Gene: SORD

6652
HEL-S-95n|SORD1
sorbitol dehydrogenase
protein-coding
15q21.1
Ensembl:ENSG00000140263 MIM:182500 Vega:OTTHUMG00000131265 UniprotKB:Q00796
NC_000015.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.486e-1 (AD)  9.722e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCYOX10.815
TIMM8A0.809
PHF200.799
PMS20.799
SLC17A50.793
AMN10.792
AGGF10.788
WDR120.787
FAM161B0.787
BLOC1S60.787

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.418
MTRNR2L6-0.394
OR4F29-0.363
MTRNR2L9-0.363
MTRNR2L10-0.349
MTRNR2L8-0.334
CSAG1-0.322
PPBP-0.318
MTRNR2L2-0.311
MMP9-0.303

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB04478Cp-166572, 2-Hydroxymethyl-4-(4-N,N-Dimethylaminosulfonyl-1-Piperazino)-PyrimidineSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0245671,1,2-trichloroethane"1,1,2-trichloroethane results in increased expression of SORD protein"1489524
C0095361,2,3-trichloropropane"1,2,3-trichloropropane results in increased activity of SORD protein"12692652
C0605681,4-dithiane"1,4-dithiane results in decreased activity of SORD"2465932
C0668412,3,7,8-tetrabromodibenzo-4-dioxin"2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of SORD protein"27604104
C0352082-amino-4,6-dinitrotoluene"2-amino-4,6-dinitrotoluene affects the expression of SORD mRNA"21346803
C0047262-dichlorobenzene2-dichlorobenzene results in increased activity of SORD protein3012827
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SORD mRNA]"19467301
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SORD mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SORD mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SORD mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SORD mRNA"27188386
C0293704-toluidine4-toluidine results in increased expression of SORD mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SORD mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SORD mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SORD mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SORD mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SORD mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of SORD protein22939915
D000082AcetaminophenAcetaminophen results in increased activity of SORD protein8742320
D000082AcetaminophenClofibrate inhibits the reaction [Acetaminophen results in increased activity of SORD protein]8742320
D000082Acetaminophen[CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of SORD protein25499718
D000082AcetaminophenABCC2 protein affects the reaction [Acetaminophen results in increased activity of SORD protein]16271353
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Diclofenac results in increased secretion of SORD protein]12763371
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SORD mRNA19770486
C038491allyl sulfideallyl sulfide inhibits the reaction [Cadmium Chloride results in decreased activity of SORD protein]18972399
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SORD mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SORD mRNA24449571
C015001arsenitearsenite results in increased expression of SORD mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in increased expression of SORD mRNA]18929588
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of SORD mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SORD mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SORD mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of SORD mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SORD mRNA26238291
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SORD mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SORD mRNA19770486
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of SORD mRNA26496021
C044887beta-methylcholinebeta-methylcholine affects the expression of SORD mRNA21179406
C095105bexarotenebexarotene results in decreased expression of SORD mRNA16648578
C053541bicalutamidebicalutamide results in increased expression of SORD mRNA15790403
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SORD mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SORD mRNA28628672
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of SORD mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of SORD mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SORD mRNA28628672
C032036bromobenzenebromobenzene results in increased activity of SORD protein3012827
D019328Buthionine SulfoximineButhionine Sulfoximine promotes the reaction [Diclofenac results in increased secretion of SORD protein]12763371
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SORD mRNA15336504
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of SORD protein24394546
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased activity of SORD protein16928893
C018475butyraldehydebutyraldehyde results in decreased expression of SORD mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SORD protein24527689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SORD mRNA24794047
D019256Cadmium Chlorideallyl sulfide inhibits the reaction [Cadmium Chloride results in decreased activity of SORD protein]18972399
D019256Cadmium ChlorideCadmium Chloride results in decreased activity of SORD protein18972399
D019256Cadmium Chloridezinc chloride inhibits the reaction [Cadmium Chloride results in decreased activity of SORD protein]18972399
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased activity of SORD protein17177172
D002251Carbon TetrachlorideDimethyl Sulfoxide inhibits the reaction [Carbon Tetrachloride results in increased activity of SORD protein]17177172
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SORD protein17374462
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased secretion of SORD protein10757424
D002251Carbon Tetrachloridecynandione A inhibits the reaction [Carbon Tetrachloride results in increased secretion of SORD protein]10757424
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SORD mRNA27858113
D002994ClofibrateClofibrate inhibits the reaction [Acetaminophen results in increased activity of SORD protein]8742320
D002994ClofibrateClofibrate results in decreased expression of SORD mRNA22300585
C018021cobaltous chloridecobaltous chloride results in decreased expression of SORD mRNA24612858
C018021cobaltous chloridecobaltous chloride results in decreased expression of SORD mRNA19376846
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SORD mRNA20971185
D003300CopperCopper results in decreased expression of SORD mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of SORD mRNA19549813
C467608CP-470711CP-470711 results in decreased activity of SORD protein18549825
C467608CP-470711[CP-470711 results in decreased activity of SORD protein] which results in decreased expression of HIF1A protein18549825
C467608CP-470711[CP-470711 results in decreased activity of SORD protein] which results in decreased expression of TF protein18549825
C467608CP-470711[CP-470711 results in decreased activity of SORD protein] which results in decreased expression of TFRC protein18549825
C007164cumene hydroperoxidecumene hydroperoxide results in increased activity of SORD protein16928893
D003520CyclophosphamideCyclophosphamide results in decreased activity of SORD protein25446862
D003520CyclophosphamidePlant Extracts inhibits the reaction [Cyclophosphamide results in decreased activity of SORD protein]25446862
D016572CyclosporineCyclosporine results in decreased expression of SORD mRNA19770486
C403944cynandione Acynandione A inhibits the reaction [Carbon Tetrachloride results in increased secretion of SORD protein]10757424
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SORD mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SORD mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SORD mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SORD mRNA28628672
D003976DiazinonDiazinon results in increased methylation of SORD gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SORD mRNA21266533
D004008DiclofenacAcetylcysteine inhibits the reaction [Diclofenac results in increased secretion of SORD protein]12763371
D004008DiclofenacButhionine Sulfoximine promotes the reaction [Diclofenac results in increased secretion of SORD protein]12763371
D004008DiclofenacDiclofenac results in increased secretion of SORD protein12763371
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SORD mRNA26924002
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SORD mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of SORD mRNA19467301
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of SORD mRNA24535843
D004121Dimethyl SulfoxideDimethyl Sulfoxide inhibits the reaction [Carbon Tetrachloride results in increased activity of SORD protein]17177172
D004610Ellagic AcidEllagic Acid results in decreased activity of SORD protein28153595
D004726EndosulfanEndosulfan results in decreased activity of SORD protein11692196
D004726EndosulfanEndosulfan results in increased activity of SORD protein8588293
C118739entinostatentinostat results in decreased expression of SORD mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SORD mRNA"27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SORD protein23301498
C024565ethylene dichlorideethylene dichloride results in decreased expression of SORD mRNA28189721
C504383fenbuconazolefenbuconazole results in increased expression of SORD mRNA15942997
D005485FlutamideFlutamide results in decreased expression of SORD mRNA24793618
D005485FlutamideFlutamide results in increased expression of SORD mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of SORD mRNA23649840
D005632FructoseFructose results in increased glycation of SORD protein8761460
D005632Fructose[Fructose results in increased glycation of SORD protein] which results in decreased activity of SORD protein8761460
D005690GalactoseGalactose results in increased expression of SORD mRNA22687555
D019833GenisteinGenistein results in decreased expression of SORD mRNA15378649
D005839GentamicinsGentamicins results in decreased expression of SORD mRNA22061828
D005897GlafenineGlafenine results in decreased expression of SORD mRNA24136188
D005947GlucoseGlucose results in increased expression of SORD mRNA16805838
D017313FenretinideFenretinide results in increased expression of SORD mRNA28973697
D006820Hyaluronic AcidHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of SORD protein]23178681
D006861Hydrogen PeroxideHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of SORD protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of SORD protein23178681
C492448ICG 001ICG 001 results in decreased expression of SORD mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SORD mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SORD mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SORD mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SORD mRNA25613284
D007501IronSORD protein affects the abundance of Iron18549825
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SORD mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SORD mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SORD mRNA28628672
D007538IsoniazidIsoniazid results in increased expression of SORD protein7401618
D007545IsoproterenolIsoproterenol results in decreased expression of SORD mRNA21335049
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of SORD mRNA15618438
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SORD mRNA21889194
C410337K 7174K 7174 results in decreased expression of SORD mRNA24086573
C008261lead acetatelead acetate results in increased expression of SORD mRNA11578147
D001556LindaneLindane affects the activity of SORD protein8519523
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SORD mRNA25613284
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SORD mRNA26378955
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SORD mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SORD mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SORD mRNA"25554681|2562005
C051752nefazodonenefazodone results in increased expression of SORD mRNA24136188
C022838nickel chloridenickel chloride results in decreased expression of SORD mRNA24612858
C000589285NP260NP260 results in increased expression of SORD protein24699182
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SORD mRNA20971185
C025589ochratoxin Aochratoxin A results in increased expression of SORD mRNA22124623
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SORD mRNA25729387
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SORD mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of SORD mRNA26272509
C046012pentanalpentanal results in increased expression of SORD mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SORD mRNA19162173
D010656PhenylephrinePhenylephrine results in decreased expression of SORD mRNA18158353
D010795Phthalic AcidsPhthalic Acids results in increased expression of SORD mRNA21061450
D010936Plant ExtractsPlant Extracts results in increased activity of SORD protein26177929
D010936Plant ExtractsPlant Extracts inhibits the reaction [Cyclophosphamide results in decreased activity of SORD protein]25446862
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of SORD mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SORD mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of SORD mRNA20726854
C045950propiconazolepropiconazole results in decreased expression of SORD mRNA21278054
D015474IsotretinoinIsotretinoin results in decreased expression of SORD mRNA20436886
D012643SeleniumSelenium results in increased expression of SORD protein1588439
D012834SilverSilver results in increased expression of SORD mRNA27131904
C080703SK&F 83959SK&F 83959 results in decreased expression of SORD protein25852303
C017947sodium arseniteCGA protein inhibits the reaction [sodium arsenite results in decreased expression of SORD protein]16483355
C017947sodium arsenitesodium arsenite results in decreased expression of SORD protein16483355
C016104sodium bichromatesodium bichromate results in decreased expression of SORD mRNA24612858
D012969Sodium FluorideSodium Fluoride results in increased expression of SORD protein28918527
D013311StreptozocinStreptozocin results in decreased expression of and results in decreased activity of SORD protein8761460
D013311StreptozocinStreptozocin results in increased expression of SORD mRNA8761460
D013311StreptozocinStreptozocin results in increased glycation of SORD protein8761460
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SORD mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SORD mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SORD mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SORD mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SORD mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SORD protein22609517
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SORD mRNA25729387
D019772TopotecanTopotecan results in decreased expression of SORD mRNA25729387
C012589trichostatin Atrichostatin A results in decreased expression of SORD mRNA24935251
D014303TrinitrotolueneTrinitrotoluene affects the expression of SORD mRNA21346803
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SORD mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SORD mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of SORD mRNA23179753|2438349
D014638VanadatesVanadates results in decreased expression of SORD mRNA22714537
D014640VancomycinVancomycin results in increased expression of SORD mRNA18930951
C025643vinclozolinvinclozolin results in increased expression of SORD mRNA22570695
C016837zinc chloridezinc chloride inhibits the reaction [Cadmium Chloride results in decreased activity of SORD protein]18972399
D019287Zinc SulfateZinc Sulfate results in decreased expression of SORD mRNA19013360

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003939L-iditol 2-dehydrogenase activity-EXP6870831  12962626  
GO:0003939L-iditol 2-dehydrogenase activity-IDA3365415  6870831  8487505  
GO:0003939L-iditol 2-dehydrogenase activity-ISS-  
GO:0005515protein binding-IPI27107014  
GO:0008270zinc ion binding-IDA12962626  
GO:0008270zinc ion binding-ISS-  
GO:0030246carbohydrate binding-NAS12962626  
GO:0042802identical protein binding-IPI16189514  21516116  
GO:0046526D-xylulose reductase activity-EXP3365415  8487505  
GO:0051287NAD binding-IDA12962626  
GO ID GO Term Qualifier Evidence PubMed
GO:0006006glucose metabolic process-TAS14965227  
GO:0006062sorbitol catabolic process-IDA3365415  6870831  8487505  12962626  
GO:0006970response to osmotic stress-IEA-  
GO:0009725response to hormone-IEA-  
GO:0019640glucuronate catabolic process to xylulose 5-phosphate-TAS-  
GO:0030317flagellated sperm motility-ISS-  
GO:0030317flagellated sperm motility-NAS16278369  
GO:0031667response to nutrient levels-IEA-  
GO:0042493response to drug-IEA-  
GO:0046370fructose biosynthetic process-IDA3365415  6870831  8487505  
GO:0046370fructose biosynthetic process-TAS-  
GO:0046686response to cadmium ion-IEA-  
GO:0046688response to copper ion-IEA-  
GO:0051160L-xylitol catabolic process-IDA8487505  
GO:0051164L-xylitol metabolic process-IDA3365415  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-TAS6177277  
GO:0005829cytosol-TAS-  
GO:0016020membrane-IDA8487505  
GO:0031514motile cilium-ISS-  
GO:0031966mitochondrial membrane-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:0070062extracellular exosome-IDA21557262  
KEGG ID KEGG Term
hsa00051Fructose and mannose metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-5652084Fructose metabolismTAS
R-HSA-5652227Fructose biosynthesisTAS
R-HSA-5661270Catabolism of glucuronate to xylulose-5-phosphateTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26647419Protein profile screening: reduced expression of Sord in the mouse epididymis induced by nicotine inhibits tyrosine phosphorylation level in capacitated spermatozoa. (2016 Mar)Dai JReproduction