Gene info: ID 6657

Gene: SOX2

GENE ID: 6657

Synonyms: ANOP3|MCOPS3

Description: SRY-box 2

Gene type: protein-coding

Location: 3q26.33

dbXrefs: Ensembl:ENSG00000181449 MIM:184429 Vega:OTTHUMG00000158222 UniprotKB:P48431

RefSeq: NG_009080.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 30

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.204e-1 (AD) 4.331e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ID4	0.904
GJA1	0.886
METTL7A	0.885
SDC2	0.884
SOX9	0.881
SLC1A3	0.879
EZR	0.877
TP53BP2	0.873
ARHGEF26	0.873
PON2	0.872

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.514
OR4F29	-0.466
TRABD2A	-0.42
ZNF860	-0.402
TYRP1	-0.398
IL12RB2	-0.397
DUSP27	-0.397
CCDC68	-0.396
PROKR2	-0.391
CACNA1F	-0.384

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SOX2 mRNA"	27291303
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SOX2 mRNA"	19114083
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with sodium arsenite] results in decreased expression of SOX2 protein	23143138
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of SOX2 protein	23143138
C025946	3-methyladenine	3-methyladenine results in increased expression of SOX2 mRNA	21681844
C471109	4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline	"[4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline co-treated with sodium arsenite] results in decreased expression of SOX2 protein"	23143138
C471109	4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline	"4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline results in decreased expression of SOX2 protein"	23143138
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX2 mRNA"	27188386
C555021	4-acetylantroquinonol B	4-acetylantroquinonol B results in decreased expression of SOX2 mRNA	26235807
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of SOX2 mRNA	26690555
C499366	Active Hexose Correlated Compound	Active Hexose Correlated Compound results in decreased expression of SOX2 protein	25202061
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of SOX2 gene	27153756
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of SOX2 mRNA	24449571
D047310	Apigenin	Apigenin results in decreased expression of SOX2 protein	27468969
D001151	Arsenic	Arsenic results in increased expression of SOX2 mRNA	23221970
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of SOX2 mRNA	24685274
C006632	arsenic trioxide	SOX2 protein results in decreased susceptibility to arsenic trioxide	21703238
C015001	arsenite	arsenite results in decreased expression of SOX2 mRNA	23974009
D001205	Ascorbic Acid	Ascorbic Acid results in increased expression of SOX2 mRNA	21166886
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of SOX2 mRNA	28189605
D001374	Azacitidine	Azacitidine results in increased expression of SOX2 mRNA	27415467
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SOX2 mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SOX2 mRNA	22228805\|2719552
D004958	Estradiol	[mono-(2-ethylhexyl)phthalate co-treated with Estradiol] affects the expression of SOX2 mRNA	27989758
D004958	Estradiol	[Estradiol binds to ESR2 protein] which results in increased expression of SOX2 mRNA	20404318
D004958	Estradiol	Estradiol results in decreased expression of SOX2 mRNA	16474171\|2532141
D004958	Estradiol	Estradiol results in increased activity of SOX2 protein	27592001
D004958	Estradiol	Estradiol results in increased expression of SOX2 mRNA	24424067
C031463	beta-glycerophosphoric acid	[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of SOX2 mRNA	28189605
C006780	bisphenol A	bisphenol A results in decreased expression of SOX2 mRNA	26322593
C006780	bisphenol A	bisphenol A promotes the reaction [CREB1 protein modified form binds to SOX2 enhancer]	28244015
C006780	bisphenol A	bisphenol A results in decreased expression of SOX2 mRNA	16474171\|2505105
C006780	bisphenol A	bisphenol A results in increased expression of SOX2 mRNA	28244015
C006780	bisphenol A	bisphenol A results in increased expression of SOX2 protein	28244015
C006780	bisphenol A	bisphenol A affects the methylation of SOX2 promoter	27334623
C006780	bisphenol A	bisphenol A results in increased expression of SOX2 mRNA	23719110\|2409059
C006780	bisphenol A	bisphenol A results in increased expression of SOX2 protein	24090592
C006780	bisphenol A	bisphenol A affects the methylation of SOX2 promoter	27415467
C006780	bisphenol A	bisphenol A results in decreased expression of SOX2 mRNA	25181051\|2909715
C006780	bisphenol A	bisphenol A results in decreased methylation of SOX2 promoter	28728135
C006780	bisphenol A	bisphenol A results in increased expression of SOX2 mRNA	27415467
C006780	bisphenol A	bisphenol A results in decreased expression of SOX2 mRNA	28819136
C006780	bisphenol A	bisphenol A results in decreased expression of SOX2 mRNA	19218331
C099813	bromochloroacetic acid	bromochloroacetic acid affects the expression of SOX2 protein	21296659
C018475	butyraldehyde	butyraldehyde results in decreased expression of SOX2 mRNA	26079696
C584509	C646 compound	C646 compound results in decreased expression of SOX2 mRNA	24736545
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of SOX2 mRNA	18974090
C037123	cadmium sulfate	cadmium sulfate results in increased expression of SOX2 mRNA	19274763
D002235	Carbofuran	Carbofuran results in decreased expression of SOX2 protein	22240977
C043211	carvedilol	carvedilol results in increased expression of SOX2 mRNA	27288437
C043211	carvedilol	carvedilol results in increased expression of SOX2 mRNA	27288437
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX2 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of SOX2 mRNA	26272509
D002737	Chloroprene	Chloroprene results in increased expression of SOX2 mRNA	23125180
C074702	chromium hexavalent ion	chromium hexavalent ion results in increased expression of SOX2 mRNA	19654923
C074702	chromium hexavalent ion	MAP2K7 protein promotes the reaction [chromium hexavalent ion results in increased expression of SOX2 mRNA]	19654923
C031180	chrysene	chrysene results in increased expression of SOX2 mRNA	26377693
D002939	Ciprofloxacin	Ciprofloxacin results in decreased expression of SOX2 protein	26947806
D003035	Cobalt	[tungsten carbide binds to Cobalt] which results in decreased expression of SOX2 mRNA	20105288
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of SOX2 mRNA	20105288
C018021	cobaltous chloride	cobaltous chloride results in increased expression of SOX2 protein	24842335
C018021	cobaltous chloride	[EPAS1 protein results in increased susceptibility to cobaltous chloride] which results in increased expression of SOX2 mRNA	25805230
C018021	cobaltous chloride	[HIF1A protein results in increased susceptibility to cobaltous chloride] which results in increased expression of SOX2 mRNA	25805230
C018021	cobaltous chloride	triptolide inhibits the reaction [cobaltous chloride results in increased expression of SOX2 protein]	24842335
C423222	cotylenin A	cotylenin A results in decreased expression of SOX2 mRNA	25672400
D003471	Cuprizone	Cuprizone results in decreased expression of SOX2 mRNA	27523638
D003471	Cuprizone	Cuprizone results in increased expression of SOX2 mRNA	26577399
D003474	Curcumin	Curcumin results in increased expression of SOX2 mRNA	25822711
D003474	Curcumin	Curcumin results in increased expression of SOX2 protein	25822711
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of SOX2 mRNA	26206603
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of SOX2 mRNA	23640034
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of SOX2 mRNA	23640034
C014347	decitabine	decitabine results in decreased expression of SOX2 mRNA	27915011
D003840	Deoxycholic Acid	Deoxycholic Acid results in increased expression of SOX2 mRNA	27151938
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SOX2 mRNA]	27941970
D003907	Dexamethasone	Dexamethasone results in decreased expression of SOX2 mRNA	28453788
D003907	Dexamethasone	[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of SOX2 mRNA	28189605
D003907	Dexamethasone	[INS co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in decreased expression of SOX2 mRNA	21350315
D016190	Carboplatin	Carboplatin results in increased expression of SOX2 mRNA	25605917
D002945	Cisplatin	[Cisplatin co-treated with Paclitaxel] results in increased expression of SOX2 mRNA	20705681
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of SOX2 mRNA	17005392
C060311	eckol	eckol results in decreased expression of SOX2 protein	21514314
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in decreased methylation of SOX2 promoter	27415467
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in increased expression of SOX2 mRNA	27415467
D005472	Fluorouracil	Fluorouracil results in decreased expression of SOX2 protein	21296659
D005480	Flurbiprofen	Flurbiprofen results in increased expression of SOX2 mRNA	16949054
D004397	Fonofos	Fonofos results in increased methylation of SOX2 promoter	22847954
D005557	Formaldehyde	Formaldehyde results in decreased expression of SOX2 mRNA	20655997
C056507	gemcitabine	gemcitabine results in increased expression of SOX2 mRNA	25605917
D019833	Genistein	Genistein results in decreased expression of SOX2 mRNA	16474171
D006582	Hexachlorophene	Hexachlorophene results in decreased expression of SOX2 mRNA	25943520
D006582	Hexachlorophene	Hexachlorophene results in decreased expression of SOX2 protein	25943520
C519562	imetelstat	imetelstat results in decreased expression of SOX2 mRNA	20824134
D015056	1-Methyl-3-isobutylxanthine	[INS co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in decreased expression of SOX2 mRNA	21350315
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to SOX2 enhancer]	24736545
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to SOX2 promoter]	24736545
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [BRD4 protein modified form binds to SOX2 enhancer]	24736545
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [BRD4 protein modified form binds to SOX2 promoter]	24736545
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [NUTM1 protein modified form binds to SOX2 enhancer]	24736545
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [NUTM1 protein modified form binds to SOX2 promoter]	24736545
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of SOX2 mRNA	24736545\|2479639
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of SOX2 protein	24736545\|2479639
C561695	(+)-JQ1 compound	SOX2 protein inhibits the reaction [(+)-JQ1 compound results in increased expression of IVL protein]	24736545
C490728	lapatinib	[lapatinib results in decreased susceptibility to lapatinib] which results in increased expression of SOX2 protein	26643609
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of SOX2 mRNA"	24972896
C010480	lupeol	lupeol results in decreased expression of SOX2 protein	20979057
C042720	mercuric bromide	mercuric bromide results in decreased expression of SOX2 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX2 mRNA"	27188386
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of SOX2 mRNA	28001369
C015358	methylparaben	methylparaben results in increased expression of SOX2 mRNA	27581495
C016599	mono-(2-ethylhexyl)phthalate	[mono-(2-ethylhexyl)phthalate co-treated with Estradiol] affects the expression of SOX2 mRNA	27989758
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of SOX2 mRNA	27989758
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of SOX2 mRNA"	25554681
C000621033	napabucasin	napabucasin results in decreased expression of SOX2 mRNA	25605917
C000621033	napabucasin	napabucasin results in decreased expression of SOX2 protein	25605917
C031721	naphthalene	naphthalene results in increased expression of SOX2 protein	16239640
C005273	naringenin	naringenin results in decreased expression of SOX2 protein	27468969
C022838	nickel chloride	nickel chloride results in increased expression of SOX2 protein	26962057
C047330	N-methylisoindigotin	N-methylisoindigotin results in decreased expression of SOX2 mRNA	26887594
C025589	ochratoxin A	ochratoxin A results in decreased expression of SOX2 mRNA	21703336
C025589	ochratoxin A	SHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of SOX2 mRNA]	21703336
D010100	Oxygen	[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of SOX2 mRNA	26305601
D017239	Paclitaxel	[Cisplatin co-treated with Paclitaxel] results in increased expression of SOX2 mRNA	20705681
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX2 mRNA"	27188386
C496932	panobinostat	panobinostat results in decreased expression of SOX2 mRNA	26272509
D010278	Parathion	Parathion results in increased methylation of SOX2 promoter	22847954
D052638	Particulate Matter	Particulate Matter results in increased expression of SOX2 mRNA	28846189
D052638	Particulate Matter	Particulate Matter results in increased expression of SOX2 protein	28846189
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of SOX2 mRNA	24098361
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of SOX2 protein	24098361
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of SOX2 mRNA	25510869
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of SOX2 protein	25510869
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX2 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of SOX2 mRNA	26272509
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of SOX2 mRNA	21061450
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls analog results in decreased expression of SOX2 mRNA	16474171
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of SOX2 protein]	23219847
D011794	Quercetin	Quercetin results in decreased expression of SOX2 protein	27468969
C059514	resveratrol	resveratrol results in decreased expression of SOX2 mRNA	21304978
C059514	resveratrol	resveratrol results in decreased expression of SOX2 protein	23651583
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of SOX2 mRNA	25895662
D012834	Silver	Silver results in decreased expression of SOX2 mRNA	26551752
D012834	Silver	Silver results in decreased expression of SOX2 mRNA	27131904
D020123	Sirolimus	Sirolimus results in increased expression of SOX2 mRNA	21681844
C017947	sodium arsenite	pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of SOX2 protein]	23219847
C017947	sodium arsenite	sodium arsenite affects the expression of SOX2 mRNA	29319823
C017947	sodium arsenite	sodium arsenite results in increased expression of SOX2 mRNA	28595984
C017947	sodium arsenite	sodium arsenite results in increased expression of SOX2 protein	23219847
C017947	sodium arsenite	[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with sodium arsenite] results in decreased expression of SOX2 protein	23143138
C017947	sodium arsenite	"[4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline co-treated with sodium arsenite] results in decreased expression of SOX2 protein"	23143138
C017947	sodium arsenite	[OGG1 gene mutant form results in increased susceptibility to sodium arsenite] which results in increased expression of SOX2 mRNA	26438402
C017947	sodium arsenite	sodium arsenite results in decreased expression of SOX2 protein	23143138
C017947	sodium arsenite	sodium arsenite results in increased expression of SOX2 mRNA	26438402
C021751	tanshinone	tanshinone results in increased expression of SOX2 mRNA	25186638
D013656	Taurocholic Acid	Taurocholic Acid results in increased expression of SOX2 mRNA	27151938
C012568	terbufos	terbufos results in increased methylation of SOX2 promoter	22847954
C020806	tetrabromobisphenol A	tetrabromobisphenol A affects the expression of SOX2 mRNA	18976794
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SOX2 mRNA	21570461\|2405805
C009495	titanium dioxide	titanium dioxide results in decreased expression of SOX2 mRNA	23557971
D014212	Tretinoin	Tretinoin results in decreased expression of SOX2 mRNA	21934132
D014212	Tretinoin	NR6A1 protein affects the reaction [Tretinoin results in decreased expression of SOX2 mRNA]	16166633
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX2 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of SOX2 mRNA	24935251\|2627250
D014260	Triclosan	Triclosan results in increased expression of SOX2 mRNA	24879426
D014260	Triclosan	Triclosan results in decreased expression of SOX2 protein	24879426
C001899	triptolide	triptolide inhibits the reaction [cobaltous chloride results in increased expression of SOX2 protein]	24842335
C002802	tungsten carbide	[tungsten carbide binds to Cobalt] which results in decreased expression of SOX2 mRNA	20105288
D014520	Urethane	Urethane results in decreased expression of SOX2 mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX2 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of SOX2 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in decreased methylation of SOX2 gene	29154799
C034028	vanadyl sulfate	vanadyl sulfate results in decreased expression of SOX2 mRNA	16330358
C025643	vinclozolin	vinclozolin results in decreased expression of SOX2 mRNA	18042343
D010205	Pantothenic Acid	Pantothenic Acid results in decreased expression of SOX2 mRNA	19397697
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX2 mRNA"	27188386
C111237	vorinostat	vorinostat results in decreased expression of SOX2 mRNA	26272509
C088658	zoledronic acid	zoledronic acid results in increased expression of SOX2 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000976	transcription regulatory region sequence-specific DNA binding	-	IEA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	IBA	21873635
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	CONTRIBUTES_TO	IBA	21873635
GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	-
GO:0003677	DNA binding	-	IDA	16153702 18285410 18407919 19427902
GO:0003677	DNA binding	-	NAS	7849401
GO:0003700	DNA-binding transcription factor activity	-	IDA	16153702 18027866
GO:0003700	DNA-binding transcription factor activity	-	NAS	7849401
GO:0005515	protein binding	-	IPI	18456656 24048479 24525231 25416956
GO:0035198	miRNA binding	-	IDA	18710938
GO:0043565	sequence-specific DNA binding	-	IDA	20713518
GO:0044212	transcription regulatory region DNA binding	-	IDA	18407919

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0000122	negative regulation of transcription by RNA polymerase II	-	ISS	-
GO:0001649	osteoblast differentiation	-	IDA	18187129
GO:0001654	eye development	-	IEP	18285410
GO:0001714	endodermal cell fate specification	-	IDA	21245162
GO:0006325	chromatin organization	-	NAS	7849401
GO:0006355	regulation of transcription, DNA-templated	-	IBA	21873635
GO:0006355	regulation of transcription, DNA-templated	-	IDA	16153702
GO:0006355	regulation of transcription, DNA-templated	-	NAS	7849401
GO:0006366	transcription by RNA polymerase II	-	IEA	-
GO:0007050	cell cycle arrest	-	IDA	18268498
GO:0007417	central nervous system development	-	IBA	21873635
GO:0009611	response to wounding	-	IEP	17982423
GO:0009653	anatomical structure morphogenesis	-	IBA	21873635
GO:0010468	regulation of gene expression	-	IMP	18388306
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0021781	glial cell fate commitment	-	NAS	17291498
GO:0021983	pituitary gland development	-	IEP	18285410
GO:0021984	adenohypophysis development	-	IEA	-
GO:0022409	positive regulation of cell-cell adhesion	-	IEA	-
GO:0030154	cell differentiation	-	IBA	21873635
GO:0030182	neuron differentiation	-	IBA	21873635
GO:0030900	forebrain development	-	IBA	21873635
GO:0030900	forebrain development	-	IEP	18285410
GO:0035019	somatic stem cell population maintenance	-	IDA	19409607
GO:0035019	somatic stem cell population maintenance	-	IMP	18388306 19736317
GO:0035019	somatic stem cell population maintenance	-	TAS	-
GO:0042246	tissue regeneration	-	IEA	-
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	-	IDA	18268498
GO:0043410	positive regulation of MAPK cascade	-	IDA	18187129
GO:0045165	cell fate commitment	-	IBA	21873635
GO:0045597	positive regulation of cell differentiation	-	IEA	-
GO:0045665	negative regulation of neuron differentiation	-	ISS	-
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	18407919
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	18027866 21245162
GO:0048839	inner ear development	-	IBA	21873635
GO:0048839	inner ear development	-	IEP	18407919
GO:0050680	negative regulation of epithelial cell proliferation	-	IDA	18268498
GO:0070848	response to growth factor	-	IDA	18187129
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	IDA	18285410
GO:0097150	neuronal stem cell population maintenance	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IC	16153702
GO:0005634	nucleus	-	IDA	17291498 18027866 18285410
GO:0005634	nucleus	-	NAS	7849401
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005667	transcription factor complex	-	TAS	19736317
GO:0005737	cytoplasm	-	IDA	18027866
GO:0005829	cytosol	-	IDA	18000303
GO:0044798	nuclear transcription factor complex	-	IBA	21873635

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-168256	Immune System	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-201681	TCF dependent signaling in response to WNT	TAS
R-HSA-2892245	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	TAS
R-HSA-2892247	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	TAS
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-452723	Transcriptional regulation of pluripotent stem cells	TAS
R-HSA-6785807	Interleukin-4 and 13 signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20371131	Autoimmunity to SOX2, clinical phenotype and survival in patients with small-cell lung cancer. (2010 Dec)	Maddison P	Lung Cancer
29416638	Nicotine-enhanced stemness and epithelial-mesenchymal transition of human umbilical cord mesenchymal stem cells promote tumor formation and growth in nude mice. (2018 Jan 2)	Li T	Oncotarget
24736592	Increased SOX2 gene copy number is associated with FGFR1 and PIK3CA gene gain in non-small cell lung cancer and predicts improved survival in early stage disease. (2014)	Toschi L	PLoS One
27150062	Association of SOX2 and Nestin DNA amplification and protein expression with clinical features and overall survival in non-small cell lung cancer: A systematic review and meta-analysis. (2016 Jun 7)	Li Q	Oncotarget
28072991	[Expression of Oct4 and Sox2 and their clinical significance in tongue squamous cell carcinoma]. (2017 Jan 9)	Jiang XD	Zhonghua Kou Qiang Yi Xue Za Zhi
26527886	SOX2 expression is associated with FGFR fusion genes and predicts favorable outcome in lung squamous cell carcinomas. (2015)	Zheng S	Onco Targets Ther
17478053	Glial-restricted precursors: patterns of expression of opioid receptors and relationship to human immunodeficiency virus-1 Tat and morphine susceptibility in vitro. (2007 Jun 8)	Buch SK	Neuroscience
28256572	Clinicopathological and molecular characterization of SMARCA4-deficient thoracic sarcomas with comparison to potentially related entities. (2017 Jun)	Yoshida A	Mod Pathol
28314692	Identification of an atypical etiological head and neck squamous carcinoma subtype featuring the CpG island methylator phenotype. (2017 Mar)	Brennan K	EBioMedicine
20675559	Clinical validation of an autoantibody test for lung cancer. (2011 Feb)	Boyle P	Ann Oncol
26806086	Damage to Olfactory Progenitor Cells Is Involved in Cigarette Smoke-Induced Olfactory Dysfunction in Mice. (2016 Mar)	Ueha R	Am J Pathol
29029509	Establishment of oral squamous cell carcinoma cell line and magnetic bead-based isolation and characterization of its CD90/CD44 subpopulations. (2017 Sep 12)	Svobodova M	Oncotarget
20631605	Sox2 protein expression is an independent poor prognostic indicator in stage I lung adenocarcinoma. (2010 Aug)	Sholl LM	Am J Surg Pathol
27123539	Cell division patterns and chromosomal segregation defects in oral cancer stem cells. (2016 Sep)	Kaseb HO	Genes Chromosomes Cancer
21138858	Immunobiomarkers in small cell lung cancer: potential early cancer signals. (2011 Mar 15)	Chapman CJ	Clin Cancer Res
25754111	YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate Self-Renewal and Vascular Mimicry of Stem-Like Cells. (2015 Jun)	Bora-Singhal N	Stem Cells
29378214	Activation of neural stem cells from quiescence drives reactive hippocampal neurogenesis after alcohol dependence. (2018 May 1)	Hayes DM	Neuropharmacology
20334723	Long-term suppression of forebrain neurogenesis and loss of neuronal progenitor cells following prolonged alcohol dependence in rats. (2010 Jun)	Hansson AC	Int J Neuropsychopharmacol
28794006	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth. (2017 Oct)	Kim BR	Mol Cell Proteomics
27497606	Ethanol-induced changes in poly (ADP ribose) polymerase and neuronal developmental gene expression. (2016 Nov)	Gavin DP	Neuropharmacology
27003941	Cigarette Smoke Delays Regeneration of the Olfactory Epithelium in Mice. (2016 Aug)	Ueha R	Neurotox Res
23700807	[Expression of SOX2 protein and its clinical significance in laryngeal carcinoma]. (2013 Feb)	Ye F	Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
24126941	Quantification of serum SOX2 DNA with FQ-PCR potentially provides a diagnostic biomarker for lung cancer. (2013 Dec)	Wu Y	Med Oncol
24802313	New insights into septo-optic dysplasia. (2014)	Saranac L	Pril (Makedon Akad Nauk Umet Odd Med Nauki)
29256636	Pluripotency transcription factors and Metabolic reprogramming of mitochondria in tumor-initiating stem-like cells. (2017 Dec 19)	Machida K	Antioxid Redox Signal
21733826	EarlyCDT-Lung: an immunobiomarker test as an aid to early detection of lung cancer. (2011 Jul)	Lam S	Cancer Prev Res (Phila)
22969842	Increased Sox2 copy number in lung squamous cell carcinomas. (2012 Jan)	Sasaki H	Exp Ther Med
22866074	Detection of MET and SOX2 amplification by quantitative real-time PCR in non-small cell lung carcinoma. (2011 Mar)	Cai YR	Oncol Lett
27899982	Expression and significance of SOX2 in non-small cell lung carcinoma. (2016 Nov)	Ying J	Oncol Lett
25736461	A contemporary review of management and prognostic factors of upper tract urothelial carcinoma. (2015 Apr)	Leow JJ	Cancer Treat Rev