Gene: SOX1

6656
-
SRY-box 1
protein-coding
13q34
Ensembl:ENSG00000182968 MIM:602148 Vega:OTTHUMG00000017362 UniprotKB:O00570
NC_000013.11
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.403e-1 (AD)  5.734e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg21385666chr13:112724270SOX1Promoter8.635e-5Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC24A30.763
DLX50.729
CALB20.696
TAC30.666
CXCL140.663
CHRNA20.658
ARX0.656
DLX20.654
GRIN2D0.647
ELFN10.639

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZFP57-0.394
CDA-0.385
OR4F5-0.375
SH2D1B-0.375
KEL-0.347
CNKSR3-0.338
TRPV5-0.337
CLEC4E-0.333
DYSF-0.333
DTHD1-0.33

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX1 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SOX1 gene27153756
C006632arsenic trioxidearsenic trioxide results in decreased expression of SOX1 mRNA26705709
D001280AtrazineAtrazine results in decreased expression of SOX1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SOX1 mRNA22316170
D004958EstradiolEstradiol results in increased expression of SOX1 mRNA27271280
C006780bisphenol Abisphenol A results in decreased expression of SOX1 mRNA27271280
C006780bisphenol AIGF1 protein inhibits the reaction [bisphenol A results in decreased expression of SOX1 mRNA]27271280
C006780bisphenol Abisphenol A affects the methylation of SOX1 promoter27334623
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of SOX1 mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SOX1 gene20938992
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SOX1 mRNA21266533
C118739entinostatentinostat results in decreased expression of SOX1 mRNA26272509
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SOX1 gene20938992
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of SOX1 mRNA17183730
C042720mercuric bromidemercuric bromide results in decreased expression of SOX1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX1 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SOX1 gene20938992
D008727MethotrexateMethotrexate results in decreased expression of SOX1 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SOX1 mRNA28001369
D010269ParaquatParaquat results in decreased expression of SOX1 mRNA25314302
D012834SilverSilver results in decreased expression of SOX1 mRNA26551752
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SOX1 mRNA24680724
D013792ThalidomideThalidomide results in decreased expression of SOX1 mRNA26217789
D014212TretinoinTretinoin results in decreased expression of SOX1 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX1 mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of SOX1 mRNA22723015
C012589trichostatin Atrichostatin A results in decreased expression of SOX1 mRNA24935251|2627250
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of SOX1 mRNA17183730
D014635Valproic AcidValproic Acid results in decreased expression of SOX1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of SOX1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SOX1 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX1 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of SOX1 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA20049565  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0003677DNA binding-NAS9337405  
GO:0003700DNA-binding transcription factor activity-NAS9337405  
GO:0005515protein binding-IPI20929579  
GO ID GO Term Qualifier Evidence PubMed
GO:0001764neuron migration-IEA-  
GO:0002089lens morphogenesis in camera-type eye-IEA-  
GO:0006325chromatin organization-NAS9337405  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0006355regulation of transcription, DNA-templated-NAS9337405  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007417central nervous system development-IBA21873635  
GO:0009653anatomical structure morphogenesis-IBA21873635  
GO:0021521ventral spinal cord interneuron specification-IEA-  
GO:0021884forebrain neuron development-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0030182neuron differentiation-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-NAS9337405  
GO:0044798nuclear transcription factor complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23907469DNA methylation of PAX1 as a biomarker for oral squamous cell carcinoma. (2014 Apr)Huang YKClin Oral Investig
23599765Abnormal methylation of seven genes and their associations with clinical characteristics in early stage non-small cell lung cancer. (2013 Apr)Zhao YOncol Lett
27865370Hypermethylated ZNF582 and PAX1 are effective biomarkers for detection of oral dysplasia and oral cancer. (2016 Nov)Cheng SJOral Oncol
18567862Lambert-Eaton myasthenic syndrome: tumor versus nontumor forms. (2008)Titulaer MJAnn N Y Acad Sci