Gene: SOX9

6662
CMD1|CMPD1|SRA1|SRXX2|SRXY10
SRY-box 9
protein-coding
17q24.3
Ensembl:ENSG00000125398 MIM:608160 Vega:OTTHUMG00000166300 UniprotKB:P48436
NG_012490.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.302e-1 (AD)  1.147e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03917138chr17:70120182SOX9Gene body3.527e-4Alcohol use disorders26763658
cg13058710chr17:70119609SOX9Gene body3.901e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TP53BP20.945
SLC1A30.927
GJA10.926
METTL7A0.926
ARHGEF260.925
PBXIP10.922
SDC20.921
PAX60.921
BMPR1B0.917
HEPH0.913

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DUSP27-0.476
CACNA1F-0.464
SAMD5-0.46
AGMAT-0.459
TYRP1-0.458
OSBPL10-0.445
TRABD2A-0.442
CNTN6-0.441
ZNF860-0.438
MCHR1-0.435

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of SOX9 mRNA"26377693
C5532941-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one"1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EGFR protein mutant form results in increased expression of SOX9 mRNA]"26455392
C5532941-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one"1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EGFR protein mutant form results in increased expression of SOX9 protein]"26455392
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SOX9 mRNA"19167446
C0573492,4-decadienal"2,4-decadienal results in decreased expression of SOX9 mRNA"22363721
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SOX9 mRNA"15215175
C0127962-butenal2-butenal results in decreased expression of SOX9 mRNA20471460
C0005949583,4,5-trihydroxy-N-(4-(thiazol-2-ylsulfamoyl)-phenyl)-benzamide"3,4,5-trihydroxy-N-(4-(thiazol-2-ylsulfamoyl)-phenyl)-benzamide results in increased expression of SOX9 mRNA"26107568
C4711094(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline"4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline inhibits the reaction [Niacinamide results in decreased expression of SOX9 protein]"24962570
C4711094(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline"4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline inhibits the reaction [IL1B protein results in decreased expression of SOX9 protein]"24962570
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SOX9 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX9 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of SOX9 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX9 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of SOX9 mRNA17562736
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of SOX9 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SOX9 mRNA22100608
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of SOX9 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SOX9 mRNA16483693
D016718Arachidonic AcidArachidonic Acid results in decreased expression of SOX9 mRNA16704987
D001151ArsenicSOX9 mRNA results in decreased susceptibility to Arsenic17976673
C015001arsenitearsenite results in increased methylation of SOX9 promoter23974009
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of SOX9 mRNA"25351596
D001205Ascorbic Acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of SOX9 mRNA26424790
D001205Ascorbic AcidIL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SOX9 mRNA]26526931
D001205Ascorbic Acidresveratrol inhibits the reaction [IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SOX9 mRNA]]26526931
D001205Ascorbic Acid[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SOX9 mRNA26526931
D001280AtrazineAtrazine results in increased expression of SOX9 mRNA22378314
D001374AzacitidineAzacitidine affects the expression of SOX9 mRNA18033690
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SOX9 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SOX9 mRNA15034205|1977048
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde[benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of SRY protein mutant form] which results in increased expression of SOX9 mRNA27576690
D001599BerberineBerberine results in decreased expression of SOX9 mRNA26478571
D004958EstradiolEstradiol results in decreased expression of SOX9 mRNA23747749
D004958EstradiolEstradiol affects the expression of SOX9 mRNA14699072
D004958Estradiol[Estradiol co-treated with EGF protein] results in increased expression of SOX9 mRNA24758408
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SOX9 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of SOX9 mRNA19167446|2010694
D004958EstradiolEstradiol results in increased expression of SOX9 mRNA19619570
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of SOX9 mRNA17404688
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of SOX9 mRNA]25210133
D004958EstradiolEstradiol results in decreased expression of SOX9 mRNA19484750
D004958EstradiolEstradiol results in increased expression of SOX9 mRNA25210133
C031463beta-glycerophosphoric acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of SOX9 mRNA26424790
C006780bisphenol Abisphenol A affects the methylation of SOX9 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of SOX9 mRNA22732146
C027561butylbenzyl phthalatebutylbenzyl phthalate results in decreased expression of SOX9 mRNA26472102
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SOX9 mRNA15336504
C584509C646 compoundC646 compound results in decreased expression of SOX9 mRNA26191083
D002251Carbon TetrachlorideCarbon Tetrachloride promotes the reaction [Ethanol results in decreased expression of SOX9 protein]28285099
D002251Carbon Tetrachloride[Ethanol co-treated with Carbon Tetrachloride] results in decreased methylation of SOX9 promoter28285099
D002251Carbon Tetrachloride[Ethanol co-treated with Carbon Tetrachloride] results in increased expression of SOX9 mRNA28285099
D002273CarcinogensCarcinogens results in increased expression of SOX9 mRNA16316942
D002330CarmustineSOX9 mRNA affects the susceptibility to Carmustine16365179
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of SOX920938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SOX9 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SOX9 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SOX9 mRNA28472532
D002922CiguatoxinsCiguatoxins affects the expression of SOX9 mRNA18353800
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of SOX9 protein]]23406266
C007095cobaltiprotoporphyrinHMOX1 mutant form inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of SOX9 protein]]]23406266
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SOX9 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of SOX9 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SOX9 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of SOX9 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of SOX9 mRNA26577399|2752363
D003474Curcumin[Curcumin co-treated with resveratrol] results in increased expression of SOX9 protein19889203
D003474CurcuminCurcumin results in increased expression of SOX9 protein19889203
D003474Curcumin[Curcumin co-treated with resveratrol] inhibits the reaction [IL1B protein results in decreased expression of SOX9 protein]19889203
D003474CurcuminCurcumin inhibits the reaction [IL1B protein results in decreased expression of SOX9 protein]19889203
D016572CyclosporineCyclosporine results in decreased expression of SOX9 mRNA19159671|2556210
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SOX9 mRNA23914054
C014347decitabinedecitabine results in increased expression of SOX9 mRNA19151715
D003907DexamethasoneDexamethasone results in increased expression of SOX9 mRNA25286332
D003907Dexamethasone[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of SOX9 mRNA26424790
D003907DexamethasoneDexamethasone promotes the reaction [BMP2 protein results in increased expression of SOX9 mRNA]17502159
D003907DexamethasoneDexamethasone promotes the reaction [TGFB1 protein results in increased expression of SOX9 mRNA]17502159
D003907DexamethasoneDexamethasone results in decreased expression of SOX9 mRNA27608943
D003907DexamethasoneDexamethasone results in increased expression of SOX9 mRNA17690025
D003907DexamethasoneIL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SOX9 mRNA]26526931
D003907Dexamethasoneresveratrol inhibits the reaction [IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SOX9 mRNA]]26526931
D003907Dexamethasone[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SOX9 mRNA26526931
D003907DexamethasoneDexamethasone results in decreased expression of SOX9 mRNA22733784
C053316di-(2-ethylhexyl) terephthalatedi-(2-ethylhexyl) terephthalate results in decreased expression of SOX9 mRNA26472102
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SOX9 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SOX9 mRNA26472102
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SOX9 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SOX9 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of SOX9 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of SOX9 mRNA25016146
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SOX9 mRNA26219507|2706063
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SOX9 protein27060630
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SOX9 mRNA26472102
C014476diethyl maleatediethyl maleate results in increased expression of SOX9 mRNA21161181
C089799diheptyl phthalatediheptyl phthalate results in decreased expression of SOX9 mRNA22112501
D002117CalcitriolCalcitriol results in decreased expression of SOX9 mRNA16002434
D002117CalcitriolCalcitriol results in increased expression of SOX9 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of SOX9 mRNA21592394
C025605diisobutyl phthalatediisobutyl phthalate results in increased expression of SOX9 mRNA22112501
C034171di-n-pentyl phthalatedi-n-pentyl phthalate results in decreased expression of SOX9 mRNA26472102
D004237DiuronDiuron results in decreased expression of SOX9 mRNA21551480
D004237DiuronDiuron results in increased expression of SOX9 mRNA25152437
D004726EndosulfanEndosulfan results in increased expression of SOX9 mRNA23747749
D004726EndosulfanEndosulfan results in decreased expression of SOX9 mRNA26615145
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of SOX9 mRNA]26455392
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of SOX9 protein]26455392
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in decreased expression of SOX9 protein26455392
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of SOX9 mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of SOX9 mRNA21233418
D000431EthanolCarbon Tetrachloride promotes the reaction [Ethanol results in decreased expression of SOX9 protein]28285099
D000431Ethanol[Ethanol co-treated with Carbon Tetrachloride] results in decreased methylation of SOX9 promoter28285099
D000431Ethanol[Ethanol co-treated with Carbon Tetrachloride] results in increased expression of SOX9 mRNA28285099
D000431EthanolEthanol results in decreased expression of SOX9 protein28285099
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOX9 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SOX9 mRNA23300682
D015025ZearalenoneZearalenone results in decreased expression of SOX9 mRNA24412631
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of SOX920938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SOX9 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SOX9 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of SOX9 mRNA28937961
D005557FormaldehydeFormaldehyde results in increased expression of SOX9 mRNA23416264
D005707Gallic AcidGallic Acid results in decreased expression of SOX9 mRNA25130855
D005707Gallic AcidGallic Acid results in decreased expression of SOX9 mRNA26107568
C004312glycidolglycidol results in decreased expression of SOX9 mRNA24915197
D017313FenretinideFenretinide results in increased expression of SOX9 mRNA28973697
D006820Hyaluronic Acid[Hyaluronic Acid co-treated with resveratrol] results in increased expression of SOX9 mRNA23595953
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of SOX9 mRNA17183730
C475919hydroxytamoxifenhydroxytamoxifen results in decreased expression of SOX9 mRNA16849584
C016517indole-3-carbinolindole-3-carbinol affects the expression of SOX9 mRNA21396975
D007501IronIron deficiency results in increased expression of SOX9 mRNA16629162
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SOX9 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SOX9 mRNA24796395|2683047
C006552kaempferolkaempferol results in increased expression of SOX9 mRNA23989061
C008261lead acetateBMP2 promotes the reaction [lead acetate results in increased expression of SOX9 mRNA]17805416
C008261lead acetatelead acetate promotes the reaction [BMP2 results in increased expression of SOX9 mRNA]17805416
C008261lead acetatelead acetate results in increased expression of SOX9 mRNA17805416
C045463leflunomideleflunomide results in increased expression of SOX9 mRNA28988120
D008701MethapyrileneMethapyrilene results in increased expression of SOX9 protein28935588
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of SOX920938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SOX9 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SOX9 mRNA20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SOX9 mRNA"20188158
D008777MethyltestosteroneMethyltestosterone results in increased expression of SOX9 mRNA29191790
D015735MifepristoneMifepristone results in increased expression of SOX9 mRNA17584828
C054999mofezolac[mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of SOX9 mRNA27050768
C054999mofezolac[mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of SOX9 protein27050768
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of SOX9 mRNA28496037
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of SOX9 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SOX9 mRNA"25554681|2562005
C029938nickel sulfatenickel sulfate results in increased expression of SOX9 mRNA18651567
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SOX9 mRNA20971185
D010100Oxygencobaltiprotoporphyrin inhibits the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of SOX9 protein]]23406266
D010100OxygenHMOX1 mutant form inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of SOX9 protein]]]23406266
D010100OxygenIL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of SOX9 protein]23406266
D010100OxygenOxygen deficiency results in increased expression of SOX9 protein23406266
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX9 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of SOX9 mRNA26272509
D010269ParaquatParaquat results in decreased expression of SOX9 mRNA26108578
D052638Particulate MatterParticulate Matter results in decreased expression of SOX9 mRNA22178795
C506614PD 0325901PD 0325901 results in decreased expression of SOX9 mRNA25119042
D015232DinoprostoneDinoprostone results in increased expression of SOX9 mRNA27050768
D015232DinoprostoneDinoprostone results in increased expression of SOX9 protein27050768
D016226Phosphorus, Dietary"Phosphorus, Dietary affects the expression of SOX9 mRNA"16311027
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SOX9 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of SOX9 mRNA18445702|2381119
D010936Plant ExtractsPlant Extracts results in decreased expression of SOX9 mRNA23557933
D011239PrednisolonePrednisolone results in decreased expression of SOX9 mRNA17379860
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of SOX9 mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of SOX9 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of SOX9 mRNA21795739
D011374ProgesteroneProgesterone results in decreased expression of SOX9 mRNA22238285
D015237DinoprostDinoprost results in increased expression of SOX9 mRNA27050768
D015237DinoprostDinoprost results in increased expression of SOX9 protein27050768
C432165pyrazolanthronepyrazolanthrone promotes the reaction [resveratrol results in increased expression of SOX9]24841706
C059514resveratrol[Curcumin co-treated with resveratrol] results in increased expression of SOX9 protein19889203
C059514resveratrolpyrazolanthrone promotes the reaction [resveratrol results in increased expression of SOX9]24841706
C059514resveratrolresveratrol inhibits the reaction [IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SOX9 mRNA]]26526931
C059514resveratrolresveratrol inhibits the reaction [Niacinamide results in decreased expression of SOX9 protein]24962570
C059514resveratrolresveratrol results in increased expression of SOX924841706
C059514resveratrolresveratrol results in increased expression of SOX9 protein19889203|2496257
C059514resveratrolSB 203580 inhibits the reaction [resveratrol results in increased expression of SOX9]24841706
C059514resveratrolSIRT1 protein affects the reaction [resveratrol results in increased expression of SOX9 protein]24962570
C059514resveratrol[SIRT1 protein binds to SOX9 protein] which affects the susceptibility to resveratrol24962570
C059514resveratrol[Hyaluronic Acid co-treated with resveratrol] results in increased expression of SOX9 mRNA23595953
C059514resveratrol[Curcumin co-treated with resveratrol] inhibits the reaction [IL1B protein results in decreased expression of SOX9 protein]19889203
C059514resveratrolresveratrol inhibits the reaction [IL1B protein results in decreased expression of SOX9 protein]19889203|2496257
C093642SB 203580SB 203580 inhibits the reaction [resveratrol results in increased expression of SOX9]24841706
C115461SC 560[SC 560 results in decreased activity of PTGS1 protein] which results in decreased expression of SOX9 mRNA27050768
C115461SC 560[SC 560 results in decreased activity of PTGS1 protein] which results in decreased expression of SOX9 protein27050768
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of SOX9 mRNA19244175
D012643SeleniumSelenium results in decreased expression of SOX9 mRNA19244175
D012715Sesame OilSesame Oil results in decreased expression of SOX9 mRNA29191790
D012822Silicon DioxideSilicon Dioxide results in increased expression of SOX9 mRNA22300531|2535159
D012834SilverSilver results in decreased expression of SOX9 mRNA26014281
D012834SilverSilver results in decreased expression of SOX9 mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of SOX9 mRNA28206643
D012999SomanSoman results in increased expression of SOX9 mRNA19281266
D013420SulfamethoxazoleSulfamethoxazole results in decreased expression of SOX9 mRNA26107568
D013629TamoxifenTamoxifen affects the expression of SOX9 mRNA14699072
D013629TamoxifenTamoxifen results in increased expression of SOX9 mRNA24769059
D013629TamoxifenTamoxifen results in increased expression of SOX9 protein24769059
C047246temozolomideSOX9 mRNA affects the susceptibility to temozolomide16365179
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of SOX9 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of SOX9 mRNA21592394
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of SOX9 mRNA22677475
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SOX9 mRNA22020769
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SOX9 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SOX9 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SOX9 mRNA15056799|1961957
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SOX9 mRNA21570461|2405805
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOX9 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SOX9 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SOX9 mRNA15034205|1977048
D013749Tetrachlorodibenzodioxin[tributyltin co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SOX9 mRNA22749964
D013849ThimerosalThimerosal results in increased expression of SOX9 mRNA24675092
C009495titanium dioxidetitanium dioxide results in decreased expression of SOX9 mRNA23557971
D014212TretinoinTretinoin results in increased expression of SOX9 mRNA16480812|2383079
D014212TretinoinTretinoin results in decreased expression of SOX9 mRNA16505366|2249843
D014212TretinoinTretinoin results in decreased expression of SOX9 protein15961395
D014212TretinoinTretinoin results in decreased expression of SOX9 mRNA23810783
D014212TretinoinTretinoin results in decreased expression of SOX9 protein23810783
C034613triacsin Ctriacsin C results in decreased expression of SOX9 mRNA16704987
C011559tributyltintributyltin results in decreased expression of SOX9 mRNA27614199
C011559tributyltin[tributyltin co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SOX9 mRNA22749964
C011559tributyltintributyltin results in decreased expression of SOX9 mRNA24513447
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX9 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SOX9 mRNA24935251|2627250
C057693troglitazonetroglitazone results in increased expression of SOX9 mRNA19140230
C113580U 0126U 0126 inhibits the reaction [EGFR protein mutant form results in increased expression of SOX9 mRNA]26455392
C113580U 0126U 0126 inhibits the reaction [EGFR protein mutant form results in increased expression of SOX9 protein]26455392
D014520UrethaneUrethane results in increased expression of SOX9 mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of SOX9 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of SOX9 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SOX9 mRNA24383497|2493525
D014635Valproic AcidValproic Acid results in increased methylation of SOX9 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of SOX9 mRNA23042728
D014638VanadatesVanadates results in increased expression of SOX9 mRNA22714537
C029297vinylidene chloridevinylidene chloride results in increased expression of SOX9 mRNA26682919
D014801Vitamin A[RARA gene mutant form co-treated with Vitamin A] results in decreased expression of SOX9 mRNA16397886
D014801Vitamin ARARG gene mutant form inhibits the reaction [[RARA gene mutant form co-treated with Vitamin A] results in decreased expression of SOX9 mRNA]16397886
D009536Niacinamide"4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline inhibits the reaction [Niacinamide results in decreased expression of SOX9 protein]"24962570
D009536NiacinamideNiacinamide results in decreased expression of SOX9 protein24962570
D009536Niacinamideresveratrol inhibits the reaction [Niacinamide results in decreased expression of SOX9 protein]24962570
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of SOX9 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of SOX9 mRNA19244175
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX9 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of SOX9 mRNA26272509
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of SOX9 mRNA"25475078
C063449zileutonzileuton results in increased expression of SOX9 mRNA19544365
C088658zoledronic acidzoledronic acid results in decreased expression of SOX9 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA20530484  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA20484372  20530484  21367821  
GO:0001158enhancer sequence-specific DNA binding-ISS-  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0003682chromatin binding-IDA20484372  
GO:0003700DNA-binding transcription factor activity-IDA10805756  
GO:0003700DNA-binding transcription factor activity-IMP8640233  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IDA20484372  21412441  
GO:0004672protein kinase activity-ISS-  
GO:0005515protein binding-IPI20530484  21346191  
GO:0008013beta-catenin binding-IEA-  
GO:0034236protein kinase A catalytic subunit binding-IPI10805756  
GO:0035326enhancer binding-IDA10805756  
GO:0043425bHLH transcription factor binding-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO:0097157pre-mRNA intronic binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0001501skeletal system development-IMP8640233  
GO:0001502cartilage condensation-ISS-  
GO:0001503ossification-IEA-  
GO:0001658branching involved in ureteric bud morphogenesis-IEA-  
GO:0001708cell fate specification-ISS-  
GO:0001837epithelial to mesenchymal transition-ISS-  
GO:0001894tissue homeostasis-ISS-  
GO:0001934positive regulation of protein phosphorylation-ISS-  
GO:0001942hair follicle development-ISS-  
GO:0002009morphogenesis of an epithelium-IBA21873635  
GO:0002053positive regulation of mesenchymal cell proliferation-ISS-  
GO:0002062chondrocyte differentiation-IBA21873635  
GO:0002062chondrocyte differentiation-ISS-  
GO:0002683negative regulation of immune system process-ISS-  
GO:0003170heart valve development-ISS-  
GO:0003179heart valve morphogenesis-ISS-  
GO:0003188heart valve formation-IEA-  
GO:0003203endocardial cushion morphogenesis-ISS-  
GO:0003413chondrocyte differentiation involved in endochondral bone morphogenesis-IMP20676705  
GO:0003415chondrocyte hypertrophy-ISS-  
GO:0006334nucleosome assembly-IDA20484372  
GO:0006338chromatin remodeling-IDA20484372  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0007010cytoskeleton organization-IEA-  
GO:0007165signal transduction-ISS-  
GO:0007173epidermal growth factor receptor signaling pathway-ISS21512138  
GO:0007219Notch signaling pathway-IEA-  
GO:0007283spermatogenesis-ISS-  
GO:0007417central nervous system development-IBA21873635  
GO:0007507heart development-IBA21873635  
GO:0008284positive regulation of cell proliferation-IMP20651055  
GO:0008584male gonad development-IEP17848411  
GO:0008584male gonad development-IMP8640233  
GO:0010564regulation of cell cycle process-IMP12420222  
GO:0010634positive regulation of epithelial cell migration-IMP21512138  
GO:0014032neural crest cell development-IEA-  
GO:0014036neural crest cell fate specification-ISS-  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-ISS-  
GO:0019100male germ-line sex determination-ISS-  
GO:0019933cAMP-mediated signaling-IDA10805756  
GO:0030155regulation of cell adhesion-IEA-  
GO:0030198extracellular matrix organization-IEA-  
GO:0030279negative regulation of ossification-ISS-  
GO:0030502negative regulation of bone mineralization-IEA-  
GO:0030850prostate gland development-IEP20103652  
GO:0030857negative regulation of epithelial cell differentiation-IEA-  
GO:0030858positive regulation of epithelial cell differentiation-ISS-  
GO:0030879mammary gland development-IEA-  
GO:0030903notochord development-IEA-  
GO:0030916otic vesicle formation-ISS-  
GO:0031018endocrine pancreas development-IEA-  
GO:0032331negative regulation of chondrocyte differentiation-ISS-  
GO:0032332positive regulation of chondrocyte differentiation-IBA21873635  
GO:0032332positive regulation of chondrocyte differentiation-IDA21401405  
GO:0032332positive regulation of chondrocyte differentiation-IMP20676705  
GO:0032808lacrimal gland development-IEA-  
GO:0034504protein localization to nucleus-IEA-  
GO:0035019somatic stem cell population maintenance-ISS-  
GO:0035622intrahepatic bile duct development-IEA-  
GO:0042127regulation of cell proliferation-ISS-  
GO:0042981regulation of apoptotic process-ISS-  
GO:0043066negative regulation of apoptotic process-IMP21367821  
GO:0043066negative regulation of apoptotic process-ISS-  
GO:0043491protein kinase B signaling-IEA-  
GO:0045662negative regulation of myoblast differentiation-ISS-  
GO:0045732positive regulation of protein catabolic process-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IMP20651055  
GO:0045893positive regulation of transcription, DNA-templated-IDA10805756  
GO:0045893positive regulation of transcription, DNA-templated-IMP20651055  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA8640233  20530484  22110751  
GO:0046533negative regulation of photoreceptor cell differentiation-ISS-  
GO:0048709oligodendrocyte differentiation-IBA21873635  
GO:0048709oligodendrocyte differentiation-IEA-  
GO:0050679positive regulation of epithelial cell proliferation-IEP20103652  
GO:0050679positive regulation of epithelial cell proliferation-ISS-  
GO:0050680negative regulation of epithelial cell proliferation-ISS-  
GO:0051216cartilage development-ISS-  
GO:0060008Sertoli cell differentiation-ISS-  
GO:0060009Sertoli cell development-IEA-  
GO:0060018astrocyte fate commitment-IEA-  
GO:0060041retina development in camera-type eye-ISS-  
GO:0060174limb bud formation-IEA-  
GO:0060221retinal rod cell differentiation-ISS-  
GO:0060441epithelial tube branching involved in lung morphogenesis-IEA-  
GO:0060487lung epithelial cell differentiation-IEA-  
GO:0060517epithelial cell proliferation involved in prostatic bud elongation-ISS-  
GO:0060532bronchus cartilage development-IEA-  
GO:0060534trachea cartilage development-IEA-  
GO:0060729intestinal epithelial structure maintenance-ISS-  
GO:0060784regulation of cell proliferation involved in tissue homeostasis-ISS-  
GO:0061036positive regulation of cartilage development-IDA21401405  
GO:0061046regulation of branching involved in lung morphogenesis-IEA-  
GO:0061138morphogenesis of a branching epithelium-ISS-  
GO:0061145lung smooth muscle development-IEA-  
GO:0065003protein-containing complex assembly-IDA20530484  
GO:0070168negative regulation of biomineral tissue development-IDA22110751  
GO:0070168negative regulation of biomineral tissue development-ISS-  
GO:0070371ERK1 and ERK2 cascade-ISS21512138  
GO:0070384Harderian gland development-IEA-  
GO:0071260cellular response to mechanical stimulus-ISS21512138  
GO:0071300cellular response to retinoic acid-IEP12420222  
GO:0071347cellular response to interleukin-1-IEP20079164  
GO:0071364cellular response to epidermal growth factor stimulus-ISS21512138  
GO:0071504cellular response to heparin-ISS21512138  
GO:0071560cellular response to transforming growth factor beta stimulus-IDA21401405  
GO:0071773cellular response to BMP stimulus-ISS-  
GO:0072034renal vesicle induction-ISS-  
GO:0072190ureter urothelium development-IEA-  
GO:0072193ureter smooth muscle cell differentiation-IEA-  
GO:0072197ureter morphogenesis-IEA-  
GO:0072289metanephric nephron tubule formation-ISS-  
GO:0090090negative regulation of canonical Wnt signaling pathway-ISS-  
GO:0090103cochlea morphogenesis-ISS-  
GO:0090184positive regulation of kidney development-ISS-  
GO:0090190positive regulation of branching involved in ureteric bud morphogenesis-ISS-  
GO:0097065anterior head development-IEA-  
GO:0098609cell-cell adhesion-IEA-  
GO:1901203positive regulation of extracellular matrix assembly-IEA-  
GO:1902894negative regulation of pri-miRNA transcription by RNA polymerase II-IDA26687115  
GO:2000020positive regulation of male gonad development-IDA21412441  
GO:2000138positive regulation of cell proliferation involved in heart morphogenesis-IEA-  
GO:2000741positive regulation of mesenchymal stem cell differentiation-IDA21401405  
GO:2000794regulation of epithelial cell proliferation involved in lung morphogenesis-IEA-  
GO:2001054negative regulation of mesenchymal cell apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA8640233  10805756  12420222  18512230  26634652  
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0032991protein-containing complex-IDA20530484  
GO:0044798nuclear transcription factor complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3769402Deactivation of the beta-catenin transactivating complexTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878166Transcriptional regulation by RUNX2TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27589569Genetic variants of SOX9 contribute to susceptibility of gliomas among Chinese population. (2016 Oct 4)Wang LOncotarget
24451080Molecular profiles of non-small cell lung cancers in cigarette smoking and never-smoking patients. (2013)Szymanowska-Narloch AAdv Med Sci
23284291Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. (2012)Hancock DBPLoS Genet
29162857Temporal expression pattern of genes during the period of sex differentiation in human embryonic gonads. (2017 Nov 21)Mamsen LSSci Rep