Gene: SRD5A2

6716
-
steroid 5 alpha-reductase 2
protein-coding
2p23.1
Ensembl:ENSG00000277893 MIM:607306 Vega:OTTHUMG00000152057 UniprotKB:P31213
NG_008365.1
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.260e-1 (AD)  4.022e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR6N10.805
DAOA0.788
DSG40.785
OR4K170.78
OR5L10.775
OR4Q30.773
LRRC300.771
TCHHL10.771
OR5T20.77
KRTAP6-20.77

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SFTPC-0.242
FAM43B-0.229
RGS9BP-0.213
TSACC-0.208
PCDH9-0.207
MAGIX-0.207
C16orf95-0.199
MLYCD-0.197
C16orf46-0.197
HSPB2-0.196

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00548Azelaic AcidSmall Molecule123-99-9ApprovedTarget
DB01126DutasterideSmall Molecule164656-23-9Approved|InvestigationalTarget
DB01216FinasterideSmall Molecule98319-26-7ApprovedTarget
DB00421SpironolactoneSmall Molecule52-01-7ApprovedTarget
DB01420Testosterone propionateSmall Molecule57-85-2Approved|Investigational|WithdrawnEnzyme
DB13943Testosterone cypionateSmall Molecule58-20-8ApprovedEnzyme
DB13944Testosterone enanthateSmall Molecule315-37-7ApprovedEnzyme
DB13946Testosterone undecanoateSmall Molecule5949-44-0Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of SRD5A2 mRNA"19162173
C0297902,2',3',4,4',5-hexachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] affects the expression of SRD5A2 protein"19464308
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of SRD5A2 mRNA"21724226
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] affects the expression of SRD5A2 protein"19464308
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] affects the expression of SRD5A2 protein"19464308
C006418adrenocorticotropin zincadrenocorticotropin zinc results in decreased expression of SRD5A2 mRNA19920212
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SRD5A2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SRD5A2 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SRD5A2 mRNA19770486
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of SRD5A2 mRNA15056816
D013196Dihydrotestosteronehydroxyflutamide inhibits the reaction [Dihydrotestosterone results in increased expression of SRD5A2 mRNA]15056816
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of SRD5A2 mRNA22131296
D013196Dihydrotestosterone[Finasteride results in decreased activity of SRD5A2 protein] which results in decreased chemical synthesis of Dihydrotestosterone20564326
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SRD5A2 mRNA16483693
C028895androstane-3,17-diol glucuronide"SRD5A2 gene SNP results in decreased abundance of androstane-3,17-diol glucuronide"17136762
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SRD5A2 mRNA24449571
D004958EstradiolEstradiol results in decreased expression of SRD5A2 mRNA20106945
C099952bifenthrinbifenthrin results in decreased expression of SRD5A2 mRNA26071804
C006780bisphenol Abisphenol A results in decreased expression of SRD5A2 mRNA25434310
C006780bisphenol Abisphenol A results in decreased expression of SRD5A2 protein25434310
C006780bisphenol Abisphenol A results in decreased expression of SRD5A2 mRNA23405234|2398439
C006780bisphenol Abisphenol A results in decreased expression of SRD5A2 protein23405234|2618613
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased activity of SRD5A2 protein17218080
D002104CadmiumCadmium results in increased expression of SRD5A2 mRNA21120746
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of SRD5A2 mRNA16938428
D002726Chlorogenic AcidChlorogenic Acid results in decreased expression of SRD5A2 mRNA20706672
D016572CyclosporineCyclosporine results in decreased expression of SRD5A2 mRNA20106945
C017160cypermethrincypermethrin results in increased expression of SRD5A2 mRNA21142847
C020735dibutyldichlorotindibutyldichlorotin results in decreased activity of SRD5A2 protein17218080
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SRD5A2 mRNA25434310
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SRD5A2 protein25434310
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SRD5A2 mRNA26948521|2707974
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in decreased activity of SRD5A2 protein17218080
D004042Dietary Fats, Unsaturated"Dietary Fats, Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of SRD5A2 mRNA]"23626681
D004042Dietary Fats, Unsaturated"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in decreased expression of SRD5A2 mRNA"23626681
D000068538DutasterideDutasteride results in decreased expression of SRD5A2 mRNA16806904
D000068538DutasterideDutasteride results in decreased activity of SRD5A2 protein20564326
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of SRD5A2 mRNA20706672
C033789fenarimolfenarimol results in decreased activity of SRD5A2 protein17218080
D018120FinasterideFinasteride results in decreased activity of SRD5A2 protein18644453
D018120FinasterideFinasteride inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA]23523586
D018120FinasterideFinasteride promotes the reaction [tributyltin inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA]]23523586
D018120FinasterideFinasteride results in decreased activity of SRD5A2 protein17218080|1864445
D018120Finasteridetributyltin promotes the reaction [Finasteride inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA]]23523586
D018120FinasterideFinasteride results in decreased activity of SRD5A2 protein19169095|2056432
D018120Finasteride[Finasteride results in decreased activity of SRD5A2 protein] which results in decreased chemical synthesis of Dihydrotestosterone20564326
D005485FlutamideFlutamide results in decreased activity of SRD5A2 protein17218080
D005620Freund's AdjuvantFreund's Adjuvant results in increased expression of SRD5A2 mRNA20846436
C069837fullerene C60fullerene C60 results in decreased expression of SRD5A2 mRNA19167457
C039281furanfuran results in increased expression of SRD5A2 mRNA22079235
D019833GenisteinGenistein results in decreased expression of SRD5A2 mRNA20706672
D017313FenretinideFenretinide results in increased expression of SRD5A2 mRNA28973697
C014290hydroxyflutamidehydroxyflutamide inhibits the reaction [Dihydrotestosterone results in increased expression of SRD5A2 mRNA]15056816
D008044LinuronLinuron results in decreased activity of SRD5A2 protein17218080
C013592mangiferinmangiferin results in decreased activity of SRD5A2 protein20823678
D008777MethyltestosteroneMethyltestosterone results in decreased activity of SRD5A2 protein17218080
D008787MetoclopramideMetoclopramide results in increased expression of SRD5A2 mRNA18978642
C028007nickel monoxidenickel monoxide results in decreased expression of SRD5A2 mRNA19167457
D016912LevonorgestrelLevonorgestrel results in increased expression of SRD5A2 mRNA21914719
C485800osajinosajin results in decreased expression of SRD5A2 mRNA20706672
C410127PCB 180"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] affects the expression of SRD5A2 protein"19464308
C023036perfluorooctanoic acid"Dietary Fats, Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of SRD5A2 mRNA]"23626681
C023036perfluorooctanoic acid"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in decreased expression of SRD5A2 mRNA"23626681
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SRD5A2 mRNA20118188|2362668
C023036perfluorooctanoic acidPPARA promotes the reaction [perfluorooctanoic acid results in increased expression of SRD5A2 mRNA]20118188
C032727piperidinepiperidine analog results in decreased activity of SRD5A2 protein10896124
C032727piperidinepiperidine analog results in decreased activity of SRD5A2 protein10896124
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SRD5A2 mRNA19710929
D059808PolyphenolsPolyphenols results in decreased expression of SRD5A2 mRNA16293270
C474837pomiferinpomiferin results in decreased expression of SRD5A2 mRNA20706672
D017035PravastatinPravastatin results in decreased expression of SRD5A2 mRNA27225895
D011245PregnadienesPregnadienes analog results in decreased activity of SRD5A2 protein18644453
D011245PregnadienesPregnadienes analog results in decreased activity of SRD5A2 protein18644453
C045362prochlorazprochloraz results in decreased activity of SRD5A2 protein17218080
D011374ProgesteroneProgesterone analog results in decreased activity of SRD5A2 protein20359488
D011429PropolisPropolis results in decreased expression of SRD5A2 mRNA20706672
C033607puerarinpuerarin results in decreased expression of SRD5A2 mRNA20706672
C059514resveratrolresveratrol results in decreased expression of SRD5A2 mRNA20706672
C059514resveratrolresveratrol inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA]25714330
C529148rosavinrosavin results in decreased expression of SRD5A2 mRNA20706672
C473295SKF 105111SKF 105111 results in decreased activity of SRD5A2 protein12957225
C009277sodium arsenatesodium arsenate results in decreased expression of SRD5A2 mRNA26393310
C075117squalestatin 1squalestatin 1 results in decreased expression of SRD5A2 mRNA27225895
C075117squalestatin 1squalestatin 1 results in increased expression of SRD5A2 mRNA27225895
D013469SulpirideSulpiride results in increased expression of SRD5A2 mRNA18978642
D013739TestosteroneFinasteride inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA]23523586
D013739TestosteroneFinasteride promotes the reaction [tributyltin inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA]]23523586
D013739TestosteroneTestosterone results in increased expression of SRD5A2 mRNA23523586
D013739Testosteronetributyltin inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA]23523586
D013739Testosteronetributyltin promotes the reaction [Finasteride inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA]]23523586
D013739Testosteroneresveratrol inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA]25714330
D013739TestosteroneTestosterone results in increased expression of SRD5A2 mRNA22131296|2571433
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SRD5A2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SRD5A2 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SRD5A2 mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SRD5A2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SRD5A2 mRNA21724226
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SRD5A2 mRNA11222880
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of SRD5A2 mRNA28973375
C011559tributyltinFinasteride promotes the reaction [tributyltin inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA]]23523586
C011559tributyltintributyltin inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA]23523586
C011559tributyltintributyltin promotes the reaction [Finasteride inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA]]23523586
C011559tributyltintributyltin results in decreased activity of SRD5A2 protein12231121
C011559tributyltintributyltin results in increased expression of SRD5A2 mRNA21683754
C030665triphenyltintriphenyltin results in decreased activity of SRD5A2 protein17218080
C016829vinyl fluoridevinyl fluoride analog results in decreased activity of SRD5A2 protein8689240
C088658zoledronic acidzoledronic acid results in increased expression of SRD5A2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00038653-oxo-5-alpha-steroid 4-dehydrogenase activity-TAS-  
GO:0009917sterol 5-alpha reductase activity-IDA1944596  
GO:0016491oxidoreductase activity-IBA21873635  
GO:0030283testosterone dehydrogenase [NAD(P)] activity-IDA10898110  
GO:0033218amide binding-IEA-  
GO:0047751cholestenone 5-alpha-reductase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006702androgen biosynthetic process-TAS-  
GO:0006706steroid catabolic process-IEA-  
GO:0007267cell-cell signaling-TAS1944596  
GO:0008209androgen metabolic process-IDA1944596  
GO:0008584male gonad development-IMP1944596  
GO:0018879biphenyl metabolic process-IEA-  
GO:0018894dibenzo-p-dioxin metabolic process-IEA-  
GO:0018963phthalate metabolic process-IEA-  
GO:0021766hippocampus development-IEA-  
GO:0021854hypothalamus development-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0031667response to nutrient levels-IEA-  
GO:0032354response to follicle-stimulating hormone-IEA-  
GO:0033574response to testosterone-IEA-  
GO:0042493response to drug-IEA-  
GO:0043434response to peptide hormone-IEA-  
GO:0048545response to steroid hormone-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO:0060348bone development-IEA-  
GO:0061370testosterone biosynthetic process-IDA10898110  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0031090organelle membrane-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0070852cell body fiber-IEA-  
KEGG ID KEGG Term
hsa00140Steroid hormone biosynthesis
hsa05215Prostate cancer
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-193048Androgen biosynthesisTAS
R-HSA-196071Metabolism of steroid hormonesTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22707254Association of V89L SRD5A2 polymorphism with craving and serum leptin levels in male alcohol addicts. (2012 Dec)Lenz BPsychopharmacology (Berl)
23532004Relationship of early-onset baldness to prostate cancer in African-American men. (2013 Apr)Zeigler-Johnson CCancer Epidemiol Biomarkers Prev
16325991A common polymorphism within the steroid 5-alpha-reductase type 2 gene and timing of menopause in Caucasian women. (2006 Apr 1)Huber AEur J Obstet Gynecol Reprod Biol