Gene: AKR1D1

6718
3o5bred|CBAS2|SRD5B1
aldo-keto reductase family 1 member D1
protein-coding
7q33
Ensembl:ENSG00000122787 MIM:604741 Vega:OTTHUMG00000155787 UniprotKB:P51857
NG_023342.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.431e-1 (AD)  4.168e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BAGE20.845
DAOA0.834
OR1S20.823
OR4Q30.819
LINC004300.819
OR4A150.817
OR4D60.816
OR4K50.813
OR4B10.813
KRTAP27-10.812

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HHATL-0.265
NOG-0.255
SORCS2-0.251
GPT-0.25
PSD2-0.241
CHRDL1-0.238
MMP15-0.238
PEX11A-0.233
PYGM-0.232
C1orf53-0.227

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00548Azelaic AcidSmall Molecule123-99-9ApprovedTarget
DB01216FinasterideSmall Molecule98319-26-7ApprovedTarget
DB074475beta-dihydrotestosteroneSmall Molecule571-22-2ExperimentalTarget
DB07557(5BETA)-PREGNANE-3,20-DIONESmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of AKR1D1 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of AKR1D1 mRNA"22698814|2890350
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of AKR1D1 mRNA]"22698814
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of AKR1D1 mRNA"27291303
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of AKR1D1 mRNA"27291303
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of AKR1D1 mRNA"19692669
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of AKR1D1 mRNA"20959002
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of AKR1D1 mRNA18544908
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of AKR1D1 mRNA"18648102
C0026567 alpha-hydroxy-4-cholesten-3-oneAKR1D1 gene mutant form inhibits the reaction [AKR1D1 protein results in increased metabolism of 7 alpha-hydroxy-4-cholesten-3-one]21185810|2118581
C0026567 alpha-hydroxy-4-cholesten-3-one[AKR1D1 protein co-treated with NADP] results in increased reduction of 7 alpha-hydroxy-4-cholesten-3-one25500266
D000082AcetaminophenAcetaminophen results in decreased expression of AKR1D1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of AKR1D1 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of AKR1D1 mRNA18544908
D016604Aflatoxin B1Aflatoxin B1 affects the expression of AKR1D1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AKR1D1 mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AKR1D1 mRNA19770486
D000450Aldosterone[AKR1D1 protein co-treated with NADP] results in increased reduction of Aldosterone25500266
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog affects the expression of AKR1D1 protein26597043
D0435825-alpha-DihydroprogesteroneAKR1D1 protein results in increased chemical synthesis of 5-alpha-Dihydroprogesterone18624455
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AKR1D1 mRNA16483693
D000728AndrogensAndrogens results in decreased activity of AKR1D1 protein17628001
D001379AzathioprineAzathioprine results in decreased expression of AKR1D1 mRNA22623647
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of AKR1D1 mRNA19737606
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of AKR1D1 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AKR1D1 mRNA21632981|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AKR1D1 mRNA19770486
D004958EstradiolEstradiol results in decreased expression of AKR1D1 mRNA20106945|2163298
C006780bisphenol Abisphenol A results in decreased expression of AKR1D1 mRNA25181051
D019819BudesonideAKR1D1 protein results in increased reduction of Budesonide21276783
D019819BudesonideBudesonide inhibits the reaction [AKR1D1 protein results in increased reduction of Hydrocortisone]21276783
D002104CadmiumCadmium results in increased expression of AKR1D1 mRNA21120746
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of AKR1D1 mRNA27339419
D002509CephaloridineCephaloridine results in increased expression of AKR1D1 mRNA18172885
C100187chloropicrinchloropicrin results in increased expression of AKR1D1 mRNA26352163
C000475cholest-4-en-3-one[AKR1D1 protein co-treated with NADP] results in increased reduction of cholest-4-en-3-one25500266
C018021cobaltous chloridecobaltous chloride results in decreased expression of AKR1D1 mRNA24386269
D003042CocaineCocaine affects the expression of AKR1D1 mRNA20187946
D009249NADP[AKR1D1 protein co-treated with NADP] results in increased reduction of 7 alpha-hydroxy-4-cholesten-3-one25500266
D009249NADP[AKR1D1 protein co-treated with NADP] results in increased reduction of Aldosterone25500266
D009249NADP[AKR1D1 protein co-treated with NADP] results in increased reduction of cholest-4-en-3-one25500266
D009249NADP[AKR1D1 protein co-treated with NADP] results in increased reduction of Corticosterone25500266
D009249NADP[AKR1D1 protein co-treated with NADP] results in increased reduction of Cortisone25500266
D009249NADP[AKR1D1 protein co-treated with NADP] results in increased reduction of Testosterone25500266
D019327Copper SulfateCopper Sulfate results in decreased expression of AKR1D1 mRNA19549813
D003345Corticosterone[AKR1D1 protein co-treated with NADP] results in increased reduction of Corticosterone25500266
D003348Cortisone[AKR1D1 protein co-treated with NADP] results in increased reduction of Cortisone25500266
C030123coumarincoumarin affects the expression of AKR1D1 mRNA16963487
D016572CyclosporineCyclosporine results in decreased expression of AKR1D1 mRNA20106945|2163298
D016572CyclosporineCyclosporine results in decreased expression of AKR1D1 mRNA23830897
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of AKR1D1 mRNA23914054
D002945CisplatinCisplatin results in increased expression of AKR1D1 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of AKR1D1 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of AKR1D1 mRNA26924002
D004041Dietary FatsDietary Fats affects the expression of AKR1D1 mRNA19680557
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of AKR1D1 mRNA20360939
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of AKR1D1 mRNA26924002
D000431EthanolEthanol results in increased expression of AKR1D1 mRNA19167417
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of AKR1D1 mRNA23649840
C007734flunisolideAKR1D1 protein results in increased reduction of flunisolide21276783
C007734flunisolideflunisolide inhibits the reaction [AKR1D1 protein results in increased reduction of Hydrocortisone]21276783
D005485FlutamideFlutamide results in decreased expression of AKR1D1 mRNA24793618
D005485FlutamideFlutamide results in increased expression of AKR1D1 mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of AKR1D1 mRNA23649840
D005839GentamicinsGentamicins results in increased expression of AKR1D1 mRNA18172885
D005978GlutathioneGlutathione deficiency results in increased expression of AKR1D1 mRNA15345336
D006854HydrocortisoneAKR1D1 protein results in increased reduction of Hydrocortisone21276783
D006854HydrocortisoneBudesonide inhibits the reaction [AKR1D1 protein results in increased reduction of Hydrocortisone]21276783
D006854Hydrocortisoneflunisolide inhibits the reaction [AKR1D1 protein results in increased reduction of Hydrocortisone]21276783
C008281limonenelimonene results in decreased expression of AKR1D1 mRNA12815608
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of AKR1D1 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AKR1D1 mRNA23179753
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of AKR1D1 mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in increased expression of AKR1D1 mRNA29191790
C517284monomethyl phthalatemonomethyl phthalate affects the expression of AKR1D1 mRNA26924002
C500085muraglitazarmuraglitazar results in increased expression of AKR1D1 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of AKR1D1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of AKR1D1 mRNA"25620056
C051752nefazodonenefazodone results in increased expression of AKR1D1 mRNA24136188
C022838nickel chloridenickel chloride affects the expression of AKR1D1 mRNA22110744
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of AKR1D1 mRNA27935865
C464660obeticholic acidobeticholic acid results in decreased expression of AKR1D1 mRNA27939613
C036567perfluorodecanoic acidperfluorodecanoic acid results in decreased expression of AKR1D1 mRNA21984479
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in decreased expression of AKR1D1 mRNA21984479
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of AKR1D1 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of AKR1D1 mRNA17681415|1942940
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of AKR1D1 mRNA21984479
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of AKR1D1 mRNA19162173
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of AKR1D1 mRNA17097637
D010634PhenobarbitalPhenobarbital results in increased expression of AKR1D1 mRNA19084549
D010634PhenobarbitalPhenobarbital affects the expression of AKR1D1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of AKR1D1 mRNA19270015
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of AKR1D1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of AKR1D1 mRNA20813756
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of AKR1D1 mRNA28903501
D011374ProgesteroneAKR1D1 protein results in increased reduction of Progesterone18624455
C045950propiconazolepropiconazole results in increased expression of AKR1D1 mRNA21278054
C015586propiverinepropiverine binds to AKR1D1 protein29273565
D011794QuercetinQuercetin results in decreased expression of AKR1D1 mRNA21632981
C089730rosiglitazonerosiglitazone affects the expression of AKR1D1 mRNA21515302
D019821SimvastatinSimvastatin results in decreased expression of AKR1D1 mRNA25055962
C016104sodium bichromatesodium bichromate affects the expression of AKR1D1 mRNA22110744
C013698tallowtallow affects the expression of AKR1D1 mRNA19680557
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of AKR1D1 mRNA15885361
D013739TestosteroneAKR1D1 gene mutant form inhibits the reaction [AKR1D1 protein results in increased metabolism of Testosterone]21185810|2118581
D013739Testosterone[AKR1D1 protein co-treated with NADP] results in increased reduction of Testosterone25500266
D013739TestosteroneTestosterone results in decreased expression of AKR1D1 mRNA21669218
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AKR1D1 mRNA20106945|2229881
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AKR1D1 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to AKR1D1 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AKR1D1 mRNA19770486|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AKR1D1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AKR1D1 mRNA20959002|2121527
D013752TetracyclineTetracycline results in increased expression of AKR1D1 mRNA16917069
D013853ThioacetamideThioacetamide results in increased expression of AKR1D1 mRNA26222700
C066340tolcaponetolcapone binds to AKR1D1 protein19783845
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of AKR1D1 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of AKR1D1 mRNA21515302
C057693troglitazonetroglitazone results in increased expression of AKR1D1 protein21315101
D014520UrethaneUrethane results in decreased expression of AKR1D1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of AKR1D1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of AKR1D1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased methylation of AKR1D1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of AKR1D1 mRNA29154799
D014640VancomycinVancomycin results in increased expression of AKR1D1 mRNA18930951
C025643vinclozolinvinclozolin results in decreased expression of AKR1D1 mRNA22615374
C029297vinylidene chloridevinylidene chloride results in decreased expression of AKR1D1 mRNA26682919
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of AKR1D1 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004032alditol:NADP+ 1-oxidoreductase activity-IBA21873635  
GO:0004033aldo-keto reductase (NADP) activity-TAS-  
GO:0005496steroid binding-TAS7508385  
GO:0008106alcohol dehydrogenase (NADP+) activity-IBA21873635  
GO:0016229steroid dehydrogenase activity-IBA21873635  
GO:0016491oxidoreductase activity-IBA21873635  
GO:0047086ketosteroid monooxygenase activity-IBA21873635  
GO:0047787delta4-3-oxosteroid 5beta-reductase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006699bile acid biosynthetic process-IDA7508385  
GO:0006699bile acid biosynthetic process-TAS-  
GO:0006707cholesterol catabolic process-IDA7508385  
GO:0007586digestion-IDA7508385  
GO:0008202steroid metabolic process-IBA21873635  
GO:0008207C21-steroid hormone metabolic process-IDA7508385  
GO:0008209androgen metabolic process-IBA21873635  
GO:0008209androgen metabolic process-IDA7508385  
GO:0030573bile acid catabolic process-IEA-  
GO:0055114oxidation-reduction process-IDA7508385  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA7508385  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00120Primary bile acid biosynthesis
hsa00140Steroid hormone biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-192105Synthesis of bile acids and bile saltsTAS
R-HSA-193368Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterolTAS
R-HSA-193775Synthesis of bile acids and bile salts via 24-hydroxycholesterolTAS
R-HSA-193807Synthesis of bile acids and bile salts via 27-hydroxycholesterolTAS
R-HSA-194068Bile acid and bile salt metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27815364Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors. (2017 Jan)Tanner JAJ Pharmacol Exp Ther