Gene: SOX3

6658
GHDX|MRGH|PHP|PHPX|SOXB
SRY-box 3
protein-coding
Xq27.1
Ensembl:ENSG00000134595 MIM:313430 Vega:OTTHUMG00000022544 UniprotKB:P41225
NG_009387.1
PubMed
0   ANCO-SNPs
CD|ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SOX110.592
CMTM50.59
PAQR60.588
TST0.581
SNX220.571
CHADL0.568
APOM0.562
DLL30.559
PEX11G0.554
TPPP30.553

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EPN3-0.449
FAM13A-0.444
RAB11FIP1-0.441
STEAP1-0.424
LRRC2-0.424
ADCY7-0.421
MET-0.42
KCNK12-0.42
IRS1-0.418
KLHL38-0.415

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SOX3 mRNA"19167446
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX3 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SOX3 gene27153756
C015001arsenitearsenite results in increased methylation of SOX3 promoter23974009
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of SOX3 mRNA"19446018
D001280AtrazineAtrazine results in decreased expression of SOX3 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SOX3 mRNA26001963
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in increased expression of SOX3 mRNA]24758408
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SOX3 mRNA19619570
D004958EstradiolEstradiol results in increased expression of SOX3 mRNA19619570|2475840
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of SOX3 mRNA25912373
C006780bisphenol Abisphenol A affects the expression of SOX3 mRNA21786754
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SOX3 mRNA28628672
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of SOX3 mRNA24763279
D004390ChlorpyrifosChlorpyrifos results in increased expression of SOX3 mRNA21356183
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in increased expression of SOX3 mRNA21356183
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SOX3 gene20938992
D003300Copper[Copper co-treated with Chlorpyrifos] results in increased expression of SOX3 mRNA21356183
D003300CopperCopper results in increased expression of SOX3 mRNA21356183
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SOX3 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of SOX3 mRNA19167446
D016572CyclosporineCyclosporine results in decreased methylation of SOX3 promoter27989131
D003561CytarabineCytarabine results in increased expression of SOX3 mRNA21198554
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SOX3 mRNA]27941970
D003907DexamethasoneDexamethasone results in decreased expression of SOX3 mRNA28453788
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SOX3 mRNA28628672
C118739entinostatentinostat results in decreased expression of SOX3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX3 mRNA"27188386
D005485FlutamideFlutamide results in increased expression of SOX3 mRNA21126777
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SOX3 gene20938992
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of SOX3 mRNA24763279
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SOX3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SOX3 mRNA28628672
C008261lead acetatelead acetate affects the expression of SOX3 mRNA24260418
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SOX3 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SOX3 mRNA26011545
D009151Mustard GasMustard Gas results in increased expression of SOX3 mRNA15674843
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX3 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of SOX3 mRNA26272509
D010416PentachlorophenolPentachlorophenol results in increased expression of SOX3 mRNA24642059
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SOX3 mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of SOX3 mRNA23557933
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of SOX3 mRNA19167446
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SOX3 mRNA25895662
D012834SilverSilver results in decreased expression of SOX3 mRNA26551752
C017947sodium arsenitesodium arsenite affects the methylation of SOX3 gene28589171
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SOX3 mRNA18495758
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SOX3 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SOX3 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SOX3 mRNA12225545
D014118Toxins, Biological"Toxins, Biological affects the expression of SOX3 mRNA"19682533
D014212TretinoinRXRA protein promotes the reaction [Tretinoin results in increased expression of SOX3 mRNA]17005281
D014212TretinoinRXRA protein promotes the reaction [Tretinoin results in increased expression of SOX3 protein]17005281
D014212TretinoinTretinoin results in decreased expression of SOX3 mRNA21934132
D014212TretinoinTretinoin results in increased expression of SOX3 mRNA17005281
D014212TretinoinTretinoin results in increased expression of SOX3 protein17005281
D014212TretinoinTretinoin results in increased expression of SOX3 mRNA16604517
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX3 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of SOX3 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of SOX3 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of SOX3 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SOX3 gene25560391
D015032ZincZinc results in increased expression of SOX3 mRNA19071009

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding-ISS-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-TAS8625802  
GO:0003714transcription corepressor activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0007417central nervous system development-IBA21873635  
GO:0007417central nervous system development-TAS8625802  
GO:0007423sensory organ development-ISS-  
GO:0007530sex determination-IMP21183788  
GO:0009653anatomical structure morphogenesis-IBA21873635  
GO:0021854hypothalamus development-ISS-  
GO:0021983pituitary gland development-ISS-  
GO:0030154cell differentiation-IBA21873635  
GO:0030182neuron differentiation-IBA21873635  
GO:0045665negative regulation of neuron differentiation-ISS-  
GO:0060324face development-ISS-  
GO:1903507negative regulation of nucleic acid-templated transcription-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0044798nuclear transcription factor complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-3769402Deactivation of the beta-catenin transactivating complexTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24802313New insights into septo-optic dysplasia. (2014)Saranac LPril (Makedon Akad Nauk Umet Odd Med Nauki)