Gene: SP4

6671
HF1B|SPR-1
Sp4 transcription factor
protein-coding
7p15.3
Ensembl:ENSG00000105866 MIM:600540 Vega:OTTHUMG00000094801 UniprotKB:Q02446
NG_050737.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.249e-1 (AD)  9.162e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STAM20.88
SNX130.861
CHD90.854
ZBTB60.85
ZNF1480.846
BROX0.843
BBS100.841
ZNF6440.839
NCOA20.838
C5orf240.838

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.498
OR4F29-0.451
CRNN-0.24
SPRR3-0.232
MUC21-0.231
SPRR2A-0.226
SPRR2D-0.223
CSAG1-0.221
NANOGNB-0.218
LCN1-0.216

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4929091,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane"SP4 protein affects the reaction [1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane results in increased expression of CDKN1A protein]"15345676
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SP4 mRNA"25614096
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in decreased expression of SP4 protein26194647
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SP4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SP4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SP4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SP4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of SP4 mRNA21420995|2223033
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of SP4 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SP4 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of SP4 mRNA20435036
C006632arsenic trioxidearsenic trioxide results in decreased expression of SP4 protein20435036
D001205Ascorbic AcidAscorbic Acid results in decreased expression of SP4 protein21919647
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SP4 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SP4 protein21987461
D001564Benzo(a)pyrenePOR protein affects the reaction [Benzo(a)pyrene results in increased expression of SP4 protein]21987461
D004958EstradiolEstradiol results in increased expression of SP4 mRNA22194820
D004958EstradiolEstradiol results in decreased expression of SP4 mRNA25210133
C006780bisphenol Abisphenol A results in increased expression of SP4 mRNA22194820
C006780bisphenol Abisphenol A affects the methylation of SP4 promoter27334623
C006780bisphenol Abisphenol A results in increased methylation of SP4 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of SP4 mRNA25181051
D003471CuprizoneCuprizone results in decreased expression of SP4 mRNA27523638
D003474CurcuminCurcumin results in decreased expression of SP4 protein18593936
D003976DiazinonDiazinon results in increased methylation of SP4 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SP4 mRNA21266533
D004041Dietary FatsDietary Fats results in increased expression of SP4 mRNA25016146
D002117CalcitriolCalcitriol results in decreased expression of SP4 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of SP4 mRNA21592394
C039281furanfuran results in decreased expression of SP4 mRNA25539665
C001277geldanamycingeldanamycin results in increased expression of SP4 mRNA26705709
D005978GlutathioneGlutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP4 protein]20435036
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of SP4 mRNA26846883
D006861Hydrogen PeroxideGlutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP4 protein]20435036
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of SP4 protein20435036
C021304hyperoside[Quercetin co-treated with hyperoside] results in decreased expression of SP4 mRNA24173369
C021304hyperoside[Quercetin co-treated with hyperoside] results in decreased expression of SP4 protein24173369
C544151jinfukangjinfukang results in decreased expression of SP4 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of SP4 mRNA26254443
D008528Mefenamic AcidMefenamic Acid results in increased expression of SP4 mRNA22194820
D008687MetforminMetformin results in decreased expression of SP4 protein26317792
D009151Mustard GasMustard Gas results in increased expression of SP4 mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SP4 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of SP4 mRNA12832660
C017096n-butoxyethanoln-butoxyethanol results in increased expression of SP4 mRNA19812364
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SP4 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of SP4 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of SP4 mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of SP4 mRNA]22629407
D010100OxygenOxygen results in increased expression of SP4 mRNA22911455
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SP4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SP4 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of SP4 mRNA18445702
D011794Quercetin[Quercetin co-treated with hyperoside] results in decreased expression of SP4 mRNA24173369
D011794Quercetin[Quercetin co-treated with hyperoside] results in decreased expression of SP4 protein24173369
D011794Quercetin[resveratrol co-treated with Quercetin] results in decreased expression of SP4 mRNA23530649
D011794Quercetin[resveratrol co-treated with Quercetin] results in decreased expression of SP4 protein23530649
C012526quercitrinquercitrin results in increased expression of SP4 mRNA25193878
C059514resveratrol[resveratrol co-treated with Quercetin] results in decreased expression of SP4 mRNA23530649
C059514resveratrol[resveratrol co-treated with Quercetin] results in decreased expression of SP4 protein23530649
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SP4 mRNA23806026
C017947sodium arsenitesodium arsenite affects the expression of SP4 mRNA29319823
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of SP4 mRNA"26680231
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of SP4 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of SP4 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SP4 mRNA17884332
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SP4 mRNA21570461|2405805
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of SP4 mRNA25975270
D013849ThimerosalThimerosal results in decreased expression of SP4 mRNA27188386
C009495titanium dioxidetitanium dioxide results in increased expression of SP4 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SP4 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of SP4 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of SP4 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SP4 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of SP4 mRNA24935251|2627250
D014520UrethaneUrethane results in increased expression of SP4 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of SP4 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased methylation of SP4 gene29154799
D014750VincristineVincristine results in decreased expression of SP4 mRNA23649840
C111237vorinostatvorinostat results in decreased expression of SP4 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IC-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003713transcription coactivator activity-IEA-  
GO:0005515protein binding-IPI25416956  26871637  
GO:0043565sequence-specific DNA binding-IDA23332764  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-IDA12560508  
GO:1903508positive regulation of nucleic acid-templated transcription-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26320294[Personalized Risk Assessment of Adverse Cardiovascular Events in Young Patients With Connective Tissue Dysplasia]. (2015)Druk IVKardiologiia
28294847[Personalized Risk Assessment of Adverse Cardiovascular Events in Young Patients With Connective Tissue Dysplasia]. (2015 Mar)Druk IVKardiologiia