Gene info: ID 6667

Gene: SP1

GENE ID: 6667

Synonyms: -

Description: Sp1 transcription factor

Gene type: protein-coding

Location: 12q13.13

dbXrefs: Ensembl:ENSG00000185591 MIM:189906 Vega:OTTHUMG00000170047 UniprotKB:P08047

RefSeq: NG_030361.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: OD|ND|AD

# Publications: 31

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.178e-1 (AD) 7.774e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ATF7	0.878
KHNYN	0.876
PHACTR4	0.872
WASF2	0.87
SH3GLB1	0.866
BNIP2	0.864
ATL3	0.863
CTDSP2	0.861
RHBDD1	0.852
HPS5	0.852

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CRH	-0.46
OR4F5	-0.43
BHLHA9	-0.415
OR4F29	-0.412
ADRA1D	-0.4
ABCC12	-0.398
GSG1	-0.384
SLC7A4	-0.383
NMU	-0.379
FBLN7	-0.376

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C025205	1,10-phenanthroline	"1,10-phenanthroline results in decreased activity of SP1 protein"	2157617
C552530	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	"1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [EP300 protein binds to SP1 protein]"	20660371
C492909	1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane	"SP1 protein affects the reaction [1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane results in increased expression of CDKN1A protein]"	15345676
D014013	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt	"SP1 protein affects the reaction [1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt results in decreased expression of TGFB1 mRNA]"	11163763
C554292	12-O-tetradecanoylphorbol-1,3-acetate	"[[9,10-Dimethyl-1,2-benzanthracene co-treated with 12-O-tetradecanoylphorbol-1,3-acetate] results in increased activity of TRP53 protein] inhibits the reaction [SP1 protein binds to SOD2 promoter]"	22009531
C554292	12-O-tetradecanoylphorbol-1,3-acetate	"[[[9,10-Dimethyl-1,2-benzanthracene co-treated with 12-O-tetradecanoylphorbol-1,3-acetate] results in increased activity of TRP53 protein] inhibits the reaction [SP1 protein binds to SOD2 promoter]] which results in decreased expression of SOD2 mRNA"	22009531
C477819	15-deoxyprostaglandin J2	15-deoxyprostaglandin J2 results in decreased expression of SP1 protein	15908479
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of SP1 mRNA"	25565004
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SP1 mRNA"	27291303
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SP1 mRNA"	27291303
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of SP1 protein]	17307335
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of SP1 protein]	17307335
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of SP1 protein]	26385185
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of SP1 protein	21351249
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SP1 protein"	22307971
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of SP1 mRNA"	18648102
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin promotes the reaction [SP1 protein binds to PLAT promoter]]	18419748
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of SP1 protein]	28867437
C041594	4-nonylphenol	[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of SP1 mRNA	29029336
C105260	4-tert-octylphenol	[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of SP1 mRNA	29029336
C513003	5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione	"5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione results in decreased expression of SP1 protein"	17409431
C513003	5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione	"5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione results in increased degradation of SP1 protein"	17409431
C513003	5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione	"[5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione results in increased degradation of SP1 protein] which results in decreased expression of AR mRNA"	17409431
C513003	5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione	"benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione results in decreased expression of SP1 protein]"	17409431
C513003	5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione	"epoxomicin inhibits the reaction [5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione results in decreased expression of SP1 protein]"	17409431
C513003	5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione	"epoxomicin inhibits the reaction [5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione results in increased degradation of SP1 protein]"	17409431
C513003	5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione	"SP1 protein inhibits the reaction [5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione results in decreased expression of AR protein]"	17409431
C513003	5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione	"SP1 protein results in decreased susceptibility to 5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione"	17409431
C106250	6,7-dimethoxy-3-phenylquinoxaline	"6,7-dimethoxy-3-phenylquinoxaline inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of SP1 protein]"	26385185
C053876	6-isopropoxy-9-oxoxanthene-2-carboxylic acid	[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of SP1 protein	19407222
C054852	7-hydroxystaurosporine	7-hydroxystaurosporine results in increased expression of SP1 mRNA	14653808
C054852	7-hydroxystaurosporine	7-hydroxystaurosporine results in increased expression of SP1 protein	14653808
C054852	7-hydroxystaurosporine	7-hydroxystaurosporine results in increased expression of SP1 mRNA	14653808
C054852	7-hydroxystaurosporine	7-hydroxystaurosporine results in increased expression of SP1 protein	14653808
D000079	Acetaldehyde	SP1 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA]	16025520
D000082	Acetaminophen	Acetaminophen affects the expression of SP1 mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Sodium Selenite results in decreased expression of SP1 protein]	16928829
D000111	Acetylcysteine	Acetylcysteine results in decreased expression of SP1 protein	18556457
D012435	S-Adenosylhomocysteine	S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter]	19770485
D012436	S-Adenosylmethionine	S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]	15983038
D012436	S-Adenosylmethionine	S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]]	15983038
D012436	S-Adenosylmethionine	S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter]	15983038
C046926	AH 23848	[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of SP1 protein	19407222
D000487	Allethrin	Allethrin results in increased activity of SP1 protein	20143881
C011512	alpha-naphthoflavone	alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]]	29094188
C011512	alpha-naphthoflavone	alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of SP1 promoter]	29094188
C011512	alpha-naphthoflavone	alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of SP1 mRNA]	29094188
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SP1 mRNA	16483693
D000643	Ammonium Chloride	Ammonium Chloride results in decreased expression of SP1 mRNA	17442060
D000643	Ammonium Chloride	Ammonium Chloride results in decreased expression of SP1 protein	17442060
D000643	Ammonium Chloride	Ammonium Chloride results in decreased phosphorylation of SP1 protein	17442060
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of SP1 mRNA	25339124
C000228	aristolochic acid I	aristolochic acid I results in increased activity of SP1 protein	21554934
C006632	arsenic trioxide	arsenic trioxide results in increased expression of SP1 protein	23103450
C006632	arsenic trioxide	[arsenic trioxide results in increased expression of SP1 protein] which results in increased expression of KCNH2 mRNA	23103450
C006632	arsenic trioxide	[arsenic trioxide results in increased expression of SP1 protein] which results in increased expression of KCNH2 protein	23103450
C006632	arsenic trioxide	arsenic trioxide affects the methylation of SP1 promoter	26046465
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [SP1 protein binds to CYTL1 promoter]	15761015
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [SP1 protein binds to MYC promoter]	15761015
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [SP1 protein binds to TERT promoter]	15761015
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [SP1 protein results in increased expression of TERT mRNA]	11714746
C006632	arsenic trioxide	arsenic trioxide promotes the reaction [Tretinoin results in increased expression of SP1 protein]	26892147
C006632	arsenic trioxide	arsenic trioxide results in decreased activity of SP1 protein	11714746
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of SP1 mRNA	20435036\|2543693
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of SP1 protein	17617380\|2043503
C006632	arsenic trioxide	arsenic trioxide results in increased oxidation of and results in decreased activity of SP1 protein	15761015
C006632	arsenic trioxide	Catechin inhibits the reaction [arsenic trioxide results in decreased expression of SP1 protein]	28768059
C006632	arsenic trioxide	MIR21 mRNA promotes the reaction [arsenic trioxide results in decreased expression of SP1 protein]	25395240
C039726	artesunate	artesunate results in decreased expression of SP1 protein	19513562
D001194	Asbestos	Asbestos results in increased expression of SP1	15636197
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite affects the expression of SP1 mRNA"	17331233
D001205	Ascorbic Acid	Ascorbic Acid results in decreased expression of SP1 protein	21919647
C005948	astaxanthine	"astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]"	23538867
C005948	astaxanthine	"astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]"	23538867
C005948	astaxanthine	"astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]"	23538867
C005948	astaxanthine	"astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]]"	23538867
C005948	astaxanthine	"[mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of and affects the localization of SP1 protein]"	23538867
C005948	astaxanthine	"mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]"	23538867
C005948	astaxanthine	"mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]]"	23538867
D001280	Atrazine	Atrazine results in increased expression of SP1 mRNA	25929836
D001374	Azacitidine	Azacitidine promotes the reaction [SP1 protein binds to KIR2DL2 promoter]	18945643
D001374	Azacitidine	Azacitidine promotes the reaction [SP1 protein binds to KIR2DL4 promoter]	18945643
D001374	Azacitidine	Azacitidine results in decreased expression of SP1 mRNA	20823114
D001374	Azacitidine	Azacitidine promotes the reaction [SP1 protein binds to AQP5 promoter]	17198683
C028559	bathocuproine sulfonate	bathocuproine sulfonate promotes the reaction [SP1 protein results in increased expression of SLC31A1 mRNA]	18483225
D001554	Benzene	Benzene results in decreased expression of SP1 mRNA	21382456
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SP1 mRNA	23306105
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the activity of SP1 protein	20624995
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of SP1 protein	21987461
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SP1 mRNA	22228805
D001564	Benzo(a)pyrene	POR protein affects the reaction [Benzo(a)pyrene affects the expression of SP1 protein]	21987461
C110772	benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone	benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [CD 437 results in increased cleavage of SP1 protein]	9343396
C110772	benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone	benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [CD 437 results in increased cleavage of SP1 protein]	9343396
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	"benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione results in decreased expression of SP1 protein]"	17409431
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [SP1 protein binds to ARNT promoter]	14529614
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of and results in increased activity of SP1 protein	14529614
C517629	benzyloxycarbonyl-valyl-alanyl-aspartic acid	benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [CD 437 results in increased cleavage of SP1 protein]	9343396
C517629	benzyloxycarbonyl-valyl-alanyl-aspartic acid	benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [CD 437 results in increased cleavage of SP1 protein]	9343396
D004958	Estradiol	Estradiol promotes the reaction [ESR1 protein binds to SP1 protein]	16675542\|2373389
D004958	Estradiol	Estradiol promotes the reaction [SP1 protein binds to VDR promoter]	17088408
D004958	Estradiol	Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [SP1 protein binds to CYP1A1 promoter]]	16675542
D004958	Estradiol	Estradiol results in increased activity of SP1 protein	17088408
D004958	Estradiol	Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to SP1 protein]]	16675542
D004958	Estradiol	U 0126 inhibits the reaction [Estradiol results in increased activity of SP1 protein]	17088408
D004958	Estradiol	Estradiol promotes the reaction [[SP1 protein binds to VEGFA promoter] which results in increased expression of VEGFA mRNA]	15774498
C070515	bisindolylmaleimide I	bisindolylmaleimide I results in increased expression of SP1 mRNA	14653808
C070515	bisindolylmaleimide I	bisindolylmaleimide I results in increased expression of SP1 protein	14653808
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in decreased activity of SP1 protein]	12499119
C006780	bisphenol A	bisphenol A affects the methylation of SP1 promoter	27334623
C006780	bisphenol A	bisphenol A results in increased expression of SP1 mRNA	25181051
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in increased activity of SP1 protein	11261509
D019328	Buthionine Sulfoximine	mithramycin A inhibits the reaction [Buthionine Sulfoximine results in increased activity of SP1 protein]	11261509
C027561	butylbenzyl phthalate	butylbenzyl phthalate results in decreased expression of SP1 mRNA	29029336
C027561	butylbenzyl phthalate	[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of SP1 mRNA	29029336
D002085	Butylhydroxybutylnitrosamine	Butylhydroxybutylnitrosamine results in increased expression of SP1 protein	24998975
D002104	Cadmium	Cadmium inhibits the reaction [SP1 protein binds to OGG1 promoter]	15760895
D002104	Cadmium	[Cadmium inhibits the reaction [SP1 protein binds to OGG1 promoter]] which results in decreased expression of OGG1 mRNA	15760895
D002104	Cadmium	Cadmium inhibits the reaction [SP1 protein binds to Zinc]	20073493
D002104	Cadmium	Cadmium inhibits the reaction [[SP1 protein binds to Zinc] which binds to SLC5A1 promoter]	20073493
D002104	Cadmium	Cadmium promotes the reaction [SP1 protein binds to MYC promoter]	24015267
D002104	Cadmium	Cadmium results in decreased activity of [SP1 protein binds to Zinc]	20073493
D002104	Cadmium	Cadmium results in decreased expression of and results in decreased activity of SP1 protein	18556457
D002104	Cadmium	SP1 protein binds to Cadmium	20073493
D002104	Cadmium	Zinc inhibits the reaction [Cadmium inhibits the reaction [[SP1 protein binds to Zinc] which binds to SLC5A1 promoter]]	20073493
D002104	Cadmium	Cadmium inhibits the reaction [SP1 protein binds to SLC5A1 promoter]	15664265
D002104	Cadmium	Cadmium promotes the reaction [MTF1 protein binds to SP1 protein]	18458062
C028031	cadmium acetate	cadmium acetate results in decreased expression of SP1 mRNA	24132751
D019256	Cadmium Chloride	[SLC39A8 mutant form results in decreased expression of SP1] which affects the susceptibility to Cadmium Chloride	18556457
D019256	Cadmium Chloride	[SLC39A8 mutant form results in decreased expression of SP1] which results in decreased uptake of Cadmium Chloride	18556457
D019256	Cadmium Chloride	SP1 affects the susceptibility to Cadmium Chloride	18556457
D019256	Cadmium Chloride	Cadmium Chloride inhibits the reaction [SP1 protein binds to and affects the expression of SLC5A1 promoter]	20060848
D019256	Cadmium Chloride	Cadmium Chloride inhibits the reaction [SP1 protein binds to and affects the expression of SLC5A2 promoter]	20060848
D019256	Cadmium Chloride	Cadmium Chloride inhibits the reaction [SP1 protein binds to SP3 protein binds to KLF4 protein binds to E2F1 protein binds to NECTIN2 promoter]	25046863
D019256	Cadmium Chloride	zinc chloride inhibits the reaction [Cadmium Chloride inhibits the reaction [SP1 protein binds to and affects the expression of SLC5A1 promoter]]	20060848
D019256	Cadmium Chloride	bisindolylmaleimide I inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in decreased activity of SP1 protein]	12499119
D019256	Cadmium Chloride	Cadmium Chloride results in increased cleavage of SP1 protein	12499119
D019256	Cadmium Chloride	Cadmium Chloride results in increased phosphorylation of and results in decreased activity of SP1 protein	12499119
C080866	cagA protein, Helicobacter pylori	"cagA protein, Helicobacter pylori results in decreased expression of SP1 protein"	26427350
C080866	cagA protein, Helicobacter pylori	"ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased expression of SP1 protein]"	26427350
D000001	Calcimycin	[Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of SP1 protein	24244623
D002166	Camptothecin	Camptothecin results in increased activity of SP1 protein	11261509
D002166	Camptothecin	mithramycin A inhibits the reaction [Camptothecin results in increased activity of SP1 protein]	11261509
D002211	Capsaicin	Capsaicin promotes the reaction [SP1 protein binds to TNFSF10 promoter]	22200406
D002211	Capsaicin	Capsaicin results in increased localization of SP1 protein	22200406
D002258	Carbonyl Cyanide m-Chlorophenyl Hydrazone	Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein]	11050244
D002258	Carbonyl Cyanide m-Chlorophenyl Hydrazone	Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein]	11050244
D002392	Catechin	Catechin inhibits the reaction [arsenic trioxide results in decreased expression of SP1 protein]	28768059
D002392	Catechin	Catechin results in increased expression of SP1 protein	28768059
C099555	CD 437	benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [CD 437 results in increased cleavage of SP1 protein]	9343396
C099555	CD 437	benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [CD 437 results in increased cleavage of SP1 protein]	9343396
C099555	CD 437	CD 437 results in increased cleavage of and results in decreased activity of SP1 protein	9343396
C099555	CD 437	CD 437 results in increased expression of SP1 protein	15059897
C099555	CD 437	Ethylmaleimide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein]	9343396
C099555	CD 437	Iodoacetamide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein]	9343396
C099555	CD 437	tyrosyl-valyl-alanyl-aspartal analog inhibits the reaction [CD 437 results in increased cleavage of SP1 protein]	9343396
C099555	CD 437	benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [CD 437 results in increased cleavage of SP1 protein]	9343396
C099555	CD 437	benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [CD 437 results in increased cleavage of SP1 protein]	9343396
C099555	CD 437	CD 437 results in increased cleavage of and results in decreased activity of SP1 protein	9343396
C099555	CD 437	Ethylmaleimide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein]	9343396
C099555	CD 437	Iodoacetamide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein]	9343396
C099555	CD 437	tyrosyl-valyl-alanyl-aspartal analog inhibits the reaction [CD 437 results in increased cleavage of SP1 protein]	9343396
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased activity of SP1 protein	16159668
D002737	Chloroprene	Chloroprene results in increased expression of SP1 mRNA	23125180
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of SP1 mRNA	24979751
D004390	Chlorpyrifos	Chlorpyrifos affects the expression of SP1 mRNA	17452286
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SP1 gene	20938992
C074702	chromium hexavalent ion	chromium hexavalent ion results in increased activity of SP1 protein	19994902
C074702	chromium hexavalent ion	STAT1 protein affects the reaction [chromium hexavalent ion results in increased activity of SP1 protein]	19994902
C068329	clofarabine	[resveratrol co-treated with clofarabine] affects the localization of SP1 protein	23146690
C068329	clofarabine	[resveratrol co-treated with clofarabine] results in decreased expression of SP1 protein	23146690
D002994	Clofibrate	Clofibrate results in increased expression of SP1 mRNA	17585979
C018021	cobaltous chloride	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of SP1 protein]	17307335
C018021	cobaltous chloride	cobaltous chloride results in increased activity of SP1 protein	17307335
C018021	cobaltous chloride	cobaltous chloride results in increased expression of SP1 protein	17307335
C018021	cobaltous chloride	HIF1A protein promotes the reaction [SP1 protein promotes the reaction [cobaltous chloride results in increased expression of DDIT4]]	17307335
C018021	cobaltous chloride	[Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 mRNA]	17307335
C018021	cobaltous chloride	[Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 protein]	17307335
C018021	cobaltous chloride	SP1 protein promotes the reaction [cobaltous chloride results in increased expression of DDIT4 mRNA]	17307335
C018021	cobaltous chloride	cobaltous chloride results in increased phosphorylation of SP1 protein	23814049
D003042	Cocaine	Cocaine affects the expression of SP1 mRNA	20187946
D003042	Cocaine	Cocaine affects the expression of SP1 protein	16179556
D003300	Copper	Copper deficiency promotes the reaction [SP1 protein results in increased expression of SLC31A1 mRNA]	22172574
D003300	Copper	Copper deficiency results in increased expression of SP1 mRNA	24132751
D003300	Copper	Copper deficiency results in increased expression of SP1 protein	22172574
D003300	Copper	Copper inhibits the reaction [SP1 protein results in increased expression of SLC31A1 mRNA]	18483225
D003300	Copper	[neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased activity of SP1 protein]	12633744
D003300	Copper	[tetrathiomolybdate results in decreased abundance of Copper] which results in increased expression of SP1 protein	22172574
D019327	Copper Sulfate	Copper Sulfate inhibits the reaction [Cisplatin results in increased expression of SP1 mRNA]	24132751
D019327	Copper Sulfate	Copper Sulfate inhibits the reaction [SP1 protein binds to SLC31A1 promoter]	22172574
D019327	Copper Sulfate	Copper Sulfate inhibits the reaction [SP1 protein binds to SP1 promoter]	22172574\|2217257
D019327	Copper Sulfate	Copper Sulfate results in decreased activity of SP1 protein	22172574\|2624105
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of SP1 mRNA	22172574\|2291443
D019327	Copper Sulfate	[Copper Sulfate results in decreased expression of SP1 mRNA] which results in decreased expression of SLC31A1 mRNA	22172574
D019327	Copper Sulfate	Copper Sulfate results in increased expression of SP1 mRNA	19549813
D019327	Copper Sulfate	Zinc Sulfate inhibits the reaction [Copper Sulfate results in decreased activity of SP1 protein]	26241054
C058120	cordycepin	cordycepin inhibits the reaction [Etoposide results in increased activity of SP1 protein]	23690541
C058120	cordycepin	cordycepin inhibits the reaction [Etoposide results in increased expression of SP1 mRNA]	23690541
C029892	cupric chloride	cupric chloride inhibits the reaction [neocuproine results in decreased expression of SP1 mRNA]	21167140
C030973	cupric oxide	cupric oxide results in increased expression of SP1 mRNA	22077320
D003474	Curcumin	Curcumin results in decreased expression of SP1 protein	18347134\|1859393
D016572	Cyclosporine	[Cyclosporine co-treated with NGF protein] affects the localization of SP1 protein	24244623
D016572	Cyclosporine	[Cyclosporine co-treated with NGF protein] promotes the reaction [SP1 protein binds to CDKN1A promoter]	24244623
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of SP1 mRNA	23640034
C014347	decitabine	[decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to CLDN3 promoter]	17986852
C014347	decitabine	[[decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to SLC25A1 promoter]] which results in increased expression of SLC25A1 mRNA	18706393
C014347	decitabine	decitabine promotes the reaction [SP1 protein binds to CIDEA promoter]	18033804
C014347	decitabine	decitabine promotes the reaction [SP1 protein binds to CLDN3 promoter]	17986852
C014347	decitabine	decitabine promotes the reaction [SP1 protein binds to GSTM2 promoter]	21246532
C014347	decitabine	decitabine promotes the reaction [SP1 protein binds to SLC25A1 promoter]	18706393
C014347	decitabine	decitabine results in increased expression of SP1 mRNA	19027835
C014347	decitabine	decitabine results in increased expression of SP1 protein	19027835
C014347	decitabine	decitabine results in increased expression of SP1 mRNA	15251184\|2791501
C014347	decitabine	[Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of SP1 mRNA	15251184
D003676	Deferoxamine	[Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased activity of SP1 protein]	12633744
D003703	Demecolcine	Demecolcine results in decreased expression of SP1 mRNA	23649840
C576677	demycarosyl-3D-digitoxosylmithramycin SK	demycarosyl-3D-digitoxosylmithramycin SK results in decreased expression of SP1 mRNA	24907531
C007262	deoxynivalenol	deoxynivalenol promotes the reaction [SP1 protein binds to KMT2A promoter]	19438726
C007262	deoxynivalenol	deoxynivalenol results in increased phosphorylation of SP1 protein	19438726
C007262	deoxynivalenol	SP1 protein promotes the reaction [deoxynivalenol results in increased expression of KMT2A mRNA]	19438726
D003976	Diazinon	Diazinon results in increased methylation of SP1 gene	22964155
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of SP1 mRNA	29029336
D003993	Dibutyl Phthalate	[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of SP1 mRNA	29029336
D002945	Cisplatin	Cisplatin results in increased expression of SP1 mRNA	22914438\|2413275
D002945	Cisplatin	Cisplatin results in increased expression of SP1 protein	24132751
D002945	Cisplatin	[Cisplatin results in increased expression of SP1 protein] which results in increased expression of SLC31A1 mRNA	24132751
D002945	Cisplatin	Copper Sulfate inhibits the reaction [Cisplatin results in increased expression of SP1 mRNA]	24132751
D002945	Cisplatin	Cisplatin results in decreased expression of SP1 mRNA	21151649
D004051	Diethylhexyl Phthalate	[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of SP1 mRNA	29029336
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of SP1 protein	25242112
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of SP1 mRNA	16714842
D015127	9,10-Dimethyl-1,2-benzanthracene	"[[9,10-Dimethyl-1,2-benzanthracene co-treated with 12-O-tetradecanoylphorbol-1,3-acetate] results in increased activity of TRP53 protein] inhibits the reaction [SP1 protein binds to SOD2 promoter]"	22009531
D015127	9,10-Dimethyl-1,2-benzanthracene	"[[[9,10-Dimethyl-1,2-benzanthracene co-treated with 12-O-tetradecanoylphorbol-1,3-acetate] results in increased activity of TRP53 protein] inhibits the reaction [SP1 protein binds to SOD2 promoter]] which results in decreased expression of SOD2 mRNA"	22009531
D011397	Promegestone	mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter]]	16807381
D011397	Promegestone	Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter]	16807381
D011397	Promegestone	Promegestone results in increased expression of SP1 mRNA	16807381
D011397	Promegestone	Promegestone results in increased expression of SP1 protein	16807381
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide promotes the reaction [SP1 protein binds to CAD promoter]	16675542
D004147	Dioxins	Dioxins affects the expression of SP1 mRNA	20463971
D004317	Doxorubicin	Doxorubicin affects the activity of SP1 protein	17108358
D004317	Doxorubicin	Doxorubicin promotes the reaction [SP1 protein binds to BIRC5 promoter]	17124180
D004317	Doxorubicin	Doxorubicin promotes the reaction [SP1 protein binds to ESR1 promoter]	19351845
D004317	Doxorubicin	Doxorubicin promotes the reaction [TP53 protein binds to SP1 protein]	19351845
C413879	EKB 569	EKB 569 results in decreased activity of SP1 protein	22242139
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SP1 protein	23301498
C078846	epoxomicin	"epoxomicin inhibits the reaction [5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione results in decreased expression of SP1 protein]"	17409431
C078846	epoxomicin	"epoxomicin inhibits the reaction [5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione results in increased degradation of SP1 protein]"	17409431
C078846	epoxomicin	epoxomicin results in increased ubiquitination of SP1 protein	17409431
D000431	Ethanol	Ethanol promotes the reaction [SP1 protein binds to FASLG promoter]	24899502
D000431	Ethanol	Ethanol promotes the reaction [SP1 protein binds to CYP2B10 promoter]	27765815
D000431	Ethanol	PPARD gene mutant form inhibits the reaction [Ethanol promotes the reaction [SP1 protein binds to CYP2B10 promoter]]	27765815
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of SP1 mRNA	16954407
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased activity of SP1 protein	15878629
D004997	Ethinyl Estradiol	SP1 protein promotes the reaction [Ethinyl Estradiol results in increased expression of AGER mRNA]	15878629
D005033	Ethylmaleimide	Ethylmaleimide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein]	9343396
D005033	Ethylmaleimide	Ethylmaleimide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein]	9343396
D005047	Etoposide	Etoposide results in increased phosphorylation of SP1 protein	17441964
D005047	Etoposide	PRKDC protein promotes the reaction [Etoposide results in increased phosphorylation of SP1 protein]	17441964
D005047	Etoposide	wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of SP1 protein]	17441964
D005047	Etoposide	cordycepin inhibits the reaction [Etoposide results in increased activity of SP1 protein]	23690541
D005047	Etoposide	cordycepin inhibits the reaction [Etoposide results in increased expression of SP1 mRNA]	23690541
D005047	Etoposide	Etoposide results in increased activity of SP1 protein	23690541
D005047	Etoposide	Etoposide results in increased expression of SP1 mRNA	23690541
C063007	exoenzyme C3, Clostridium botulinum	"exoenzyme C3, Clostridium botulinum results in increased expression of SP1 mRNA"	27351882
D005472	Fluorouracil	Fluorouracil promotes the reaction [[TP53 protein binds to SP1 protein] which binds to CDKN1A promoter]	15489892
D005472	Fluorouracil	SP1 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]	18927307
D005485	Flutamide	Flutamide results in increased expression of SP1 mRNA	24793618
D005492	Folic Acid	Folic Acid inhibits the reaction [SP1 protein binds to IGF1R promoter]	16728583
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SP1 gene	20938992
C070081	fulvestrant	fulvestrant promotes the reaction [SP1 protein binds to ESRRA promoter]	20211987
D019833	Genistein	Genistein promotes the reaction [SP1 protein binds to VDR promoter]	17088408
D019833	Genistein	Genistein results in increased activity of SP1 protein	17088408
D019833	Genistein	Genistein results in increased expression of SP1 protein	24685904
D019833	Genistein	U 0126 inhibits the reaction [Genistein results in increased activity of SP1 protein]	17088408
D005839	Gentamicins	Gentamicins results in increased expression of SP1 mRNA	22061828
C097367	ginsenoside Rg3	"ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased expression of SP1 protein]"	26427350
D005947	Glucose	Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein]	11050244
D005947	Glucose	Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein]	11050244
D005947	Glucose	Glucose results in decreased phosphorylation of SP1 protein	11050244
D005947	Glucose	[Glucose results in increased chemical synthesis of Superoxides] which results in increased glycosylation of SP1 protein	11050244
D005947	Glucose	[[Glucose results in increased chemical synthesis of Superoxides] which results in increased glycosylation of SP1 protein] which results in increased expression of SERPINE1	11050244
D005947	Glucose	Glucose results in increased O-linked glycosylation of SP1 protein	11050244
D005947	Glucose	manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein]	11050244
D005947	Glucose	manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein]	11050244
D005947	Glucose	Thenoyltrifluoroacetone inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein]	11050244
D005947	Glucose	Thenoyltrifluoroacetone inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein]	11050244
D005947	Glucose	SOD2 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein]	11050244
D005947	Glucose	SOD2 protein inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein]	11050244
D005947	Glucose	UCP1 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein]	11050244
D005947	Glucose	UCP1 protein inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein]	11050244
D005947	Glucose	Glucose promotes the reaction [SP1 protein results in increased expression of SERPINE1 mRNA]	11050244
D005947	Glucose	[Glucose results in increased chemical synthesis of Superoxides] which results in decreased phosphorylation of SP1 protein	11696579
D005947	Glucose	[Glucose results in increased chemical synthesis of Superoxides] which results in increased O-linked glycosylation of SP1 protein	11696579
D005947	Glucose	[INS protein co-treated with Glucose] results in decreased expression of SP1 mRNA	22634610
D005978	Glutathione	Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP1 protein]	20435036
D005978	Glutathione	Glutathione results in decreased expression of SP1	18556457
C086566	glycitein	glycitein promotes the reaction [SP1 protein binds to VDR promoter]	17088408
C086566	glycitein	glycitein results in increased activity of SP1 protein	17088408
C086566	glycitein	U 0126 inhibits the reaction [glycitein results in increased activity of SP1 protein]	17088408
C007956	homocysteic acid	homocysteic acid results in increased activity of SP1 protein	11261509
C007956	homocysteic acid	mithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP1 protein]	11261509
D017313	Fenretinide	Fenretinide results in increased cleavage of and results in decreased activity of SP1 protein	9343396
D017313	Fenretinide	Fenretinide results in increased expression of SP1 mRNA	28973697
D006861	Hydrogen Peroxide	Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP1 protein]	20435036
D006861	Hydrogen Peroxide	Hydrogen Peroxide inhibits the reaction [SP1 protein binds to NOS3 promoter]	19105596
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of SP1 protein	20435036
D006861	Hydrogen Peroxide	SB 203580 inhibits the reaction [Hydrogen Peroxide promotes the reaction [SP1 protein results in increased expression of CAV1 protein]]	17108117
D006861	Hydrogen Peroxide	Hydrogen Peroxide inhibits the reaction [CAT protein promotes the reaction [SP1 protein binds to AHR promoter]]	21569840
D006861	Hydrogen Peroxide	Hydrogen Peroxide inhibits the reaction [[CAT protein promotes the reaction [SP1 protein binds to AHR promoter]] which results in increased expression of AHR mRNA]	21569840
D006861	Hydrogen Peroxide	Hydrogen Peroxide inhibits the reaction [SP1 protein binds to AHR promoter]	20478378\|2156984
D006861	Hydrogen Peroxide	Hydrogen Peroxide inhibits the reaction [[SP1 protein binds to AHR promoter] which results in increased expression of AHR mRNA]	21569840
D006861	Hydrogen Peroxide	Hydrogen Peroxide promotes the reaction [SP1 protein binds to CAV1 promoter]	17108117
D006861	Hydrogen Peroxide	Hydrogen Peroxide promotes the reaction [SP1 protein results in increased expression of CAV1 protein]	17108117
C021304	hyperoside	[Quercetin co-treated with hyperoside] inhibits the reaction [MIR27A mRNA results in increased expression of SP1 mRNA]	24173369
C021304	hyperoside	[Quercetin co-treated with hyperoside] results in decreased expression of SP1 mRNA	24173369
C021304	hyperoside	[Quercetin co-treated with hyperoside] results in decreased expression of SP1 protein	24173369
C016517	indole-3-carbinol	indole-3-carbinol analog inhibits the reaction [SP1 protein binds to CDK6 promoter]	20570586
C016517	indole-3-carbinol	indole-3-carbinol results in decreased activity of SP1 protein	16082211
D007460	Iodoacetamide	Iodoacetamide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein]	9343396
D007460	Iodoacetamide	Iodoacetamide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein]	9343396
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SP1 mRNA	25613284
C051890	irinotecan	irinotecan analog results in decreased expression of SP1 mRNA	18927307
C051890	irinotecan	irinotecan results in increased phosphorylation of SP1 protein	17441964
C051890	irinotecan	SP1 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]	18927307
D007501	Iron	[Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased activity of SP1 protein]	12633744
D007545	Isoproterenol	EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA]	10710348
D007545	Isoproterenol	[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA	10710348
C477508	jaceosidin	SP1 protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]	27729209
C477508	jaceosidin	SP1 protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein]	27729209
D007854	Lead	Lead results in increased expression of SP1 protein	22272629
D007854	Lead	Lead results in decreased activity of SP1 protein	11377384
C008261	lead acetate	lead acetate results in increased expression of SP1 protein	24462621
C008261	lead acetate	tolfenamic acid inhibits the reaction [lead acetate results in increased expression of SP1 protein]	24462621
C008261	lead acetate	lead acetate results in increased expression of SP1 mRNA	23973560
C008261	lead acetate	lead acetate results in increased expression of SP1 mRNA	23867794\|2426041
C008261	lead acetate	lead acetate results in increased expression of SP1 protein	23867794
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased activity of SP1 protein"	25680285
D008070	Lipopolysaccharides	Lipopolysaccharides promotes the reaction [SP1 protein binds to BAG3 promoter]	22020323
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SP1 mRNA	21911040
D008070	Lipopolysaccharides	trichostatin A inhibits the reaction [Lipopolysaccharides results in increased expression of SP1 mRNA]	21911040
D008070	Lipopolysaccharides	Sodium Selenite inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of SP1 protein]	15650415
D008345	Manganese	Manganese results in increased activity of and results in increased expression of SP1 protein	21169227
D008345	Manganese	Manganese promotes the reaction [SP1 protein modified form binds to CASP3 promoter]	22975163
D008345	Manganese	Manganese results in increased phosphorylation of and results in increased activity of SP1 protein	22975163
C097284	manganese(III)-tetrakis(4-benzoic acid)porphyrin	manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein]	11050244
C097284	manganese(III)-tetrakis(4-benzoic acid)porphyrin	manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein]	11050244
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of SP1 mRNA	16507785
D008627	Mercuric Chloride	Mercuric Chloride results in decreased activity of SP1 protein	11377384
D008665	Metalloporphyrins	[Metalloporphyrins affects the abundance of [Reactive Oxygen Species co-treated with Reactive Nitrogen Species]] which results in decreased activity of SP1 protein	20003708
D008687	Metformin	Metformin inhibits the reaction [SP1 protein results in increased expression of AHR protein]	25110054
D008687	Metformin	Metformin results in decreased expression of SP1 protein	25110054\|2631779
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SP1 gene	20938992
D008748	Methylcholanthrene	alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]]	29094188
D008748	Methylcholanthrene	alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of SP1 promoter]	29094188
D008748	Methylcholanthrene	alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of SP1 mRNA]	29094188
D008748	Methylcholanthrene	Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]	29094188
D008748	Methylcholanthrene	Methylcholanthrene results in increased acetylation of SP1 promoter	29094188
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of SP1 mRNA	29094188
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of SP1 mRNA	28001369
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of SP1 protein	28736149
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of SP1 mRNA	26011545
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"SP1 affects the susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"	25851821
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of and affects the localization of SP1 protein"	23538867
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA"	23538867
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]"	23538867
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]"	23538867
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]"	23538867
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]]"	23538867
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of and affects the localization of SP1 protein]"	23538867
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]"	23538867
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]"	23538867
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]"	23538867
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]]"	23538867
C008493	methylselenic acid	methylselenic acid inhibits the reaction [SP1 protein binds to BIRC5 promoter]	17876054
C100075	mibolerone	mibolerone promotes the reaction [SP1 protein binds to AR protein]	15661808
C100075	mibolerone	[Quercetin co-treated with mibolerone] promotes the reaction [SP1 protein binds to JUN protein]	20148354
C100075	mibolerone	[Quercetin co-treated with mibolerone] promotes the reaction [SP1 protein binds to JUN protein binds to AR protein]	20148354
C100075	mibolerone	Quercetin promotes the reaction [mibolerone promotes the reaction [SP1 protein binds to AR protein]]	15661808
C066851	mithramycin A	mithramycin A inhibits the reaction [Buthionine Sulfoximine results in increased activity of SP1 protein]	11261509
C066851	mithramycin A	mithramycin A inhibits the reaction [Camptothecin results in increased activity of SP1 protein]	11261509
C066851	mithramycin A	mithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP1 protein]	11261509
C066851	mithramycin A	mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter]]	16807381
C066851	mithramycin A	mithramycin A inhibits the reaction [SP1 protein binds to CDKN1A promoter]	15489892
C066851	mithramycin A	mithramycin A inhibits the reaction [SP1 protein binds to HSD17B2 promoter]	16807381
C066851	mithramycin A	mithramycin A inhibits the reaction [[SP1 protein binds to TINF2 promoter] which results in increased expression of TINF2 mRNA]	21731707
C066851	mithramycin A	mithramycin A inhibits the reaction [SP1 protein results in increased expression of ZBTB7A mRNA]	25875864
C066851	mithramycin A	mithramycin A inhibits the reaction [[TP53 protein binds to SP1 protein] which results in increased expression of BBC3 mRNA]	15489892
C066851	mithramycin A	mithramycin A inhibits the reaction [[TP53 protein binds to SP1 protein] which results in increased expression of CDKN1A mRNA]	15489892
C066851	mithramycin A	mithramycin A results in decreased expression of SP1 mRNA	24907531
C066851	mithramycin A	mithramycin A results in decreased expression of SP1 protein	26427350
C066851	mithramycin A	mithramycin A inhibits the reaction [CAT protein promotes the reaction [SP1 protein binds to AHR promoter]]	21569840
C066851	mithramycin A	mithramycin A inhibits the reaction [[CAT protein promotes the reaction [SP1 protein binds to AHR promoter]] which results in increased expression of AHR mRNA]	21569840
C066851	mithramycin A	mithramycin A inhibits the reaction [SP1 protein binds to AHR promoter]	20478378\|2156984
C066851	mithramycin A	mithramycin A inhibits the reaction [[SP1 protein binds to AHR promoter] which results in increased expression of AHR mRNA]	21569840
C066851	mithramycin A	"astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]"	23538867
C066851	mithramycin A	"astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]]"	23538867
C066851	mithramycin A	"[mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of and affects the localization of SP1 protein]"	23538867
C066851	mithramycin A	"mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]"	23538867
C066851	mithramycin A	"mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]"	23538867
C066851	mithramycin A	"mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]"	23538867
C066851	mithramycin A	"mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]]"	23538867
C066851	mithramycin A	mithramycin A results in decreased activity of SP1 protein	17124180\|1898024
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of SP1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of SP1 mRNA"	25554681
C002701	neocuproine	cupric chloride inhibits the reaction [neocuproine results in decreased expression of SP1 mRNA]	21167140
C002701	neocuproine	neocuproine results in decreased expression of SP1 mRNA	21167140
C002701	neocuproine	[neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased activity of SP1 protein]	12633744
D009532	Nickel	Nickel results in increased activity of SP1 protein	19403854
C028007	nickel monoxide	nickel monoxide results in decreased expression of SP1 mRNA	19167457
D009538	Nicotine	Nicotine promotes the reaction [GATA4 protein binds to SP1 protein]	24089524
D009538	Nicotine	Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein]	24089524
D009538	Nicotine	Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter]	24089524
D009538	Nicotine	Nicotine promotes the reaction [GATA6 protein binds to SP1 protein]	24089524
D009538	Nicotine	Nicotine promotes the reaction [[GATA6 protein binds to SP1 protein] which binds to CHRNA7 protein]	24089524
D026422	S-Nitrosoglutathione	S-Nitrosoglutathione results in increased activity of SP1 protein	14766015
C069741	norcantharidin	norcantharidin results in decreased activity of SP1 protein	19616522
C069741	norcantharidin	SP1 protein affects the reaction [norcantharidin results in decreased expression of MMP9 mRNA]	19616522
C025589	ochratoxin A	ochratoxin A results in decreased activity of SP1 protein	21554934
C025589	ochratoxin A	ochratoxin A results in decreased expression of SP1 mRNA	21554934
C090046	olomoucine	olomoucine results in increased expression of SP1 protein	14653808
C090046	olomoucine	olomoucine results in increased expression of SP1 mRNA	14653808
C090046	olomoucine	olomoucine results in increased expression of SP1 protein	14653808
C030110	oxaliplatin	oxaliplatin inhibits the reaction [SP1 protein binds to DUT promoter]	19015155
D010100	Oxygen	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of SP1 protein]	17307335
D010100	Oxygen	Oxygen deficiency results in increased expression of SP1 protein	17307335
D010100	Oxygen	SP1 protein affects the reaction [Oxygen deficiency results in increased expression of DDIT4 mRNA]	17307335
D010100	Oxygen	Oxygen deficiency results in increased phosphorylation of SP1 protein	23814049
C500026	palbociclib	palbociclib inhibits the reaction [[PDGFB protein binds to PDGFB protein] inhibits the reaction [RB1 protein binds to SP1 protein]]	21880723
C500026	palbociclib	palbociclib promotes the reaction [RB1 protein binds to SP1 protein]	21880723
D010396	Penicillamine	Penicillamine results in increased expression of SP1 mRNA	22914438
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of SP1 mRNA	23892564
D010634	Phenobarbital	Phenobarbital affects the expression of SP1 mRNA	23091169
D010656	Phenylephrine	EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA]	10710348
D010656	Phenylephrine	[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA	10710348
D010795	Phthalic Acids	Phthalic Acids results in increased expression of SP1 mRNA	21061450
D010936	Plant Extracts	Plant Extracts affects the localization of SP1 protein	23201449
D010936	Plant Extracts	Plant Extracts inhibits the reaction [SP1 protein binds to PLAU promoter]	23201449
D010936	Plant Extracts	Plant Extracts results in decreased activity of SP1 protein	23201449
D008926	Plicamycin	Plicamycin inhibits the reaction [SP1 protein binds to CDKN1A promoter]	24244623
D008926	Plicamycin	Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter]	21603612
D008926	Plicamycin	[Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter]] which results in increased expression of TNFSF10 protein	21603612
D008926	Plicamycin	Plicamycin results in decreased activity of SP1 protein	15946989
D008926	Plicamycin	[Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 mRNA]	17307335
D008926	Plicamycin	[Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 protein]	17307335
D008926	Plicamycin	Plicamycin results in decreased expression of SP1 mRNA	23814049
D008926	Plicamycin	Plicamycin results in decreased activity of SP1 protein	15690306\|1629175
C045950	propiconazole	propiconazole results in decreased expression of SP1 mRNA	21278054
D047428	Protein Kinase Inhibitors	Protein Kinase Inhibitors inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of SP1 protein]	26385185
C107773	pterostilbene	SP1 protein affects the reaction [[pterostilbene co-treated with Quercetin] results in increased expression of SOD2 protein]	18852136
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]	23816505
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein]	23816505
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of SP1 protein]	26385185
D011794	Quercetin	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin promotes the reaction [SP1 protein binds to PLAT promoter]]	18419748
D011794	Quercetin	[Quercetin co-treated with hyperoside] inhibits the reaction [MIR27A mRNA results in increased expression of SP1 mRNA]	24173369
D011794	Quercetin	[Quercetin co-treated with hyperoside] results in decreased expression of SP1 mRNA	24173369
D011794	Quercetin	[Quercetin co-treated with hyperoside] results in decreased expression of SP1 protein	24173369
D011794	Quercetin	[Quercetin co-treated with mibolerone] promotes the reaction [SP1 protein binds to JUN protein]	20148354
D011794	Quercetin	[Quercetin co-treated with mibolerone] promotes the reaction [SP1 protein binds to JUN protein binds to AR protein]	20148354
D011794	Quercetin	Quercetin inhibits the reaction [SP1 protein binds to BIRC5 promoter]	18377872
D011794	Quercetin	Quercetin inhibits the reaction [SP1 protein promotes the reaction [AR protein results in increased expression of HK2 mRNA]]	15661808
D011794	Quercetin	Quercetin inhibits the reaction [SP1 protein promotes the reaction [AR protein results in increased expression of KLK3 mRNA]]	15661808
D011794	Quercetin	Quercetin inhibits the reaction [SP1 protein results in increased expression of AR mRNA]	15661808
D011794	Quercetin	Quercetin promotes the reaction [AR protein binds to SP1 protein]	15661808
D011794	Quercetin	Quercetin promotes the reaction [mibolerone promotes the reaction [SP1 protein binds to AR protein]]	15661808
D011794	Quercetin	Quercetin promotes the reaction [SP1 protein binds to PLAT promoter]	18419748
D011794	Quercetin	Quercetin results in decreased expression of SP1 protein	18377872
D011794	Quercetin	Quercetin results in increased activity of SP1 protein	18980244
D011794	Quercetin	[resveratrol co-treated with Quercetin] results in decreased expression of SP1 mRNA	23530649
D011794	Quercetin	[resveratrol co-treated with Quercetin] results in decreased expression of SP1 protein	23530649
D011794	Quercetin	SP1 protein affects the reaction [[pterostilbene co-treated with Quercetin] results in increased expression of SOD2 protein]	18852136
D011794	Quercetin	SP1 protein promotes the reaction [Quercetin results in increased expression of TNFRSF10B mRNA]	18980244
D011794	Quercetin	MAPK14 protein promotes the reaction [Quercetin promotes the reaction [SP1 protein binds to ABCA1 promoter]]	22711909
D011794	Quercetin	Quercetin promotes the reaction [SP1 protein binds to ABCA1 promoter]	22711909
D011794	Quercetin	Quercetin promotes the reaction [SP1 protein binds to NR1H3 promoter]	22711909
D011794	Quercetin	SP1 protein affects the reaction [Quercetin results in decreased activity of AR protein]	20148354
D011794	Quercetin	SP1 protein affects the reaction [Quercetin results in decreased expression of AR mRNA]	20148354
D011796	Quinacrine	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of SP1 protein]	28867437
D011796	Quinacrine	BTRC protein inhibits the reaction [Quinacrine results in increased expression of SP1 protein]	28867437
D011796	Quinacrine	FOXP3 protein affects the reaction [Quinacrine results in increased expression of SP1 protein]	28867437
D011796	Quinacrine	MIR183 mRNA affects the reaction [Quinacrine results in increased expression of SP1 protein]	28867437
D011796	Quinacrine	Quinacrine promotes the reaction [SP1 protein binds to BAX promoter]	28867437
D011796	Quinacrine	Quinacrine results in increased expression of and results in increased stability of SP1 protein	28867437
D026361	Reactive Nitrogen Species	[Metalloporphyrins affects the abundance of [Reactive Oxygen Species co-treated with Reactive Nitrogen Species]] which results in decreased activity of SP1 protein	20003708
D017382	Reactive Oxygen Species	[Metalloporphyrins affects the abundance of [Reactive Oxygen Species co-treated with Reactive Nitrogen Species]] which results in decreased activity of SP1 protein	20003708
C059514	resveratrol	resveratrol affects the localization of SP1 protein	23437203
C059514	resveratrol	[resveratrol co-treated with clofarabine] affects the localization of SP1 protein	23146690
C059514	resveratrol	[resveratrol co-treated with clofarabine] results in decreased expression of SP1 protein	23146690
C059514	resveratrol	[resveratrol co-treated with Quercetin] results in decreased expression of SP1 mRNA	23530649
C059514	resveratrol	[resveratrol co-treated with Quercetin] results in decreased expression of SP1 protein	23530649
C059514	resveratrol	resveratrol inhibits the reaction [SP1 protein binds to HDAC1 protein]	25875864
C059514	resveratrol	resveratrol inhibits the reaction [SP1 protein binds to PLAU promoter]	23437203
C059514	resveratrol	resveratrol inhibits the reaction [SP1 protein binds to ZBTB7A promoter]	25875864
C059514	resveratrol	resveratrol inhibits the reaction [SP1 protein results in increased expression of ZBTB7A mRNA]	25875864
C059514	resveratrol	resveratrol inhibits the reaction [TNF protein results in increased activity of SP1 protein]	16614140
C059514	resveratrol	resveratrol promotes the reaction [HDAC1 protein binds to SP1 protein]	25875864
C059514	resveratrol	resveratrol promotes the reaction [SP1 protein binds to DDIT3 promoter]	17049495
C059514	resveratrol	resveratrol results in decreased acetylation of SP1 protein	25875864
C059514	resveratrol	resveratrol results in decreased activity of SP1 protein	23437203
C059514	resveratrol	resveratrol results in increased activity of SP1 protein	17049495
C059514	resveratrol	resveratrol results in decreased expression of SP1 protein	25505154
C059514	resveratrol	resveratrol results in decreased activity of SP1 protein	18420994
C059514	resveratrol	resveratrol results in decreased expression of SP1 mRNA	25905778
C104586	roscovitine	roscovitine results in increased expression of SP1 protein	14653808
C104586	roscovitine	roscovitine results in increased expression of SP1 mRNA	14653808
C104586	roscovitine	roscovitine results in increased expression of SP1 protein	14653808
C089730	rosiglitazone	rosiglitazone results in decreased expression of SP1 protein	15908479
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of SP1 mRNA	21427059
C093642	SB 203580	SB 203580 inhibits the reaction [Hydrogen Peroxide promotes the reaction [SP1 protein results in increased expression of CAV1 protein]]	17108117
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of SP1 mRNA	25351596
D012834	Silver	Silver results in decreased expression of SP1 mRNA	26551752
D012835	Silver Nitrate	Silver Nitrate results in increased expression of SP1 mRNA	24132751
D019821	Simvastatin	Simvastatin inhibits the reaction [SP1 binds to COL1A1 promoter]	16575855
C017947	sodium arsenite	sodium arsenite results in increased expression of SP1 mRNA	23562784
C016104	sodium bichromate	sodium bichromate results in increased activity of SP1 protein	10411148
D012965	Sodium Chloride	pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]	23816505
D012965	Sodium Chloride	pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein]	23816505
D012965	Sodium Chloride	Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]	23816505
D012965	Sodium Chloride	Sodium Chloride results in increased expression of SP1 protein	23816505
D012965	Sodium Chloride	U 0126 inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]	23816505
D012965	Sodium Chloride	U 0126 inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein]	23816505
D012965	Sodium Chloride	[[SP1 protein co-treated with JUN protein] binds to CLDN4 promoter] promotes the reaction [Sodium Chloride results in increased expression of CLDN4 protein]	23816505
D018038	Sodium Selenite	Acetylcysteine inhibits the reaction [Sodium Selenite results in decreased expression of SP1 protein]	16928829
D018038	Sodium Selenite	[Sodium Selenite results in decreased activity of SP1 protein] which results in decreased expression of AR protein	16928829
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of and results in decreased activity of SP1 protein	16928829
D018038	Sodium Selenite	Sodium Selenite inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of SP1 protein]	15650415
D013481	Superoxides	[Glucose results in increased chemical synthesis of Superoxides] which results in increased glycosylation of SP1 protein	11050244
D013481	Superoxides	[[Glucose results in increased chemical synthesis of Superoxides] which results in increased glycosylation of SP1 protein] which results in increased expression of SERPINE1	11050244
D013481	Superoxides	[Glucose results in increased chemical synthesis of Superoxides] which results in decreased phosphorylation of SP1 protein	11696579
D013481	Superoxides	[Glucose results in increased chemical synthesis of Superoxides] which results in increased O-linked glycosylation of SP1 protein	11696579
D000952	Antigens, Polyomavirus Transforming	"Antigens, Polyomavirus Transforming results in increased expression of SP1 mRNA"	26680231
D013629	Tamoxifen	Tamoxifen promotes the reaction [[ESR1 protein binds to SP1 protein] which binds to E2F1 promoter]	20215421
D013629	Tamoxifen	Tamoxifen promotes the reaction [[[ESR1 protein binds to SP1 protein] which binds to E2F1 promoter] which results in increased expression of E2F1 mRNA]	20215421
D013629	Tamoxifen	Tamoxifen promotes the reaction [SP1 protein binds to ESR1 protein]	20215421
D013629	Tamoxifen	Tamoxifen promotes the reaction [SP1 protein binds to ESRRA promoter]	20211987
D013629	Tamoxifen	Tamoxifen promotes the reaction [[SP1 protein binds to PEMT promoter] which results in decreased expression of PEMT mRNA]	20150657
C076852	terameprocol	terameprocol inhibits the reaction [SP1 protein results in increased expression of ABCB1 mRNA]	16544145
C076852	terameprocol	terameprocol results in decreased activity of SP1 protein	16544145
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of SP1 mRNA	20189893
D013749	Tetrachlorodibenzodioxin	Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [SP1 protein binds to CYP1A1 promoter]]	16675542
D013749	Tetrachlorodibenzodioxin	[SP1 protein binds to CYP1B1 enhancer] promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]	12801909
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to SP1 protein]]	16675542
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased phosphorylation of SP1 protein	20971882
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased activity of SP1 protein	9707505
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SP1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of SP1 mRNA	15251184
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SP1 mRNA	14708085\|2405805
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the activity of SP1 protein	11926288
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of SP1 mRNA	28973375
D013755	Tetradecanoylphorbol Acetate	SP1 protein affects the susceptibility to Tetradecanoylphorbol Acetate	10669635
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased activity of SP1 protein	10669635
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of SP1 mRNA	10669635
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of SP1 protein	10669635
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of SP1 protein	24244623
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate promotes the reaction [SP1 protein binds to CDKN1A promoter]	15978937
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate promotes the reaction [[SP1 protein binds to SOD2 promoter] which results in increased expression of SOD2 mRNA]	10669635
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased activity of SP1 protein	15978937
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of SP1 mRNA	27351882
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SP1 mRNA	25613284
C020809	tetrathiomolybdate	tetrathiomolybdate promotes the reaction [SP1 protein binds to SLC31A1 promoter]	22172574
C020809	tetrathiomolybdate	tetrathiomolybdate promotes the reaction [SP1 protein binds to SP1 promoter]	22172574\|2217257
C020809	tetrathiomolybdate	[tetrathiomolybdate results in decreased abundance of Copper] which results in increased expression of SP1 protein	22172574
C020809	tetrathiomolybdate	tetrathiomolybdate results in increased activity of SP1 protein	22172574
C020809	tetrathiomolybdate	tetrathiomolybdate results in increased expression of SP1	22172574
C020809	tetrathiomolybdate	tetrathiomolybdate results in increased expression of SP1 mRNA	22914438
D013792	Thalidomide	Thalidomide results in decreased activity of SP1 protein	10533722
D013804	Thenoyltrifluoroacetone	Thenoyltrifluoroacetone inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein]	11050244
D013804	Thenoyltrifluoroacetone	Thenoyltrifluoroacetone inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein]	11050244
D008063	Thioctic Acid	Thioctic Acid results in increased phosphorylation of and results in decreased activity of SP1 protein	21351249
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased activity of SP1 protein	24706507
C009500	tolfenamic acid	tolfenamic acid inhibits the reaction [lead acetate results in increased expression of SP1 protein]	24462621
D014212	Tretinoin	arsenic trioxide promotes the reaction [Tretinoin results in increased expression of SP1 protein]	26892147
D014212	Tretinoin	Tretinoin promotes the reaction [SP1 protein binds to FOLR2 promoter]	16740727
D014212	Tretinoin	Tretinoin promotes the reaction [SP1 protein binds to HAS2 promoter]	17307735
D014212	Tretinoin	Tretinoin promotes the reaction [SP1 protein binds to PDK4 promoter]	16757381
D014212	Tretinoin	Tretinoin results in increased activity of SP1 protein	16757381
D014212	Tretinoin	Tretinoin results in increased expression of SP1 mRNA	23724009
D014212	Tretinoin	Tretinoin results in increased expression of SP1 protein	26892147
D014212	Tretinoin	trichostatin A promotes the reaction [Tretinoin promotes the reaction [SP1 protein binds to FOLR2 promoter]]	16740727
D014212	Tretinoin	Tretinoin results in increased activity of SP1 protein	17097063
C447082	tricarbonyldichlororuthenium (II) dimer	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of SP1 protein]	26385185
C447082	tricarbonyldichlororuthenium (II) dimer	"6,7-dimethoxy-3-phenylquinoxaline inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of SP1 protein]"	26385185
C447082	tricarbonyldichlororuthenium (II) dimer	AKT1 protein promotes the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of SP1 protein]	26385185
C447082	tricarbonyldichlororuthenium (II) dimer	Protein Kinase Inhibitors inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of SP1 protein]	26385185
C447082	tricarbonyldichlororuthenium (II) dimer	pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of SP1 protein]	26385185
C447082	tricarbonyldichlororuthenium (II) dimer	SP1 protein promotes the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 protein]	26385185
C447082	tricarbonyldichlororuthenium (II) dimer	tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of SP1 protein	26385185
D014241	Trichloroethylene	Trichloroethylene results in increased expression of SP1 mRNA	21135412
C012589	trichostatin A	[decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to CLDN3 promoter]	17986852
C012589	trichostatin A	[[decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to SLC25A1 promoter]] which results in increased expression of SLC25A1 mRNA	18706393
C012589	trichostatin A	SP1 protein affects the reaction [trichostatin A affects the expression of GDF15 mRNA]	18801729
C012589	trichostatin A	trichostatin A affects the expression of SP1 mRNA	18801729
C012589	trichostatin A	trichostatin A affects the expression of SP1 protein	18801729
C012589	trichostatin A	trichostatin A inhibits the reaction [Lipopolysaccharides results in increased expression of SP1 mRNA]	21911040
C012589	trichostatin A	trichostatin A promotes the reaction [SP1 protein binds to PDK4 promoter]	16757381
C012589	trichostatin A	trichostatin A promotes the reaction [SP1 protein binds to SLC25A1 promoter]	18706393
C012589	trichostatin A	trichostatin A promotes the reaction [Tretinoin promotes the reaction [SP1 protein binds to FOLR2 promoter]]	16740727
C012589	trichostatin A	trichostatin A results in increased activity of SP1 protein	16757381
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SP1 mRNA"	23306105
C057693	troglitazone	troglitazone results in decreased expression of SP1 protein	15908479\|1740943
C057693	troglitazone	troglitazone results in increased degradation of SP1 protein	17409431
C057693	troglitazone	[troglitazone results in increased degradation of SP1 protein] which results in decreased expression of AR mRNA	17409431
C057693	troglitazone	troglitazone results in decreased expression of SP1 mRNA	28973697
C118632	tyrosyl-valyl-alanyl-aspartal	tyrosyl-valyl-alanyl-aspartal analog inhibits the reaction [CD 437 results in increased cleavage of SP1 protein]	9343396
C118632	tyrosyl-valyl-alanyl-aspartal	tyrosyl-valyl-alanyl-aspartal analog inhibits the reaction [CD 437 results in increased cleavage of SP1 protein]	9343396
C113580	U 0126	U 0126 inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]	23816505
C113580	U 0126	U 0126 inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein]	23816505
C113580	U 0126	U 0126 inhibits the reaction [Estradiol results in increased activity of SP1 protein]	17088408
C113580	U 0126	U 0126 inhibits the reaction [Genistein results in increased activity of SP1 protein]	17088408
C113580	U 0126	U 0126 inhibits the reaction [glycitein results in increased activity of SP1 protein]	17088408
D014520	Urethane	Urethane results in decreased expression of SP1 mRNA	28818685
D014635	Valproic Acid	Valproic Acid promotes the reaction [SP1 protein binds to XPC promoter]	21507255
D014635	Valproic Acid	Valproic Acid results in decreased expression of SP1 mRNA	23179753\|2800136
D014635	Valproic Acid	Valproic Acid results in decreased expression of SP1 mRNA	21427059
D014750	Vincristine	Vincristine results in decreased expression of SP1 mRNA	23649840
C111237	vorinostat	SP1 protein promotes the reaction [vorinostat results in increased expression of CDKN1A mRNA]	11126357
C009687	wortmannin	wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of SP1 protein]	17441964
D015032	Zinc	Cadmium inhibits the reaction [SP1 protein binds to Zinc]	20073493
D015032	Zinc	Cadmium inhibits the reaction [[SP1 protein binds to Zinc] which binds to SLC5A1 promoter]	20073493
D015032	Zinc	Cadmium results in decreased activity of [SP1 protein binds to Zinc]	20073493
D015032	Zinc	SP1 protein binds to Zinc	20073493
D015032	Zinc	Zinc deficiency results in increased activity of SP1 protein	18356318
D015032	Zinc	Zinc inhibits the reaction [Cadmium inhibits the reaction [[SP1 protein binds to Zinc] which binds to SLC5A1 promoter]]	20073493
D015032	Zinc	Zinc promotes the reaction [MTF1 protein binds to SP1 protein]	18458062
D015032	Zinc	Zinc promotes the reaction [MTF1 protein promotes the reaction [EP300 protein binds to SP1 protein]]	18458062
D015032	Zinc	Zinc deficiency results in decreased expression of SP1 protein	21893222
D019345	Zinc Acetate	Zinc Acetate results in increased expression of SP1 mRNA	24132751
C016837	zinc chloride	zinc chloride results in increased activity of SP1 protein	9330853
C016837	zinc chloride	zinc chloride inhibits the reaction [Cadmium Chloride inhibits the reaction [SP1 protein binds to and affects the expression of SLC5A1 promoter]]	20060848
D019287	Zinc Sulfate	Zinc Sulfate inhibits the reaction [Copper Sulfate results in decreased activity of SP1 protein]	26241054
C088658	zoledronic acid	zoledronic acid results in increased expression of SP1 mRNA	20977926

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	-	IDA	14979875
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	16691198 21659522
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	ISS	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	IBA	21873635
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	21659522
GO:0000987	proximal promoter sequence-specific DNA binding	-	ISS	10362258
GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	16691198
GO:0001103	RNA polymerase II repressing transcription factor binding	-	ISS	-
GO:0003677	DNA binding	-	IDA	12560508
GO:0003690	double-stranded DNA binding	-	IDA	20371611
GO:0003700	DNA-binding transcription factor activity	-	IDA	12169688 12560508
GO:0005515	protein binding	-	IPI	7824954 8551580 8657141 9328340 9466902 10393239 10976766 10987820 11237613 11988536 12021324 12665574 12665582 12670868 12771217 12847090 15710382 17024177 17075044 17418410 17474147 18003922 18519037 19070619 19505873 19666599 20936779 21184768 21297662 21555589 21831840 24396070 25609694
GO:0008022	protein C-terminus binding	-	IPI	10816420
GO:0008134	transcription factor binding	-	IPI	14988427 20716579
GO:0035035	histone acetyltransferase binding	-	IEA	-
GO:0042803	protein homodimerization activity	-	IDA	10393239
GO:0042826	histone deacetylase binding	-	IPI	17827154 18850004
GO:0043425	bHLH transcription factor binding	-	ISS	-
GO:0043565	sequence-specific DNA binding	-	IDA	12169688
GO:0044212	transcription regulatory region DNA binding	-	IDA	18293083 18850004
GO:0046872	metal ion binding	-	IEA	-
GO:0070491	repressing transcription factor binding	-	IPI	16691198
GO:0071837	HMG box domain binding	-	IPI	16582099

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006355	regulation of transcription, DNA-templated	-	IDA	12169688 12560508
GO:0006357	regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0010628	positive regulation of gene expression	-	IMP	23802567 24244514
GO:0016032	viral process	-	IEA	-
GO:0032869	cellular response to insulin stimulus	-	IEA	-
GO:0033194	response to hydroperoxide	-	ISS	-
GO:0042795	snRNA transcription by RNA polymerase II	-	TAS	-
GO:0043536	positive regulation of blood vessel endothelial cell migration	-	IMP	23802567
GO:0043923	positive regulation by host of viral transcription	-	IDA	2833704
GO:0045540	regulation of cholesterol biosynthetic process	-	TAS	-
GO:0045766	positive regulation of angiogenesis	-	IMP	23802567
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	12771217 14580349
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	2833704 12169688 16691198 19263243 27030318
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IGI	14979875
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IMP	14979875
GO:0045944	positive regulation of transcription by RNA polymerase II	-	TAS	-
GO:0048511	rhythmic process	-	IEA	-
GO:0100057	regulation of phenotypic switching by transcription from RNA polymerase II promoter	-	IC	21659522
GO:1904828	positive regulation of hydrogen sulfide biosynthetic process	-	IDA	21659522
GO:1905564	positive regulation of vascular endothelial cell proliferation	-	IMP	23802567

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000790	nuclear chromatin	-	IDA	15831516 21659522 27030318
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IC	3139301 12169688
GO:0005654	nucleoplasm	-	IDA	12498690
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IEA	-
GO:0017053	transcriptional repressor complex	-	IDA	16691198
GO:0032993	protein-DNA complex	-	ISS	10362258

KEGG ID	KEGG Term
hsa04350	TGF-beta signaling pathway
hsa05016	Huntington's disease

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	TAS
R-HSA-170834	Signaling by TGF-beta Receptor Complex	TAS
R-HSA-1989781	PPARA activates gene expression	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	TAS
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	TAS
R-HSA-2559583	Cellular Senescence	TAS
R-HSA-2559585	Oncogene Induced Senescence	TAS
R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-6807505	RNA polymerase II transcribes snRNA genes	TAS
R-HSA-6807505	RNA polymerase II transcribes snRNA genes	IEA
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-8939211	ESR-mediated signaling	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-8957322	Metabolism of steroids	TAS
R-HSA-9006931	Signaling by Nuclear Receptors	TAS
R-HSA-9006936	Signaling by TGF-beta family members	TAS
R-HSA-9018519	Estrogen-dependent gene expression	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20696214	A transcriptional regulatory element critical for CHRNB4 promoter activity in vivo. (2010 Nov 10)	Scofield MD	Neuroscience
24566004	Combined effects of collagen type I alpha1 (COL1A1) Sp1 polymorphism and osteoporosis risk factors on bone mineral density in Turkish postmenopausal women. (2014 May 1)	Kurt-Sirin O	Gene
26612555	Secondhand smoke induces hepatic apoptosis and fibrosis in hamster fetus. (2016 Sep)	Huang CW	Hum Exp Toxicol
9622381	A new genetic variant in the Sp1 binding cis-element of cholecystokinin gene promoter region and relationship to alcoholism. (1998 May)	Harada S	Alcohol Clin Exp Res
28423585	The rs1550117 A>G variant in DNMT3A gene promoter significantly increases non-small cell lung cancer susceptibility in a Han Chinese population. (2017 Apr 4)	Wang J	Oncotarget
18226133	Effects of hormone replacement therapy on bone mineral density in Turkish patients with or without COL1A1 Sp1 binding site polymorphism. (2008 Feb)	Simsek M	J Obstet Gynaecol Res
18559624	MDM2 promoter polymorphism and pancreatic cancer risk and prognosis. (2008 Jun 15)	Asomaning K	Clin Cancer Res
15266830	[Protective and therapeutic effect of pulmonary surfactant on the experimental chronic obstructive pulmonary disease in hamsters]. (2004 Jun)	Li L	Zhongguo Yi Xue Ke Xue Yuan Xue Bao
22751465	Mithramycin represses basal and cigarette smoke-induced expression of ABCG2 and inhibits stem cell signaling in lung and esophageal cancer cells. (2012 Aug 15)	Zhang M	Cancer Res
12438229	Correlation between a single nucleotide polymorphism in the matrix metalloproteinase-2 promoter and risk of lung cancer. (2002 Nov 15)	Yu C	Cancer Res
24706507	Lumbrokinase from earthworm extract ameliorates second-hand smoke-induced cardiac fibrosis. (2015 Sep)	Lai CH	Environ Toxicol
26369651	Impact of the introduction of standardised packaging on smokers' brand awareness and identification in Australia. (2015 Sep 15)	Balmford J	Drug Alcohol Rev
10220011	No association between C-45T polymorphism in the Sp1 binding site of the promoter region of the cholecystokinin gene and alcoholism. (1999 Feb 22)	Ishiguro H	Psychiatry Res
24277932	Ethanol-induced upregulation of 10-formyltetrahydrofolate dehydrogenase helps relieve ethanol-induced oxidative stress. (2014 Feb)	Hsiao TH	Mol Cell Biol
16009674	Influence of IL-6, COL1A1, and VDR gene polymorphisms on bone mineral density in Crohn's disease. (2005 Nov)	Todhunter CE	Gut
27990118	Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies. (2016)	Thompson MD	Front Pharmacol
6970355	Effect of smoking on maternal blood SP1 levels in late pregnancy. (1981 Feb)	Lee JN	Obstet Gynecol
21957825	Elevated levels of DNA methylation at the OPRM1 promoter in blood and sperm from male opioid addicts. (2011 Jul-Aug)	Chorbov VM	J Opioid Manag
10803770	Genetic polymorphism of the CCK gene in patients with alcohol withdrawal symptoms. (2000 Apr)	Okubo T	Alcohol Clin Exp Res
18617682	Identification of a cigarette smoke-responsive region in the distal MMP-1 promoter. (2009 Jan)	Mercer BA	Am J Respir Cell Mol Biol
26744613	Study of regulatory promoter polymorphism (-248 G>A) of Bax gene in patients with gastric cancer in the northern provinces of Iran. (2016 Winter)	Mirmajidi SH	Gastroenterol Hepatol Bed Bench
10889557	Function of the C-36 to T polymorphism in the human cholecystokinin gene promoter. (2000 Jul)	Hansen TV	Mol Psychiatry
24089524	Nicotine induces the up-regulation of the alpha7-nicotinic receptor (alpha7-nAChR) in human squamous cell lung cancer cells via the Sp1/GATA protein pathway. (2013 Nov 15)	Brown KC	J Biol Chem
10697413	Regulation of the mammalian alcohol dehydrogenase genes. (2000)	Edenberg HJ	Prog Nucleic Acid Res Mol Biol
9610745	Collagen Ialpha1 Sp1 polymorphism, bone mass, and bone turnover in healthy French premenopausal women: the OFELY study. (1998 May)	Garnero P	J Bone Miner Res
15767339	PTGS2 (COX-2) -765G > C promoter variant reduces risk of colorectal adenoma among nonusers of nonsteroidal anti-inflammatory drugs. (2005 Mar)	Ulrich CM	Cancer Epidemiol Biomarkers Prev
11566920	Effect of a COL1A1 Sp1 binding site polymorphism on arterial pulse wave velocity: an index of compliance. (2001 Sep)	Brull DJ	Hypertension
24358207	Nicotine-induced expression of low-density lipoprotein receptor in oral epithelial cells. (2013)	Ito S	PLoS One
11509018	Cholecystokinin (CCK) gene as a possible risk factor for smoking: a replication in two independent samples. (2001 Aug)	Comings DE	Mol Genet Metab
19718407	Polymorphism of a COLIA1 gene Sp1 binding site in Korean women with pelvic organ prolapse. (2009 Aug 31)	Cho HJ	Yonsei Med J
17854076	A variant of the Cockayne syndrome B gene ERCC6 confers risk of lung cancer. (2008 Jan)	Lin Z	Hum Mutat