Gene: BPI

671
BPIFD1|rBPI
bactericidal permeability increasing protein
protein-coding
20q11.23
Ensembl:ENSG00000101425 MIM:109195 Vega:OTTHUMG00000032441 UniprotKB:P17213
NG_047016.1
PubMed
0   ANCO-SNPs
OD|ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.929e-1 (AD)  3.353e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CEACAM80.884
DEFA30.822
DEFA40.809
CEACAM30.796
PARP150.789
MS4A30.786
SLAMF70.783
SLAMF60.767
TCN10.767
LILRB20.761

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAGIX-0.493
MYADML2-0.474
SVOP-0.471
EXTL1-0.469
PRKCZ-0.469
HRH3-0.467
BCL11A-0.467
SYT3-0.464
KCNC2-0.463
CHRNA4-0.462

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04178Di-Stearoyl-3-Sn-PhosphatidylcholineSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of BPI mRNA"23829299
D000082AcetaminophenAcetaminophen affects the expression of BPI mRNA17562736
C006632arsenic trioxidearsenic trioxide results in increased expression of BPI mRNA15761015|2045855
C547126AZM551248AZM551248 results in increased expression of BPI mRNA22323515
C006780bisphenol Abisphenol A affects the expression of BPI mRNA25181051
C037123cadmium sulfatecadmium sulfate results in increased expression of BPI mRNA12064557|1467641
D002509CephaloridineCephaloridine results in increased expression of BPI mRNA18500788
D003520CyclophosphamideCyclophosphamide results in decreased expression of BPI mRNA17403535
D003976DiazinonDiazinon results in increased methylation of BPI gene22964155
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of BPI mRNA25613284
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of BPI mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of BPI mRNA25613284
D008777MethyltestosteroneMethyltestosterone results in decreased expression of BPI mRNA29191790
D009534NiclosamideNiclosamide results in decreased expression of BPI mRNA26452273
D010100OxygenOxygen deficiency results in decreased expression of BPI mRNA24205000
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of BPI mRNA26705709
D012715Sesame OilSesame Oil results in increased expression of BPI mRNA29191790
C017947sodium arsenitesodium arsenite affects the methylation of BPI gene28589171
D012969Sodium FluorideSodium Fluoride results in increased expression of BPI protein28918527
C061133tamibarotenetamibarotene results in increased expression of BPI mRNA15498508
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of BPI mRNA25613284
D014212TretinoinTretinoin results in increased expression of BPI mRNA15498508
D014635Valproic AcidValproic Acid affects the expression of BPI mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001530lipopolysaccharide binding-IDA8409400  
GO ID GO Term Qualifier Evidence PubMed
GO:0019730antimicrobial humoral response-TAS-  
GO:0032715negative regulation of interleukin-6 production-IDA8409400  
GO:0032717negative regulation of interleukin-8 production-IDA8409400  
GO:0032720negative regulation of tumor necrosis factor production-IDA8409400  
GO:0043031negative regulation of macrophage activation-IDA8409400  
GO:0043312neutrophil degranulation-TAS-  
GO:0050829defense response to Gram-negative bacterium-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0016020membrane-IEA-  
GO:0035578azurophil granule lumen-TAS-  
GO:0035580specific granule lumen-TAS-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-6803157Antimicrobial peptidesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
2365797[Clinical picture and background for progression of peripheral arteriosclerosis in Japanese patients with coronary artery disease]. (1990 Apr)Takita TNihon Ika Daigaku Zasshi
11378852Scanning of estrogen receptor alpha (ERalpha) and thyroid hormone receptor alpha (TRalpha) genes in patients with psychiatric diseases: four missense mutations identified in ERalpha gene. (2001 May 8)Feng JAm J Med Genet
10447663Priming of cytokine release and increased levels of bactericidal permeability-increasing protein in the blood of animal facility workers. (1999 Aug)Borm PJInt Arch Occup Environ Health
23803696Innate immunity gene polymorphisms and the risk of colorectal neoplasia. (2013 Nov)Chang CMCarcinogenesis
1518686Maternal smoking and behavior problems of children. (1992 Sep)Weitzman MPediatrics
20174761Circulating bactericidal/permeability-increasing protein (BPI) is associated with serum lipids and endothelial function. (2010 Apr)Esteve EThromb Haemost