Gene: SPARC

6678
BM-40|OI17|ON
secreted protein acidic and cysteine rich
protein-coding
5q33.1
Ensembl:ENSG00000113140 MIM:182120 Vega:OTTHUMG00000130122 UniprotKB:P09486
NG_042174.1
PubMed
0   ANCO-SNPs
ND
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.720e-1 (AD)  8.403e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEC11A0.805
YBX10.778
H3F3B0.773
ID30.773
RPS15A0.764
RASL120.759
TMBIM40.758
LMO20.757
MAPRE10.756
MYL12A0.756

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.495
OR4F5-0.465
ABCC12-0.397
KCNB2-0.381
CALHM1-0.374
NEUROD6-0.373
BCL11A-0.369
EMX1-0.366
NEUROD2-0.362
LRFN2-0.361

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11093Calcium CitrateSmall Molecule813-94-5ApprovedTarget
DB11348Calcium PhosphateSmall Molecule10103-46-5ApprovedTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of SPARC mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SPARC mRNA"28903501
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SPARC mRNA"28973690
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SPARC mRNA"20959002
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SPARC mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SPARC mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPARC mRNA"27188386
C0293704-toluidine4-toluidine results in decreased expression of SPARC mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPARC mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SPARC mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SPARC mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of SPARC mRNA28959563
D019386AlendronateAlendronate affects the expression of SPARC mRNA16079270
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid affects the expression of SPARC mRNA24098073
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SPARC mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SPARC mRNA24449571
D016718Arachidonic AcidArachidonic Acid results in decreased expression of SPARC mRNA16704987
D001151ArsenicArsenic affects the methylation of SPARC gene25304211
C015001arsenitearsenite results in decreased expression of SPARC mRNA23974009
C015001arsenitearsenite results in increased methylation of SPARC promoter23974009
D017638Asbestos, Crocidolite"Asbestos, Crocidolite inhibits the reaction [SPARC gene mutant form results in decreased expression of SFTPC mRNA]"19446018
D017638Asbestos, Crocidolite"Asbestos, Crocidolite inhibits the reaction [SPARC gene mutant form results in increased expression of ABHD2 mRNA]"19446018
D017638Asbestos, Crocidolite"Asbestos, Crocidolite inhibits the reaction [SPARC gene mutant form results in increased expression of GUCY2E mRNA]"19446018
D017638Asbestos, Crocidolite"Asbestos, Crocidolite inhibits the reaction [SPARC gene mutant form results in increased expression of HCN2 mRNA]"19446018
D017638Asbestos, Crocidolite"Asbestos, Crocidolite inhibits the reaction [SPARC gene mutant form results in increased expression of ITSN1 mRNA]"19446018
D017638Asbestos, Crocidolite"Asbestos, Crocidolite inhibits the reaction [SPARC gene mutant form results in increased expression of KBTBD11 mRNA]"19446018
D017638Asbestos, Crocidolite"Asbestos, Crocidolite inhibits the reaction [SPARC gene mutant form results in increased expression of MAPKAPK5 mRNA]"19446018
D017638Asbestos, Crocidolite"Asbestos, Crocidolite inhibits the reaction [SPARC gene mutant form results in increased expression of MORF4L1 mRNA]"19446018
D017638Asbestos, Crocidolite"Asbestos, Crocidolite inhibits the reaction [SPARC gene mutant form results in increased expression of RECQL mRNA]"19446018
D017638Asbestos, Crocidolite"Asbestos, Crocidolite inhibits the reaction [SPARC gene mutant form results in increased expression of SAA3 mRNA]"19446018
D017638Asbestos, Crocidolite"Asbestos, Crocidolite inhibits the reaction [SPARC gene mutant form results in increased expression of SAR1B mRNA]"19446018
D017638Asbestos, Crocidolite"Asbestos, Crocidolite inhibits the reaction [SPARC gene mutant form results in increased expression of ZNHIT2 mRNA]"19446018
D017638Asbestos, Crocidolite"SPARC protein results in increased susceptibility to Asbestos, Crocidolite"19446018
C011669ascorbate-2-phosphateascorbate-2-phosphate results in decreased expression of SPARC mRNA17306970
D001205Ascorbic Acid[Cholecalciferol co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] results in increased expression of SPARC protein17692823
D001241AspirinAspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of SPARC protein]17303692
D001280AtrazineAtrazine results in increased expression of SPARC mRNA25929836
C547126AZM551248AZM551248 results in increased expression of SPARC mRNA22323515
D001507BeclomethasoneBeclomethasone results in increased expression of SPARC mRNA23656298
D001554BenzeneBenzene results in decreased expression of SPARC mRNA19162166
D001554Benzene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of SPARC mRNA17905399
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of SPARC mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SPARC mRNA22610609
D001599BerberineBerberine results in increased expression of SPARC mRNA26478571
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of SPARC mRNA19693291
D004958EstradiolEstradiol results in decreased expression of SPARC mRNA19693291
C031463beta-glycerophosphoric acidbeta-glycerophosphoric acid results in decreased expression of SPARC mRNA17171500
C031463beta-glycerophosphoric acidCalcitriol promotes the reaction [beta-glycerophosphoric acid results in decreased expression of SPARC mRNA]17171500
C031463beta-glycerophosphoric acidparicalcitol promotes the reaction [beta-glycerophosphoric acid results in decreased expression of SPARC mRNA]17171500
C031463beta-glycerophosphoric acid[Cholecalciferol co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] results in increased expression of SPARC protein17692823
C095105bexarotenebexarotene results in increased expression of SPARC mRNA17178900
C006780bisphenol Abisphenol A results in decreased expression of SPARC mRNA29275510
C006780bisphenol Abisphenol A affects the expression of SPARC mRNA21786754
C006780bisphenol Abisphenol A affects the expression of SPARC mRNA25181051
C006780bisphenol Abisphenol A affects the expression of SPARC protein20219716
C006780bisphenol Abisphenol A results in decreased expression of SPARC protein20219716
D001761BleomycinSPARC protein results in increased susceptibility to Bleomycin19446018
C032688boric acidboric acid affects the expression of SPARC mRNA24704097
D002065BuspironeBuspirone results in decreased expression of SPARC mRNA24136188
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of SPARC mRNA15336504
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SPARC mRNA15963989
D002104CadmiumCadmium results in decreased expression of SPARC mRNA20570719
D002104CadmiumCadmium results in increased expression of SPARC mRNA9232954
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SPARC mRNA23644582
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SPARC mRNA20837119
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SPARC protein20837119
D002164CamphorCamphor analog affects the expression of SPARC mRNA24704097
C571005capseal Icapseal I results in increased expression of SPARC mRNA20850672
C571006capseal IIcapseal II results in increased expression of SPARC mRNA20850672
D002220CarbamazepineCarbamazepine affects the expression of SPARC mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SPARC mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SPARC mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SPARC mRNA16239168|1705623
D002330CarmustineSPARC mRNA affects the susceptibility to Carmustine16365179
C054133casticincasticin results in decreased expression of SPARC mRNA27862857
C054133casticincasticin results in increased expression of SPARC mRNA28444820
C084597chlorcyclizinechlorcyclizine results in increased expression of SPARC mRNA21058326
D004390ChlorpyrifosChlorpyrifos results in decreased expression of SPARC mRNA20350560
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPARC mRNA20938992
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased expression of SPARC mRNA]19924377
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of SPARC mRNA15467011
D003300CopperCopper results in decreased secretion of SPARC protein19635393
D003300CopperCopper results in increased expression of SPARC mRNA16629173
C029892cupric chloridecupric chloride results in increased expression of SPARC mRNA21072851
D003471CuprizoneCuprizone results in increased expression of SPARC mRNA26577399
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SPARC mRNA]18200517
D003520CyclophosphamideCyclophosphamide results in increased expression of SPARC mRNA17403535
D003520CyclophosphamideCyclophosphamide results in decreased expression of SPARC mRNA15331540
D016572CyclosporineCyclosporine results in decreased expression of SPARC mRNA20106945|2556210
D003561CytarabineCytarabine results in decreased expression of SPARC mRNA21198554
D003634DDTDDT results in increased expression of SPARC mRNA25014179
C014347decitabine[decitabine affects the methylation of SPARC promoter] which affects the expression of SPARC mRNA18458674|1845867
C014347decitabine[decitabine affects the methylation of SPARC promoter] which affects the susceptibility to Fluorouracil18458674
C014347decitabinedecitabine inhibits the reaction [DNMT3A protein binds to SPARC promoter]19177197
C014347decitabinedecitabine results in increased expression of SPARC mRNA17397030|1917719
C014347decitabinedecitabine results in increased expression of SPARC protein19177197
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SPARC mRNA]27941970
D003907DexamethasoneDexamethasone results in decreased expression of SPARC mRNA9232954
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SPARC mRNA27392435
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] results in decreased expression of SPARC mRNA20705681
D002945CisplatinCisplatin results in decreased expression of SPARC mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of SPARC mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of SPARC mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of SPARC mRNA18042831|1903023
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of SPARC mRNA]19030233
D004041Dietary FatsDietary Fats results in increased expression of SPARC mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of SPARC mRNA]21852083
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of SPARC mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of SPARC mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of SPARC mRNA19638242
D002117CalcitriolCalcitriol promotes the reaction [beta-glycerophosphoric acid results in decreased expression of SPARC mRNA]17171500
D002117CalcitriolCalcitriol results in increased expression of SPARC protein19092814
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of SPARC mRNA25380136
C024629dimethyl phthalatedimethyl phthalate results in increased expression of SPARC mRNA26924002
D004237DiuronDiuron results in decreased expression of SPARC mRNA25152437
D004237DiuronDiuron results in increased expression of SPARC mRNA21551480
D004317DoxorubicinDoxorubicin results in increased expression of SPARC mRNA15870702
D004317DoxorubicinDoxorubicin results in increased expression of SPARC mRNA15033991
D004967EstrogensEstrogens results in increased expression of SPARC mRNA25014179
D004967EstrogensEstrogens affects the expression of SPARC mRNA24098073
D000431EthanolEthanol affects the expression of SPARC mRNA24355176
D000431EthanolEthanol results in increased expression of SPARC mRNA15963989
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SPARC mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SPARC mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SPARC mRNA16079270
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SPARC mRNA17557909
C034096ethoxyacetic acidethoxyacetic acid affects the expression of SPARC mRNA24704097
D005038EthylnitrosoureaEthylnitrosourea results in increased expression of SPARC mRNA15954086
C540355fenamidonefenamidone results in increased expression of SPARC mRNA27029645
D005472Fluorouracil[decitabine affects the methylation of SPARC promoter] which affects the susceptibility to Fluorouracil18458674
D005472FluorouracilSPARC protein results in increased susceptibility to Fluorouracil15902309
D005472FluorouracilFluorouracil affects the expression of SPARC mRNA24704097
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPARC mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of SPARC mRNA23649840
C070081fulvestrantfulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of SPARC mRNA]26362186
C039281furanfuran results in increased expression of SPARC mRNA27387713
D005665FurosemideFurosemide results in increased expression of SPARC mRNA16526316
C057580gallocatecholgallocatechol results in increased expression of SPARC mRNA21877759
C013172gamma-oryzanolgamma-oryzanol affects the expression of SPARC mRNA24098073
D019833GenisteinGenistein results in increased expression of SPARC mRNA21877759
D005947Glucosecobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased expression of SPARC mRNA]19924377
D005947GlucoseGlucose results in decreased expression of SPARC mRNA19924377
D005960GlucosidesGlucosides analog affects the expression of SPARC mRNA24098073
C010176halofuginonehalofuginone results in increased expression of SPARC mRNA17180598
D017313FenretinideFenretinide results in decreased expression of SPARC mRNA28973697
D007213IndomethacinIndomethacin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SPARC mRNA]17994277
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of SPARC mRNA25613284
C051890irinotecan[irinotecan co-treated with SPARC protein] results in increased expression of CDKN2A mRNA20164124
C051890irinotecan[irinotecan co-treated with SPARC protein] results in increased expression of CDKN2A protein20164124
D007529IsoflavonesIsoflavones affects the expression of SPARC mRNA16365062
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SPARC mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SPARC mRNA23086925
C410337K 7174K 7174 results in decreased expression of SPARC mRNA24086573
C017461lead nitrate[nickel chloride co-treated with lead nitrate] results in decreased expression of SPARC mRNA19187980
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SPARC mRNA27339419
D019808LosartanLosartan results in decreased expression of SPARC mRNA15100363
D008274MagnesiumMagnesium results in increased expression of SPARC protein10397942
D008713MethimazoleMethimazole results in increased expression of SPARC mRNA17403546
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPARC mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SPARC mRNA23179753
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of SPARC mRNA27544571
C030957methylmercury II[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of SPARC mRNA17905399
C030957methylmercury IImethylmercury II results in increased expression of SPARC mRNA17905399
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SPARC mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SPARC mRNA23649840
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of SPARC mRNA12634122
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of SPARC promoter18448484
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of SPARC mRNA22108045
C517284monomethyl phthalatemonomethyl phthalate results in increased expression of SPARC mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SPARC mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of SPARC mRNA25380136
C051752nefazodonenefazodone results in decreased expression of SPARC mRNA24136188
C022838nickel chloride[nickel chloride co-treated with lead nitrate] results in decreased expression of SPARC mRNA19187980
C022838nickel chloridenickel chloride results in decreased expression of SPARC mRNA19187980
C012655nimesulidenimesulide results in decreased expression of SPARC mRNA24136188
C072936notoginsenoside R1fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of SPARC mRNA]26362186
C072936notoginsenoside R1notoginsenoside R1 results in increased expression of SPARC mRNA26362186
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SPARC mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of SPARC mRNA25729387
D010100OxygenGPR68 protein affects the reaction [Oxygen deficiency results in increased expression of SPARC mRNA]28174749
D010100OxygenOxygen deficiency results in increased expression of SPARC mRNA28174749
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] results in decreased expression of SPARC mRNA20705681
D017239PaclitaxelPaclitaxel results in increased expression of SPARC mRNA19682730
D000073878Palm OilPalm Oil results in increased expression of SPARC mRNA18042831
D010269ParaquatParaquat results in decreased expression of SPARC mRNA15458575
C084656paricalcitolparicalcitol promotes the reaction [beta-glycerophosphoric acid results in decreased expression of SPARC mRNA]17171500
D010433PentylenetetrazolePentylenetetrazole affects the expression of SPARC mRNA21503142
C494474perchlorateperchlorate results in increased expression of SPARC mRNA17403546
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in decreased expression of SPARC mRNA21984479
D010634PhenobarbitalPhenobarbital affects the expression of SPARC mRNA19159669
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPARC mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SPARC mRNA26272509
D010894PiroxicamPiroxicam results in decreased expression of SPARC mRNA21858171
D010936Plant ExtractsPlant Extracts affects the expression of SPARC mRNA24098073
D011192Potassium DichromatePotassium Dichromate results in increased expression of SPARC mRNA23608068
D011205Povidone[Silver analog co-treated with Povidone] results in decreased expression of SPARC mRNA25194297
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of SPARC mRNA19693291
D011374ProgesteroneProgesterone results in decreased expression of SPARC mRNA19690047
D011441PropylthiouracilPropylthiouracil results in increased expression of SPARC mRNA17403546
C513428pyrachlostrobinpyrachlostrobin results in increased expression of SPARC mRNA27029645
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of SPARC mRNA16079270
C059514resveratrolresveratrol results in decreased expression of SPARC mRNA16084059
C059514resveratrolresveratrol results in decreased expression of SPARC protein16084059
C059514resveratrolresveratrol results in decreased expression of SPARC mRNA19228061
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of SPARC mRNA]21852083
C089032rimonabantrimonabant affects the expression of SPARC mRNA19030233
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of SPARC mRNA]19030233
C089730rosiglitazonerosiglitazone results in increased expression of SPARC mRNA21172411
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of SPARC mRNA"21148743
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SPARC mRNA22431001
D012834SilverSilver analog results in increased expression of SPARC mRNA22727896
D012834Silver[Silver analog co-treated with Povidone] results in decreased expression of SPARC mRNA25194297
C080703SK&F 83959SK&F 83959 results in increased expression of SPARC protein25852303
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of SPARC promoter18448484
C017947sodium arsenitesodium arsenite results in decreased expression of SPARC mRNA20837119
C017947sodium arsenitesodium arsenite results in decreased expression of SPARC protein20837119
C017947sodium arsenitesodium arsenite results in increased expression of SPARC mRNA20371982
C017947sodium arsenitesodium arsenite results in decreased expression of SPARC mRNA18812580
D012969Sodium FluorideDKK1 protein inhibits the reaction [Sodium Fluoride results in increased expression of SPARC mRNA]24300170
D012969Sodium FluorideSodium Fluoride results in increased expression of SPARC mRNA24300170
D012999SomanSoman results in increased expression of SPARC mRNA19281266
D013311StreptozocinStreptozocin results in increased expression of SPARC mRNA12660331
D013311StreptozocinStreptozocin results in increased expression of SPARC protein12660331
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in decreased expression of SPARC mRNA16214533
C446685systhanesysthane affects the expression of SPARC mRNA24704097
C047246temozolomideSPARC mRNA affects the susceptibility to temozolomide16365179
D013739TestosteroneTestosterone results in increased expression of SPARC mRNA19693291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SPARC mRNA11489354|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SPARC mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SPARC mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SPARC mRNA28077779
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SPARC mRNA11752688
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of SPARC mRNA25613284
D013853ThioacetamideSPARC protein affects the reaction [Thioacetamide results in increased expression of COL1A2 mRNA]23408952
D013853ThioacetamideSPARC protein affects the reaction [Thioacetamide results in increased expression of MMP2 mRNA]23408952
D013853ThioacetamideSPARC protein affects the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]23408952
D013853ThioacetamideSPARC protein affects the reaction [Thioacetamide results in increased expression of TGFB1 protein]23408952
D013853ThioacetamideSPARC protein affects the susceptibility to Thioacetamide23408952
D013853ThioacetamideThioacetamide results in increased expression of SPARC mRNA23408952
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of SPARC mRNA28943392
C096900thrombin receptor-activating peptide SFLLRNPNDKYAspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of SPARC protein]17303692
C096900thrombin receptor-activating peptide SFLLRNPNDKYthrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of SPARC protein17303692
C009495titanium dioxidetitanium dioxide results in decreased expression of SPARC mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SPARC mRNA28111298
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SPARC mRNA25729387
D019772TopotecanTopotecan results in increased expression of SPARC mRNA25729387
D014192TrapidilTrapidil affects the reaction [PTH protein affects the expression of SPARC mRNA]18635661
D014212TretinoinTretinoin affects the expression of SPARC mRNA24704097
D014212TretinoinTretinoin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SPARC mRNA]17994277
D014212TretinoinTretinoin results in increased expression of SPARC mRNA24977338
C034613triacsin Ctriacsin C results in decreased expression of SPARC mRNA16704987
D014241Trichloroethylene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of SPARC mRNA17905399
D014241TrichloroethyleneTrichloroethylene results in increased expression of SPARC mRNA19448997
C012589trichostatin Atrichostatin A results in decreased expression of SPARC mRNA15901671
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SPARC mRNA]18200517
D014302Trinitrobenzenesulfonic AcidIndomethacin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SPARC mRNA]17994277
D014302Trinitrobenzenesulfonic AcidTretinoin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SPARC mRNA]17994277
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of SPARC mRNA17994277|1820051
D014635Valproic AcidValproic Acid affects the expression of SPARC mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SPARC mRNA23179753|2915479
D014635Valproic AcidValproic Acid results in increased expression of SPARC mRNA23179753|2718838
D014635Valproic AcidValproic Acid affects the expression of SPARC mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of SPARC mRNA15901671
D014640VancomycinVancomycin results in decreased expression of SPARC mRNA18930951
C029297vinylidene chloridevinylidene chloride results in increased expression of SPARC mRNA26682919
D002762Cholecalciferol[Cholecalciferol co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] results in increased expression of SPARC protein17692823

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IBA21873635  
GO:0005509calcium ion binding-IDA7034958  
GO:0005515protein binding-IPI3402455  18808384  19011090  20926826  
GO:0005518collagen binding-IBA21873635  
GO:0005518collagen binding-IDA7034958  9501084  
GO:0050840extracellular matrix binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001503ossification-IEA-  
GO:0001937negative regulation of endothelial cell proliferation-IDA12867428  
GO:0002576platelet degranulation-TAS-  
GO:0006898receptor-mediated endocytosis-TAS-  
GO:0007507heart development-IEA-  
GO:0009629response to gravity-IEA-  
GO:0010288response to lead ion-IEA-  
GO:0010595positive regulation of endothelial cell migration-IDA12867428  
GO:0016525negative regulation of angiogenesis-IDA12867428  
GO:0022604regulation of cell morphogenesis-IDA15389586  
GO:0030198extracellular matrix organization-TAS-  
GO:0030324lung development-IEA-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0033591response to L-ascorbic acid-IEA-  
GO:0034097response to cytokine-IEA-  
GO:0042060wound healing-IEA-  
GO:0043434response to peptide hormone-IEA-  
GO:0043473pigmentation-IEA-  
GO:0045471response to ethanol-IEA-  
GO:0046686response to cadmium ion-IEA-  
GO:0048839inner ear development-IEA-  
GO:0048856anatomical structure development-IBA21873635  
GO:0051384response to glucocorticoid-IEA-  
GO:0051591response to cAMP-IEA-  
GO:0051592response to calcium ion-IEA-  
GO:0060348bone development-IEA-  
GO:0071363cellular response to growth factor stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005604basement membrane-IEA-  
GO:0005615extracellular space-IBA21873635  
GO:0005737cytoplasm-IDA3400777  11856645  15389586  
GO:0005737cytoplasmNOTIDA1737102  
GO:0005739mitochondrionNOTIDA1737102  
GO:0005886plasma membraneNOTIDA1737102  
GO:0009986cell surface-IDA3400777  15389586  
GO:0016363nuclear matrix-IDA15389586  
GO:0031091platelet alpha granule-IDA1737102  
GO:0031092platelet alpha granule membrane-IDA1737102  
GO:0031093platelet alpha granule lumen-TAS-  
GO:0071682endocytic vesicle lumen-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-2173782Binding and Uptake of Ligands by Scavenger ReceptorsTAS
R-HSA-3000178ECM proteoglycansTAS
R-HSA-3000497Scavenging by Class H ReceptorsTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19841986Molecular characterization of chronic obstructive pulmonary disease-related non-small cell lung cancer through aberrant methylation and alterations of EGFR signaling. (2010 Mar)Suzuki MAnn Surg Oncol
25126876Polymorphisms in SPARC and coal workers' pneumoconiosis risk in a Chinese population. (2014)Wang TPLoS One
11809426Relation of coronary artery disease and cerebrovascular disease with atherosclerosis of the thoracic aorta in the general population. (2002 Feb 1)Agmon YAm J Cardiol
27822069SPARC is a possible predictive marker for albumin-bound paclitaxel in non-small-cell lung cancer. (2016)Komiya KOnco Targets Ther
23114088SPARC expression and prognostic value in non-small cell lung cancer. (2012 Nov)Huang YChin J Cancer
11243271Association of atrial fibrillation and aortic atherosclerosis: a population-based study. (2001 Mar)Agmon YMayo Clin Proc
11044425Independent association of high blood pressure and aortic atherosclerosis: A population-based study. (2000 Oct 24)Agmon YCirculation