Gene: SPTB

6710
EL3|HS2|HSPTB1|SPH2
spectrin beta, erythrocytic
protein-coding
14q23.3
Ensembl:ENSG00000070182 MIM:182870 Vega:OTTHUMG00000171550 UniprotKB:P11277
NG_016202.2
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.563e-1 (AD)  5.112e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs229609chr14:64833092 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs1875053chr14:64788300 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07119168chr14:65225253SPTB1.460e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GRIN2B0.937
DPP60.934
CHRNB20.933
CHRM40.931
ABLIM20.926
PLXNA40.924
DLG30.924
WSCD20.924
SLC12A50.923
MMP240.922

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.552
REST-0.548
MYL3-0.545
HEY2-0.539
RNF135-0.531
COPZ2-0.531
RAB13-0.529
GNG11-0.527
RAI14-0.524
CLEC2B-0.524

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0271321-anilino-8-naphthalenesulfonate1-anilino-8-naphthalenesulfonate binds to [SPTA1 protein binds to SPTB protein]15492010
D020106AcrylamideAcrylamide results in decreased expression of SPTB mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SPTB gene27153756
C006632arsenic trioxidearsenic trioxide results in increased expression of SPTB mRNA20458559
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of SPTB gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SPTB mRNA22228805
D004958EstradiolEstradiol promotes the reaction [SPTB protein binds to ESR1 protein]27156127
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of SPTB mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of SPTB mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of SPTB mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of SPTB protein24552547
C006780bisphenol Abisphenol A results in increased methylation of SPTB gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased degradation of [SPTA1 protein binds to SPTB protein]15040847
D019327Copper SulfateCopper Sulfate results in decreased expression of SPTB mRNA19549813
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SPTB mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SPTB mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of SPTB mRNA28962523
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SPTB mRNA26924002
C024629dimethyl phthalatedimethyl phthalate affects the expression of SPTB mRNA26924002
D019791GuanidineGuanidine affects the folding of [SPTA1 protein binds to SPTB protein]15711878
D019791GuanidineGuanidine inhibits the reaction [prodan binds to [SPTA1 protein binds to SPTB protein]]15711878
D007854LeadLead affects the expression of SPTB mRNA28903495
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SPTB mRNA26924002
C017096n-butoxyethanoln-butoxyethanol results in increased expression of SPTB mRNA19812364
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of SPTB mRNA]"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of SPTB mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of SPTB mRNA]"21673326
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SPTB mRNA23608068
C038517prodanGuanidine inhibits the reaction [prodan binds to [SPTA1 protein binds to SPTB protein]]15711878
C038517prodanprodan binds to [SPTA1 protein binds to SPTB protein]15492010
C038517prodanUrea inhibits the reaction [prodan binds to [SPTA1 protein binds to SPTB protein]]15711878
D012293RifampinRifampin results in increased expression of SPTB mRNA24552687
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of SPTB mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SPTB mRNA25895662
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SPTB mRNA15716485
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SPTB mRNA26377647
D014212TretinoinTretinoin results in decreased expression of SPTB mRNA23724009
C012589trichostatin Atrichostatin A results in decreased expression of SPTB mRNA15901671
D014508UreaUrea affects the folding of [SPTA1 protein binds to SPTB protein]15711878
D014508UreaUrea inhibits the reaction [prodan binds to [SPTA1 protein binds to SPTB protein]]15711878
D014635Valproic AcidValproic Acid results in decreased expression of SPTB mRNA15901671
D014635Valproic AcidValproic Acid results in increased methylation of SPTB gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SPTB mRNA21427059
D014810Vitamin EVitamin E results in decreased expression of SPTB mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-TAS2195026  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005200structural constituent of cytoskeleton-IEA-  
GO:0005515protein binding-IPI10751147  12820899  16060676  20197550  23414517  
GO:0030506ankyrin binding-IPI8159688  
GO:0051015actin filament binding-IDA16060676  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0006888ER to Golgi vesicle-mediated transport-TAS-  
GO:0007010cytoskeleton organization-IEA-  
GO:0007411axon guidance-TAS-  
GO:0051693actin filament capping-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005794Golgi apparatus-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0008091spectrin-IEA-  
GO:0014731spectrin-associated cytoskeleton-IDA379653  
GO:0015629actin cytoskeleton-TAS10950304  
GO:0031235intrinsic component of the cytoplasmic side of the plasma membrane-TAS10950304  
GO:0032991protein-containing complex-IDA16060676  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-199977ER to Golgi Anterograde TransportTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-373760L1CAM interactionsTAS
R-HSA-373760L1CAM interactionsIEA
R-HSA-375165NCAM signaling for neurite out-growthTAS
R-HSA-375165NCAM signaling for neurite out-growthIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-445095Interaction between L1 and AnkyrinsTAS
R-HSA-445095Interaction between L1 and AnkyrinsIEA
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6807878COPI-mediated anterograde transportTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25486289Interpregnancy Interval and Anti-inflammatory Cervical Cytokines among Women with Previous Spontaneous Preterm Birth. (2015 Jun)Shree RAm J Perinatol
27550735Racial disparities in cervical length for prediction of preterm birth in a low risk population. (2017 Aug)Buck JNJ Matern Fetal Neonatal Med