Gene: SQLE

6713
-
squalene epoxidase
protein-coding
8q24.13
Ensembl:ENSG00000104549 MIM:602019 Vega:OTTHUMG00000164990 UniprotKB:Q14534
NC_000008.11
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.598e-2 (AD)  3.906e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACAT20.902
HMGCR0.879
FDFT10.879
SC5D0.874
HMGCS10.868
FDPS0.859
IDI10.85
NSDHL0.848
INSIG10.838
DHCR240.837

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.513
OR4F29-0.482
MTRNR2L10-0.433
MTRNR2L8-0.424
MTRNR2L6-0.424
MTRNR2L9-0.422
MTRNR2L2-0.409
P2RY14-0.382
TTLL10-0.368
MMP9-0.362

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00735NaftifineSmall Molecule65472-88-0ApprovedTarget
DB00857TerbinafineSmall Molecule91161-71-6Approved|InvestigationalTarget
DB01091ButenafineSmall Molecule101828-21-1ApprovedTarget
DB04927NM100060Small Molecule-InvestigationalTarget
DB08846Ellagic AcidSmall Molecule476-66-4InvestigationalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of SQLE mRNA"19162173
C0184061-(3-trifluoromethylphenyl)piperazine1-(3-trifluoromethylphenyl)piperazine results in increased expression of SQLE mRNA26821219
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SQLE mRNA"22698814|2890350
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SQLE mRNA]"22698814
C4901661-(4-methoxyphenyl)piperazine1-(4-methoxyphenyl)piperazine results in increased expression of SQLE mRNA26821219
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of SQLE mRNA28329830
C0780921-piperonylpiperazine1-piperonylpiperazine results in increased expression of SQLE mRNA26821219
C00358522-hydroxycholesterol22-hydroxycholesterol results in decreased expression of SQLE mRNA19426978
C0761592,3-dichloro-1-propanol"2,3-dichloro-1-propanol results in decreased expression of SQLE mRNA"25424538
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of SQLE mRNA"28433925
C0109142,4-diaminotoluene"2,4-diaminotoluene results in decreased expression of SQLE mRNA"20713471
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SQLE mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SQLE mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SQLE mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SQLE mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SQLE mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SQLE mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SQLE mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SQLE mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SQLE mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SQLE mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SQLE mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SQLE mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SQLE mRNA11793227|2906747
D000082AcetaminophenAcetaminophen affects the expression of SQLE mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of SQLE mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SQLE mRNA]17585979
D020106AcrylamideAcrylamide results in increased expression of SQLE mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SQLE mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SQLE gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SQLE mRNA19770486
D000638AmiodaroneAmiodarone results in increased expression of SQLE mRNA24489787
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SQLE mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of SQLE mRNA"22863853
D000965AntimonyAntimony results in decreased expression of SQLE mRNA17547211
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in decreased expression of SQLE mRNA17547211
C519728archazolid Barchazolid B results in increased expression of SQLE mRNA25218289
C006632arsenic trioxidearsenic trioxide results in decreased expression of SQLE mRNA27829220
C406592azaspiracidazaspiracid results in increased expression of SQLE mRNA28939011
D001379AzathioprineAzathioprine results in decreased expression of SQLE mRNA22623647
D001554BenzeneBenzene affects the expression of SQLE mRNA15878777
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of SQLE mRNA26377693
D019324beta-NaphthoflavoneAHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of SQLE mRNA]22234961
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of SQLE mRNA22234961
D019324beta-NaphthoflavoneAHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of SQLE mRNA]22234961
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of SQLE mRNA22234961
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SQLE mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SQLE mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SQLE mRNA22228805
D004958EstradiolEstradiol results in decreased expression of SQLE mRNA19484750
D004958EstradiolEstradiol results in increased expression of SQLE mRNA14664709
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid affects the expression of SQLE mRNA18192240
C044887beta-methylcholinebeta-methylcholine affects the expression of SQLE mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SQLE mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of SQLE mRNA19371625
C006780bisphenol Abisphenol A results in increased expression of SQLE mRNA25047013
C006780bisphenol Abisphenol A results in increased expression of SQLE mRNA21932408|2516818
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of SQLE mRNA"28433925
C006780bisphenol Abisphenol A results in increased expression of SQLE mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SQLE mRNA22079614
D001973BromodeoxyuridineBromodeoxyuridine results in increased expression of SQLE mRNA24910943
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SQLE mRNA15336504
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of SQLE mRNA14729362
C584509C646 compoundC646 compound results in decreased expression of SQLE mRNA26191083
D002104CadmiumCadmium results in increased expression of SQLE mRNA24067728
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SQLE mRNA25993096
C037123cadmium sulfate[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of SQLE mRNA18654764
D002110CaffeineCaffeine results in decreased expression of SQLE mRNA11793227
D002110CaffeineCaffeine results in decreased expression of SQLE mRNA20864626
D002110CaffeineCaffeine results in increased expression of SQLE mRNA25868845
D002330CarmustineSQLE mRNA affects the susceptibility to Carmustine16365179
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SQLE mRNA23650126
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SQLE mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of SQLE mRNA26272509
C100187chloropicrinchloropicrin results in decreased expression of SQLE mRNA26352163|2847649
D004390ChlorpyrifosChlorpyrifos results in increased expression of SQLE mRNA25424538
D002791Cholesterol, Dietary"Cholesterol, Dietary deficiency results in increased expression of SQLE mRNA"20926756
D002922CiguatoxinsCiguatoxins affects the expression of SQLE mRNA18353800
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of SQLE mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of SQLE mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SQLE mRNA]17585979
C018021cobaltous chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of SQLE mRNA18654764
C018021cobaltous chloridecobaltous chloride results in decreased expression of SQLE mRNA19320972
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SQLE mRNA20971185
D003300CopperCopper results in decreased expression of SQLE mRNA17205981
D003300CopperCopper results in increased expression of SQLE mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of SQLE mRNA19549813
D019327Copper SulfateCopper Sulfate results in increased expression of SQLE mRNA12860252
D003314Corn OilCorn Oil affects the expression of SQLE mRNA16360708
D003474CurcuminCurcumin affects the expression of SQLE mRNA27208389
D003474CurcuminCurcumin results in decreased expression of SQLE mRNA27208389
D016572CyclosporineCyclosporine results in decreased expression of SQLE mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of SQLE mRNA19770486
D003907DexamethasoneDexamethasone results in increased expression of SQLE mRNA21356098
D003907DexamethasoneDexamethasone results in increased expression of SQLE mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SQLE mRNA28628672
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SQLE mRNA16054899
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SQLE mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SQLE mRNA21266533|2174549
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of SQLE mRNA28962523
D002945CisplatinCisplatin results in decreased expression of SQLE mRNA27594783
D004008DiclofenacDiclofenac results in increased expression of SQLE mRNA26934552
D004041Dietary FatsDietary Fats affects the expression of SQLE mRNA19680557
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of SQLE mRNA28433925
D004041Dietary FatsDietary Fats results in decreased expression of SQLE mRNA15238619|1903023
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of SQLE mRNA28433925
D019422Dietary SucroseDietary Sucrose results in increased expression of SQLE mRNA26033743
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of SQLE mRNA"28433925
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of SQLE mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SQLE mRNA18164116
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of SQLE mRNA19638242
C115058difenoconazoledifenoconazole results in increased expression of SQLE mRNA28263823
D002117CalcitriolCalcitriol results in increased expression of SQLE mRNA16002434
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of SQLE mRNA17547211
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of SQLE mRNA18242016
D004317DoxorubicinDoxorubicin results in decreased expression of SQLE mRNA15205334
C118739entinostatentinostat results in decreased expression of SQLE mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SQLE mRNA22079256
D000431EthanolEthanol results in increased expression of SQLE mRNA17920746
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of SQLE mRNA17347304
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SQLE mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SQLE mRNA16174780|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SQLE mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SQLE mRNA17351261
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SQLE mRNA15901920
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SQLE mRNA16174780
C002994ethylene dimethanesulfonateethylene dimethanesulfonate results in decreased expression of SQLE mRNA22711419
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SQLE mRNA23649840
D015025ZearalenoneZearalenone results in decreased expression of SQLE mRNA19371625|2542453
D005228Fatty Acids, Essential"Fatty Acids, Essential deficiency results in increased expression of SQLE mRNA"23333450
D011345FenofibrateFenofibrate results in increased expression of SQLE mRNA23063693
D011345FenofibrateNR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SQLE mRNA]23063693
D011345FenofibrateNR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SQLE mRNA]23063693
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride results in increased expression of SQLE mRNA24356939
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of SQLE mRNA17347304
D005419FlavonoidsFlavonoids results in decreased expression of SQLE mRNA18035473
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of SQLE mRNA28329830
C007738fluoranthenefluoranthene results in decreased expression of SQLE mRNA28329830
D005472FluorouracilFluorouracil results in decreased expression of SQLE mRNA15205334
D005473FluoxetineFluoxetine results in decreased expression of SQLE mRNA21852994
C061365flusilazoleflusilazole affects the expression of SQLE mRNA21195148
C061365flusilazoleflusilazole results in increased expression of SQLE mRNA22664269
D005557FormaldehydeFormaldehyde results in decreased expression of SQLE mRNA20655997|2364984
C039281furanfuran results in increased expression of SQLE mRNA24183702
D019833GenisteinGenistein results in decreased expression of SQLE mRNA19371625
D005897GlafenineGlafenine results in increased expression of SQLE mRNA24136188
C409722hexaconazolehexaconazole affects the expression of SQLE mRNA21195148
D017313FenretinideFenretinide results in decreased expression of SQLE mRNA28973697
D017313FenretinideFenretinide results in increased expression of SQLE mRNA28973697
D006861Hydrogen Peroxide[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SQLE mRNA18032389
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of SQLE mRNA14729362
C492448ICG 001ICG 001 results in decreased expression of SQLE mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SQLE mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SQLE mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SQLE mRNA28628672
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SQLE mRNA16054899
D007529IsoflavonesIsoflavones affects the expression of SQLE mRNA16365062
D007545IsoproterenolIsoproterenol results in increased expression of SQLE mRNA21335049
C016527isoquercitrin[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SQLE mRNA18032389
D007649KetamineKetamine results in decreased expression of SQLE mRNA20080153
D007654KetoconazoleKetoconazole results in increased expression of SQLE mRNA28263823
C029891lead chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of SQLE mRNA18654764
C045463leflunomideleflunomide results in decreased expression of SQLE mRNA28988120
C045463leflunomideleflunomide results in decreased expression of SQLE mRNA19751817
D001556LindaneLindane results in increased expression of SQLE mRNA17785943
C042720mercuric bromidemercuric bromide results in decreased expression of SQLE mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SQLE mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SQLE mRNA23649840
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of SQLE mRNA12634122
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of SQLE mRNA19840844
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of SQLE mRNA23118965
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of SQLE protein24625837
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SQLE mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SQLE mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SQLE mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SQLE mRNA"25554681
C461488N-benzylpiperazineN-benzylpiperazine results in increased expression of SQLE mRNA26821219
C017096n-butoxyethanoln-butoxyethanol results in increased expression of SQLE mRNA19812364
C022838nickel chloridenickel chloride results in decreased expression of SQLE mRNA17312168
C028007nickel monoxidenickel monoxide results in increased expression of SQLE mRNA19167457
C570896NSC305787NSC305787 results in increased expression of SQLE mRNA27137931
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SQLE mRNA20971185
D019319Okadaic Acid[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of SQLE mRNA19840844
C016340o,p'-DDT"o,p'-DDT results in decreased expression of SQLE mRNA"19371625
D010081OxazoloneOxazolone results in increased expression of SQLE mRNA18242016
D010126OzoneOzone results in decreased expression of SQLE mRNA16716893
D000073878Palm OilPalm Oil affects the expression of SQLE mRNA19680557
D010269ParaquatParaquat results in decreased expression of SQLE mRNA21371552
D010269ParaquatParaquat affects the expression of SQLE mRNA16854511
D010269ParaquatParaquat results in decreased expression of SQLE mRNA18198484
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SQLE mRNA19162173
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of SQLE mRNA19429403|2093613
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SQLE mRNA17560707|1916217
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SQLE mRNA25868421
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SQLE protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SQLE mRNA23978341
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SQLE mRNA17681415|1942940
D010634PhenobarbitalPhenobarbital affects the expression of SQLE mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of SQLE mRNA19162173
D010656PhenylephrinePhenylephrine results in increased expression of SQLE mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SQLE mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SQLE mRNA26272509
D010665PhenylpropanolaminePhenylpropanolamine results in increased expression of SQLE mRNA27756839
D010795Phthalic AcidsPhthalic Acids results in decreased expression of SQLE mRNA15728792
D010840PhytosterolsAPOE gene mutant form affects the reaction [Phytosterols results in increased expression of SQLE mRNA]18155511
D010852PicrotoxinPicrotoxin results in decreased expression of SQLE mRNA15170462
C006253pirinixic acidpirinixic acid results in decreased expression of SQLE mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of SQLE mRNA11798191|1846767
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of SQLE mRNA]18467677|2005976
D010936Plant ExtractsPlant Extracts results in increased expression of SQLE mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SQLE mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SQLE mRNA22079256
D011374ProgesteroneProgesterone results in increased expression of SQLE mRNA23012394
D011374ProgesteroneProgesterone results in decreased expression of SQLE mRNA22238285
D011411PropanilPropanil results in decreased expression of SQLE mRNA24356939
C045950propiconazolepropiconazole results in increased expression of SQLE mRNA21278054
C045950propiconazolepropiconazole results in increased expression of SQLE mRNA28970091
D011441PropylthiouracilPropylthiouracil results in decreased expression of SQLE mRNA24780913
D011794QuercetinQuercetin results in increased expression of SQLE mRNA21356098
D011794QuercetinQuercetin results in decreased expression of SQLE mRNA21632981
C049331racecadotrilracecadotril results in increased expression of SQLE mRNA25424538
C059514resveratrolresveratrol results in decreased expression of SQLE mRNA19371625
D012312RitodrineRitodrine results in decreased expression of SQLE mRNA23370008
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SQLE mRNA16054899
C009250sevofluranesevoflurane affects the expression of SQLE mRNA15967596
D012969Sodium FluorideSodium Fluoride results in decreased expression of SQLE mRNA21340527
D053260SootSoot results in increased expression of SQLE mRNA22461453
C446685systhanesysthane results in increased expression of SQLE mRNA19409404
C013698tallowtallow affects the expression of SQLE mRNA19680557
D013629TamoxifenTamoxifen affects the expression of SQLE mRNA17555576|2093736
D013629TamoxifenTamoxifen results in decreased expression of SQLE mRNA25123088
C047246temozolomideSQLE mRNA affects the susceptibility to temozolomide16365179
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SQLE mRNA26377647|2892240
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of SQLE mRNA"28433925
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SQLE mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SQLE mRNA28238261
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SQLE mRNA11752688
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SQLE mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of SQLE mRNA22378314
D013849ThimerosalThimerosal results in decreased expression of SQLE mRNA27188386
D013853ThioacetamideThioacetamide results in decreased expression of SQLE mRNA11793227
D013853ThioacetamideThioacetamide results in increased expression of SQLE mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of SQLE mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SQLE mRNA28065790
C082097tocotrienol, delta"tocotrienol, delta results in increased expression of SQLE mRNA"21356098
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of SQLE mRNA"18242016
C052342topiramatetopiramate results in decreased expression of SQLE mRNA16979414
C032910triadimefontriadimefon affects the expression of SQLE mRNA21195148
C032910triadimefontriadimefon results in increased expression of SQLE mRNA17178688
C032910triadimefontriadimefon results in increased expression of SQLE mRNA19409404|1942368
D014241TrichloroethyleneTrichloroethylene results in decreased expression of SQLE mRNA25549359
C012589trichostatin Atrichostatin A affects the expression of SQLE mRNA28542535
D014260TriclosanTriclosan results in decreased expression of SQLE mRNA25554385
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SQLE mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of SQLE mRNA25572481
D014415TunicamycinTunicamycin results in decreased expression of SQLE mRNA22378314
C406224valdecoxibvaldecoxib results in increased expression of SQLE mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SQLE mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SQLE mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SQLE mRNA19101580|2317975
D014635Valproic AcidValproic Acid affects the expression of SQLE mRNA17963808
D014638VanadatesVanadates results in decreased expression of SQLE mRNA22714537
D014640VancomycinVancomycin results in decreased expression of SQLE mRNA18930951
C025643vinclozolinvinclozolin results in increased expression of SQLE mRNA22570695
D012256RiboflavinRiboflavin results in increased expression of SQLE mRNA21356098
C111237vorinostatvorinostat results in decreased expression of SQLE mRNA27188386
C088658zoledronic acidzoledronic acid results in increased expression of SQLE mRNA20977926|2471476
C088658zoledronic acidzoledronic acid results in increased expression of SQLE mRNA18325729

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004506squalene monooxygenase activity-IBA21873635  
GO:0004506squalene monooxygenase activity-NAS9286711  
GO:0004506squalene monooxygenase activity-TAS-  
GO:0050660flavin adenine dinucleotide binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006695cholesterol biosynthetic process-TAS-  
GO:0006725cellular aromatic compound metabolic process-IEA-  
GO:0008203cholesterol metabolic process-IBA21873635  
GO:0010033response to organic substance-IEA-  
GO:0016126sterol biosynthetic process-IBA21873635  
GO:0016126sterol biosynthetic process-NAS9286711  
GO:0045540regulation of cholesterol biosynthetic process-TAS-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0031090organelle membrane-IEA-  
KEGG ID KEGG Term
hsa00100Steroid biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)TAS
R-HSA-191273Cholesterol biosynthesisTAS
R-HSA-2426168Activation of gene expression by SREBF (SREBP)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26767013Expression and significance of squalene epoxidase in squamous lung cancerous tissues and pericarcinoma tissues. (2014 Jul)Zhang HYThorac Cancer