Gene: SPINK1

6690
PCTT|PSTI|Spink3|TATI|TCP
serine peptidase inhibitor, Kazal type 1
protein-coding
5q32
Ensembl:ENSG00000164266 MIM:167790 Vega:OTTHUMG00000129730 UniprotKB:P00995
NG_008356.2
PubMed
0   ANCO-SNPs
ND|AD
17   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.375e-1 (AD)  1.629e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PNLIPRP10.928
GP20.925
CELA3B0.921
PLA2G1B0.914
CPB10.909
CELA3A0.892
CTRB10.885
CELA2A0.863
CTRB20.861
SYCN0.855

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SH2D1B-0.204
FOXN4-0.202
OPRK1-0.193
CHAF1A-0.189
GOLGA8N-0.185
KIF22-0.182
POTEG-0.18
TM4SF20-0.179
UPK2-0.179
BAAT-0.179

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0122771,2-diamino-4-nitrobenzene"1,2-diamino-4-nitrobenzene results in decreased expression of SPINK1 mRNA"17070881
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of SPINK1 mRNA"19162173
C0353141-nitropropane1-nitropropane results in increased expression of SPINK1 mRNA17070881
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SPINK1 mRNA"23146750
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of SPINK1 mRNA"21920950
C0109142,4-diaminotoluene"2,4-diaminotoluene results in decreased expression of SPINK1 mRNA"17070881
C0252352,6-diaminotoluene"2,6-diaminotoluene results in increased expression of SPINK1 mRNA"17070881
C0147062-nitro-4-phenylenediamine2-nitro-4-phenylenediamine results in decreased expression of SPINK1 mRNA17070881
C0166172-nitropropane2-nitropropane results in decreased expression of SPINK1 mRNA17070881
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SPINK1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPINK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPINK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPINK1 mRNA"27188386
C0286764-acetylaminofluorene4-acetylaminofluorene results in increased expression of SPINK1 mRNA17070881
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPINK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPINK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPINK1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SPINK1 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SPINK1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SPINK1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SPINK1 mRNA21632981
C103303alitretinoinalitretinoin results in increased expression of SPINK1 mRNA16648578
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SPINK1 mRNA16483693
C519728archazolid Barchazolid B results in increased expression of SPINK1 mRNA25218289
D001151ArsenicArsenic affects the methylation of SPINK1 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of SPINK1 mRNA"25351596
D001379AzathioprineAzathioprine results in increased expression of SPINK1 mRNA28138970
C447119bazedoxifene[Progesterone co-treated with bazedoxifene] results in increased expression of SPINK1 mRNA18367319
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of SPINK1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SPINK1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SPINK1 mRNA23735875
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of SPINK1 mRNA18367319
C095105bexarotene[bexarotene co-treated with Tamoxifen] results in increased expression of SPINK1 mRNA17630414
C095105bexarotenebexarotene results in increased expression of SPINK1 mRNA16648578
C006780bisphenol Abisphenol A results in decreased expression of SPINK1 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of SPINK1 mRNA26079696
D002104CadmiumCadmium results in increased expression of SPINK1 mRNA21172416
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SPINK1 mRNA26314618
D019256Cadmium Chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SPINK1 mRNA12634122
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SPINK1 mRNA16239168
D002509CephaloridineCephaloridine results in decreased expression of SPINK1 mRNA18500788
C023600chromic oxide[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SPINK1 mRNA12634122
C017133chromous chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SPINK1 mRNA12634122
D002922CiguatoxinsCiguatoxins affects the expression of SPINK1 mRNA18353800
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of SPINK1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of SPINK1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of SPINK1 mRNA20106945|2163298
D016572CyclosporineCyclosporine results in decreased expression of SPINK1 mRNA19770486
D003561CytarabineCytarabine results in increased expression of SPINK1 mRNA21198554
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SPINK1 mRNA23914054
C000944dicrotophosdicrotophos results in decreased expression of SPINK1 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of SPINK1 mRNA22609946
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SPINK1 mRNA28085963
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of SPINK1 mRNA18164116
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of SPINK1 mRNA19638242
D004178DiquatDiquat results in increased expression of SPINK1 mRNA21172416
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of SPINK1 mRNA12655031
D004918Erythromycin EstolateErythromycin Estolate results in increased expression of SPINK1 mRNA24412560
D000431EthanolEthanol results in decreased expression of SPINK1 mRNA17920746
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SPINK1 mRNA17108234
C082360fipronilfipronil results in increased expression of SPINK1 mRNA23962444
D005419FlavonoidsFlavonoids results in decreased expression of SPINK1 mRNA18035473
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased expression of SPINK1 mRNA17070881
D005485FlutamideFlutamide results in decreased expression of SPINK1 mRNA24136188
D005485FlutamideFlutamide results in increased expression of SPINK1 mRNA24793618
D005492Folic AcidFolic Acid results in increased expression of SPINK1 mRNA17868486
D005620Freund's AdjuvantFreund's Adjuvant results in increased expression of SPINK1 mRNA21149847
C039281furanfuran results in decreased expression of SPINK1 mRNA15120968|2553966
C508665gold (III) porphyrin 1agold (III) porphyrin 1a results in decreased expression of SPINK1 mRNA16206274
C016517indole-3-carbinolindole-3-carbinol affects the expression of SPINK1 mRNA21396975
C111332Lasofoxifene[Progesterone co-treated with Lasofoxifene] results in increased expression of SPINK1 mRNA18367319
C008261lead acetate[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SPINK1 mRNA12634122
D008628MercuryMercury results in decreased expression of SPINK1 mRNA22688007
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of SPINK1 mRNA12634122
D009151Mustard GasMustard Gas results in increased expression of SPINK1 mRNA15674844
C051752nefazodonenefazodone results in decreased expression of SPINK1 mRNA24136188
D009532NickelNickel results in decreased expression of SPINK1 mRNA25583101
C014707nitrosobenzylmethylamine[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of SPINK1 mRNA12517797
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of SPINK1 mRNA20971185
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPINK1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of SPINK1 mRNA26272509
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of SPINK1 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SPINK1 mRNA16221955
D010615PhenacetinPhenacetin results in increased expression of SPINK1 mRNA17082564
D010634PhenobarbitalPhenobarbital affects the expression of SPINK1 mRNA19159669
C030299phenylhydrazinephenylhydrazine results in increased expression of SPINK1 mRNA17082564
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPINK1 mRNA"27188386
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SPINK1 mRNA19710929
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SPINK1 mRNA19162173
D011374ProgesteroneProgesterone affects the expression of SPINK1 mRNA17251523
D011374Progesterone[Progesterone co-treated with bazedoxifene] results in increased expression of SPINK1 mRNA18367319
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of SPINK1 mRNA18367319
D011374Progesterone[Progesterone co-treated with Lasofoxifene] results in increased expression of SPINK1 mRNA18367319
D011374Progesterone[Progesterone co-treated with Raloxifene Hydrochloride] results in increased expression of SPINK1 mRNA18367319
D011794QuercetinQuercetin results in decreased expression of SPINK1 mRNA21632981
D020849Raloxifene Hydrochloride[Progesterone co-treated with Raloxifene Hydrochloride] results in increased expression of SPINK1 mRNA18367319
C089730rosiglitazonerosiglitazone results in increased expression of SPINK1 mRNA25572481
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SPINK1 mRNA25895662
C009277sodium arsenatesodium arsenate results in increased expression of SPINK1 mRNA12727804
C017947sodium arseniteCARM1 mutant form promotes the reaction [sodium arsenite results in increased expression of SPINK1 mRNA]23699174
C017947sodium arsenitePRMT1 mutant form promotes the reaction [sodium arsenite results in increased expression of SPINK1 mRNA]23699174
C017947sodium arsenite[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SPINK1 mRNA12634122
C017947sodium arsenitesodium arsenite results in increased expression of SPINK1 mRNA23699174
D013629Tamoxifen[bexarotene co-treated with Tamoxifen] results in increased expression of SPINK1 mRNA17630414
D013739TestosteroneTestosterone affects the expression of SPINK1 mRNA17003280
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SPINK1 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SPINK1 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SPINK1 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SPINK1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SPINK1 mRNA16054898|2121527
D013853ThioacetamideThioacetamide results in decreased expression of SPINK1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of SPINK1 mRNA23409001
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of SPINK1 gene27618143
C012589trichostatin Atrichostatin A results in increased expression of SPINK1 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SPINK1 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPINK1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of SPINK1 mRNA23179753|2438349
C029297vinylidene chloridevinylidene chloride results in increased expression of SPINK1 protein14565772
D024483Vitamin K 3Vitamin K 3 affects the expression of SPINK1 mRNA20044591
D015032Zinc[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of SPINK1 mRNA12517797
D015032ZincZinc deficiency results in increased expression of SPINK1 mRNA11717422
C016837zinc chloridezinc chloride results in decreased expression of SPINK1 mRNA18947441
C088658zoledronic acidzoledronic acid results in increased expression of SPINK1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004866endopeptidase inhibitor activity-TAS7142173  
GO:0005515protein binding-IPI14507909  
GO ID GO Term Qualifier Evidence PubMed
GO:0010751negative regulation of nitric oxide mediated signal transduction-IEA-  
GO:0048240sperm capacitation-IEA-  
GO:0050732negative regulation of peptidyl-tyrosine phosphorylation-IEA-  
GO:0090281negative regulation of calcium ion import-IEA-  
GO:2001256regulation of store-operated calcium entry-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18663346Alcoholic pancreatitis: new pathogenetic insights. (2008 Aug)Lucrezio LMinerva Med
28454201[Identical Variants Different Disease Course - Genetics of Chronic Pancreatitis]. (2017 May)Beer SDtsch Med Wochenschr
27518468Genetically Determined Chronic Pancreatitis but not Alcoholic Pancreatitis Is a Strong Risk Factor for Pancreatic Cancer. (2016 Nov)Midha SPancreas
16958673Gene-environment factors that contribute to alcoholic pancreatitis in humans. (2006 Oct)Whitcomb DCJ Gastroenterol Hepatol
25569187The Common Chymotrypsinogen C (CTRC) Variant G60G (C.180T) Increases Risk of Chronic Pancreatitis But Not Recurrent Acute Pancreatitis in a North American Population. (2015 Jan 8)LaRusch JClin Transl Gastroenterol
11950817Mutations in serine protease inhibitor Kazal type 1 are strongly associated with chronic pancreatitis. (2002 May)Drenth JPGut
22109105PRSS1 intron mutations in patients with pancreatic cancer and chronic pancreatitis. (2012 Feb)Gao FMol Med Rep
24624459Pancreatitis Overview (1993)LaRusch J-
23751316Clinical and morphological characteristics of sporadic genetically determined pancreatitis as compared to idiopathic pancreatitis: higher risk of pancreatic cancer in CFTR variants. (2013)Hamoir CDigestion
18336667Individual susceptibility to alcoholic pancreatitis. (2008 Mar)Apte MVJ Gastroenterol Hepatol
17031196Chronic pancreatitis. (2001 Sep)Chari STCurr Opin Gastroenterol
22608493[Chronic pancreatitis: beyond alcohol]. (2012 Oct)Vaquero Raya ECGastroenterol Hepatol
16111090Genetics of pancreatitis. (2005)Keim VScand J Surg
18953248Clinical and radiological outcome of patients suffering from chronic pancreatitis associated with gene mutations. (2008 Nov)Frulloni LPancreas
27253233Frequency of Tabagism and N34S and P55S Mutations of Serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) and R254W Mutation of Chymotrypsin C (CTRC) in Patients With Chronic Pancreatitis and Controls. (2016 Oct)da Costa MZPancreas
26081616RNA-seq analysis of lung adenocarcinomas reveals different gene expression profiles between smoking and nonsmoking patients. (2015 Nov)Li YTumour Biol
15528021Genetic counseling for hereditary pancreatitis--the role of molecular genetics testing for the cationic trypsinogen gene, cystic fibrosis and serine protease inhibitor Kazal type 1. (2004 Dec)Ellis IGastroenterol Clin North Am