Gene: BRCA1

672
BRCAI|BRCC1|BROVCA1|FANCS|IRIS|PNCA4|PPP1R53|PSCP|RNF53
BRCA1, DNA repair associated
protein-coding
17q21.31
Ensembl:ENSG00000012048 MIM:113705 Vega:OTTHUMG00000157426 UniprotKB:P38398
NG_005905.2
PubMed
0   ANCO-SNPs
ND|AD
63   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.446e-1 (AD)  8.389e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RDX0.82
GAB10.816
CDK60.806
TBC1D120.806
SLC44A10.801
CDK190.8
ZFP570.793
CCNE20.789
BBX0.789
PLA2G160.787

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRTN3-0.417
PNOC-0.412
CHRNA2-0.405
SHISA8-0.403
ELFN1-0.379
GRIN2D-0.377
VGF-0.372
TAC3-0.37
TCERG1L-0.37
CALB2-0.37

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of BRCA1 mRNA"23626729
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of BRCA1 mRNA"22698814|2890350
C0326681-nitropyrene1-nitropyrene results in decreased expression of BRCA1 mRNA21540303
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]"12473173
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of BRCA1 mRNA"20566336
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of BRCA1 mRNA]20206645
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]20206645
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of BRCA1 mRNA]"20206645
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of BRCA1 mRNA"19167446
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]"12473173
C4257842-(4-amino-3-methylphenyl)-5-fluorobenzothiazole[2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole binds to AHR protein] which results in increased activity of BRCA1 protein18259752
C4257842-(4-amino-3-methylphenyl)-5-fluorobenzothiazoleBRCA1 protein promotes the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYP1A1 mRNA]16567799
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of BRCA1 protein"12203372
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of BRCA1 mRNA25088246
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [BRCA1 results in increased expression of ATM mRNA]22832221
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of BRCA1 mRNA"23196670
C4228633,4,5,4'-tetrahydroxystilbene"3,4,5,4'-tetrahydroxystilbene results in decreased expression of BRCA1 mRNA"11181455
C0917683'-methoxy-4'-nitroflavone3'-methoxy-4'-nitroflavone inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]16489025
C4711094(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline"4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline results in decreased expression of BRCA1 mRNA"19934314
C5756314-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile"4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile affects the expression of BRCA1 mRNA"21218783
C0067574-biphenylamine4-biphenylamine results in decreased expression of BRCA1 mRNA24857880
C0652504-hydroxy-equilenin4-hydroxy-equilenin results in decreased expression of BRCA1 mRNA15135645
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BRCA1 mRNA21167638
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone[Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of BRCA1 mRNA21167638
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in decreased expression of BRCA1 mRNA"19936915
C0671348-oxo-7-hydrodeoxyguanosine[BRCA1 gene mutant form results in increased susceptibility to Ethanol] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine26629949
D000082AcetaminophenAcetaminophen results in increased expression of BRCA1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of BRCA1 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of BRCA1 mRNA17942131
D000082AcetaminophenAcetaminophen results in increased activity of BRCA1 protein25858767
D020106AcrylamideAcrylamide results in decreased expression of BRCA1 mRNA28606764
C027955aflatoxin G1aflatoxin G1 results in increased activity of BRCA1 protein23907605
C027955aflatoxin G1aflatoxin G1 results in increased expression of BRCA1 protein modified form23907605
C027955aflatoxin G1Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form]23907605
C027955aflatoxin G1Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form]23907605
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]16489025
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased activity of BRCA1 protein]18259752
D0150812-Naphthylamine2-Naphthylamine results in decreased expression of BRCA1 mRNA18247414
D000638AmiodaroneAmiodarone results in increased expression of BRCA1 mRNA24489787
D000643Ammonium ChlorideAmmonium Chloride affects the expression of BRCA1 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of BRCA1 mRNA"22863853
D001115ArecolineArecoline results in decreased expression of BRCA1 mRNA17682004
D001151ArsenicArsenic affects the methylation of BRCA1 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of BRCA1 mRNA20458559
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of BRCA1 mRNA"17331233
D001241AspirinAspirin results in decreased expression of BRCA1 mRNA20457246|2051444
D001280AtrazineAtrazine results in decreased expression of BRCA1 mRNA22378314
C056612benzo(a)pyrene-DNA adductBRCA1 protein affects the abundance of benzo(a)pyrene-DNA adduct21256203
D053119BenzophenanthridinesBenzophenanthridines analog results in decreased expression of BRCA1 mRNA23117580
D001564Benzo(a)pyreneARNT protein affects the reaction [BRCA1 protein affects the susceptibility to Benzo(a)pyrene]21507987
D001564Benzo(a)pyreneBenzo(a)pyrene inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]16489025
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [BRCA1 protein binds to NFE2L2 promoter]21507987
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [[BRCA1 protein binds to NFE2L2 promoter] which results in increased expression of NFE2L2 mRNA]21507987
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [BRCA1 protein binds to UGT1A1 promoter]21507987
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [[BRCA1 protein binds to UGT1A1 promoter] which results in increased expression of UGT1A1 mRNA]21507987
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [BRCA1 protein binds to UGT1A9 promoter]21507987
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [[BRCA1 protein binds to UGT1A9 promoter] which results in increased expression of UGT1A9 mRNA]21507987
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BRCA1 mRNA11782367|1824741
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BRCA1 mRNA28461126
D001564Benzo(a)pyreneBRCA1 inhibits the reaction [Benzo(a)pyrene results in increased abundance of Reactive Oxygen Species]22192953
D001564Benzo(a)pyreneBRCA1 protein affects the reaction [Benzo(a)pyrene promotes the reaction [ARNT protein binds to NFE2L2 promoter]]21507987
D001564Benzo(a)pyreneBRCA1 protein affects the reaction [Benzo(a)pyrene promotes the reaction [ARNT protein binds to UGT1A1 promoter]]21507987
D001564Benzo(a)pyreneBRCA1 protein affects the reaction [Benzo(a)pyrene promotes the reaction [ARNT protein binds to UGT1A9 promoter]]21507987
D001564Benzo(a)pyreneBRCA1 protein affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]21507987
D001564Benzo(a)pyreneBRCA1 protein affects the reaction [Benzo(a)pyrene results in increased expression of NFE2L2 protein]21507987
D001564Benzo(a)pyreneBRCA1 protein affects the reaction [Benzo(a)pyrene results in increased expression of UGT1A1 mRNA]21507987
D001564Benzo(a)pyreneBRCA1 protein affects the reaction [Benzo(a)pyrene results in increased expression of UGT1A1 protein]21507987
D001564Benzo(a)pyreneBRCA1 protein affects the reaction [Benzo(a)pyrene results in increased expression of UGT1A9 mRNA]21507987
D001564Benzo(a)pyreneBRCA1 protein affects the reaction [Benzo(a)pyrene results in increased expression of UGT1A9 protein]21507987
D001564Benzo(a)pyreneBRCA1 protein affects the susceptibility to Benzo(a)pyrene21507987
D001564Benzo(a)pyreneNFE2L2 protein affects the reaction [BRCA1 protein affects the susceptibility to Benzo(a)pyrene]21507987
D001564Benzo(a)pyreneNFE2L2 protein inhibits the reaction [BRCA1 inhibits the reaction [Benzo(a)pyrene results in increased abundance of Reactive Oxygen Species]]22192953
D001564Benzo(a)pyreneTP53 protein promotes the reaction [Benzo(a)pyrene results in decreased expression of BRCA1 mRNA]11782367
D001564Benzo(a)pyreneUGT1A1 protein affects the reaction [BRCA1 protein affects the susceptibility to Benzo(a)pyrene]21507987
D001564Benzo(a)pyreneUGT1A9 protein affects the reaction [BRCA1 protein affects the susceptibility to Benzo(a)pyrene]21507987
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BRCA1 mRNA17942131
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BRCA1 mRNA20713471
D001564Benzo(a)pyreneBRCA1 protein affects the susceptibility to Benzo(a)pyrene21507987
D001564Benzo(a)pyreneERCC1 protein affects the reaction [BRCA1 protein affects the susceptibility to Benzo(a)pyrene]21507987
D001564Benzo(a)pyreneXPC protein affects the reaction [BRCA1 protein affects the susceptibility to Benzo(a)pyrene]21507987
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BRCA1 mRNA"11782367|2038263
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BRCA1 protein"11782367
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"TP53 protein promotes the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BRCA1 mRNA]"11782367
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"TP53 protein promotes the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BRCA1 protein]"11782367
D004958Estradiol"2,2',3',4,4',5-hexachlorobiphenyl inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]"12473173
D004958Estradiol2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]20206645
D004958Estradiol"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]"12473173
D004958Estradiol3'-methoxy-4'-nitroflavone inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]16489025
D004958EstradiolAHR protein affects the reaction [Estradiol results in increased expression of BRCA1 mRNA]16489025
D004958EstradiolAHR protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of BRCA1 protein]]20631324
D004958Estradiol[AHR protein binds to ESR1 protein] affects the reaction [Estradiol results in increased expression of BRCA1 mRNA]16489025
D004958Estradiolalpha-naphthoflavone inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]16489025
D004958EstradiolBenzo(a)pyrene inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]16489025
D004958EstradiolBRCA1 protein affects the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA3 protein]]18997820
D004958EstradiolBRCA1 protein affects the reaction [Estradiol results in increased expression of CCND1 mRNA]18997820
D004958EstradiolBRCA1 protein affects the reaction [Estradiol results in increased expression of MYC mRNA]18997820
D004958EstradiolBRCA1 protein affects the reaction [Estradiol results in increased expression of PGR mRNA]18997820
D004958EstradiolBRCA1 protein inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of AKT1 protein]18997820
D004958EstradiolBRCA1 protein inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of MAPK1 protein]18997820
D004958EstradiolBRCA1 protein inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of MAPK3 protein]18997820
D004958EstradiolBRCA1 protein promotes the reaction [indole-3-carbinol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]11110848
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]24758408
D004958EstradiolEstradiol affects the localization of BRCA1 protein16061635
D004958Estradiol[Estradiol co-treated with resveratrol] inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BRCA1 promoter]]20631324
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [DNMT1 protein binds to BRCA1 promoter]20631324
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [MBD2 protein binds to BRCA1 promoter]20631324
D004958EstradiolEstradiol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BRCA1 promoter]]16489025|2063132
D004958EstradiolEstradiol promotes the reaction [EP300 protein binds to BRCA1 promoter]16489025
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to BRCA1 promoter]16489025
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to CREBBP protein binds to BRCA1 protein]16417649
D004958EstradiolEstradiol promotes the reaction [NCOA1 protein binds to BRCA1 promoter]16489025
D004958EstradiolEstradiol results in decreased expression of BRCA1 mRNA23373633
D004958EstradiolEstradiol results in increased expression of BRCA1 mRNA12473173|1648902
D004958EstradiolEstradiol results in increased expression of BRCA1 protein20631324|2219762
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]12473173|2020664
D004958EstradiolPCB 180 inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]12473173
D004958Estradiolresveratrol inhibits the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]20631324
D004958Estradiolresveratrol inhibits the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [MBD2 protein binds to BRCA1 promoter]]20631324
D004958Estradiol[[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] promotes the reaction [AHR protein binds to BRCA1 promoter]] inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]20631324|2063132
D004958Estradiol[[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] promotes the reaction [AHR protein binds to BRCA1 promoter]] inhibits the reaction [Estradiol results in increased expression of BRCA1 protein]20631324|2063132
D004958Estradiol[Tetrachlorodibenzodioxin co-treated with Estradiol] promotes the reaction [HDAC1 protein binds to BRCA1 promoter]16489025
D004958EstradiolTetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [EP300 protein binds to BRCA1 promoter]]16489025
D004958EstradiolTetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [NCOA1 protein binds to BRCA1 promoter]]16489025
D004958EstradiolTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]12473173|1648902
D004958EstradiolTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of BRCA1 protein]20631324|2219762
D004958EstradiolEstradiol results in increased expression of BRCA1 mRNA25210133
C023888beta-hexachlorocyclohexane2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of BRCA1 mRNA]20206645
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in increased expression of BRCA1 mRNA20206645
C023888beta-hexachlorocyclohexanefulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of BRCA1 mRNA]20206645
C044887beta-methylcholinebeta-methylcholine affects the expression of BRCA1 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of BRCA1 mRNA16029874
C006780bisphenol Abisphenol A results in increased expression of BRCA1 mRNA22576693
C006780bisphenol Abisphenol A results in increased expression of BRCA1 protein25933419
C006780bisphenol Abisphenol A results in increased methylation of BRCA1 gene22258036
C006780bisphenol ABRCA1 protein affects the reaction [bisphenol A results in increased activity of ESR1 protein]20868731
C006780bisphenol ABRCA1 protein affects the susceptibility to bisphenol A20868731
C006780bisphenol AMYC protein promotes the reaction [bisphenol A results in increased expression of BRCA1 protein]25933419
C006780bisphenol Abisphenol A results in increased methylation of BRCA1 promoter27312807
C006780bisphenol ABRCA1 gene mutant form results in increased susceptibility to bisphenol A20868731
C006780bisphenol Abisphenol A results in decreased expression of BRCA1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of BRCA1 mRNA27208089
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of BRCA1 mRNA17942131
D000069286BortezomibBortezomib results in decreased expression of BRCA1 mRNA21917757
D000069286BortezomibBortezomib results in decreased ubiquitination of BRCA1 protein21917757
D000069286BortezomibBRCA1 mutant form results in increased susceptibility to Bortezomib25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in decreased expression of AKR7A2 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in decreased expression of CCNF mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in decreased expression of CCNG2 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in decreased expression of CRYGEP mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in decreased expression of DAPK2 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in decreased expression of DLGAP5 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in decreased expression of EGLN3 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in decreased expression of FZD2 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in decreased expression of HIST1H3E mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in decreased expression of LGR4 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in decreased expression of RPS7P5 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in decreased expression of THRA mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in decreased expression of TNFAIP8L1 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in decreased expression of TNKS mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased activity of E2F1 protein25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased cleavage of PARP1 protein25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of ARID3B mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of ATF3 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of BIRC3 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of CCNB1 protein25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of CRYAB mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of CTH mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of DUSP5 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of ERN1 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of FGF21 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of GADD45A mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of GDF15 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of HECW1 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of HIKESHI mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of IL7R mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of KRTAP21-1 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of MIR568 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of PAWR mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of PCYT1A mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of RND3 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of TNFAIP3 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of TNFRSF9 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of TRIB3 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of TRIML2 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of ZNF613 mRNA25522274
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased phosphorylation of RB1 protein25522274
D000069286BortezomibTP53BP1 protein affects the reaction [[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased cleavage of PARP1 protein]25522274
D000069286BortezomibTP53BP1 protein affects the reaction [[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased phosphorylation of RB1 protein]25522274
D000069286BortezomibBRCA1 gene mutant form results in increased susceptibility to Bortezomib25522274
D000069286BortezomibBRCA1 protein inhibits the reaction [BRCA1 gene mutant form results in increased susceptibility to Bortezomib]25522274|2552227
C016274bromoacetatebromoacetate results in decreased expression of BRCA1 mRNA19753638
D002104CadmiumCadmium results in decreased expression of BRCA1 mRNA23256528
D002104CadmiumCadmium results in decreased expression of BRCA1 mRNA20049202
D002104CadmiumCadmium results in decreased expression of BRCA1 protein20049202
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of BRCA1 mRNA26525392
D002166CamptothecinBRCA1 mRNA results in decreased susceptibility to Camptothecin25269479
D002166CamptothecinCamptothecin results in decreased expression of BRCA1 mRNA10344722
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of BRCA1 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of BRCA1 mRNA12734012
C524865carfilzomibBRCA1 mutant form results in increased susceptibility to carfilzomib25522274
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BRCA1 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of BRCA1 mRNA19376846
D019327Copper SulfateCopper Sulfate affects the expression of BRCA1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of BRCA1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of BRCA1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of BRCA1 mRNA19167446
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of BRCA1 mRNA21878529
C038459curdlancurdlan results in decreased expression of BRCA1 mRNA23543010
D003513CycloheximideCycloheximide inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of BRCA1 mRNA]10344722
D016572CyclosporineCyclosporine results in decreased expression of BRCA1 mRNA21632981|2556210
D016572CyclosporineCyclosporine results in decreased expression of BRCA1 mRNA17942131|1977048
C004742daidzeindaidzein results in increased expression of BRCA1 mRNA17266178
D000069439DasatinibDasatinib results in decreased expression of BRCA1 mRNA20579391
C114768decamethylcyclopentasiloxanedecamethylcyclopentasiloxane affects the expression of BRCA1 mRNA27601420
C114768decamethylcyclopentasiloxanedecamethylcyclopentasiloxane results in decreased expression of BRCA1 protein27601420
C014347decitabinedecitabine affects the localization of BRCA1 protein modified form17991895
C107676deguelindeguelin results in decreased expression of BRCA1 mRNA22227970
D016190CarboplatinCarboplatin results in decreased activity of BRCA1 protein20878461
C023614dibenzofurandibenzofuran analog results in decreased expression of BRCA1 mRNA20566336
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of BRCA1 mRNA21266533
D002945CisplatinBRCA1 mutant form promotes the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased activity of and results in increased phosphorylation of CHEK1 protein]]]21875941
D002945CisplatinBRCA1 mutant form promotes the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]]21875941
D002945CisplatinBRCA1 mutant form promotes the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form results in increased susceptibility to Cisplatin]]21875941
D002945CisplatinBRCA1 protein results in decreased susceptibility to Cisplatin20603439
D002945CisplatinBRCA1 results in decreased susceptibility to Cisplatin21633166|2185461
D002945CisplatinCisplatin results in decreased activity of BRCA1 protein20878461
D002945CisplatinCisplatin results in increased expression of BRCA1 mRNA20623183|2759478
D002945CisplatinCisplatin results in increased expression of BRCA1 protein20623183
D002945CisplatinESR2 protein inhibits the reaction [Cisplatin results in increased expression of BRCA1 mRNA]20623183
D002945CisplatinESR2 protein inhibits the reaction [Cisplatin results in increased expression of BRCA1 protein]20623183
D002945Cisplatinvorinostat inhibits the reaction [BRCA1 results in decreased susceptibility to Cisplatin]21854619
D002945CisplatinBRCA1 results in decreased susceptibility to Cisplatin21771338
D002945CisplatinCisplatin results in increased expression of BRCA1 mRNA21151649
D002945CisplatinCisplatin results in increased phosphorylation of BRCA1 protein22006019
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased expression of BRCA1 mRNA20206645
D003633Dichlorodiphenyl Dichloroethylenefulvestrant inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of BRCA1 mRNA]20206645
D004008DiclofenacDiclofenac results in increased expression of BRCA1 mRNA26934552
D004026DieldrinDieldrin results in increased expression of BRCA1 mRNA23041725
D004026DieldrinDieldrin affects the expression of BRCA1 mRNA22546817
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of BRCA1 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of BRCA1 mRNA]17854601
D002117CalcitriolCalcitriol promotes the reaction [Testosterone results in decreased expression of BRCA1 mRNA]21592394
D002117CalcitriolCalcitriol results in decreased expression of BRCA1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of BRCA1 mRNA21592394
D002117CalcitriolTestosterone promotes the reaction [Calcitriol results in decreased expression of BRCA1 mRNA]21592394
D0151279,10-Dimethyl-1,2-benzanthracene"BRCA1 protein affects the susceptibility to 9,10-Dimethyl-1,2-benzanthracene"21507987
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene inhibits the reaction [A gene mutant form results in decreased expression of BRCA1 protein]"25448685
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of BRCA1 protein"25448685
D0151279,10-Dimethyl-1,2-benzanthracene"A gene mutant form inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BRCA1 protein]"25448685
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of BRCA1 mRNA"23969067
D004317DoxorubicinDoxorubicin inhibits the reaction [BRCA1 protein binds to ATM promoter]22832221
D004317DoxorubicinDoxorubicin inhibits the reaction [[RBBP8 protein binds to BRCA1 protein binds to E2F1 protein] which results in increased expression of ATM mRNA]22832221
D004317DoxorubicinDoxorubicin results in decreased expression of BRCA1 mRNA10344722|1560731
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of BRCA1 mRNA25839702
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of BRCA1 mRNA22079256
D000069347Erlotinib Hydrochloride[Erlotinib Hydrochloride results in decreased activity of EGFR protein] which results in decreased phosphorylation of BRCA1 protein23548265
D000431EthanolBRCA1 gene mutant form promotes the reaction [Ethanol results in increased phosphorylation of H2AFX protein]26629949
D000431EthanolBRCA1 gene mutant form results in increased susceptibility to Ethanol26629949
D000431Ethanol[BRCA1 gene mutant form results in increased susceptibility to Ethanol] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine26629949
D000431Ethanol[BRCA1 gene mutant form results in increased susceptibility to Ethanol] which results in increased phosphorylation of H2AFX protein26629949
D000431Ethanol[BRCA1 protein affects the expression of ERCC6 mRNA] which affects the susceptibility to Ethanol26629949
D000431Ethanol[BRCA1 protein affects the expression of OGG1 mRNA] which affects the susceptibility to Ethanol26629949
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of BRCA1 mRNA23550701
D005047EtoposideBRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of CDK2 protein]16417649
D005047EtoposideBRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of RAD52 protein]16417649
D005047EtoposideBRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of RAD54L protein]16417649
D005047EtoposideBRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC2 protein]16417649
D005047EtoposideBRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC3 protein]16417649
D005047EtoposideBRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC4 protein]16417649
D005047EtoposideEtoposide results in decreased expression of BRCA1 mRNA15607317
D005047EtoposideEtoposide results in increased expression of BRCA1 protein26259609
D005047Etoposidepifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of BRCA1 protein]26259609
D015025ZearalenoneZearalenone results in increased expression of BRCA1 mRNA28965971
D015025ZearalenoneZearalenone results in increased expression of BRCA1 mRNA28552778
D005419FlavonoidsFlavonoids results in increased expression of BRCA1 mRNA18035473
C024352fludarabine[LAQ824 co-treated with fludarabine] results in decreased expression of BRCA1 mRNA18852132
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of BRCA1 mRNA19167416
D005472FluorouracilFluorouracil results in decreased expression of BRCA1 mRNA15607317|1798267
D005472FluorouracilFluorouracil results in increased expression of BRCA1 mRNA16101138|1655759
D005472FluorouracilTP53 protein inhibits the reaction [Fluorouracil results in decreased expression of BRCA1 mRNA]17982676
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of BRCA1 mRNA24657277
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BRCA1 mRNA20938992
C070081fulvestrantfulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of BRCA1 mRNA]20206645
C070081fulvestrantfulvestrant inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of BRCA1 mRNA]20206645
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]12473173|2020664
C070081fulvestrant"fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of BRCA1 mRNA]"20206645
C070081fulvestrantfulvestrant results in decreased expression of BRCA1 mRNA20206645
C039281furanfuran results in decreased expression of BRCA1 mRNA25539665
C039281furanfuran results in increased expression of BRCA1 mRNA22079235
C056507gemcitabinegemcitabine results in increased expression of BRCA1 mRNA20103597
C056507gemcitabineBRCA1 results in decreased susceptibility to gemcitabine21771338
D019833GenisteinGenistein results in increased expression of BRCA1 mRNA16434996|1726617
D019833GenisteinGenistein results in increased expression of BRCA1 protein16434996
D019833Genistein[indole-3-carbinol co-treated with Genistein] results in increased expression of BRCA1 protein16434996
D006046Gold[Polyethyleneimine binds to Gold] which results in decreased expression of BRCA1 mRNA28433809
C024035hexamethylcyclotrisiloxanehexamethylcyclotrisiloxane affects the expression of BRCA1 mRNA27601420
C024035hexamethylcyclotrisiloxanehexamethylcyclotrisiloxane results in decreased expression of BRCA1 protein27601420
D006861Hydrogen PeroxideBRCA1 protein results in decreased susceptibility to Hydrogen Peroxide15520196
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of BRCA1 mRNA22539617
C016517indole-3-carbinolBRCA1 protein promotes the reaction [indole-3-carbinol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]11110848
C016517indole-3-carbinol[indole-3-carbinol co-treated with Genistein] results in increased expression of BRCA1 protein16434996
C016517indole-3-carbinolindole-3-carbinol promotes the reaction [AHR protein binds to BRCA1 protein]18259752
C016517indole-3-carbinolindole-3-carbinol results in increased expression of BRCA1 mRNA16434996
C016517indole-3-carbinolindole-3-carbinol results in increased expression of BRCA1 protein11110848|1643499
C090712iniparibBRCA1 protein results in decreased susceptibility to iniparib21707865
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BRCA1 mRNA25613284
C544151jinfukangjinfukang results in increased expression of BRCA1 mRNA27392435
C561695(+)-JQ1 compound[GNAQ gene mutant form results in increased susceptibility to (+)-JQ1 compound] which results in decreased expression of BRCA1 protein26397223
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of BRCA1 mRNA24796395|2596192
C477361LAQ824[LAQ824 co-treated with fludarabine] results in decreased expression of BRCA1 mRNA18852132
C008261lead acetatelead acetate results in decreased expression of BRCA1 mRNA22613225
C038753leptomycin B[leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of BRCA1 mRNA20803015
C038753leptomycin Bleptomycin B results in decreased expression of BRCA1 mRNA20803015
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of BRCA1 mRNA"24972896
D008154LucanthoneLucanthone results in decreased expression of BRCA1 mRNA21148553
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of BRCA1 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of BRCA1 mRNA26378955
D008694Methamphetamine[BRCA1 protein affects the expression of ERCC6 mRNA] which affects the susceptibility to Methamphetamine26629949
D008694Methamphetamine[BRCA1 protein affects the expression of OGG1 mRNA] which affects the susceptibility to Methamphetamine26629949
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BRCA1 mRNA20938992
D008727MethotrexateBRCA1 mutant form promotes the reaction [TP53 mutant form results in increased susceptibility to Methotrexate]21875941
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of BRCA1 mRNA24657277
D008727MethotrexateMethotrexate results in increased expression of BRCA1 mRNA21678067
D008730MethoxsalenMethoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form]23907605
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to BRCA1 protein]18259752
D008748MethylcholanthreneMethylcholanthrene results in increased expression of BRCA1 mRNA20713471
C005223methyleugenolmethyleugenol results in decreased expression of BRCA1 mRNA21659616|2601163
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of BRCA1 mRNA23649840
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of BRCA1 mRNA12634122
D015741MetriboloneMetribolone results in increased expression of BRCA1 mRNA17010196
D016685MitomycinBRCA1 protein mutant form results in increased susceptibility to Mitomycin26320175
C028577monobutyl phthalatemonobutyl phthalate affects the expression of BRCA1 mRNA20864626
C005246myristicinmyristicin results in decreased expression of BRCA1 mRNA24792648
C017096n-butoxyethanoln-butoxyethanol results in increased expression of BRCA1 mRNA19812364
C022838nickel chloridenickel chloride results in decreased expression of BRCA1 mRNA28472268
C022838nickel chloridenickel chloride results in decreased expression of BRCA1 protein28472268
D009538NicotineNicotine inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form]23907605
D009538NicotineNicotine results in decreased expression of BRCA1 mRNA18247414
D009588Nitrogen Mustard CompoundsCycloheximide inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of BRCA1 mRNA]10344722
D009588Nitrogen Mustard CompoundsNitrogen Mustard Compounds results in decreased expression of BRCA1 mRNA10344722
C122062NSC 674495BRCA1 protein promotes the reaction [NSC 674495 results in increased expression of CYP1A1 mRNA]16567799
C122062NSC 674495NSC 674495 promotes the reaction [AHR protein binds to BRCA1 protein]18259752
C024064octamethylcyclotetrasiloxaneoctamethylcyclotetrasiloxane affects the expression of BRCA1 mRNA27601420
C024064octamethylcyclotetrasiloxaneoctamethylcyclotetrasiloxane results in decreased expression of BRCA1 protein27601420
C531550olaparibBRCA1 affects the susceptibility to olaparib21633166
C016340o,p'-DDT"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of BRCA1 mRNA]"20206645
C016340o,p'-DDT"fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of BRCA1 mRNA]"20206645
C016340o,p'-DDT"o,p'-DDT results in increased expression of BRCA1 mRNA"20206645
C030110oxaliplatinoxaliplatin results in decreased activity of BRCA1 protein20878461
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of BRCA1 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of BRCA1 mRNA26516004
D010100OxygenOxygen deficiency results in decreased expression of BRCA1 protein17599377|2847226
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of BRCA1 mRNA25658374
D010126OzoneOzone results in decreased expression of BRCA1 mRNA24336422
D017239PaclitaxelPaclitaxel results in decreased expression of BRCA1 mRNA15607317
D010269ParaquatBRCA1 protein results in decreased susceptibility to Paraquat15520196
D052638Particulate MatterParticulate Matter results in decreased expression of BRCA1 mRNA22048643
C410127PCB 180PCB 180 inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]12473173
D010634PhenobarbitalPhenobarbital affects the expression of BRCA1 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of BRCA1 mRNA23091169
C030090phosphoramide mustardphosphoramide mustard affects the expression of BRCA1 mRNA25497287
C030090phosphoramide mustardphosphoramide mustard results in increased expression of BRCA1 mRNA26708502
C030090phosphoramide mustardphosphoramide mustard results in increased expression of BRCA1 protein25497287
C121565pifithrinpifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of BRCA1 protein]26259609
C006253pirinixic acidpirinixic acid results in decreased expression of BRCA1 mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of BRCA1 mRNA17950772
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of BRCA1 mRNA]17950772
D010936Plant ExtractsPlant Extracts results in increased expression of BRCA1 mRNA23557933
D011094Polyethyleneimine[Polyethyleneimine binds to Gold] which results in decreased expression of BRCA1 mRNA28433809
C019536potassium bromatepotassium bromate results in increased expression of BRCA1 mRNA22539617
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of BRCA1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of BRCA1 mRNA22079256
D011285Pregnenolone Carbonitrile"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of BRCA1 mRNA"23626729
C479580procyanidin B2procyanidin B2 results in increased expression of BRCA1 mRNA25839702
D011398PromethazinePromethazine results in decreased expression of BRCA1 mRNA26011634
C005556propionaldehydepropionaldehyde results in decreased expression of BRCA1 mRNA26079696
C513428pyrachlostrobinpyrachlostrobin results in increased expression of BRCA1 mRNA27029645
D011794QuercetinQuercetin results in increased expression of BRCA1 mRNA14715546|2163298
D017382Reactive Oxygen SpeciesBRCA1 inhibits the reaction [Benzo(a)pyrene results in increased abundance of Reactive Oxygen Species]22192953
D017382Reactive Oxygen SpeciesNFE2L2 protein inhibits the reaction [BRCA1 inhibits the reaction [Benzo(a)pyrene results in increased abundance of Reactive Oxygen Species]]22192953
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of BRCA1 mRNA19167446
C059514resveratrol[Estradiol co-treated with resveratrol] inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BRCA1 promoter]]20631324
C059514resveratrolPARP1 protein affects the reaction [resveratrol results in increased expression of BRCA1 protein]25533949
C059514resveratrolresveratrol affects the expression of and affects the phosphorylation of BRCA1 protein19559722
C059514resveratrolresveratrol affects the localization of BRCA1 protein19559722
C059514resveratrolresveratrol inhibits the reaction [AHR protein results in decreased expression of BRCA1]20631324
C059514resveratrolresveratrol inhibits the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]20631324
C059514resveratrolresveratrol inhibits the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [MBD2 protein binds to BRCA1 promoter]]20631324
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BRCA1 promoter]]22197621
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]22197621
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT3A protein binds to BRCA1 promoter]]22197621
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT3B protein binds to BRCA1 promoter]]22197621
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [MBD2 protein binds to BRCA1 promoter]]22197621
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of BRCA1 mRNA]22197621
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of BRCA1 protein]20631324|2219762
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased methylation of BRCA1 promoter]22197621
C059514resveratrolresveratrol results in increased expression of BRCA1 mRNA15149879
C059514resveratrolresveratrol results in increased expression of BRCA1 protein25533949
C059514resveratrolSTF-118804 inhibits the reaction [resveratrol results in increased expression of BRCA1 protein]25533949
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]24136580
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of BRCA1 mRNA]24136580
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of BRCA1 protein]24136580
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased methylation of BRCA1 promoter]24136580
C059514resveratrolresveratrol results in increased expression of BRCA1 mRNA24136580
C059514resveratrolresveratrol results in increased expression of BRCA1 protein24136580
C547185riccardin Driccardin D affects the phosphorylation of and affects the activity of BRCA1 protein24069304
C547185riccardin Driccardin D results in decreased expression of BRCA1 mRNA24069304
D012402RotenoneRotenone results in increased expression of BRCA1 mRNA18191903
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of BRCA1 mRNA21427059
C017947sodium arsenitesodium arsenite results in increased expression of BRCA1 mRNA12760830
C017947sodium arsenitesodium arsenite affects the expression of BRCA1 mRNA16507464
C017947sodium arsenite[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of BRCA1 mRNA16368122
C016104sodium bichromatesodium bichromate results in increased expression of BRCA1 mRNA22155349
D018038Sodium SeleniteSodium Selenite results in decreased expression of BRCA1 mRNA10344722
C000593977STF-118804STF-118804 inhibits the reaction [resveratrol results in increased expression of BRCA1 protein]25533949
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of BRCA1 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of BRCA1 mRNA26378955
D013467SulindacSulindac results in decreased expression of BRCA1 mRNA16273229
C061133tamibarotenetamibarotene results in decreased expression of BRCA1 mRNA15498508
D013629TamoxifenBRCA1 affects the activity of Tamoxifen15750629
D013629TamoxifenBRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]]18997820
D013629TamoxifenBRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOR2 protein]]18997820
D013629TamoxifenBRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to PHB2 protein]]18997820
D013629TamoxifenBRCA1 protein affects the reaction [Tamoxifen promotes the reaction [NCOR2 protein binds to CCND1 promoter]]18997820
D013629TamoxifenBRCA1 protein affects the reaction [Tamoxifen results in decreased expression of CCND1 mRNA]18997820
D013629TamoxifenBRCA1 protein affects the reaction [Tamoxifen results in decreased expression of MYC mRNA]18997820
D013629TamoxifenBRCA1 protein affects the reaction [Tamoxifen results in decreased expression of PGR mRNA]18997820
D013629TamoxifenBRCA1 protein results in increased susceptibility to Tamoxifen18997820
D013629Tamoxifen[Tamoxifen co-treated with BRCA1 protein mutant form] results in decreased expression of ESR1 protein15750629
D013739TestosteroneCalcitriol promotes the reaction [Testosterone results in decreased expression of BRCA1 mRNA]21592394
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of BRCA1 mRNA21592394
D013739TestosteroneTestosterone promotes the reaction [Calcitriol results in decreased expression of BRCA1 mRNA]21592394
D013739TestosteroneTestosterone results in decreased expression of BRCA1 mRNA21592394
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of BRCA1 mRNA20189893
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of BRCA1 protein]]20631324
D013749Tetrachlorodibenzodioxinalpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased activity of BRCA1 protein]18259752
D013749TetrachlorodibenzodioxinARNT protein affects the reaction [Tetrachlorodibenzodioxin promotes the reaction [BRCA1 protein binds to CYP1B1 promoter]]16567799
D013749TetrachlorodibenzodioxinBRCA1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]16567799
D013749TetrachlorodibenzodioxinBRCA1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]16567799
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with resveratrol] inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BRCA1 promoter]]20631324
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [DNMT1 protein binds to BRCA1 promoter]20631324
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [MBD2 protein binds to BRCA1 promoter]20631324
D013749TetrachlorodibenzodioxinEstradiol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BRCA1 promoter]]16489025|2063132
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]20631324
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [MBD2 protein binds to BRCA1 promoter]]20631324
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BRCA1 promoter]]22197621
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]22197621
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT3A protein binds to BRCA1 promoter]]22197621
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT3B protein binds to BRCA1 promoter]]22197621
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [MBD2 protein binds to BRCA1 promoter]]22197621
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of BRCA1 mRNA]22197621
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of BRCA1 protein]20631324|2219762
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased methylation of BRCA1 promoter]22197621
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BRCA1 mRNA22298810|2257421
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] promotes the reaction [AHR protein binds to BRCA1 promoter]20631324
D013749Tetrachlorodibenzodioxin[[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] promotes the reaction [AHR protein binds to BRCA1 promoter]] inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]20631324|2063132
D013749Tetrachlorodibenzodioxin[[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] promotes the reaction [AHR protein binds to BRCA1 promoter]] inhibits the reaction [Estradiol results in increased expression of BRCA1 protein]20631324|2063132
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Estradiol] promotes the reaction [HDAC1 protein binds to BRCA1 promoter]16489025
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [DNMT1 protein binds to BRCA1 promoter]20631324
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [EP300 protein binds to BRCA1 promoter]]16489025
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [NCOA1 protein binds to BRCA1 promoter]]16489025
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]12473173|1648902
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of BRCA1 protein]20631324|2219762
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [MBD2 protein binds to BRCA1 promoter]20631324
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BRCA1 promoter]16489025|2063132
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BRCA1 protein]18259752
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [BRCA1 protein binds to CYP1A1 promoter]16567799
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [BRCA1 protein binds to CYP1B1 promoter]16567799
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]22197621
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [DNMT3A protein binds to BRCA1 promoter]22197621
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [DNMT3B protein binds to BRCA1 promoter]22197621
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [HDAC1 protein binds to BRCA1 promoter]16489025
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [MBD2 protein binds to BRCA1 promoter]22197621
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BRCA1 mRNA22197621
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BRCA1 protein20631324|2219762
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased methylation of BRCA1 promoter22197621
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of BRCA1 mRNA21167638
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BRCA1 mRNA19465110
D013749TetrachlorodibenzodioxinBRCA1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]16567799
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]24136580
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of BRCA1 mRNA]24136580
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of BRCA1 protein]24136580
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased methylation of BRCA1 promoter]24136580
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BRCA1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHRR protein binds to BRCA1 promoter]24136580
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]24136580
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BRCA1 mRNA24136580
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BRCA1 protein24136580
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased methylation of BRCA1 promoter24136580
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BRCA124136580
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased methylation of BRCA1 promoter24136580
D013755Tetradecanoylphorbol Acetate[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of BRCA1 mRNA16368122
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BRCA1 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of BRCA1 mRNA16434996
D019284ThapsigarginThapsigargin results in increased expression of BRCA1 protein16434996
D013853ThioacetamideThioacetamide results in decreased expression of BRCA1 mRNA26011634
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of BRCA1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of BRCA1 mRNA25729387
D014112ToxapheneToxaphene results in increased expression of BRCA1 mRNA12473173
C034697transplatintransplatin results in decreased activity of BRCA1 protein20878461
D014212TretinoinTretinoin results in decreased expression of BRCA1 mRNA15498508
D014212TretinoinTretinoin results in increased expression of BRCA1 mRNA16054129
D014212TretinoinTretinoin results in increased expression of BRCA1 mRNA17198874
C012589trichostatin Atrichostatin A results in decreased expression of BRCA1 mRNA23770000
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of BRCA1 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of BRCA1 mRNA19140230
D014415TunicamycinTunicamycin results in increased expression of BRCA1 protein16434996
D014520UrethaneUrethane results in decreased expression of BRCA1 mRNA28818685
D014527Uric AcidNLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of BRCA1 mRNA]23619996
D014527Uric AcidUric Acid results in decreased expression of BRCA1 mRNA23619996
D014635Valproic AcidValproic Acid results in decreased expression of BRCA1 mRNA20585447|2800136
D014635Valproic AcidValproic Acid results in increased methylation of BRCA1 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of BRCA1 mRNA24913804
D014635Valproic AcidValproic Acid results in increased expression of BRCA1 mRNA24913804
D014638VanadatesVanadates results in decreased expression of BRCA1 mRNA22714537
C521013veliparibBRCA1 affects the susceptibility to veliparib21633166
C521013veliparibBRCA1 protein results in decreased susceptibility to veliparib21707865
C029297vinylidene chloridevinylidene chloride results in increased expression of BRCA1 mRNA26682919
D014800VitalliumVitallium analog results in decreased expression of BRCA1 mRNA23825117
C111237vorinostatvorinostat inhibits the reaction [BRCA1 results in decreased susceptibility to Cisplatin]21854619
C111237vorinostatvorinostat results in decreased expression of BRCA1 protein21854619

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-TAS9662397  
GO:0003684damaged DNA binding-IEA-  
GO:0003713transcription coactivator activity-IMP9662397  
GO:0003713transcription coactivator activity-NAS15572661  
GO:0003723RNA binding-IDA12419249  
GO:0004842ubiquitin-protein transferase activity-IBA21873635  
GO:0004842ubiquitin-protein transferase activity-IDA12890688  17349954  19117993  20351172  
GO:0005515protein binding-IPI8944023  9497340  9528852  9662397  9774970  9811458  
9926942  10477523  10855792  11090615  11244506  11301010  
11573085  11739404  11751867  11836499  11877377  12242698  
12354784  12419185  14550570  14576432  14576433  14654789  
15107825  15265711  15674350  15965487  15983032  16326698  
16452482  17334399  17511879  17525332  17525340  17581638  
17643121  17873885  18001824  18001825  18716619  19117993  
19261748  19369211  20016594  20016603  20160719  20351172  
21240188  21407215  21444675  21673012  21988832  22110403  
22193777  23624935  23680151  26649820  26807646  
GO:0008270zinc ion binding-IEA-  
GO:0015631tubulin binding-NAS12214252  
GO:0019899enzyme binding-IPI15965487  
GO:0031625ubiquitin protein ligase binding-IPI17873885  
GO:0044212transcription regulatory region DNA binding-IDA20820192  
GO:0050681androgen receptor binding-NAS15572661  
GO:0070063RNA polymerase binding-IDA9662397  
GO ID GO Term Qualifier Evidence PubMed
GO:0000724double-strand break repair via homologous recombination-IBA21873635  
GO:0000724double-strand break repair via homologous recombination-IDA17349954  
GO:0000729DNA double-strand break processing-TAS-  
GO:0006260DNA replication-TAS-  
GO:0006301postreplication repair-IDA17349954  
GO:0006302double-strand break repair-IDA22186889  
GO:0006302double-strand break repair-IMP17525340  17643121  19261748  
GO:0006303double-strand break repair via nonhomologous end joining-TAS-  
GO:0006349regulation of gene expression by genetic imprinting-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IMP9662397  
GO:0006359regulation of transcription by RNA polymerase III-TAS10918303  
GO:0006633fatty acid biosynthetic process-IEA-  
GO:0006915apoptotic process-TAS10918303  
GO:0006974cellular response to DNA damage stimulus-TAS10910365  
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator-TAS10918303  
GO:0007059chromosome segregation-IMP15965487  
GO:0007098centrosome cycle-IEA-  
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage-IDA14654789  
GO:0009048dosage compensation by inactivation of X chromosome-IBA21873635  
GO:0010212response to ionizing radiation-IMP17525340  17643121  19261748  
GO:0010575positive regulation of vascular endothelial growth factor production-IMP23415688  
GO:0010628positive regulation of gene expression-IMP23415688  
GO:0016567protein ubiquitination-IDA17349954  
GO:0016579protein deubiquitination-TAS-  
GO:0030521androgen receptor signaling pathway-NAS15572661  
GO:0031398positive regulation of protein ubiquitination-IDA15965487  
GO:0033147negative regulation of intracellular estrogen receptor signaling pathway-IMP17505062  
GO:0035066positive regulation of histone acetylation-IBA21873635  
GO:0035066positive regulation of histone acetylation-IDA20820192  
GO:0035067negative regulation of histone acetylation-IBA21873635  
GO:0042127regulation of cell proliferation-TAS10918303  
GO:0042981regulation of apoptotic process-TAS10918303  
GO:0043009chordate embryonic development-IBA21873635  
GO:0043627response to estrogen-IDA8895509  
GO:0044030regulation of DNA methylation-IEA-  
GO:0044818mitotic G2/M transition checkpoint-IEA-  
GO:0045717negative regulation of fatty acid biosynthetic process-IBA21873635  
GO:0045717negative regulation of fatty acid biosynthetic process-IMP16326698  
GO:0045739positive regulation of DNA repair-IMP17525340  17643121  19261748  
GO:0045766positive regulation of angiogenesis-IMP23415688  
GO:0045892negative regulation of transcription, DNA-templated-IDA16288014  
GO:0045893positive regulation of transcription, DNA-templated-IDA20160719  
GO:0045893positive regulation of transcription, DNA-templated-NAS15572661  
GO:0045893positive regulation of transcription, DNA-templated-TAS10918303  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA16331276  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP20820192  
GO:0046600negative regulation of centriole replication-NAS12214252  
GO:0051571positive regulation of histone H3-K4 methylation-IDA20820192  
GO:0051572negative regulation of histone H3-K4 methylation-IEA-  
GO:0051573negative regulation of histone H3-K9 methylation-IDA20820192  
GO:0051574positive regulation of histone H3-K9 methylation-IEA-  
GO:0051865protein autoubiquitination-IDA12890688  20351172  
GO:0070317negative regulation of G0 to G1 transition-TAS-  
GO:0070512positive regulation of histone H4-K20 methylation-IDA20820192  
GO:0071158positive regulation of cell cycle arrest-IBA21873635  
GO:0071158positive regulation of cell cycle arrest-IDA21102443  
GO:0071356cellular response to tumor necrosis factor-IMP23415688  
GO:0071681cellular response to indole-3-methanol-IDA10868478  
GO:0072425signal transduction involved in G2 DNA damage checkpoint-IMP17525340  17643121  19261748  
GO:0085020protein K6-linked ubiquitination-IDA12890688  20351172  
GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors-IMP23415688  
GO:2000378negative regulation of reactive oxygen species metabolic process-IMP23415688  
GO:2000617positive regulation of histone H3-K9 acetylation-IDA20820192  
GO:2000620positive regulation of histone H4-K16 acetylation-IDA20820192  
GO ID GO Term Qualifier Evidence PubMed
GO:0000151ubiquitin ligase complex-NAS14976165  
GO:0000800lateral element-IDA9774970  
GO:0005634nucleus-IDA17525340  17643121  20160719  23855721  
GO:0005654nucleoplasm-TAS-  
GO:0005694chromosome-ISS-  
GO:0005737cytoplasm-IDA20160719  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA21282464  
GO:0008274gamma-tubulin ring complex-NAS12214252  
GO:0031436BRCA1-BARD1 complex-IBA21873635  
GO:0031436BRCA1-BARD1 complex-IDA12890688  15265711  19117993  20351172  
GO:0032991protein-containing complex-IDA9774970  
GO:0070531BRCA1-A complex-IBA21873635  
GO:0070531BRCA1-A complex-IDA17525340  17525341  17525342  19261748  19261749  
GO:1990904ribonucleoprotein complex-IDA18809582  
KEGG ID KEGG Term
hsa04120Ubiquitin mediated proteolysis
Reactome ID Reactome Term Evidence
R-HSA-1221632Meiotic synapsisIEA
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2990846SUMOylationTAS
R-HSA-3108214SUMOylation of DNA damage response and repair proteinsTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5685938HDR through Single Strand Annealing (SSA)TAS
R-HSA-5685942HDR through Homologous Recombination (HRR)TAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689901Metalloprotease DUBsTAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693537Resolution of D-Loop StructuresTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693554Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)TAS
R-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693568Resolution of D-loop Structures through Holliday Junction IntermediatesTAS
R-HSA-5693571Nonhomologous End-Joining (NHEJ)TAS
R-HSA-5693579Homologous DNA Pairing and Strand ExchangeTAS
R-HSA-5693606DNA Double Strand Break ResponseTAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchangeTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6796648TP53 Regulates Transcription of DNA Repair GenesTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-69473G2/M DNA damage checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953750Transcriptional Regulation by E2F6TAS
R-HSA-912446Meiotic recombinationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24755492Risk factors for ovarian cancers with and without microsatellite instability. (2014 May)Segev YInt J Gynecol Cancer
28417775Breast cancer in the Arctic - changes over the past decades. (2012 Jan)Fredslund SOInt J Circumpolar Health
27907901Serum AMH levels in healthy women from BRCA1/2 mutated families: are they reduced? (2016 Nov)van Tilborg TCHum Reprod
16184554Homozygous deletion of p16INK4a and tobacco carcinogen exposure in nonsmall cell lung cancer. (2006 Mar 15)Kraunz KSInt J Cancer
29709729Smoking and FGFR2 rs2981582 variant independently modulate male breast cancer survival: A population-based study in Tuscany, Italy. (2018 Apr 27)Zanna IBreast
9605638Protective effect of cigarette smoking on breast cancer risk in women with BRCA1 or BRCA2 mutations??? (1998 May 20)Baron JAJ Natl Cancer Inst
18037339Genetic polymorphisms and micronucleus formation: a review of the literature. (2008 Mar-Apr)Iarmarcovai GMutat Res
16898859Use of dietary supplements among women at high risk of hereditary breast and ovarian cancer (HBOC) tested for cancer susceptibility. (2006)Alamian ANutr Cancer
16261399Influence of selected lifestyle factors on breast and ovarian cancer risk in BRCA1 mutation carriers from Poland. (2006 Jan)Gronwald JBreast Cancer Res Treat
27852187Prevention of breast cancer. (2016 Nov 21)Olver INMed J Aust
8062169Behavioral science in translational research and cancer control. (1994 Aug 15)Morrow GRCancer
22901290Breast cancer in the Arctic--changes over the past decades. (2012 Aug 16)Fredslund SOInt J Circumpolar Health
23749772A functional BRCA1 coding sequence genetic variant contributes to risk of esophageal squamous cell carcinoma. (2013 Oct)Zhang XCarcinogenesis
27966054Lifestyle Risk Factors for Breast Cancer in BRCA1/2-Mutation Carriers Around Childbearing Age. (2017 Aug)van Erkelens AJ Genet Couns
29330845The association between smoking and cancer incidence in BRCA1 and BRCA2 mutation carriers. (2018 Jun 1)Ko KPInt J Cancer
23674270BRCA1 polymorphisms and breast cancer epidemiology in the Western New York exposures and breast cancer (WEB) study. (2013 Jul)Ricks-Santi LJGenet Epidemiol
17307805CYP17 genotype is associated with short menstrual cycles, early oral contraceptive use and BRCA mutation status in young healthy women. (2007 Apr)Henningson MMol Hum Reprod
23748177Risk factors for ovarian cancers with and without microsatellite instability. (2013 Jul)Segev YInt J Gynecol Cancer
18566573Promoter methylation of cancer-related genes in gastric carcinoma. (2008 Jun)Poplawski TExp Oncol
21873261Genetic risk prediction in complex disease. (2011 Oct 15)Jostins LHum Mol Genet
24649266Exploratory study on the correlation between 14 lung cancer-related gene expression and specific clinical characteristics of NSCLC patients. (2013 Sep)Han YMol Clin Oncol
15095307Smoking and the risk of breast cancer among carriers of BRCA mutations. (2004 Jun 20)Ghadirian PInt J Cancer
9605646Effect of smoking on breast cancer in carriers of mutant BRCA1 or BRCA2 genes. (1998 May 20)Brunet JSJ Natl Cancer Inst
17972172Smoking and risk of breast cancer in carriers of mutations in BRCA1 or BRCA2 aged less than 50 years. (2008 May)-Breast Cancer Res Treat
20445803Weight History, Smoking, Physical Activity and Breast Cancer Risk among French-Canadian Women Non-Carriers of More Frequent BRCA1/2 Mutations. (2009)Bissonauth VJ Cancer Epidemiol
21761160Variation in breast cancer risk with mutation position, smoking, alcohol, and chest X-ray history, in the French National BRCA1/2 carrier cohort (GENEPSO). (2011 Dec)Lecarpentier JBreast Cancer Res Treat
27094481Anti-Mullerian hormone serum concentrations of women with germline BRCA1 or BRCA2 mutations. (2016 May)Phillips KAHum Reprod
16244359The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers. (2006 Mar)Colilla SCarcinogenesis
11795442Hormonal prevention of hereditary breast cancer. (2001 Dec)Narod SAAnn N Y Acad Sci
16541324Diet, lifestyle and BRCA-related breast cancer risk among French-Canadians. (2006 Aug)Nkondjock ABreast Cancer Res Treat
24933103Associations of polymorphisms in DNA repair genes and MDR1 gene with chemotherapy response and survival of non-small cell lung cancer. (2014)Du YPLoS One
28975393Smoking and physical inactivity increase cancer prevalence in BRCA-1 and BRCA-2 mutation carriers: results from a retrospective observational analysis. (2017 Dec)Grill SArch Gynecol Obstet
23362014Comparison of age at natural menopause in BRCA1/2 mutation carriers with a non-clinic-based sample of women in northern California. (2013 May 1)Lin WTCancer
11920551Utilization of BRCA1/2 genetic testing in the clinical setting: report from a single institution. (2002 Mar 15)Lee SCCancer
11291558The role of genetic factors in the etiology of pancreatic adenocarcinoma: an update. (2001)Chappuis POCancer Invest
25838159Risk factors for endometrial cancer among women with a BRCA1 or BRCA2 mutation: a case control study. (2015 Sep)Segev YFam Cancer
25532426Bone mineral density and fractures after risk-reducing salpingo-oophorectomy in women at increased risk for breast and ovarian cancer. (2015 Feb)Fakkert IEEur J Cancer
28472989Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stages. (2017 May 4)Yang MJ Hematol Oncol
29197760Lifetime exposure to ambient air pollution and methylation of tumor suppressor genes in breast tumors. (2018 Feb)Callahan CLEnviron Res
26569048Genital Cancers in Women: Ovarian Cancer. (2015 Nov)Kuznia ALFP Essent
26003539Correlation between BRCA1 and TopBP1 protein expression and clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy. (2015 Jul)Wang LRCancer Chemother Pharmacol
16118051Impact of teenage oral contraceptive use in a population-based series of early-onset breast cancer cases who have undergone BRCA mutation testing. (2005 Oct)Jernstrom HEur J Cancer
18663989[How to reduce the incidence of breast cancer]. (2008 Jan)Rochefort HBull Acad Natl Med
29290209Self-compassion, physical fitness and climacteric symptoms in oophorectomized BRCA1/2 mutation carriers. (2018 Feb)Arts-de Jong MMaturitas
18483851Smoking and the risk of breast cancer in BRCA1 and BRCA2 carriers: an update. (2009 Mar)Ginsburg OBreast Cancer Res Treat
27513691Association of BRCA1 Mutations with Impaired Ovarian Reserve: Connection Between Infertility and Breast/Ovarian Cancer Risk. (2016 Dec)Giordano SJ Adolesc Young Adult Oncol
28592245In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)El-Aarag SABMC Med Genomics
16054976Mechanisms of alcohol-associated cancers: introduction and summary of the symposium. (2005 Apr)Purohit VAlcohol
25010056Cigarette smoking in women after BRCA1/2 genetic test disclosure: a 5-year follow-up study of the GENEPSO PS cohort. (2015 Feb)Julian-Reynier CGenet Med
25813726Gene promoter methylation and DNA repair capacity in monozygotic twins with discordant smoking habits. (2015 Feb)Ottini LMutat Res Genet Toxicol Environ Mutagen
12544504Risk factors and risk reduction of breast and ovarian cancer. (2003 Feb)Brekelmans CTCurr Opin Obstet Gynecol
24144839A common polymorphism in pre-microRNA-146a is associated with lung cancer risk in a Korean population. (2014 Jan 15)Jeon HSGene
27326821Do BRCA1/2 mutation carriers have an earlier onset of natural menopause? (2016 Aug)van Tilborg TCMenopause
26671626Sources of polycyclic aromatic hydrocarbons are associated with gene-specific promoter methylation in women with breast cancer. (2016 Feb)White AJEnviron Res
18269778Bilateral prophylactic oophorectomy and bilateral prophylactic mastectomy in a prospective cohort of unaffected BRCA1 and BRCA2 mutation carriers. (2007 Dec)Friebel TMClin Breast Cancer
24824314Modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: systematic review and meta-analysis. (2014 Jun)Friebel TMJ Natl Cancer Inst
12670518Epidemiology of pancreatic cancer: an overview. (2003)Ghadirian PCancer Detect Prev
17289874Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer. (2007 Feb 1)Lee MNClin Cancer Res
22093627[EGFR gene copy number, ERCC1 and BRCA1 protein expression and their relationship in non-small cell lung cancer]. (2011 Jul)Deng QHZhonghua Zhong Liu Za Zhi
28729482BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity. (2017 Oct)Tacconi EMEMBO Mol Med
15040392Epidemiology of breast cancer among BRCA mutation carriers: an overview. (2004 Mar 8)Nkondjock ACancer Lett
26542178Prognostic value of ERCC1, RRM1, BRCA1 and SETDB1 in early stage of non-small cell lung cancer. (2016 Aug)Lafuente-Sanchis AClin Transl Oncol
10464641Evaluation of genotype data in clinical risk assessment: methods and application to BRCA1, BRCA2, and N-acetyl transferase-2 genotypes in breast cancer. (1997-1998)Rebbeck TRGenet Test