Gene: SP3

6670
SPR2
Sp3 transcription factor
protein-coding
2q31.1
Ensembl:ENSG00000172845 MIM:601804 Vega:OTTHUMG00000132333 UniprotKB:Q02447
NG_029153.1
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.326e-1 (AD)  8.567e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNPO10.907
SUZ120.904
UBXN40.903
MARCH70.898
CD1640.892
COPB10.892
LMAN10.89
SYNCRIP0.886
FNDC3A0.886
UBE2J10.885

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.645
OR4F29-0.618
LCN1-0.177
SPRR2D-0.176
SPRR2A-0.172
TGM3-0.162
TMPRSS11B-0.159
OR8G1-0.154
MUC21-0.153
KCNG2-0.146

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of SP3 mRNA28329830
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SP3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SP3 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SP3 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SP3 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SP3 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of SP3 mRNA20435036
C006632arsenic trioxidearsenic trioxide results in decreased expression of SP3 protein20435036
D001205Ascorbic AcidAscorbic Acid results in decreased expression of SP3 protein21919647
D001554BenzeneBenzene results in increased expression of SP3 mRNA21382456
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SP3 mRNA22300585
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SP3 mRNA"19150397
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SP3 protein]25068794
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SP3 protein25068794
C044887beta-methylcholinebeta-methylcholine affects the expression of SP3 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of SP3 mRNA26562050
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased activity of SP3 protein11261509
D019328Buthionine Sulfoximinemithramycin A inhibits the reaction [Buthionine Sulfoximine results in increased activity of SP3 protein]11261509
C584509C646 compoundC646 compound results in decreased expression of SP3 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [SP1 protein binds to SP3 protein binds to KLF4 protein binds to E2F1 protein binds to NECTIN2 promoter]25046863
D002166CamptothecinCamptothecin results in increased activity of SP3 protein11261509
D002166Camptothecinmithramycin A inhibits the reaction [Camptothecin results in increased activity of SP3 protein]11261509
D002220CarbamazepineCarbamazepine affects the expression of SP3 mRNA25979313
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of SP3 mRNA24763279
D002994ClofibrateClofibrate affects the expression of SP3 mRNA16081524
D003300CopperCopper affects the expression of SP3 protein22172574
D019327Copper SulfateCopper Sulfate results in increased expression of SP322172574
D003474CurcuminCurcumin results in decreased expression of SP3 protein18593936
D003630DaunorubicinDaunorubicin results in increased expression of SP3 protein19698806
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SP3 mRNA23914054
C014347decitabine[decitabine co-treated with trichostatin A] promotes the reaction [SP3 protein binds to CLDN3 promoter]17986852
C014347decitabinedecitabine promotes the reaction [SP3 protein binds to CIDEA promoter]18033804
C014347decitabinedecitabine promotes the reaction [SP3 protein binds to CLDN3 promoter]17986852
C576677demycarosyl-3D-digitoxosylmithramycin SKdemycarosyl-3D-digitoxosylmithramycin SK results in decreased expression of SP3 mRNA24907531
C000944dicrotophosdicrotophos results in decreased expression of SP3 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SP3 mRNA26924002
D004051Diethylhexyl Phthalatebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SP3 protein]25068794
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate inhibits the reaction [SP3 protein binds to NGB promoter]25068794
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate inhibits the reaction [SP3 protein binds to PTGS2 promoter]25068794
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased acetylation of and results in increased ubiquitination of SP3 protein25068794
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SP3 protein25068794
D004051Diethylhexyl PhthalateHDAC4 mutant form inhibits the reaction [Diethylhexyl Phthalate results in decreased acetylation of and results in increased ubiquitination of SP3 protein]25068794
D004051Diethylhexyl PhthalateMC1568 inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [SP3 protein binds to NGB promoter]]25068794
D004051Diethylhexyl PhthalateMC1568 inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [SP3 protein binds to PTGS2 promoter]]25068794
D004051Diethylhexyl PhthalateMC1568 inhibits the reaction [Diethylhexyl Phthalate results in decreased acetylation of and results in increased ubiquitination of SP3 protein]25068794
D004051Diethylhexyl PhthalateMC1568 inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SP3 protein]25068794
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SP3 protein25068794
D004051Diethylhexyl PhthalateHDAC4 mutant form inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SP3 protein]25068794
D011397Promegestonemithramycin A inhibits the reaction [Promegestone promotes the reaction [SP3 protein binds to HSD17B2 promoter]]16807381
D011397PromegestonePromegestone promotes the reaction [SP3 protein binds to HSD17B2 promoter]16807381
D011397PromegestonePromegestone results in increased expression of SP3 mRNA16807381
D011397PromegestonePromegestone results in increased expression of SP3 protein16807381
C024629dimethyl phthalatedimethyl phthalate affects the expression of SP3 mRNA26924002
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SP3 protein23301498
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SP3 mRNA17942748
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of SP3 mRNA28329830
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of SP3 mRNA]15016801
C070081fulvestrantfulvestrant promotes the reaction [SP3 protein binds to ESRRA promoter]20211987
D005839GentamicinsGentamicins results in decreased expression of SP3 mRNA22061828
D005978GlutathioneGlutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP3 protein]20435036
D006046GoldGold results in decreased expression of SP3 mRNA25523186
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of SP3 mRNA24763279
C007956homocysteic acidhomocysteic acid results in increased activity of SP3 protein11261509
C007956homocysteic acidmithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP3 protein]11261509
D006861Hydrogen PeroxideGlutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP3 protein]20435036
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of SP3 protein20435036
C021304hyperoside[Quercetin co-treated with hyperoside] results in decreased expression of SP3 mRNA24173369
C021304hyperoside[Quercetin co-treated with hyperoside] results in decreased expression of SP3 protein24173369
C544151jinfukangjinfukang results in decreased expression of SP3 mRNA27392435
D007854LeadLead results in increased expression of SP3 protein22272629
C017461lead nitratelead nitrate affects the reaction [SP3 affects the expression of MT1 mRNA]11891201
C017461lead nitratelead nitrate affects the reaction [SP3 affects the expression of MT2 mRNA]11891201
C017461lead nitratelead nitrate results in decreased expression of SP3 mRNA11891201
C045463leflunomideleflunomide results in increased expression of SP3 mRNA28988120
C577554MC1568MC1568 inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [SP3 protein binds to NGB promoter]]25068794
C577554MC1568MC1568 inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [SP3 protein binds to PTGS2 promoter]]25068794
C577554MC1568MC1568 inhibits the reaction [Diethylhexyl Phthalate results in decreased acetylation of and results in increased ubiquitination of SP3 protein]25068794
C577554MC1568MC1568 inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SP3 protein]25068794
C577554MC1568MC1568 promotes the reaction [SP3 protein binds to PTGS2 promoter]25068794
C577554MC1568MC1568 results in increased expression of SP3 protein25068794
D008687MetforminMetformin results in decreased expression of SP3 protein26317792
D008727MethotrexateMethotrexate affects the expression of SP3 mRNA18502557
D008752Methylene ChlorideMethylene Chloride results in increased expression of SP3 mRNA28392392
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SP3 mRNA28001369
C066851mithramycin Amithramycin A inhibits the reaction [Buthionine Sulfoximine results in increased activity of SP3 protein]11261509
C066851mithramycin Amithramycin A inhibits the reaction [Camptothecin results in increased activity of SP3 protein]11261509
C066851mithramycin Amithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP3 protein]11261509
C066851mithramycin Amithramycin A inhibits the reaction [Promegestone promotes the reaction [SP3 protein binds to HSD17B2 promoter]]16807381
C066851mithramycin Amithramycin A inhibits the reaction [SP3 protein binds to HSD17B2 promoter]16807381
C066851mithramycin Amithramycin A results in decreased expression of SP3 mRNA24907531
C520007mithramycin SKmithramycin SK results in decreased expression of SP3 mRNA24907531
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SP3 mRNA26924002
C029938nickel sulfatenickel sulfate results in increased expression of SP3 mRNA18651567
D026422S-NitrosoglutathioneS-Nitrosoglutathione results in decreased activity of SP3 protein14766015
D026422S-NitrosoglutathioneS-Nitrosoglutathione results in increased activity of SP3 protein14766015
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SP3 mRNA27153767
D010634PhenobarbitalPhenobarbital affects the expression of SP3 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of SP3 mRNA19270015
D010672PhenytoinPhenytoin results in increased expression of SP3 mRNA14741686
C006253pirinixic acidpirinixic acid results in increased expression of SP3 mRNA18301758
D011192Potassium DichromatePotassium Dichromate results in increased expression of SP3 mRNA23608068
D011794Quercetin[Quercetin co-treated with hyperoside] results in decreased expression of SP3 mRNA24173369
D011794Quercetin[Quercetin co-treated with hyperoside] results in decreased expression of SP3 protein24173369
D011794Quercetin[resveratrol co-treated with Quercetin] results in decreased expression of SP3 mRNA23530649
D011794Quercetin[resveratrol co-treated with Quercetin] results in decreased expression of SP3 protein23530649
C059514resveratrol[resveratrol co-treated with Quercetin] results in decreased expression of SP3 mRNA23530649
C059514resveratrol[resveratrol co-treated with Quercetin] results in decreased expression of SP3 protein23530649
C002979selenomethylselenocysteineselenomethylselenocysteine metabolite promotes the reaction [SP3 protein binds to BMF promoter]25321483
D012834SilverSilver results in decreased expression of SP3 mRNA27131904
C009277sodium arsenatesodium arsenate results in decreased expression of SP3 mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of SP3 mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of SP3 mRNA12016162
D013629TamoxifenTamoxifen promotes the reaction [SP3 protein binds to ESRRA promoter]20211987
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SP3 mRNA24058054
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SP3 mRNA17942748
C020809tetrathiomolybdatetetrathiomolybdate results in decreased expression of SP322172574
D014118Toxins, Biological"Toxins, Biological affects the expression of SP3 mRNA"19682533
C012589trichostatin A[decitabine co-treated with trichostatin A] promotes the reaction [SP3 protein binds to CLDN3 promoter]17986852
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SP3 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SP3 mRNA24935251|2627250
D014635Valproic AcidValproic Acid affects the expression of SP3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SP3 mRNA23179753|2519280
D014635Valproic AcidValproic Acid results in decreased methylation of SP3 gene28853863|2915479
C025643vinclozolinvinclozolin results in increased expression of SP3 mRNA23555832
C111237vorinostatSP3 protein promotes the reaction [vorinostat results in increased expression of CDKN1A mRNA]11126357

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA14979875  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0000987proximal promoter sequence-specific DNA binding-ISS10362258  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0003682chromatin binding-IEA-  
GO:0005515protein binding-IPI10391891  10816575  11237613  12176973  17130167  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001503ossification-IEA-  
GO:0001779natural killer cell differentiation-IEA-  
GO:0001829trophectodermal cell differentiation-IEA-  
GO:0001889liver development-IEA-  
GO:0001892embryonic placenta development-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IDA12560508  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0030183B cell differentiation-IEA-  
GO:0030217T cell differentiation-IEA-  
GO:0030219megakaryocyte differentiation-IEA-  
GO:0030224monocyte differentiation-IEA-  
GO:0030324lung development-IEA-  
GO:0030851granulocyte differentiation-IEA-  
GO:0043353enucleate erythrocyte differentiation-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IMP20091743  
GO:0045892negative regulation of transcription, DNA-templated-NAS9278495  
GO:0045893positive regulation of transcription, DNA-templated-IDA12771217  
GO:0045893positive regulation of transcription, DNA-templated-NAS9278495  
GO:0045944positive regulation of transcription by RNA polymerase II-IGI14979875  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP14979875  
GO:0048596embryonic camera-type eye morphogenesis-IEA-  
GO:0048706embryonic skeletal system development-IEA-  
GO:0060136embryonic process involved in female pregnancy-IEA-  
GO:0060216definitive hemopoiesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IC12560508  
GO:0005654nucleoplasm-TAS-  
GO:0016605PML body-IEA-  
GO:0017053transcriptional repressor complex-IEA-  
GO:0032993protein-DNA complex-ISS10362258  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2990846SUMOylationTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-3232118SUMOylation of transcription factorsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22140090Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. (2012 Mar 15)Zhou XHum Mol Genet
10889557Function of the C-36 to T polymorphism in the human cholecystokinin gene promoter. (2000 Jul)Hansen TVMol Psychiatry
15266830[Protective and therapeutic effect of pulmonary surfactant on the experimental chronic obstructive pulmonary disease in hamsters]. (2004 Jun)Li LZhongguo Yi Xue Ke Xue Yuan Xue Bao