Gene: SOX10

6663
DOM|PCWH|WS2E|WS4|WS4C
SRY-box 10
protein-coding
22q13.1
Ensembl:ENSG00000100146 MIM:602229 Vega:OTTHUMG00000149913 UniprotKB:P56693
NG_007948.1
PubMed
0   ANCO-SNPs
CD|OD|ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.470e-1 (AD)  3.013e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RTKN0.922
ELOVL10.887
C10orf900.883
HSPA20.88
CPNE20.875
PLLP0.874
GLTP0.873
CNP0.87
SLAIN10.868
BOK0.868

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.436
OR4F5-0.409
CNGB1-0.405
OR4F29-0.395
CNTN5-0.394
PCDH8-0.39
FREM3-0.379
KAZALD1-0.368
C16orf47-0.366
NPBWR1-0.36

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX10 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX10 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX10 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX10 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX10 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX10 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX10 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX10 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX10 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX10 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of SOX10 mRNA28959563
D0435825-alpha-Dihydroprogesterone5-alpha-Dihydroprogesterone results in increased expression of SOX10 mRNA17478888
D0435825-alpha-Dihydroprogesterone5-alpha-Dihydroprogesterone results in increased expression of SOX10 protein17478888
D001205Ascorbic AcidAscorbic Acid results in increased expression of SOX10 mRNA15305145
D001280AtrazineAtrazine results in decreased expression of SOX10 mRNA25929836
D000069286BortezomibBortezomib results in decreased expression of SOX10 mRNA20830808
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SOX10 mRNA20360939
D003471CuprizoneCuprizone results in decreased expression of SOX10 mRNA26577399|2752363
D019422Dietary SucroseDietary Sucrose results in increased expression of SOX10 mRNA26033743
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SOX10 mRNA20360939
D002117CalcitriolCalcitriol results in increased expression of SOX10 mRNA26485663
C472511dimethylarsinous aciddimethylarsinous acid results in decreased expression of SOX10 protein26024302
D005047EtoposideSOX10 protein affects the susceptibility to Etoposide16217747
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of SOX10 mRNA]20578043
C102521GGTI 298GGTI 298 results in increased expression of SOX10 mRNA20578043
D006046GoldGold analog results in decreased expression of SOX10 mRNA23549158
D007052IbuprofenIbuprofen results in increased expression of SOX10 mRNA28201806
D007854LeadLead results in decreased expression of SOX10 mRNA19921347
D008148Lovastatingeranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of SOX10 mRNA]20578043
D008148LovastatinLovastatin results in increased expression of SOX10 mRNA20578043
D008148LovastatinPPARG protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA]20578043
D008148LovastatinPTEN protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA]20578043
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SOX10 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SOX10 mRNA19651682
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of SOX10 mRNA26024302
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of SOX10 protein26024302
D009532NickelNickel results in decreased expression of SOX10 mRNA24768652|2558310
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SOX10 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SOX10 mRNA27935865
C025589ochratoxin Aochratoxin A affects the expression of SOX10 mRNA24792326
C025589ochratoxin ASHH protein inhibits the reaction [ochratoxin A affects the expression of SOX10 mRNA]24792326
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX10 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of SOX10 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX10 mRNA"27188386
D010795Phthalic AcidsPhthalic Acids results in decreased expression of SOX10 mRNA21061450
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SOX10 mRNA27935865
D011374ProgesteroneProgesterone results in increased expression of SOX10 mRNA17478888
D011374ProgesteroneProgesterone results in increased expression of SOX10 protein17478888
C406527R 115866R 115866 results in decreased expression of SOX10 protein17047027
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of SOX10 mRNA21427059
C017947sodium arsenitesodium arsenite results in decreased expression of SOX10 mRNA26024302
C017947sodium arsenitesodium arsenite results in decreased expression of SOX10 protein26024302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SOX10 mRNA24058054
D019284ThapsigarginThapsigargin results in decreased expression of SOX10 mRNA20830808
D014212Tretinoin[Tretinoin co-treated with EGF protein co-treated with NOG protein] results in increased expression of SOX10 mRNA17196394
D014212TretinoinTretinoin results in increased expression of SOX10 mRNA17038669
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX10 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SOX10 mRNA24935251|2627250
C040533trimethyltin chloridetrimethyltin chloride results in decreased expression of SOX10 mRNA19651682
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX10 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of SOX10 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased expression of SOX10 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of SOX10 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SOX10 mRNA21427059
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX10 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of SOX10 mRNA26272509
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SOX10 mRNA27935865
C108830Y 27632Y 27632 results in increased expression of SOX10 mRNA20578043

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0003677DNA binding-ISS-  
GO:0003700DNA-binding transcription factor activity-ISS-  
GO:0003713transcription coactivator activity-TAS9722528  
GO:0005515protein binding-IPI11029584  16214168  16494873  
GO:0008134transcription factor binding-IEA-  
GO:0042802identical protein binding-IPI11029584  
GO:1990841promoter-specific chromatin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0001755neural crest cell migration-IBA21873635  
GO:0002009morphogenesis of an epithelium-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-TAS9722528  
GO:0006368transcription elongation from RNA polymerase II promoter-IEA-  
GO:0007417central nervous system development-IBA21873635  
GO:0007422peripheral nervous system development-IBA21873635  
GO:0009653anatomical structure morphogenesis-TAS9425902  
GO:0010626negative regulation of Schwann cell proliferation-IEA-  
GO:0014003oligodendrocyte development-ISS-  
GO:0022010central nervous system myelination-ISS-  
GO:0031643positive regulation of myelination-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0048484enteric nervous system development-IBA21873635  
GO:0048709oligodendrocyte differentiation-IBA21873635  
GO:0048709oligodendrocyte differentiation-ISS-  
GO:0048863stem cell differentiation-IEA-  
GO:0071393cellular response to progesterone stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000785chromatin-IEA-  
GO:0005634nucleus-IDA18512230  
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-IDA-  
GO:0005741mitochondrial outer membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22712019Forced Abstinence from Cocaine Self-Administration is Associated with DNA Methylation Changes in Myelin Genes in the Corpus Callosum: a Preliminary Study. (2012)Nielsen DAFront Psychiatry
29434341Hyalinizing clear cell carcinoma of the bronchial glands: presentation of three cases and pathological comparisons with salivary gland counterparts and bronchial mucoepidermoid carcinomas. (2018 Feb 12)Takamatsu MMod Pathol
21323953Sox10-positive sustentacular cells in neuroendocrine carcinoma of the lung. (2011 Jan)Tsuta KHistopathology
29260792A Novel Role for Oligodendrocyte Precursor Cells (OPCs) and Sox10 in Mediating Cellular and Behavioral Responses to Heroin. (2018 May)Martin JANeuropsychopharmacology
28879079Intrathoracic ganglioneuroma presenting as an endobronchial mass. (2017)Nokes BTRespir Med Case Rep