Gene info: ID 6660

Gene: SOX5

GENE ID: 6660

Synonyms: L-SOX5|L-SOX5B|L-SOX5F|LAMSHF

Description: SRY-box 5

Gene type: protein-coding

Location: 12p12.1

dbXrefs: Ensembl:ENSG00000134532 MIM:604975 Vega:OTTHUMG00000169026 UniprotKB:P35711

RefSeq: NG_029612.2

Retrived from: PubMed|SNP Mapped

SNPs: 6 ANCO-SNPs

Phenotype: ND|AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.196e-1 (AD) 7.249e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs7309268	chr12:24407310 (GRCh38.p7)	G>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs550338	chr12:24359103 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs1357251	chr12:24222667 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs11047279	chr12:24140368 (GRCh38.p7)	C>T	nicotine dependence	SNV(Single Nucleotide Variation)
rs12229376	chr12:23976502 (GRCh38.p7)	G>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs11047179	chr12:23969997 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DOCK7	0.829
OPHN1	0.816
GABRA2	0.816
AHCYL2	0.814
ARHGAP5	0.801
NEBL	0.8
NADK2	0.799
TMEM47	0.797
RAB30	0.797
PIK3C2A	0.796

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.413
OR4F29	-0.368
NPW	-0.306
GNG8	-0.271
NANOGNB	-0.27
GAL	-0.261
TMEM31	-0.26
L1TD1	-0.255
CLPSL1	-0.253
CD247	-0.253

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX5 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX5 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX5 mRNA"	27188386
C496492	abrine	abrine results in decreased expression of SOX5 mRNA	22595364
D000082	Acetaminophen	Acetaminophen affects the expression of SOX5 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of SOX5 gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SOX5 mRNA	16483693
C015001	arsenite	arsenite results in increased methylation of SOX5 promoter	23974009
C547126	AZM551248	AZM551248 results in decreased expression of SOX5 mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SOX5 mRNA	22316170\|2623829
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SOX5 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SOX5 mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SOX5 mRNA"	20382639
C006780	bisphenol A	bisphenol A affects the expression of SOX5 mRNA	20170705
C006780	bisphenol A	bisphenol A results in increased methylation of SOX5 promoter	27271280
C006780	bisphenol A	[bisphenol A co-treated with Genistein] results in increased methylation of SOX5 gene	28505145
C006780	bisphenol A	bisphenol A results in decreased expression of SOX5 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of SOX5 gene	28505145
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SOX5 mRNA	22079614
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of SOX5 mRNA	17484886
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX5 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of SOX5 mRNA	26272509
D019327	Copper Sulfate	Copper Sulfate affects the expression of SOX5 mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in decreased expression of SOX5 mRNA	25562108
C107676	deguelin	deguelin results in increased expression of SOX5 mRNA	19861542
C007262	deoxynivalenol	deoxynivalenol results in increased expression of SOX5 mRNA	23792671
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SOX5 mRNA]	27941970
D003907	Dexamethasone	Dexamethasone results in increased expression of SOX5 mRNA	22733784
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of SOX5 mRNA	19850644
D004051	Diethylhexyl Phthalate	PPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of SOX5 mRNA]	19850644
C118739	entinostat	entinostat results in decreased expression of SOX5 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX5 mRNA"	27188386
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of SOX5 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of SOX5 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOX5 mRNA	17942748
D019833	Genistein	Genistein results in decreased expression of SOX5 mRNA	26865667
D019833	Genistein	[bisphenol A co-treated with Genistein] results in increased methylation of SOX5 gene	28505145
C045463	leflunomide	leflunomide results in increased expression of SOX5 mRNA	28988120
C045463	leflunomide	leflunomide results in decreased expression of SOX5 mRNA	19751817
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of SOX5 mRNA	28001369
D008767	Methylmercury Compounds	[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in increased expression of SOX5 mRNA	20020106
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of SOX5 mRNA	26011545
D009151	Mustard Gas	Mustard Gas results in increased expression of SOX5 mRNA	15674844
D010634	Phenobarbital	Phenobarbital results in decreased expression of SOX5 mRNA	23091169
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX5 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of SOX5 mRNA	26272509
D011078	Polychlorinated Biphenyls	[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in increased expression of SOX5 mRNA	20020106
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of SOX5 mRNA	23608068
C045950	propiconazole	propiconazole results in decreased expression of SOX5 mRNA	21278054
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of SOX5 mRNA	23221170
D013629	Tamoxifen	Tamoxifen affects the expression of SOX5 mRNA	17555576
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SOX5 mRNA	21570461\|2405805
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOX5 mRNA	17942748
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of SOX5 mRNA	20133372
D014212	Tretinoin	Tretinoin results in decreased expression of SOX5 mRNA	21934132
D014212	Tretinoin	Tretinoin results in increased expression of SOX5 mRNA	23724009
C011559	tributyltin	tributyltin results in decreased expression of SOX5 mRNA	24513447
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SOX5 mRNA"	26179874
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of SOX5 mRNA	29024780
C057693	troglitazone	troglitazone results in decreased expression of SOX5 mRNA	28973697
D014635	Valproic Acid	Valproic Acid affects the expression of SOX5 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of SOX5 mRNA	28001369
D014635	Valproic Acid	Valproic Acid results in decreased expression of SOX5 mRNA	23042728
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of SOX5 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0003677	DNA binding	-	IEA	-
GO:0003700	DNA-binding transcription factor activity	-	TAS	8812465
GO:0005515	protein binding	-	IPI	21262861 22458338 25416956

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	-
GO:0006366	transcription by RNA polymerase II	-	TAS	8812465
GO:0007399	nervous system development	-	IBA	21873635
GO:0032332	positive regulation of chondrocyte differentiation	-	IBA	21873635
GO:0032332	positive regulation of chondrocyte differentiation	-	IDA	21401405
GO:0045165	cell fate commitment	-	IBA	21873635
GO:0045892	negative regulation of transcription, DNA-templated	-	IBA	21873635
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0055059	asymmetric neuroblast division	-	IGI	23946438
GO:0061036	positive regulation of cartilage development	-	IDA	21401405
GO:0071560	cellular response to transforming growth factor beta stimulus	-	IDA	21401405
GO:2000741	positive regulation of mesenchymal stem cell differentiation	-	IDA	21401405

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24876173	The clinical and genetic features of COPD-asthma overlap syndrome. (2014 Aug)	Hardin M	Eur Respir J