Gene: SPN

6693
CD43|GALGP|GPL115|LSN
sialophorin
protein-coding
16p11.2
Ensembl:ENSG00000197471 MIM:182160 Vega:OTTHUMG00000097765 UniprotKB:P16150
NC_000016.10
PubMed
0   ANCO-SNPs
ND
13   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.374e-1 (AD)  9.204e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg23083984chr16:29675846SPN4.600e-12Smoking27651444
cg06177555chr16:29678624SPN9.200e-9Smoking27651444
cg01681367chr16:29676071SPN1.300e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYO1F0.86
GPR650.843
PIK3R50.842
TMC80.838
SASH30.837
ARHGAP300.836
GPSM30.836
MFNG0.835
MS4A70.835
CMTM70.834

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYADML2-0.464
MARCH4-0.458
BDH1-0.448
TMEM179-0.447
LRTM2-0.446
HAS1-0.442
KCNB2-0.439
NEUROD6-0.438
TMEM191C-0.436
F7-0.435

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SPN mRNA"19114083
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of SPN mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of SPN mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SPN mRNA23385219
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of SPN mRNA"23195993
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SPN mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SPN mRNA24449571
D001285AtropineSPN protein results in increased susceptibility to Atropine18711009
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of SPN mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to SPN promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SPN mRNA21569818
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of SPN mRNA18692832
C006780bisphenol Abisphenol A results in decreased expression of SPN mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SPN gene28505145
D000069286BortezomibBortezomib results in decreased expression of SPN mRNA20977926
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SPN mRNA25993096
D002737ChloropreneChloroprene results in decreased expression of SPN mRNA23125180
D002737ChloropreneChloroprene results in decreased expression of SPN mRNA23125180
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SPN mRNA28472532
D003300CopperCopper deficiency results in increased expression of SPN mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of SPN mRNA26577399
D002945CisplatinCisplatin results in decreased expression of SPN mRNA22023808
C000944dicrotophosdicrotophos results in increased expression of SPN mRNA28302478
D019422Dietary SucroseDietary Sucrose results in increased expression of SPN mRNA26033743
D000431EthanolEthanol results in decreased expression of SPN mRNA17920746
C064925gadodiamidegadodiamide results in increased expression of SPN mRNA20959327
D019833GenisteinGenistein results in decreased expression of SPN mRNA24967385
D005839GentamicinsGentamicins results in increased expression of SPN mRNA22061828
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SPN mRNA25613284
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SPN mRNA23649840
D008790MetoprololSPN protein results in decreased susceptibility to Metoprolol18711009
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SPN mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SPN mRNA"25554681
D009532NickelNickel results in decreased expression of SPN mRNA23195993
D011224PrazosinSPN protein results in decreased susceptibility to Prazosin18711009
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of SPN mRNA18692832
D011441PropylthiouracilPropylthiouracil results in decreased expression of SPN mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of SPN mRNA16079270
D012834SilverSilver results in increased expression of SPN mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SPN mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SPN mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of SPN mRNA27760801
C009495titanium dioxidetitanium dioxide results in increased expression of SPN mRNA23557971
D014118Toxins, Biological"Toxins, Biological affects the expression of SPN mRNA"19682533
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SPN mRNA19042947
D014294TrimethaphanSPN protein results in decreased susceptibility to Trimethaphan18711009
D014635Valproic AcidValproic Acid results in increased methylation of SPN gene29154799
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of SPN mRNA25423262
C025643vinclozolinvinclozolin affects the expression of SPN mRNA19015723
D015032ZincZinc deficiency results in decreased expression of SPN mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IEA-  
GO:0030544Hsp70 protein binding-IPI20633027  
GO:0031072heat shock protein binding-IPI20633027  
GO ID GO Term Qualifier Evidence PubMed
GO:0002296T-helper 1 cell lineage commitment-IDA18036228  
GO:0006935chemotaxis-TAS10753822  
GO:0006955immune response-TAS2023632  
GO:0006968cellular defense response-TAS1683685  
GO:0007162negative regulation of cell adhesion-TAS10753822  
GO:0007163establishment or maintenance of cell polarity-TAS10753822  
GO:0007165signal transduction-TAS2023632  
GO:0032609interferon-gamma production-IDA18036228  
GO:0042130negative regulation of T cell proliferation-ISS-  
GO:0042535positive regulation of tumor necrosis factor biosynthetic process-IDA10899905  
GO:0042742defense response to bacterium-IDA10899905  
GO:0050900leukocyte migration-TAS-  
GO:0050901leukocyte tethering or rolling-ISS-  
GO:2000404regulation of T cell migration-ISS-  
GO:2000406positive regulation of T cell migration-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001931uropod-ISS-  
GO:0005615extracellular space-IDA10899905  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS2023632  
GO:0005902microvillus-ISS-  
GO:0009986cell surface-IDA20605918  
GO:0016020membrane-HDA19946888  
GO:0016605PML body-IEA-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-210991Basigin interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18402653Management of SPN in France. Pathways for definitive diagnosis of solitary pulmonary nodule: a multicentre study in 18 French districts. (2008 Apr 10)Alzahouri KBMC Cancer
24962823Prevalence and variables associated with solitary pulmonary nodules in a routine clinic-based population: a cross-sectional study. (2014 Sep)Gomez-Saez NEur Radiol
20740111Risk of proximal colonic neoplasms in asymptomatic adults older than 50 years found to have distal hyperplastic polyps on routine colorectal cancer screening. (2010 Summer)Collins BDPerm J
29502371[Risk factor analysis of the patients with solitary pulmonary nodules and establishment of a prediction model for the probability of malignancy]. (2018 Feb 23)Wang XZhonghua Zhong Liu Za Zhi
18940947The evaluation and management of the solitary pulmonary nodule. (2008 Sep)Soubani AOPostgrad Med J
25989269Long-term adverse outcomes in survivors of childhood bone sarcoma: the British Childhood Cancer Survivor Study. (2015 Jun 9)Fidler MMBr J Cancer
26323809Peripheral neuropathy in HIV patients in sub-Saharan Africa failing first-line therapy and the response to second-line ART in the EARNEST trial. (2016 Feb)Arenas-Pinto AJ Neurovirol
14662420Glutathione S-transferase M1 or T1 null genotype as a risk factor for developing multiple primary neoplasms in the upper aero-digestive tract, in Indian males using tobacco. (2004 Jan)Jhavar SOral Oncol
26623107Establishment of a mathematic model for predicting malignancy in solitary pulmonary nodules. (2015 Oct)Zhang MJ Thorac Dis
25561761Comparison of three mathematical prediction models in patients with a solitary pulmonary nodule. (2014 Dec)Zhang XChin J Cancer Res
27180754[Establishment of a predicting model to evaluate the probability of malignancy or benign in patients with solid solitary pulmonary nodules]. (2016 May 10)Xiang YZhonghua Yi Xue Za Zhi
24205175Novel and convenient method to evaluate the character of solitary pulmonary nodule-comparison of three mathematical prediction models and further stratification of risk factors. (2013)Xiao FPLoS One
25331391[Diagnostic value of serum tumor markers in differentiating malignant from benign solitary pulmonary nodules]. (2014 Oct 18)Ni LFBeijing Da Xue Xue Bao Yi Xue Ban