Gene: SRD5A1

6715
S5AR 1
steroid 5 alpha-reductase 1
protein-coding
5p15.31
Ensembl:ENSG00000145545 MIM:184753 Vega:OTTHUMG00000090456 UniprotKB:P18405
NC_000005.10
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
4   
1.117e-1 (AD)  3.370e-1 (ND)   (Frontal_Cortex)
9.844e-1 (AD)  8.480e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIF3A0.956
PPP3CB0.955
MAPK90.953
TTC90.949
GPRASP20.948
ATP6V1A0.947
NSF0.947
MAP2K40.946
PAK30.945
RAB3C0.945

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.535
RNF135-0.501
MAGEA12-0.495
HEY2-0.494
REST-0.483
S100A12-0.482
YES1-0.479
CNN2-0.479
IL18RAP-0.476
CXCR2-0.475

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00367LevonorgestrelSmall Molecule797-63-7Approved|InvestigationalTarget
DB01126DutasterideSmall Molecule164656-23-9Approved|InvestigationalTarget
DB01216FinasterideSmall Molecule98319-26-7ApprovedTarget
DB09389NorgestrelSmall Molecule6533-00-2ApprovedTarget
DB00421SpironolactoneSmall Molecule52-01-7ApprovedTarget
DB06412OxymetholoneSmall Molecule434-07-1Approved|IllicitEnzyme
DB01420Testosterone propionateSmall Molecule57-85-2Approved|Investigational|WithdrawnEnzyme
DB13943Testosterone cypionateSmall Molecule58-20-8ApprovedEnzyme
DB13944Testosterone enanthateSmall Molecule315-37-7ApprovedEnzyme
DB13946Testosterone undecanoateSmall Molecule5949-44-0Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of SRD5A1 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SRD5A1 mRNA"22698814
C03156317-N,N-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one"17-N,N-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one results in decreased activity of SRD5A1 protein"8142312
C0297902,2',3',4,4',5-hexachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] affects the expression of SRD5A1 protein"19464308
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of SRD5A1 mRNA"21724226
C5471242,3-dibromopropyl-2,4,6-tribromophenyl ether"2,3-dibromopropyl-2,4,6-tribromophenyl ether metabolite results in decreased expression of SRD5A1 mRNA"26318274
C5471242,3-dibromopropyl-2,4,6-tribromophenyl ether"2,3-dibromopropyl-2,4,6-tribromophenyl ether results in decreased expression of SRD5A1 mRNA"26318274
C5471242,3-dibromopropyl-2,4,6-tribromophenyl ether"2,3-dibromopropyl-2,4,6-tribromophenyl ether analog results in decreased expression of SRD5A1 mRNA"25454221
C5471242,3-dibromopropyl-2,4,6-tribromophenyl ether"2,3-dibromopropyl-2,4,6-tribromophenyl ether results in decreased expression of SRD5A1 mRNA"25454221
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] affects the expression of SRD5A1 protein"19464308
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of SRD5A1 mRNA"16984957
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SRD5A1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SRD5A1 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] affects the expression of SRD5A1 protein"19464308
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of SRD5A1 mRNA"16984957
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SRD5A1 mRNA"20959002
C0087454,4'-bisphenol F"4,4'-bisphenol F results in increased expression of SRD5A1 mRNA"25576683
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SRD5A1 mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SRD5A1 mRNA"25380136
D020106AcrylamideAcrylamide results in decreased expression of SRD5A1 mRNA22459607
D000242Cyclic AMPCyclic AMP results in increased expression of SRD5A1 mRNA25576683
C028952allopregnan-20 alpha-ol-3-oneSRD5A1 protein results in increased chemical synthesis of allopregnan-20 alpha-ol-3-one25463305
C016836allopregnane-3,20-diol"SRD5A1 protein results in increased chemical synthesis of allopregnane-3,20-diol"25463305
C000610085allyl 2,4,6-tribromophenyl ether"allyl 2,4,6-tribromophenyl ether results in decreased expression of SRD5A1 mRNA"25454221
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of SRD5A1 mRNA28522335
D0435825-alpha-DihydroprogesteroneSRD5A1 protein results in increased chemical synthesis of 5-alpha-Dihydroprogesterone25463305
D0435825-alpha-Dihydroprogesterone[SRD5A1 protein results in increased metabolism of Progesterone] which results in increased chemical synthesis of 5-alpha-Dihydroprogesterone23183084
D013196DihydrotestosteroneAR protein affects the reaction [vinclozolin inhibits the reaction [Dihydrotestosterone results in increased expression of SRD5A1 mRNA]]25324206
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of SRD5A1 mRNA25324206|2545422
D013196Dihydrotestosteronevinclozolin inhibits the reaction [Dihydrotestosterone results in increased expression of SRD5A1 mRNA]25324206
D013196DihydrotestosteroneDihydrotestosterone affects the expression of SRD5A1 mRNA22131296
D013196DihydrotestosteroneSRD5A1 protein results in increased chemical synthesis of Dihydrotestosterone28535922
D013196Dihydrotestosterone[SRD5A1 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of Dihydrotestosterone28535922
D013196DihydrotestosteroneSRD5A1 protein results in increased chemical synthesis of Dihydrotestosterone21688280
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SRD5A1 mRNA16483693
D000728AndrogensAndrogens results in decreased expression of SRD5A1 mRNA17628001
C006632arsenic trioxidearsenic trioxide results in decreased expression of SRD5A1 mRNA19769630
D001280AtrazineAtrazine results in decreased expression of SRD5A1 mRNA23591565
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of SRD5A1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SRD5A1 mRNA27195522
C044887beta-methylcholinebeta-methylcholine affects the expression of SRD5A1 mRNA21179406
C095105bexarotenebexarotene results in decreased expression of SRD5A1 mRNA16648578
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of SRD5A1 mRNA25576683
C006780bisphenol Abisphenol A affects the expression of SRD5A1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SRD5A1 mRNA24586524
C006780bisphenol Abisphenol A results in increased expression of SRD5A1 mRNA23525218
C006780bisphenol Abisphenol A results in decreased expression of SRD5A1 mRNA23405234|2398439
C006780bisphenol Abisphenol A results in decreased expression of SRD5A1 protein23405234|2406605
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SRD5A1 mRNA24014645
C027561butylbenzyl phthalatebutylbenzyl phthalate results in decreased expression of SRD5A1 mRNA19560483
D002104CadmiumCadmium results in increased expression of SRD5A1 mRNA24376830
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SRD5A1 mRNA24794047
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SRD5A1 mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SRD5A1 mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SRD5A1 mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SRD5A1 mRNA18178546|2920848
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SRD5A1 protein29208485
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SRD5A1 gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of SRD5A1 mRNA18353800
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SRD5A1 mRNA17602206
D005576ColforsinColforsin results in increased expression of SRD5A1 mRNA22461451
D019327Copper SulfateCopper Sulfate results in decreased expression of SRD5A1 mRNA19549813
C015763cumene[cumene co-treated with KRAS gene mutant form] results in decreased expression of SRD5A1 mRNA18648096
D003471CuprizoneCuprizone results in decreased expression of SRD5A1 mRNA27523638
C093628cyproconazolecyproconazole results in increased expression of SRD5A1 mRNA22334560
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SRD5A1 mRNA24317228
D003687DehydroepiandrosteroneSRD5A1 protein affects the metabolism of Dehydroepiandrosterone15261307
C020735dibutyldichlorotindibutyldichlorotin results in decreased activity of SRD5A1 protein12231121
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SRD5A1 mRNA19560483
D004008DiclofenacDiclofenac results in decreased expression of SRD5A1 mRNA26934552
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SRD5A1 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of SRD5A1 mRNA25016146
D004042Dietary Fats, Unsaturated"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in decreased expression of SRD5A1 mRNA"23626681
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SRD5A1 mRNA19560483
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of SRD5A1 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SRD5A1 mRNA17602206
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of SRD5A1 mRNA28943392
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of SRD5A1 mRNA25380136
C034171di-n-pentyl phthalatedi-n-pentyl phthalate results in decreased expression of SRD5A1 mRNA19560483
D004237DiuronDiuron results in increased expression of SRD5A1 mRNA21551480
D004317DoxorubicinSRD5A1 protein affects the susceptibility to Doxorubicin16217747
D000068538DutasterideDutasteride results in decreased activity of SRD5A1 protein16806904
D000068538DutasterideDutasteride results in decreased expression of SRD5A1 mRNA16806904
D000068538DutasterideDutasteride results in decreased activity of SRD5A1 protein18559427|2056432
D004394DydrogesteroneDydrogesterone results in decreased expression of SRD5A1 mRNA23183084
C109476epoxiconazoleepoxiconazole results in increased expression of SRD5A1 mRNA22334560
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of SRD5A1 mRNA17347304
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SRD5A1 mRNA16940010
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SRD5A1 mRNA23550701
D018120Finasteride[Finasteride co-treated with Testosterone] results in increased expression of SRD5A1 mRNA23523586
D018120Finasteride[Finasteride co-treated with tributyltin co-treated with Testosterone] results in increased expression of SRD5A1 mRNA23523586
D018120FinasterideFinasteride results in decreased activity of SRD5A1 protein8142312|8689240
D018120FinasterideFinasteride results in decreased activity of SRD5A1 protein20359488
D018120FinasterideFinasteride results in decreased activity of SRD5A1 protein12736327|1749999
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of SRD5A1 mRNA17347304
D015725FluconazoleFluconazole results in decreased expression of SRD5A1 mRNA16643972
D005485Flutamide[Testosterone co-treated with Flutamide] results in increased expression of SRD5A1 mRNA22009729
D005485FlutamideFlutamide results in decreased expression of SRD5A1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SRD5A1 gene20938992
C521787ganoderol Bganoderol B results in decreased activity of SRD5A1 protein17499997
D017313FenretinideFenretinide results in increased expression of SRD5A1 mRNA28973697
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of SRD5A1 mRNA16849584
C016517indole-3-carbinolindole-3-carbinol affects the expression of SRD5A1 mRNA21396975
D007213IndomethacinIndomethacin results in increased expression of SRD5A1 mRNA18299717
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SRD5A1 mRNA25613284
D007529Isoflavones[selenomethylselenocysteine co-treated with Isoflavones] results in decreased activity of SRD5A1 protein19025659
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of SRD5A1 mRNA24435446
D007854LeadLead affects the expression of SRD5A1 mRNA28903495
C045463leflunomideleflunomide results in decreased expression of SRD5A1 mRNA24136188
D008044LinuronLinuron results in decreased expression of SRD5A1 mRNA28705778
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SRD5A1 mRNA27339419
C015329lycopenelycopene results in decreased expression of SRD5A1 mRNA15084515
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SRD5A1 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SRD5A1 mRNA26011545
D008787MetoclopramideMetoclopramide results in increased expression of SRD5A1 mRNA18978642
D008942MitoxantroneSRD5A1 protein affects the susceptibility to Mitoxantrone16217747
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SRD5A1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SRD5A1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SRD5A1 mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of SRD5A1 mRNA25380136
C051752nefazodonenefazodone results in decreased expression of SRD5A1 mRNA24136188
C028007nickel monoxidenickel monoxide results in increased expression of SRD5A1 mRNA19167457
C012655nimesulidenimesulide results in decreased expression of SRD5A1 mRNA24136188
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of SRD5A1 mRNA19716841
C572573N-nitroso-tris-chloroethylureaN-nitroso-tris-chloroethylurea results in increased expression of SRD5A1 mRNA27935865
D016912LevonorgestrelLevonorgestrel results in increased expression of SRD5A1 mRNA21914719
C108709oleoyl-estroneoleoyl-estrone results in increased expression of SRD5A1 mRNA19793540
D009966OrphenadrineOrphenadrine affects the expression of SRD5A1 mRNA23665939
D010047Ovalbumin[Ovalbumin affects the susceptibility to Particulate Matter] which results in decreased expression of SRD5A1 mRNA19176365
D010100OxygenOxygen deficiency results in increased expression of SRD5A1 mRNA20880076
D052638Particulate Matter[Ovalbumin affects the susceptibility to Particulate Matter] which results in decreased expression of SRD5A1 mRNA19176365
C410127PCB 180"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] affects the expression of SRD5A1 protein"19464308
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased activity of SRD5A1 protein28535922
C023036perfluorooctanoic acid"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in decreased expression of SRD5A1 mRNA"23626681
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SRD5A1 mRNA17681415|2362668
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased activity of SRD5A1 protein28535922
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SRD5A1 mRNA19162173
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of SRD5A1 mRNA17097637
D010634PhenobarbitalPhenobarbital results in decreased expression of SRD5A1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of SRD5A1 mRNA19363144
C032727piperidinepiperidine analog results in decreased activity of SRD5A1 protein10896124
C032727piperidinepiperidine analog results in decreased activity of SRD5A1 protein10896124
C006253pirinixic acidpirinixic acid results in decreased expression of SRD5A1 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of SRD5A1 mRNA19162173
D010936Plant ExtractsPlant Extracts results in decreased activity of SRD5A1 protein8142312
D011280PregnanoloneSRD5A1 protein results in increased chemical synthesis of Pregnanolone25463305
D011280PregnanoloneSRD5A1 protein results in increased chemical synthesis of Pregnanolone12957225
D011374ProgesteroneProgesterone results in decreased expression of SRD5A1 protein23183084
D011374ProgesteroneSRD5A1 protein results in increased metabolism of Progesterone23183084
D011374Progesterone[SRD5A1 protein results in increased metabolism of Progesterone] which results in increased chemical synthesis of 5-alpha-Dihydroprogesterone23183084
D011374ProgesteroneSRD5A1 protein results in increased reduction of Progesterone25463305
D011374ProgesteroneSRD5A1 protein affects the metabolism of Progesterone15555913
D011374ProgesteroneProgesterone analog results in decreased activity of SRD5A1 protein20359488
D011374ProgesteroneSRD5A1 protein affects the metabolism of Progesterone15261307
D011374ProgesteroneSRD5A1 protein results in increased metabolism of Progesterone12957225
C045950propiconazolepropiconazole results in increased expression of SRD5A1 mRNA22334560
C045950propiconazolepropiconazole results in decreased expression of SRD5A1 mRNA16643972
D011441PropylthiouracilPropylthiouracil results in decreased expression of SRD5A1 mRNA24780913
D054328Proton Pump InhibitorsProton Pump Inhibitors results in decreased expression of SRD5A1 mRNA25626140
D015474IsotretinoinIsotretinoin results in decreased expression of SRD5A1 mRNA20436886
C002979selenomethylselenocysteine[selenomethylselenocysteine co-treated with Isoflavones] results in decreased activity of SRD5A1 protein19025659
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SRD5A1 mRNA25351596
D012834SilverSilver analog results in increased expression of SRD5A1 mRNA27746313
D012834SilverSilver analog results in increased expression of SRD5A1 protein27746313
C473295SKF 105111SKF 105111 results in decreased activity of SRD5A1 protein12957225
D012906SmokeSmoke affects the expression of SRD5A1 mRNA23693141
D013469SulpirideSulpiride results in increased expression of SRD5A1 mRNA18978642
C037565terbutylazineterbutylazine results in decreased expression of SRD5A1 mRNA23591565
D013739Testosterone[Finasteride co-treated with Testosterone] results in increased expression of SRD5A1 mRNA23523586
D013739Testosterone[Finasteride co-treated with tributyltin co-treated with Testosterone] results in increased expression of SRD5A1 mRNA23523586
D013739TestosteroneSRD5A1 promotes the reaction [Testosterone results in increased expression of CPD mRNA]21688280
D013739TestosteroneTestosterone results in increased expression of SRD5A1 mRNA23523586
D013739Testosterone[tributyltin co-treated with Testosterone] results in increased expression of SRD5A1 mRNA23523586
D013739Testosterone[Testosterone co-treated with Flutamide] results in increased expression of SRD5A1 mRNA22009729
D013739TestosteroneTestosterone results in increased expression of SRD5A1 mRNA22009729
D013739TestosteroneSRD5A1 protein results in increased metabolism of Testosterone28535922
D013739Testosterone[SRD5A1 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of Dihydrotestosterone28535922
D013739TestosteroneTestosterone results in increased expression of SRD5A1 mRNA22131296
D013739TestosteroneSRD5A1 protein results in increased metabolism of Testosterone21688280
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of SRD5A1 mRNA25576683
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SRD5A1 mRNA20067830
D013749TetrachlorodibenzodioxinAHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SRD5A1 mRNA]16984957
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SRD5A1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SRD5A1 mRNA16984957|1879615
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SRD5A1 mRNA16054898|1817854
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SRD5A1 mRNA25613284
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of SRD5A1 mRNA28943392
D013853ThioacetamideThioacetamide results in decreased expression of SRD5A1 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SRD5A1 protein27818348
D019772TopotecanSRD5A1 protein affects the susceptibility to Topotecan16217747
C032910triadimefontriadimefon results in decreased expression of SRD5A1 mRNA19423681
C011559tributyltin[Finasteride co-treated with tributyltin co-treated with Testosterone] results in increased expression of SRD5A1 mRNA23523586
C011559tributyltin[tributyltin co-treated with Testosterone] results in increased expression of SRD5A1 mRNA23523586
C011559tributyltintributyltin results in decreased activity of SRD5A1 protein12231121
D014241TrichloroethyleneTrichloroethylene results in decreased expression of SRD5A1 mRNA19448997
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SRD5A1 mRNA"26743178
D014520UrethaneUrethane results in increased expression of SRD5A1 mRNA28818685
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SRD5A1 gene25560391
D014747VinblastineSRD5A1 protein affects the susceptibility to Vinblastine16217747
C025643vinclozolinAR protein affects the reaction [vinclozolin inhibits the reaction [Dihydrotestosterone results in increased expression of SRD5A1 mRNA]]25324206
C025643vinclozolinvinclozolin inhibits the reaction [Dihydrotestosterone results in increased expression of SRD5A1 mRNA]25324206
C025643vinclozolinvinclozolin results in decreased expression of SRD5A1 mRNA23034163
C016829vinyl fluoridevinyl fluoride analog results in decreased activity of SRD5A1 protein8689240
D014810Vitamin EVitamin E affects the expression of SRD5A1 mRNA20447326
D015032ZincZinc results in increased expression of SRD5A1 mRNA18172885

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00038653-oxo-5-alpha-steroid 4-dehydrogenase activity-IBA21873635  
GO:00038653-oxo-5-alpha-steroid 4-dehydrogenase activity-IDA17986282  
GO:00038653-oxo-5-alpha-steroid 4-dehydrogenase activity-TAS-  
GO:0009055electron transfer activity-TAS1686016  
GO:0016491oxidoreductase activity-IBA21873635  
GO:0033218amide binding-IEA-  
GO:0047751cholestenone 5-alpha-reductase activity-IEA-  
GO:0070402NADPH binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001655urogenital system development-IEA-  
GO:0001889liver development-IEA-  
GO:0006694steroid biosynthetic process-IBA21873635  
GO:0006702androgen biosynthetic process-TAS-  
GO:0007530sex determination-NAS1686016  
GO:0008584male gonad development-IEA-  
GO:0009267cellular response to starvation-IEA-  
GO:0014850response to muscle activity-IEA-  
GO:0016101diterpenoid metabolic process-IEA-  
GO:0021510spinal cord development-IEA-  
GO:0021766hippocampus development-IEA-  
GO:0021794thalamus development-IEA-  
GO:0021854hypothalamus development-IEA-  
GO:0021983pituitary gland development-IEA-  
GO:0021987cerebral cortex development-IEA-  
GO:0022900electron transport chain-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0032354response to follicle-stimulating hormone-IEA-  
GO:0032869cellular response to insulin stimulus-IEA-  
GO:0042428serotonin metabolic process-IEA-  
GO:0042747circadian sleep/wake cycle, REM sleep-IEA-  
GO:0043627response to estrogen-IEA-  
GO:0060348bone development-IEA-  
GO:0060416response to growth hormone-IEA-  
GO:0060992response to fungicide-IEA-  
GO:0071320cellular response to cAMP-IEA-  
GO:0071363cellular response to growth factor stimulus-IEA-  
GO:0071392cellular response to estradiol stimulus-IEA-  
GO:0071394cellular response to testosterone stimulus-IEA-  
GO:0071549cellular response to dexamethasone stimulus-IEA-  
GO:0071872cellular response to epinephrine stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0031090organelle membrane-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0043209myelin sheath-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0070852cell body fiber-IEA-  
KEGG ID KEGG Term
hsa00140Steroid hormone biosynthesis
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-193048Androgen biosynthesisTAS
R-HSA-196071Metabolism of steroid hormonesTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24838369Variation in AKR1C3, which encodes the neuroactive steroid synthetic enzyme 3alpha-HSD type 2 (17beta-HSD type 5), moderates the subjective effects of alcohol. (2014 Sep)Milivojevic VPsychopharmacology (Berl)
21849985A genomewide linkage scan of cocaine dependence and major depressive episode in two populations. (2011 Nov)Yang BZNeuropsychopharmacology
23197595Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy. (2013 Mar)O'Shaughnessy PJMol Hum Reprod
21323680Variation in genes encoding the neuroactive steroid synthetic enzymes 5alpha-reductase type 1 and 3alpha-reductase type 2 is associated with alcohol dependence. (2011 May)Milivojevic VAlcohol Clin Exp Res