Gene: SORL1

6653
C11orf32|LR11|LRP9|SORLA|SorLA-1|gp250
sortilin related receptor 1
protein-coding
11q24.1
Ensembl:ENSG00000137642 MIM:602005 Vega:OTTHUMG00000166057 UniprotKB:Q92673
NG_023313.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.665e-1 (AD)  4.842e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14239983chr11:121337384SORL18.000e-11Smoking27651444
cg10908953chr11:121322456SORL19.300e-10Smoking27651444
cg22327175chr11:121323934SORL11.000e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLTC0.938
ATP2A20.937
MYH100.935
DNAJC180.934
PPM1L0.934
MAPK100.931
PFKM0.93
EFR3A0.93
NDUFS10.929
FAM49A0.929

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.556
OR4F29-0.502
TFPI2-0.454
CSAG1-0.446
RAI14-0.442
HEY2-0.433
PGF-0.425
HAS2-0.418
C9orf135-0.41
CST7-0.409

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of SORL1 mRNA25596134
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of SORL1 mRNA25596134
C0131862,3-pentanedione"2,3-pentanedione results in decreased expression of SORL1 mRNA"25710175
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SORL1 mRNA"21346803
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of SORL1 mRNA25088246
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SORL1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SORL1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SORL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SORL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SORL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SORL1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of SORL1 mRNA21420995
D000082AcetaminophenAcetaminophen results in decreased expression of SORL1 mRNA25596134|2906747
D000082AcetaminophenAcetaminophen affects the expression of SORL1 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of SORL1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SORL1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SORL1 mRNA27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of SORL1 mRNA21757418
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of SORL1 mRNA28522335
D000639AmitriptylineAmitriptyline results in decreased expression of SORL1 mRNA22341215
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SORL1 mRNA24449571
D001151ArsenicArsenic affects the expression of SORL1 mRNA18414638
D001151ArsenicArsenic affects the methylation of SORL1 gene25304211
C058317arsenic disulfidearsenic disulfide results in decreased expression of SORL1 mRNA12890387
D001280AtrazineAtrazine results in decreased expression of SORL1 mRNA25929836
C547126AZM551248AZM551248 results in decreased expression of SORL1 mRNA22323515
D001554BenzeneBenzene results in increased expression of SORL1 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SORL1 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SORL1 mRNA26238291
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of SORL1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SORL1 mRNA22300585
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SORL1 mRNA21839799
D004958EstradiolEstradiol results in increased expression of SORL1 mRNA21185374
C095105bexarotene[bexarotene co-treated with Tamoxifen] results in increased expression of SORL1 mRNA17630414
C006780bisphenol Abisphenol A results in decreased expression of SORL1 mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of SORL1 gene22576693
C006780bisphenol Abisphenol A results in decreased expression of SORL1 mRNA25181051
D002110CaffeineCaffeine results in decreased expression of SORL1 mRNA25868845
D002220CarbamazepineCarbamazepine affects the expression of SORL1 mRNA25979313
C004656chloroacetaldehydechloroacetaldehyde affects the expression of SORL1 mRNA25596134
C059262cidofovircidofovir results in decreased expression of SORL1 mRNA25596134
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of SORL1 mRNA16197558
C039671ciglitazone[ciglitazone binds to PPARG protein] which results in increased expression of SORL1 mRNA16197558
D004002Clodronic AcidClodronic Acid results in increased expression of SORL1 mRNA25596134
D002994ClofibrateClofibrate results in decreased expression of SORL1 mRNA25270620
D002994ClofibrateClofibrate results in increased expression of SORL1 mRNA22300585
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SORL1 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of SORL1 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in increased expression of and results in increased secretion of SORL1 protein23486467
D003042CocaineCocaine results in decreased expression of SORL1 mRNA17898221
D019327Copper SulfateCopper Sulfate results in decreased expression of SORL1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SORL1 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of SORL1 mRNA27989131
D016572CyclosporineCyclosporine results in decreased expression of SORL1 mRNA25596134
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SORL1 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SORL1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of SORL1 mRNA25596134|2759478
D004041Dietary FatsDietary Fats results in decreased expression of SORL1 mRNA19030233
C014476diethyl maleatediethyl maleate results in decreased expression of SORL1 mRNA21161181
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SORL1 mRNA17602206
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of SORL1 mRNA19638242
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of SORL1 mRNA22129741
C024629dimethyl phthalatedimethyl phthalate affects the expression of SORL1 mRNA26924002
D004237DiuronDiuron results in decreased expression of SORL1 mRNA21551480
D004317DoxorubicinSORL1 protein affects the susceptibility to Doxorubicin16217747
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SORL1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SORL1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SORL1 mRNA17942748
C540355fenamidonefenamidone results in increased expression of SORL1 mRNA27029645
D011345FenofibrateFenofibrate results in decreased expression of SORL1 mRNA25596134
D011345FenofibrateFenofibrate results in increased expression of SORL1 mRNA25596134
D018120FinasterideFinasteride results in increased expression of SORL1 mRNA24136188
C082360fipronilfipronil results in increased expression of SORL1 mRNA23962444
D005485FlutamideFlutamide results in decreased expression of SORL1 mRNA24136188
D005839GentamicinsGentamicins results in increased expression of SORL1 mRNA22061828
C409722hexaconazolehexaconazole results in increased expression of SORL1 mRNA22045034
D017313FenretinideFenretinide results in increased expression of SORL1 mRNA28973697
D012701Serotoninsarpogrelate inhibits the reaction [Serotonin results in increased expression of SORL1 mRNA]24650663
D012701SerotoninSerotonin results in increased expression of SORL1 mRNA24650663
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SORL1 mRNA20044591
C013038hydroxyhydroquinonehydroxyhydroquinone results in decreased expression of SORL1 mRNA17572062
D007052IbuprofenIbuprofen results in decreased expression of SORL1 mRNA25596134
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of SORL1 mRNA22129741
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SORL1 mRNA25613284
C544151jinfukangjinfukang results in increased expression of SORL1 mRNA27392435
C045463leflunomideleflunomide results in increased expression of SORL1 mRNA28988120
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SORL1 mRNA26378955
D008687MetforminMetformin results in decreased expression of SORL1 mRNA25596134
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to SORL1 promoter]20348232
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [ARNT protein binds to SORL1 promoter]20348232
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [Methylcholanthrene results in increased expression of SORL1 mRNA]20348232
D008748MethylcholanthreneMethylcholanthrene results in increased expression of SORL1 mRNA20348232
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SORL1 mRNA23179753|2718838
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SORL1 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SORL1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SORL1 mRNA"25554681
C029938nickel sulfatenickel sulfate results in increased expression of SORL1 mRNA22714537
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] affects the expression of SORL1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of SORL1 mRNA25729387
D010100OxygenOxygen deficiency promotes the reaction [HIF1A protein binds to SORL1 promoter]23486467
D010100OxygenOxygen deficiency promotes the reaction [SORL1 protein binds to PLAUR protein]23486467
D010100OxygenOxygen deficiency results in increased expression of and results in increased secretion of SORL1 protein23486467
D010100Oxygen[Oxygen deficiency results in increased expression of HIF1A protein] which results in increased expression of SORL1 protein23486467
D010100OxygenOxygen deficiency results in increased expression of SORL1 mRNA23486467|2559613
D010100OxygenOxygen deficiency results in increased expression of SORL1 mRNA24205000
D010100OxygenOxygen deficiency results in increased expression of SORL1 protein23486467
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of SORL1 mRNA26705709
C046012pentanalpentanal results in increased expression of SORL1 mRNA26079696
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of SORL1 mRNA23602845
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SORL1 mRNA17560707
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SORL1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SORL1 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of SORL1 mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of SORL1 mRNA22484513
D011374ProgesteroneProgesterone results in increased expression of SORL1 mRNA23012394
C005556propionaldehydepropionaldehyde results in increased expression of SORL1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of SORL1 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of SORL1 mRNA27029645
C012526quercitrinquercitrin results in decreased expression of SORL1 mRNA25193878
C089730rosiglitazonerosiglitazone results in decreased expression of SORL1 mRNA25596134
C089730rosiglitazonerosiglitazone results in increased expression of SORL1 mRNA25596134
C064294sarpogrelatesarpogrelate inhibits the reaction [Serotonin results in increased expression of SORL1 mRNA]24650663
D012822Silicon DioxideSilicon Dioxide results in increased expression of SORL1 mRNA23221170
D012906SmokeSmoke results in decreased expression of SORL1 mRNA21095227
C017947sodium arsenitesodium arsenite affects the methylation of SORL1 gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of SORL1 mRNA22714537
D012999SomanSoman results in decreased expression of SORL1 mRNA19281266
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SORL1 mRNA26378955
D013629TamoxifenTamoxifen affects the expression of SORL1 mRNA17555576
D013629Tamoxifen[bexarotene co-treated with Tamoxifen] results in increased expression of SORL1 mRNA17630414
C501413tesaglitazartesaglitazar results in increased expression of SORL1 mRNA21515302
D013739TestosteroneTestosterone results in decreased expression of SORL1 mRNA20403060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SORL1 gene]19574409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SORL1 mRNA19574409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SORL1 mRNA11489354|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SORL1 mRNA24680724
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SORL1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SORL1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SORL1 mRNA21215274
D013752TetracyclineTetracycline results in decreased expression of SORL1 mRNA16917069
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SORL1 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of SORL1 mRNA27188386
D013853ThioacetamideThioacetamide results in decreased expression of SORL1 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SORL1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of SORL1 gene26756918
D019772TopotecanSORL1 protein affects the susceptibility to Topotecan16217747
D019772Topotecan[oxaliplatin co-treated with Topotecan] affects the expression of SORL1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of SORL1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of SORL1 mRNA21934132|2372400
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SORL1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of SORL1 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SORL1 mRNA19042947
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of SORL1 mRNA29024780
D014635Valproic AcidValproic Acid affects the expression of SORL1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SORL1 mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of SORL1 mRNA19101580
D014635Valproic AcidValproic Acid results in increased expression of SORL1 mRNA22045034
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SORL1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of SORL1 mRNA23034163
D024483Vitamin K 3Vitamin K 3 affects the expression of SORL1 mRNA20044591
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SORL1 mRNA"27188386
D015032ZincZinc deficiency results in increased expression of SORL1 mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001540amyloid-beta binding-IDA24523320  
GO:0001540amyloid-beta binding-IPI16407538  
GO:0004888transmembrane signaling receptor activity-TAS9157966  
GO:0005041low-density lipoprotein particle receptor activity-TAS20005821  
GO:0005515protein binding-IPI11821067  14764453  16174740  16407538  17855360  24001769  
GO:0030169low-density lipoprotein particle binding-IPI17326667  
GO:0030306ADP-ribosylation factor binding-IPI17855360  
GO ID GO Term Qualifier Evidence PubMed
GO:0006605protein targeting-IDA16407538  
GO:0006605protein targeting-IMP16174740  
GO:0006622protein targeting to lysosome-IDA24523320  
GO:0006869lipid transport-IEA-  
GO:0006892post-Golgi vesicle-mediated transport-IDA17855360  
GO:0006898receptor-mediated endocytosis-TAS9157966  
GO:0007165signal transduction-IEA-  
GO:0008203cholesterol metabolic process-IEA-  
GO:0014910regulation of smooth muscle cell migration-IDA14764453  
GO:0032091negative regulation of protein binding-IDA16407538  
GO:0032460negative regulation of protein oligomerization-IMP21989385  
GO:0034067protein localization to Golgi apparatus-IDA17855360  
GO:0043407negative regulation of MAP kinase activity-ISS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0045053protein retention in Golgi apparatus-IDA17855360  
GO:0045732positive regulation of protein catabolic process-IDA24523320  
GO:0050768negative regulation of neurogenesis-ISS-  
GO:0051604protein maturation-IDA17855360  
GO:0070863positive regulation of protein exit from endoplasmic reticulum-IMP17855360  
GO:1901215negative regulation of neuron death-ISS-  
GO:1902430negative regulation of amyloid-beta formation-IDA16407538  22621900  
GO:1902430negative regulation of amyloid-beta formation-IMP17855360  21989385  24001769  24523320  
GO:1902771positive regulation of choline O-acetyltransferase activity-ISS-  
GO:1902948negative regulation of tau-protein kinase activity-ISS-  
GO:1902953positive regulation of ER to Golgi vesicle-mediated transport-IMP17855360  
GO:1902955positive regulation of early endosome to recycling endosome transport-IMP22621900  
GO:1902960negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process-IDA16407538  
GO:1902960negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process-IMP17855360  21989385  
GO:1902963negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process-IMP17855360  21989385  
GO:1902966positive regulation of protein localization to early endosome-IMP22621900  
GO:1902997negative regulation of neurofibrillary tangle assembly-ISS-  
GO:2001137positive regulation of endocytic recycling-IMP22621900  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005615extracellular space-IDA14764453  
GO:0005641nuclear envelope lumen-IDA17855360  21989385  
GO:0005768endosome-IDA16174740  
GO:0005769early endosome-IDA24001769  
GO:0005769early endosome-IMP22621900  
GO:0005783endoplasmic reticulum-IDA17855360  
GO:0005794Golgi apparatus-IDA16174740  
GO:0005802trans-Golgi network-IDA24001769  
GO:0005887integral component of plasma membrane-TAS9157966  
GO:0010008endosome membrane-TAS-  
GO:0016020membrane-IDA14764453  
GO:0031985Golgi cisterna-IDA17855360  
GO:0034362low-density lipoprotein particle-IEA-  
GO:0055037recycling endosome-IMP22621900  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-977225Amyloid fiber formationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28199971Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget