Gene: SPR

6697
SDR38C1
sepiapterin reductase
protein-coding
2p13.2
Ensembl:ENSG00000116096 MIM:182125 Vega:OTTHUMG00000129777 UniprotKB:P35270
NG_008234.1
PubMed
0   ANCO-SNPs
CD|OD|ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.504e-3 (AD)  7.280e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STIP10.845
RBM40.816
AHSA10.813
JMJD60.813
CHORDC10.812
LMAN2L0.807
MRPS60.799
PLOD10.785
FKBP40.783
TRAF20.779

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.412
CNGA1-0.407
MYLK2-0.406
TPH1-0.4
CCT6B-0.385
OR4F29-0.383
RBM3-0.375
KLRF1-0.366
CCDC141-0.365
STARD6-0.361

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02637Oxaloacetate IonSmall MoleculeExperimentalTarget
DB034612'-Monophosphoadenosine 5'-DiphosphoriboseSmall MoleculeExperimentalTarget
DB03886BiopterinSmall MoleculeExperimentalTarget
DB04275N-Acetyl SerotoninSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0131862,3-pentanedione"2,3-pentanedione results in decreased expression of SPR mRNA"25710175
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SPR mRNA"18648102
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to SPR protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to SPR protein]26598702
D000638AmiodaroneAmiodarone results in increased expression of SPR mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SPR mRNA16483693
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to SPR protein]26598702
C006632arsenic trioxideSPR protein results in decreased susceptibility to arsenic trioxide20707922
D001280AtrazineAtrazine results in decreased expression of SPR mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SPR mRNA21715664
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SPR mRNA22374506
C006780bisphenol Abisphenol A results in increased expression of SPR mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of SPR mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of SPR mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SPR protein24527689
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of SPR mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SPR gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of SPR mRNA22941251
D009249NADPNADP binds to and results in increased activity of SPR protein25526675
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SPR mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of SPR mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SPR mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SPR mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SPR mRNA27392435
D002945CisplatinCisplatin results in increased expression of SPR mRNA27392435
D004317DoxorubicinSPR protein affects the susceptibility to Doxorubicin16217747
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SPR gene20938992
C492448ICG 001ICG 001 results in increased expression of SPR mRNA26191083
D007501IronIron deficiency results in increased expression of SPR mRNA16629162
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SPR mRNA27392435
C410337K 7174K 7174 results in decreased expression of SPR mRNA24086573
D007854LeadSPR gene SNP affects the susceptibility to [lead acetate results in increased abundance of Lead]26859824
C008261lead acetateSPR gene SNP affects the susceptibility to [lead acetate results in increased abundance of Lead]26859824
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SPR gene20938992
D008748MethylcholanthreneMethylcholanthrene results in increased expression of SPR mRNA18804290
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SPR mRNA21527772
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of SPR protein19716841
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SPR mRNA20971185
C025589ochratoxin Aochratoxin A results in decreased expression of SPR mRNA23358140
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SPR mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of SPR mRNA25729387
D010634PhenobarbitalPhenobarbital results in increased expression of SPR mRNA19270015
C045950propiconazolepropiconazole results in increased metabolism of SPR protein19714882
D011748PyrogallolPyrogallol results in increased expression of SPR mRNA20362636
C017947sodium arsenitesodium arsenite results in increased expression of SPR mRNA21281968|2271453
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SPR mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SPR mRNA27913140
C009495titanium dioxidetitanium dioxide results in decreased expression of SPR mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SPR mRNA25729387
D019772TopotecanTopotecan results in decreased expression of SPR mRNA25729387
C012589trichostatin Atrichostatin A results in decreased expression of SPR mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SPR mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of SPR mRNA29154799
D014635Valproic AcidValproic Acid results in decreased expression of SPR mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SPR gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004033aldo-keto reductase (NADP) activity-TAS1883349  
GO:0004757sepiapterin reductase activity-IBA21873635  
GO:0004757sepiapterin reductase activity-ISS-  
GO:0004757sepiapterin reductase activity-TAS-  
GO:0050661NADP binding-TAS1883349  
GO ID GO Term Qualifier Evidence PubMed
GO:0006729tetrahydrobiopterin biosynthetic process-IBA21873635  
GO:0006729tetrahydrobiopterin biosynthetic process-TAS1883349  
GO:0006809nitric oxide biosynthetic process-IDA15197144  
GO:0050999regulation of nitric-oxide synthase activity-TAS-  
GO:0051186cofactor metabolic process-TAS-  
GO:0055114oxidation-reduction process-TAS1883349  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa00790Folate biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1474151Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulationTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-202131Metabolism of nitric oxideTAS
R-HSA-203615eNOS activationTAS
R-HSA-203765eNOS activation and regulationTAS
R-HSA-8978934Metabolism of cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28483948High-Affinity Internalizing Human scFv-Fc Antibody for Targeting FGFR1-Overexpressing Lung Cancer. (2017 Aug)Sokolowska-Wedzina AMol Cancer Res
25977072Alterations in plasma vascular endothelial growth factor levels in patients with schizophrenia before and after treatment. (2015 Jul 30)Lee BHPsychiatry Res
26694430Effect of Length of Stay on Smoking among Turkish and Eastern European Immigrants in Germany--Interpretation in the Light of the Smoking Epidemic Model and the Acculturation Theory. (2015 Dec 15)Reiss KInt J Environ Res Public Health