504830  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
12394320Rates of smoking in the households of cardiac patients. (2002 Oct)Hevey DJ Cardiovasc Risk
25981179The Effects of Parental Health Shocks on Adult Offspring Smoking Behavior and Self-Assessed Health. (2016 Aug)Darden MHealth Econ
21938565[Bladder cancer at an early age in father and son]. (2011 Dec)Ovsiannikov DUrologe A
25031933Pregnancy in a patient with cancer and heart failure: challenges and complexities. (2012 Mar)Fadol APJ Adv Pract Oncol
26056182R331W Missense Mutation of Oncogene YAP1 Is a Germline Risk Allele for Lung Adenocarcinoma With Medical Actionability. (2015 Jul 10)Chen HYJ Clin Oncol
28771952Prevalence and determinants of frailty and associated comorbidities among older Gurkha welfare pensioners in Nepal. (2017 Dec)Devkota SGeriatr Gerontol Int
11341066Cocaine addicts and their families. An empirical study of the processes of identification. (2001 Apr)Pinheiro RTInt J Psychoanal
3172784Identifying developmental paradigms leading to alcoholism. (1988 Jul)McCord JJ Stud Alcohol
11602138[Invassive infections caused by Group A streptococci: clinical characteristics and microbiological analyses in 31 cases]. (2001 Oct)Bosch TEnferm Infecc Microbiol Clin
647614Anorexia nervosa in boys. (1978 Apr)Sreenivasan UCan Psychiatr Assoc J
7474821[Genetic aspects of heart lesions in patients with chronic alcoholism]. (1995)Mamontova NSKlin Med (Mosk)
9246794Sir Austin Bradford Hill: medical statistics and the quantitative approach to prevention of disease. (1997 Jun)Wilkinson LAddiction
302694Analysis of familial factors in bipolar affective illness. (1977 Sep)Johnson GFArch Gen Psychiatry
22593996[Genetic determinants of the alcohol dependence syndrome: searching for an endophenotype associated with sweet liking in families with alcohol addiction]. (2011)Jablonski MAnn Acad Med Stetin
19434065Assortative weight gain in mother-daughter and father-son pairs: an emerging source of childhood obesity. Longitudinal study of trios (EarlyBird 43). (2009 Jul)Perez-Pastor EMInt J Obes (Lond)
24520500Cigarette smoking and cardiovascular risk in young women with polycystic ovary syndrome. (2014 Jan)Morotti EInt J Fertil Steril
9622448More vasopressin mRNA in the paraventricular hypothalamic nucleus of alcohol-preferring rats and high alcohol-drinking rats selectively bred for high alcohol preference. (1998 May)Hwang BHAlcohol Clin Exp Res
8427042Heritable and life-style determinants of bone mineral density. (1993 Jan)Krall EAJ Bone Miner Res
20078833Maternal smoking during pregnancy and intellectual performance in young adult Swedish male offspring. (2010 Jan)Lundberg FPaediatr Perinat Epidemiol
22166656Performance of brain MRI of a two generation father-and-son family with long-term smoking caffeinum natrio benzoicum. (2010 Dec)Sun WLChin Med J (Engl)
23746309The heritability of circulating testosterone, oestradiol, oestrone and sex hormone binding globulin concentrations in men: the Framingham Heart Study. (2014 Feb)Travison TGClin Endocrinol (Oxf)
8714337Women offenders and reentry issues. (1996 Jan-Mar)Taylor SDJ Psychoactive Drugs