Gene info: ID 6720

Gene: SREBF1

GENE ID: 6720

Synonyms: SREBP1|bHLHd1

Description: sterol regulatory element binding transcription factor 1

Gene type: protein-coding

Location: 17p11.2

dbXrefs: Ensembl:ENSG00000072310 MIM:184756 Vega:OTTHUMG00000059313 UniprotKB:P36956

RefSeq: NG_029029.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.493e-1 (AD) 6.824e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg13639244	chr17:17717006	SREBF1	Gene body	4.036e-4	Alcohol use disorders	26763658
cg16912637	chr17:17720273	SREBF1	Gene body	4.318e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
LLGL1	0.807
PLXNB1	0.793
CHADL	0.792
OPLAH	0.79
SLC27A1	0.789
HIP1R	0.782
NAGLU	0.781
KIAA1755	0.774
SLC35B2	0.772
CUEDC1	0.769

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.508
OR4F29	-0.471
FER1L6	-0.283
DSC1	-0.267
DSG2	-0.259
KLHL38	-0.251
BEND4	-0.25
RGPD5	-0.246
C17orf112	-0.245
MUC15	-0.243

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB03756	Doconexent	Small Molecule	6217-54-5	Approved\|Investigational	Target
DB11133	Omega-3 fatty acids	Small Molecule	329042-31-1	Approved\|Nutraceutical	Target

ID	Drug Name	Action	PubMed
C025205	1,10-phenanthroline	"[1,10-phenanthroline results in decreased activity of MBTPS2 protein] which affects the localization of SREBF1 protein"	21355074
C025205	1,10-phenanthroline	"[1,10-phenanthroline results in decreased activity of MBTPS2 protein] which results in decreased cleavage of SREBF1 protein"	21355074
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of SREBF1 mRNA"	19162173
C031763	1,3-butadiene	"1,3-butadiene results in decreased expression of SREBF1 mRNA"	21147608
C033489	1,3-dichloro-2-propanol	"1,3-dichloro-2-propanol results in increased expression of SREBF1 protein"	24333398
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [[Progesterone co-treated with Estradiol] results in increased expression of SREBF1 mRNA]"	21768169
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SREBF1 mRNA"	24878338\|2890350
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of SREBF1 mRNA"	19095052
C019273	2,2-bis(4-glycidyloxyphenyl)propane	"2,2-bis(4-glycidyloxyphenyl)propane results in decreased expression of SREBF1 protein"	22726273
C003585	22-hydroxycholesterol	[22-hydroxycholesterol co-treated with alitretinoin] inhibits the reaction [arsenic trioxide results in decreased expression of SREBF1 protein]	27622732
C003585	22-hydroxycholesterol	22-hydroxycholesterol promotes the reaction [SREBF1 protein binds to ALDH1A1 promoter]	16763553
C003585	22-hydroxycholesterol	22-hydroxycholesterol promotes the reaction [SREBF1 protein binds to ALDH1A2 promoter]	16763553
C003585	22-hydroxycholesterol	22-hydroxycholesterol results in increased expression of SREBF1 mRNA	16763553
C003585	22-hydroxycholesterol	22-hydroxycholesterol results in increased expression of SREBF1 protein	16763553
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of SREBF1 mRNA]"	21851831
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of SREBF1 mRNA"	20005886\|2185183
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]"	23756648
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"Tetrachlorodibenzodioxin promotes the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of SREBF1 mRNA]"	21851831
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of SREBF1 mRNA"	21346803
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF7 protein results in increased expression of SREBF1 protein]	16162944
C007997	25-hydroxycholesterol	25-hydroxycholesterol results in increased expression of SREBF1 protein	19260826
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of SREBF1 mRNA"	21346803
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in decreased expression of SREBF1 mRNA	28167099
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in decreased expression of SREBF1 protein	28167099
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide inhibits the reaction [Diethylstilbestrol results in increased expression of SREBF1 protein]	22710028
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SREBF1 mRNA"	23994337
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of SREBF1 mRNA"	18648102
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of SREBF1 mRNA"	25380136
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in decreased expression of SREBF1 mRNA"	22504055
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SREBF1 mRNA"	27188386
C041594	4-nonylphenol	4-nonylphenol results in increased expression of SREBF1 mRNA	24388992
C105260	4-tert-octylphenol	4-tert-octylphenol results in decreased expression of SREBF1 mRNA	26164745
C105260	4-tert-octylphenol	4-tert-octylphenol results in decreased expression of SREBF1 protein	26164745
C573233	5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one	"5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one affects the expression of SREBF1 mRNA"	24646949
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 mRNA]]"	23319015
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 protein]]"	23319015
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein]"	23465592
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SREBF1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [cinnamic aldehyde results in decreased expression of SREBF1 mRNA]"	21401097
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol metabolite inhibits the reaction [TO-901317 results in increased expression of SREBF1 mRNA]]"	24633463
C475093	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA"	21768169
C475093	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of SREBF1 mRNA"	27180240
C475093	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	"Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA]"	21768169
C475093	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	"NR1I3 mutant form inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA]"	21768169
C475093	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	"NR1I3 mutant form inhibits the reaction [Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA]]"	21768169
C475093	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	"NR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA]]"	21768169
C475093	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA]"	21768169
C475093	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	"Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA]"	21768169
C099958	acanthoic acid	acanthoic acid inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]	28964808
C099958	acanthoic acid	acanthoic acid inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]	28964808
D000079	Acetaldehyde	Acetaldehyde results in increased expression of SREBF1 protein	12612910
D000079	Acetaldehyde	Acetaldehyde results in increased expression of SREBF1 protein	12036955
D000082	Acetaminophen	Acetaminophen results in decreased expression of SREBF1 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of SREBF1 mRNA	17562736
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of SREBF1 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SREBF1 mRNA]	17585979
D000082	Acetaminophen	Acetaminophen results in decreased expression of SREBF1 mRNA	17202758\|1720276
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of SREBF1 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of SREBF1 mRNA	21641981\|2715375
D016604	Aflatoxin B1	[sulforafan co-treated with Aflatoxin B1] affects the expression of SREBF1 mRNA	25450479
C096920	AGN 193109	AGN 193109 inhibits the reaction [Tretinoin results in increased expression of SREBF1 mRNA]	16505366
D000438	Alcohols	Alcohols results in increased expression of SREBF1 protein	28803762
D000438	Alcohols	Apigenin inhibits the reaction [Alcohols results in increased expression of SREBF1 protein]	28803762
D000438	Alcohols	Glutathione inhibits the reaction [Alcohols results in increased expression of SREBF1 protein]	28803762
D000452	Aldrin	Aldrin results in increased expression of SREBF1 mRNA	18579281
C103303	alitretinoin	[22-hydroxycholesterol co-treated with alitretinoin] inhibits the reaction [arsenic trioxide results in decreased expression of SREBF1 protein]	27622732
D000493	Allopurinol	Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF1 protein]	23647015
D000493	Allopurinol	Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF1 protein]	23647015
D000493	Allopurinol	Allopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF1 mRNA]	23647015
D000493	Allopurinol	Allopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF1 protein]	23647015
C038491	allyl sulfide	allyl sulfide inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]	22138249
C038491	allyl sulfide	allyl sulfide inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]	22138249
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of SREBF1 mRNA	16541421
D017962	alpha-Linolenic Acid	alpha-Linolenic Acid results in decreased expression of SREBF1 mRNA	14563831
D015081	2-Naphthylamine	2-Naphthylamine results in decreased expression of SREBF1 mRNA	18247414
D000638	Amiodarone	Amiodarone results in decreased expression of SREBF1 mRNA	28962527
D000638	Amiodarone	Amiodarone results in decreased expression of SREBF1 mRNA	17202758
D000639	Amitriptyline	Amitriptyline results in increased cleavage of and results in increased activity of SREBF1 protein	16324787
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SREBF1 mRNA	16483693
D047310	Apigenin	Apigenin inhibits the reaction [Alcohols results in increased expression of SREBF1 protein]	28803762
C004984	apocarotenal	apocarotenal results in increased expression of SREBF1 mRNA	17034753
C026987	aroclor 1260	aroclor 1260 inhibits the reaction [Dietary Fats results in decreased expression of SREBF1 mRNA]	24998970
D001151	Arsenic	[APOE protein affects the susceptibility to Arsenic] which results in increased expression of SREBF1 protein	22719926
C006632	arsenic trioxide	[22-hydroxycholesterol co-treated with alitretinoin] inhibits the reaction [arsenic trioxide results in decreased expression of SREBF1 protein]	27622732
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of SREBF1 mRNA	20339114\|2045855
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of SREBF1 protein	20339114\|2762273
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of SREBF1 mRNA	20339114
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of SREBF1 protein	20339114
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA	25932594
D001205	Ascorbic Acid	bexarotene promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]	25932594
D001205	Ascorbic Acid	rosiglitazone promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]	25932594
D001205	Ascorbic Acid	tributyltin promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]	25932594
C512174	atheronal-A	atheronal-A inhibits the reaction [TO-901317 results in increased expression of SREBF1 mRNA]	27703007
D000069059	Atorvastatin Calcium	Atorvastatin Calcium inhibits the reaction [Fructose results in increased activity of SREBF1 protein]	19053045
D001280	Atrazine	[lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of SREBF1 mRNA	24440342
C562236	aza-(6)-gingerol	[Dietary Fats co-treated with aza-(6)-gingerol] results in decreased expression of SREBF1 mRNA	21851089
C406592	azaspiracid	azaspiracid results in increased expression of SREBF1 mRNA	28939011
C006680	baicalein	baicalein results in decreased expression of SREBF1 mRNA	24560969
C006680	baicalein	baicalein results in decreased expression of SREBF1 protein	24560969
D001554	Benzene	Benzene results in increased expression of SREBF1 mRNA	19162166
D001554	Benzene	Benzene affects the expression of SREBF1 mRNA	15878777
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in decreased expression of SREBF1 mRNA	23994337
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SREBF1 mRNA	18247414\|2010694
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased mutagenesis of SREBF1 gene	25435355
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the reaction [GCLM gene mutant form results in decreased expression of SREBF1 mRNA]	24291350
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SREBF1 mRNA	26303333
D001599	Berberine	Berberine results in decreased expression of SREBF1 mRNA	26478571
D001599	Berberine	Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 mRNA]	20564506
D001599	Berberine	Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 protein]	20564506
D001599	Berberine	Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 mRNA]	20564506
D001599	Berberine	Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 protein]	20564506
D019207	beta Carotene	beta Carotene results in increased expression of SREBF1 mRNA	17034753
D004958	Estradiol	"Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA]"	21768169
D004958	Estradiol	Estradiol inhibits the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]	21768169
D004958	Estradiol	"NR1I3 mutant form inhibits the reaction [Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA]]"	21768169
D004958	Estradiol	NR1I3 mutant form inhibits the reaction [Estradiol inhibits the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]]	21768169
D004958	Estradiol	"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA]"	21768169
D004958	Estradiol	[Progesterone co-treated with Estradiol] inhibits the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]	21768169
D004958	Estradiol	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [[Progesterone co-treated with Estradiol] results in increased expression of SREBF1 mRNA]"	21768169
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in increased expression of SREBF1 mRNA	21768169
D004958	Estradiol	Estradiol results in decreased expression of SREBF1 mRNA	26164745
D004958	Estradiol	Estradiol results in decreased expression of SREBF1 protein	26164745
C031463	beta-glycerophosphoric acid	[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA	25932594
C031463	beta-glycerophosphoric acid	bexarotene promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]	25932594
C031463	beta-glycerophosphoric acid	rosiglitazone promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]	25932594
C031463	beta-glycerophosphoric acid	tributyltin promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]	25932594
C023888	beta-hexachlorocyclohexane	beta-hexachlorocyclohexane results in decreased expression of SREBF1 mRNA	25270620
C095105	bexarotene	bexarotene promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]	25932594
C095105	bexarotene	bexarotene results in increased expression of SREBF1 mRNA	23292798
D001629	Bezafibrate	SREBF1 protein inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]	11779144
D001629	Bezafibrate	Bezafibrate results in decreased expression of SREBF1 mRNA	19124612
D001629	Bezafibrate	Bezafibrate results in decreased expression of SREBF1 protein	19124612
D001629	Bezafibrate	[Bezafibrate results in decreased expression of SREBF1] which results in decreased abundance of Triglycerides	19124612
D001629	Bezafibrate	Bezafibrate results in increased expression of SREBF1 mRNA	19124612
D001629	Bezafibrate	Bezafibrate results in increased expression of SREBF1 protein	19124612
D001629	Bezafibrate	PPARA protein affects the susceptibility to [Bezafibrate results in decreased expression of SREBF1 mRNA]	19124612
D001629	Bezafibrate	PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SREBF1 protein]	19124612
D001629	Bezafibrate	Bezafibrate inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	26190035
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of SREBF1 mRNA	27003841
C006780	bisphenol A	bisphenol A results in increased expression of SREBF1 mRNA	25047013\|2561950
C006780	bisphenol A	bisphenol A results in increased expression of SREBF1 protein	28483554
C006780	bisphenol A	MIR192 mRNA inhibits the reaction [bisphenol A results in increased expression of SREBF1 mRNA]	28483554
C006780	bisphenol A	MIR192 mRNA inhibits the reaction [bisphenol A results in increased expression of SREBF1 protein]	28483554
C006780	bisphenol A	"N-piperidinyl-(8-chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydrobenzo(6,7)cyclohepta(1,2-c)pyrazole-3-carboxamide) inhibits the reaction [bisphenol A results in increased expression of SREBF1 mRNA]"	27014939
C006780	bisphenol A	SREBF1 protein affects the reaction [bisphenol A results in increased expression of FASN mRNA]	28483554
C006780	bisphenol A	SREBF1 protein affects the reaction [bisphenol A results in increased expression of PPARG mRNA]	28483554
C006780	bisphenol A	bisphenol A affects the expression of SREBF1 mRNA alternative form	21932408
C006780	bisphenol A	bisphenol A affects the expression of SREBF1 protein	21932408
C006780	bisphenol A	bisphenol A affects the methylation of SREBF1 promoter	27334623
C006780	bisphenol A	bisphenol A promotes the reaction [NFE2L2 protein binds to SREBF1 promoter]	28796629
C006780	bisphenol A	bisphenol A results in decreased expression of SREBF1 mRNA	24959901
C006780	bisphenol A	bisphenol A results in decreased methylation of SREBF1 promoter	27502578\|2879662
C006780	bisphenol A	bisphenol A results in increased expression of and results in increased phosphorylation of SREBF1 protein	28796629
C006780	bisphenol A	bisphenol A results in increased expression of SREBF1 mRNA	21932408\|2511112
C006780	bisphenol A	bisphenol A results in increased expression of SREBF1 protein	28483554
C006780	bisphenol A	MIR192 mRNA inhibits the reaction [bisphenol A results in increased expression of SREBF1 mRNA]	28483554
C006780	bisphenol A	MIR192 mRNA inhibits the reaction [bisphenol A results in increased expression of SREBF1 protein]	28483554
C006780	bisphenol A	SREBF1 mRNA promotes the reaction [bisphenol A results in increased expression of FASN mRNA]	27502578
C006780	bisphenol A	SREBF1 mRNA results in increased susceptibility to bisphenol A	27502578
C006780	bisphenol A	"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]"	23756648
C006780	bisphenol A	bisphenol A inhibits the reaction [SREBF1 protein binds to CPT1A promoter]	25748669
C006780	bisphenol A	bisphenol A promotes the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	25112833
C006780	bisphenol A	bisphenol A promotes the reaction [Dietary Fats results in increased expression of SREBF1 protein]	25112833
C006780	bisphenol A	bisphenol A results in decreased expression of SREBF1 mRNA	28657538
C006780	bisphenol A	bisphenol A results in increased expression of SREBF1 mRNA	20019905\|2511283
C006780	bisphenol A	bisphenol A results in increased expression of SREBF1 protein	25112833\|2885990
C006780	bisphenol A	Dietary Fats promotes the reaction [bisphenol A results in increased expression of SREBF1 mRNA]	25112833
C006780	bisphenol A	Dietary Fats promotes the reaction [bisphenol A results in increased expression of SREBF1 protein]	25112833
C512161	bisphenol A glucuronide	bisphenol A glucuronide results in increased expression of SREBF1 mRNA	26018136
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of SREBF1 mRNA	25270620
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of SREBF1 mRNA	17553608
C032688	boric acid	boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of SREBF1 mRNA]	28285642
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of SREBF1 mRNA	22079614
D002065	Buspirone	Buspirone results in decreased expression of SREBF1 mRNA	24136188
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in decreased expression of SREBF1 mRNA	20482862
C497192	cacalol	cacalol inhibits the reaction [SREBF1 protein binds to FAS promoter]	20665104
C497192	cacalol	cacalol results in decreased expression of SREBF1 protein	20665104
D002104	Cadmium	Cadmium results in decreased expression of SREBF1 mRNA	28315714
D002104	Cadmium	myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased expression of SREBF1 protein]	25240712
D002104	Cadmium	[Streptozocin co-treated with Cadmium] results in increased expression of SREBF1 protein	25240712
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of SREBF1 mRNA	23741332
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of SREBF1 mRNA	26352046
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of SREBF1 mRNA	25993096
C040048	caffeic acid	[Metformin co-treated with caffeic acid] results in decreased expression of SREBF1 protein	28576465
D000074262	Canola Oil	Canola Oil metabolite results in increased expression of SREBF1 mRNA	27363782
D000074262	Canola Oil	Starch analog inhibits the reaction [Canola Oil metabolite results in increased expression of SREBF1 mRNA]	27363782
C006698	carbendazim	carbendazim results in increased expression of SREBF1 mRNA	26071454
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of SREBF1 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of SREBF1 mRNA	17202758\|1752207
D002331	Carnitine	Carnitine inhibits the reaction [Stavudine results in increased expression of SREBF1 mRNA]	18299183
C043211	carvedilol	carvedilol inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]	22413959
D002392	Catechin	Catechin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	23365609
C086276	cerivastatin	SREBF1 protein inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]	11779144
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in decreased expression of SREBF1 mRNA	16269825
D048271	Chitosan	Chitosan inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	28987369
D048271	Chitosan	[Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	28987369
D020355	Cholates	"[cocoa butter co-treated with Cholesterol, Dietary co-treated with Cholates] results in increased expression of SREBF1 mRNA"	25814186
D002784	Cholesterol	[lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of SREBF1 mRNA	24440342
D002784	Cholesterol	[lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of SREBF1 mRNA	24440342
D002791	Cholesterol, Dietary	"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of SREBF1 mRNA"	19509184
D002791	Cholesterol, Dietary	"[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased cleavage of SREBF1 protein"	27394961
D002791	Cholesterol, Dietary	"Cholesterol, Dietary results in increased expression of SREBF1 mRNA"	16763553
D002791	Cholesterol, Dietary	"Cholesterol, Dietary results in increased expression of SREBF1 protein"	16763553
D002791	Cholesterol, Dietary	"MET gene mutant form promotes the reaction [[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased cleavage of SREBF1 protein]"	27394961
D002791	Cholesterol, Dietary	"[Cholesterol, Dietary co-treated with Dietary Carbohydrates] results in increased expression of SREBF1 protein"	22579924
D002791	Cholesterol, Dietary	"Cholesterol, Dietary results in increased expression of SREBF1 protein"	22579924\|2701929
D002791	Cholesterol, Dietary	"[cocoa butter co-treated with Cholesterol, Dietary co-treated with Cholates] results in increased expression of SREBF1 mRNA"	25814186
D002791	Cholesterol, Dietary	"oleuropein inhibits the reaction [Cholesterol, Dietary results in increased expression of SREBF1 protein]"	27019295
D002791	Cholesterol, Dietary	"Plant Preparations inhibits the reaction [Cholesterol, Dietary results in increased expression of SREBF1 protein]"	22579924
D002794	Choline	Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]	19593819
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA	19593819\|2897353
D002794	Choline	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]]	19593819
D002794	Choline	pirinixic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]	19593819
D002922	Ciguatoxins	Ciguatoxins affects the expression of SREBF1 mRNA	18353800
C012843	cinnamic aldehyde	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [cinnamic aldehyde results in decreased expression of SREBF1 mRNA]"	21401097
C012843	cinnamic aldehyde	cinnamic aldehyde results in decreased expression of SREBF1 mRNA	21401097
C503589	cis-9, trans-11-conjugated linoleic acid	"cis-9, trans-11-conjugated linoleic acid affects the expression of SREBF1 mRNA"	17327424
D015283	Citalopram	Citalopram results in increased cleavage of and results in increased activity of SREBF1 protein	16324787
D002994	Clofibrate	Clofibrate results in increased expression of SREBF1 mRNA	27089845
D002994	Clofibrate	Clofibrate results in increased expression of SREBF1 mRNA	16081524
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of SREBF1 mRNA	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of SREBF1 mRNA	23811191
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SREBF1 mRNA]	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of SREBF1 mRNA	17522070
D002997	Clomipramine	Clomipramine results in increased cleavage of and results in increased activity of SREBF1 protein	16324787
D003024	Clozapine	Clozapine results in increased expression of SREBF1 mRNA	17052361
D003024	Clozapine	Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 mRNA]	20564506
D003024	Clozapine	Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 protein]	20564506
D003024	Clozapine	Clozapine results in increased expression of SREBF1 mRNA	19682446\|2056450
D003024	Clozapine	Clozapine results in increased expression of SREBF1 protein	20564506
C007095	cobaltiprotoporphyrin	[SIRT1 gene mutant form co-treated with cobaltiprotoporphyrin] results in increased expression of SREBF1 mRNA	26026874
C007095	cobaltiprotoporphyrin	[SIRT1 gene mutant form co-treated with cobaltiprotoporphyrin] results in increased expression of SREBF1 protein	26026874
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of SREBF1 mRNA	19320972
C018021	cobaltous chloride	cobaltous chloride results in increased expression of SREBF1 mRNA	19376846\|2291766
C052387	cocoa butter	"[cocoa butter co-treated with Cholesterol, Dietary co-treated with Cholates] results in increased expression of SREBF1 mRNA"	25814186
D003300	Copper	[Disulfiram binds to Copper] which results in increased expression of SREBF1 mRNA	24690739
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of SREBF1 mRNA	20971185
D003300	Copper	Copper results in decreased expression of SREBF1 mRNA	17205981
D003300	Copper	[ATP7B protein affects the susceptibility to Copper] which affects the expression of SREBF1 mRNA	23112546
D003300	Copper	Copper deficiency affects the localization of SREBF1 protein	11110846
D003300	Copper	[Fructose co-treated with Copper deficiency] results in increased expression of SREBF1 protein	25813056
D003300	Copper	gadolinium chloride inhibits the reaction [[Fructose co-treated with Copper deficiency] results in increased expression of SREBF1 protein]	25813056
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of SREBF1 mRNA	24854705
D019327	Copper Sulfate	Sodium Selenite inhibits the reaction [Copper Sulfate results in decreased expression of SREBF1 mRNA]	24854705
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of SREBF1 mRNA	23660017
D003314	Corn Oil	Corn Oil affects the expression of SREBF1 mRNA	16360708
D003345	Corticosterone	[Corticosterone co-treated with oleoyl-estrone] affects the expression of SREBF1 mRNA	19545626
D003471	Cuprizone	Cuprizone results in increased expression of SREBF1 mRNA	26577399\|2752363
D003474	Curcumin	Curcumin affects the expression of SREBF1 mRNA	27208389
D003474	Curcumin	Curcumin affects the expression of SREBF1 protein	27208389
D003474	Curcumin	Curcumin results in decreased expression of SREBF1 mRNA	27208389
C057862	cyanoginosin LR	cyanoginosin LR results in decreased expression of SREBF1 mRNA	17654400
D016572	Cyclosporine	Cyclosporine results in decreased expression of SREBF1 mRNA	20106945\|2708984
D016572	Cyclosporine	Cyclosporine results in increased expression of SREBF1 mRNA	25562108
C037304	cyhalothrin	cyhalothrin results in increased expression of SREBF1 mRNA	27348886
C017180	decamethrin	decamethrin results in decreased expression of SREBF1 mRNA	23401056
C014347	decitabine	[decitabine co-treated with Depsipeptides] results in increased expression of SREBF1 mRNA	17064661
D003897	Desmosterol	Desmosterol results in increased expression of SREBF1 mRNA	19260826
D003897	Desmosterol	Desmosterol results in increased expression of SREBF1 protein	19260826
D003703	Demecolcine	Demecolcine results in decreased expression of SREBF1 mRNA	23649840
D003847	Deoxyglucose	Deoxyglucose results in increased expression of SREBF1 mRNA	10913129
D047630	Depsipeptides	[decitabine co-treated with Depsipeptides] results in increased expression of SREBF1 mRNA	17064661
D047630	Depsipeptides	Depsipeptides results in increased expression of SREBF1 mRNA	17064661
D003907	Dexamethasone	[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA	26200599
D003907	Dexamethasone	[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA	25932594
D003907	Dexamethasone	bexarotene promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]	25932594
D003907	Dexamethasone	Dexamethasone results in increased expression of SREBF1 mRNA	25047013\|2700384
D003907	Dexamethasone	Dichlorodiphenyl Dichloroethylene promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]	26200599
D003907	Dexamethasone	rosiglitazone promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]	25932594
D003907	Dexamethasone	tributyltin promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]	25932594
D003907	Dexamethasone	boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of SREBF1 mRNA]	28285642
D003907	Dexamethasone	[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SREBF1 protein	18586010
D003907	Dexamethasone	[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of SREBF1 mRNA	28285642
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SREBF1 mRNA	16054899
D003907	Dexamethasone	EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SREBF1 mRNA]	16054899
D003907	Dexamethasone	[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SREBF1 protein	11101056
D003907	Dexamethasone	Quercetin inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SREBF1 protein]	18586010
D003907	Dexamethasone	Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SREBF1 protein]	11101056
D003907	Dexamethasone	sodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of SREBF1 mRNA]	28285642
D003907	Dexamethasone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SREBF1 mRNA]	16054899
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of SREBF1 mRNA	21266533
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of SREBF1 mRNA	28962523
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of SREBF1 mRNA	27392435
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]	26200599
D018119	Stavudine	Carnitine inhibits the reaction [Stavudine results in increased expression of SREBF1 mRNA]	18299183
D018119	Stavudine	Stavudine results in increased expression of SREBF1 mRNA	18299183
D004040	Dietary Carbohydrates	"[Cholesterol, Dietary co-treated with Dietary Carbohydrates] results in increased expression of SREBF1 protein"	22579924
D004041	Dietary Fats	ANGPTL4 protein modified form affects the reaction [Dietary Fats affects the expression of SREBF1 mRNA]	28842503
D004041	Dietary Fats	Dietary Fats results in increased expression of SREBF1 mRNA	22658938
D004041	Dietary Fats	Dietary Fats results in increased expression of SREBF1 mRNA	24709573
D004041	Dietary Fats	"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of SREBF1 mRNA"	19509184
D004041	Dietary Fats	[Fructose co-treated with Dietary Fats co-treated with TO-901317] results in increased expression of SREBF1 mRNA	19509184
D004041	Dietary Fats	zerumbone inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	24709573
D004041	Dietary Fats	aroclor 1260 inhibits the reaction [Dietary Fats results in decreased expression of SREBF1 mRNA]	24998970
D004041	Dietary Fats	Dietary Fats affects the expression of SREBF1 mRNA	19680557\|2884250
D004041	Dietary Fats	[Dietary Fats co-treated with aza-(6)-gingerol] results in decreased expression of SREBF1 mRNA	21851089
D004041	Dietary Fats	[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of SREBF1 mRNA	21462320\|2827569
D004041	Dietary Fats	[Dietary Fats deficiency co-treated with Ethanol] results in increased expression of SREBF1 protein	12036955
D004041	Dietary Fats	Dietary Fats promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of SREBF1 mRNA]	27713108
D004041	Dietary Fats	Dietary Fats results in decreased expression of SREBF1 mRNA	24959901\|2499897
D004041	Dietary Fats	Dietary Fats results in increased expression of SREBF1 mRNA	15238619\|1793231
D004041	Dietary Fats	Dietary Fats results in increased expression of SREBF1 protein	20513351\|2668010
D004041	Dietary Fats	gastrodin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	26634892
D004041	Dietary Fats	ginsenoside Re inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	21971952
D004041	Dietary Fats	naringin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	22198281
D004041	Dietary Fats	NFE2L2 protein affects the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	27311796
D004041	Dietary Fats	PPARGC1B protein inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	17932310
D004041	Dietary Fats	Quercetin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of SREBF1 mRNA]	21462320
D004041	Dietary Fats	Quercetin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	24025686
D004041	Dietary Fats	[resveratrol co-treated with Dietary Fats] results in decreased expression of SREBF1 mRNA	24985011
D004041	Dietary Fats	"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]"	23756648
D004041	Dietary Fats	Tetrachlorodibenzodioxin promotes the reaction [Dietary Fats results in decreased expression of SREBF1 mRNA]	27713108
D004041	Dietary Fats	Thymol inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein]	26680107
D004041	Dietary Fats	Bezafibrate inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	26190035
D004041	Dietary Fats	bisphenol A promotes the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	25112833
D004041	Dietary Fats	bisphenol A promotes the reaction [Dietary Fats results in increased expression of SREBF1 protein]	25112833
D004041	Dietary Fats	Catechin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	23365609
D004041	Dietary Fats	Chitosan inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	28987369
D004041	Dietary Fats	[Dietary Fats co-treated with Ethanol] results in increased expression of SREBF1 mRNA	24275070
D004041	Dietary Fats	Dietary Fats promotes the reaction [bisphenol A results in increased expression of SREBF1 mRNA]	25112833
D004041	Dietary Fats	Dietary Fats promotes the reaction [bisphenol A results in increased expression of SREBF1 protein]	25112833
D004041	Dietary Fats	Dietary Fats results in decreased expression of SREBF1 mRNA	24450870
D004041	Dietary Fats	Dietary Fats results in increased expression of SREBF1 mRNA	22464149\|2336560
D004041	Dietary Fats	Dietary Fats results in increased expression of SREBF1 protein	23026700\|2331901
D004041	Dietary Fats	[Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	28987369
D004041	Dietary Fats	Fish Oils inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	28987369
D004041	Dietary Fats	[Margarine co-treated with Dietary Fats] results in increased expression of SREBF1 mRNA	24450870
D004041	Dietary Fats	[Olive Oil co-treated with Dietary Fats] results in increased expression of SREBF1 mRNA	24450870
D004041	Dietary Fats	Plant Extracts inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	23365609
D004041	Dietary Fats	Plant Extracts inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein]	23026700
D004041	Dietary Fats	quercetin 3-O-glucuronide inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	26190035
D004041	Dietary Fats	Saponins inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein]	23319015
D004041	Dietary Fats	Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	22464149
D019422	Dietary Sucrose	[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of SREBF1 mRNA	21462320\|2827569
D019422	Dietary Sucrose	Quercetin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of SREBF1 mRNA]	21462320
D004051	Diethylhexyl Phthalate	"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]"	23756648
C014476	diethyl maleate	diethyl maleate results in decreased expression of SREBF1 mRNA	21161181
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of SREBF1 mRNA	21527772
D004054	Diethylstilbestrol	2-chloro-5-nitrobenzanilide inhibits the reaction [Diethylstilbestrol results in increased expression of SREBF1 protein]	22710028
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of SREBF1 mRNA	22710028
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of SREBF1 protein	22710028
C039060	dihydroartemisinin	[dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]	27939985
C039060	dihydroartemisinin	[dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]	27939985
C039060	dihydroartemisinin	dihydroartemisinin inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]	27939985
C039060	dihydroartemisinin	dihydroartemisinin inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]	27939985
D002117	Calcitriol	Calcitriol results in decreased expression of SREBF1 mRNA	16368784
C042080	diisodecyl phthalate	diisodecyl phthalate results in increased expression of SREBF1 mRNA	25825955
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of SREBF1 mRNA"	22485181
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of SREBF1 mRNA	25380136
C550453	dioxinodehydroeckol	dioxinodehydroeckol results in decreased expression of SREBF1 mRNA	20385110
C550453	dioxinodehydroeckol	dioxinodehydroeckol results in decreased expression of SREBF1 protein	20385110
C076126	disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate	"disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of SREBF1 mRNA"	20184727
D004221	Disulfiram	[Disulfiram binds to Copper] which results in increased expression of SREBF1 mRNA	24690739
D004281	Docosahexaenoic Acids	Docosahexaenoic Acids results in decreased expression of SREBF1 mRNA	15949695
C098320	efavirenz	efavirenz results in decreased expression of SREBF1 mRNA	21619898
D015118	Eicosapentaenoic Acid	Eicosapentaenoic Acid results in decreased expression of SREBF1 mRNA	15949695
C118739	entinostat	entinostat results in increased expression of SREBF1 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SREBF1 mRNA"	27188386
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of SREBF1 mRNA	20064776
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of SREBF1 mRNA	20816778
D004917	Erythromycin	Erythromycin results in increased expression of SREBF1 mRNA	27503388
D004917	Erythromycin	[Penicillin G co-treated with Erythromycin] results in increased expression of SREBF1 mRNA	27503388
D004918	Erythromycin Estolate	Erythromycin Estolate results in decreased expression of SREBF1 mRNA	17522070
D000431	Ethanol	allyl sulfide inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]	22138249
D000431	Ethanol	[dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]	27939985
D000431	Ethanol	[dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]	27939985
D000431	Ethanol	dihydroartemisinin inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]	27939985
D000431	Ethanol	dihydroartemisinin inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]	27939985
D000431	Ethanol	Ethanol results in decreased expression of SREBF1 protein	28062356
D000431	Ethanol	Ethanol results in increased expression of SREBF1 mRNA	27939985
D000431	Ethanol	Ethanol results in increased expression of SREBF1 protein	22138249\|2793998
D000431	Ethanol	NR1H4 protein inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]	27939985
D000431	Ethanol	NR1H4 protein inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]	27939985
D000431	Ethanol	obeticholic acid inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]	27939985
D000431	Ethanol	acanthoic acid inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]	28964808
D000431	Ethanol	acanthoic acid inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]	28964808
D000431	Ethanol	allyl sulfide inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]	22138249
D000431	Ethanol	[Dietary Fats deficiency co-treated with Ethanol] results in increased expression of SREBF1 protein	12036955
D000431	Ethanol	[Ethanol results in decreased activity of SIRT1 protein] which results in increased acetylation of and results in increased localization of and results in increased activity of SREBF1 protein	18239056
D000431	Ethanol	Ethanol results in decreased expression of SREBF1 mRNA	22173916\|2888257
D000431	Ethanol	Ethanol results in increased activity of SREBF1 protein	18620774
D000431	Ethanol	Ethanol results in increased expression of SREBF1 mRNA	18620774\|1916741
D000431	Ethanol	Ethanol results in increased expression of SREBF1 protein	18755807\|2213824
D000431	Ethanol	NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]]	27837167
D000431	Ethanol	NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]]	27837167
D000431	Ethanol	NFE2L2 protein affects the reaction [Ethanol results in increased expression of SREBF1 mRNA]	22627062
D000431	Ethanol	pirinixic acid inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]	18620774
D000431	Ethanol	[PPARD gene mutant form results in increased susceptibility to Ethanol] which results in increased activity of SREBF1 protein	23851158
D000431	Ethanol	resveratrol inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]	18755807
D000431	Ethanol	rosiglitazone inhibits the reaction [Ethanol results in decreased expression of SREBF1 mRNA]	22173916
D000431	Ethanol	tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]	27837167
D000431	Ethanol	tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]	27837167
D000431	Ethanol	carvedilol inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]	22413959
D000431	Ethanol	[Dietary Fats co-treated with Ethanol] results in increased expression of SREBF1 mRNA	24275070
D000431	Ethanol	Ethanol affects the localization of SREBF1 protein	19371623
D000431	Ethanol	Ethanol promotes the reaction [SREBF1 protein binds to FAS promoter]	19371623
D000431	Ethanol	Ethanol results in decreased expression of SREBF1 mRNA	16098508
D000431	Ethanol	Ethanol results in increased acetylation of and results in increased activity of SREBF1 protein	18239056
D000431	Ethanol	Ethanol results in increased expression of SREBF1 mRNA	19371623\|2241395
D000431	Ethanol	Ethanol results in increased expression of SREBF1 protein	12036955\|2685492
D000431	Ethanol	honokiol inhibits the reaction [Ethanol affects the localization of SREBF1 protein]	19371623
D000431	Ethanol	honokiol inhibits the reaction [Ethanol promotes the reaction [SREBF1 protein binds to FAS promoter]]	19371623
D000431	Ethanol	honokiol inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]	19371623
D000431	Ethanol	[Oleic Acid co-treated with Palmitic Acid co-treated with Ethanol] results in increased expression of SREBF1 protein	26854922
D000431	Ethanol	Plant Extracts inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]	27795452
D000431	Ethanol	resveratrol inhibits the reaction [Ethanol results in increased acetylation of and results in increased activity of SREBF1 protein]	18239056
D000431	Ethanol	Scopoletin inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]	26115886
D000431	Ethanol	Silymarin inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]	26115886\|2779545
D000431	Ethanol	SIRT1 protein inhibits the reaction [Ethanol results in increased acetylation of and results in increased activity of SREBF1 protein]	18239056
D004997	Ethinyl Estradiol	[lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of SREBF1 mRNA	24440342
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of SREBF1 mRNA	17108234
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of SREBF1 mRNA	23649840
D000069438	Ezetimibe	Ezetimibe results in decreased expression of SREBF1 mRNA	16177187
D000069438	Ezetimibe	[Ezetimibe co-treated with Simvastatin] results in increased expression of SREBF1 mRNA	17130282
D005227	Fatty Acids	[Fatty Acids co-treated with INS protein] results in increased expression of SREBF1 mRNA	24648896
D005227	Fatty Acids	[Fatty Acids co-treated with INS protein] results in increased expression of SREBF1 protein	24648896
D005227	Fatty Acids	Quercetin inhibits the reaction [[Fatty Acids co-treated with INS protein] results in increased expression of SREBF1 mRNA]	24648896
D005227	Fatty Acids	Quercetin inhibits the reaction [[Fatty Acids co-treated with INS protein] results in increased expression of SREBF1 protein]	24648896
D005229	Fatty Acids, Monounsaturated	"Fatty Acids, Monounsaturated results in increased expression of SREBF1 mRNA"	22658938
D005230	Fatty Acids, Nonesterified	"Fatty Acids, Nonesterified results in decreased expression of SREBF1 mRNA"	24121055
D005230	Fatty Acids, Nonesterified	"Fatty Acids, Nonesterified results in increased expression of and affects the localization of SREBF1 protein"	23465592
D005230	Fatty Acids, Nonesterified	"Fatty Acids, Nonesterified results in increased expression of SREBF1 mRNA"	23465592\|2473586
D005230	Fatty Acids, Nonesterified	"Fatty Acids, Nonesterified results in increased expression of SREBF1 protein"	23465592\|2473586
D005230	Fatty Acids, Nonesterified	"Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SREBF1 mRNA]"	24735863
D005230	Fatty Acids, Nonesterified	"Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SREBF1 protein]"	24735863
D005230	Fatty Acids, Nonesterified	"hugan qingzhi inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SREBF1 mRNA]"	24735863
D005230	Fatty Acids, Nonesterified	"hugan qingzhi inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SREBF1 protein]"	24735863
D005230	Fatty Acids, Nonesterified	"S-allylcysteine inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of and affects the localization of SREBF1 protein]"	23465592
D005230	Fatty Acids, Nonesterified	"S-allylcysteine inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SREBF1 mRNA]"	23465592
D011345	Fenofibrate	"Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SREBF1 mRNA]"	24735863
D011345	Fenofibrate	"Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SREBF1 protein]"	24735863
D011345	Fenofibrate	Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]	19593819
D011345	Fenofibrate	Fenofibrate results in increased expression of SREBF1 mRNA	23063693
D011345	Fenofibrate	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]]	19593819
D011345	Fenofibrate	NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SREBF1 mRNA]	23063693
D011345	Fenofibrate	NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SREBF1 mRNA]	23063693
D011345	Fenofibrate	[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]	26973390
D005395	Fish Oils	Fish Oils results in decreased expression of SREBF1 mRNA	22464816
D005395	Fish Oils	Fish Oils results in decreased activity of SREBF1 protein	18620774
D005395	Fish Oils	[Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	28987369
D005395	Fish Oils	Fish Oils inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	28987369
D005557	Formaldehyde	Formaldehyde results in decreased expression of SREBF1 mRNA	23649840
D005632	Fructose	"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of SREBF1 mRNA"	19509184
D005632	Fructose	[Fructose co-treated with Dietary Fats co-treated with TO-901317] results in increased expression of SREBF1 mRNA	19509184
D005632	Fructose	Fructose affects the localization of SREBF1 protein alternative form	22698815
D005632	Fructose	Fructose results in increased expression of SREBF1 mRNA	10913129\|1506698
D005632	Fructose	Fructose results in increased expression of SREBF1 protein	15066988
D005632	Fructose	Phenylbutyrates inhibits the reaction [Fructose affects the localization of SREBF1 protein alternative form]	22698815
D005632	Fructose	Phenylbutyrates inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]	22698815
D005632	Fructose	SCD1 affects the reaction [Fructose results in increased expression of SREBF1 protein]	15066988
D005632	Fructose	SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]	15066988
D005632	Fructose	SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]	15066988
D005632	Fructose	SREBF1 promoter SNP affects the susceptibility to Fructose	15123654
D005632	Fructose	Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]]	15066988
D005632	Fructose	Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]]	15066988
D005632	Fructose	Atorvastatin Calcium inhibits the reaction [Fructose results in increased activity of SREBF1 protein]	19053045
D005632	Fructose	[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]	26973390
D005632	Fructose	[Fructose co-treated with Copper deficiency] results in increased expression of SREBF1 protein	25813056
D005632	Fructose	Fructose promotes the reaction [RBMX protein binds to SREBF1 promoter]	17188681
D005632	Fructose	Fructose results in increased expression of and results in increased activity of SREBF1 protein	19053045
D005632	Fructose	Fructose results in increased expression of SREBF1 mRNA	11934685\|1834647
D005632	Fructose	Fructose results in increased expression of SREBF1 protein	19799862
D005632	Fructose	gadolinium chloride inhibits the reaction [[Fructose co-treated with Copper deficiency] results in increased expression of SREBF1 protein]	25813056
D005632	Fructose	resveratrol inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]	26973390
D005632	Fructose	rosiglitazone inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]	19196556
D005632	Fructose	Tea inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]	19193814
C069837	fullerene C60	fullerene C60 results in increased expression of SREBF1 mRNA	19167457
C056933	fumonisin B1	fumonisin B1 results in decreased expression of SREBF1 mRNA	16221962
C039281	furan	furan results in decreased expression of SREBF1 mRNA	26194646
C038958	gadolinium chloride	gadolinium chloride inhibits the reaction [[Fructose co-treated with Copper deficiency] results in increased expression of SREBF1 protein]	25813056
D005690	Galactose	Galactose results in increased expression of SREBF1 mRNA	10913129
C045345	gastrodin	gastrodin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	26634892
D019833	Genistein	[Genistein co-treated with mono-(2-ethylhexyl)phthalate] affects the expression of SREBF1 mRNA	27181934
C049864	ginsenoside Re	ginsenoside Re results in decreased expression of SREBF1 mRNA	21971952
C049864	ginsenoside Re	ginsenoside Re inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	21971952
C046905	glucosamine 6-O-sulfate	glucosamine 6-O-sulfate results in decreased expression of SREBF1 mRNA	19520133
C046905	glucosamine 6-O-sulfate	glucosamine 6-O-sulfate results in decreased expression of SREBF1 protein	19520133
C001293	glucosamine 6-phosphate	glucosamine 6-phosphate results in decreased expression of SREBF1 protein	19427183
D005947	Glucose	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 mRNA]]"	23319015
D005947	Glucose	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 protein]]"	23319015
D005947	Glucose	Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF1 protein]	23647015
D005947	Glucose	Glucose results in increased expression of SREBF1 mRNA	23319015
D005947	Glucose	Glucose results in increased expression of SREBF1 protein	23319015\|2364701
D005947	Glucose	L 709049 analog inhibits the reaction [Glucose results in increased expression of SREBF1 protein]	23647015
D005947	Glucose	Niacinamide inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 protein]]	23319015
D005947	Glucose	platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 mRNA]	23319015
D005947	Glucose	platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 protein]	23319015
D005947	Glucose	Quercetin inhibits the reaction [Glucose results in increased expression of SREBF1 protein]	23647015
D005947	Glucose	STO 609 inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 mRNA]]	23319015
D005947	Glucose	Glucose results in increased expression of SREBF1 mRNA	10913129\|1506698
D005947	Glucose	Glucose results in increased expression of SREBF1 protein	23090186
D005947	Glucose	resveratrol inhibits the reaction [Glucose results in increased expression of SREBF1 protein]	23090186
D005947	Glucose	Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF1 protein]	23647015
D005947	Glucose	Glucose results in increased expression of SREBF1 protein	23647015
D005947	Glucose	L 709049 analog inhibits the reaction [Glucose results in increased expression of SREBF1 protein]	23647015
D005947	Glucose	Quercetin inhibits the reaction [Glucose results in increased expression of SREBF1 protein]	23647015
D005978	Glutathione	Glutathione inhibits the reaction [Alcohols results in increased expression of SREBF1 protein]	28803762
D006046	Gold	[Polyethyleneimine binds to Gold] which results in decreased expression of SREBF1 mRNA	28433809
C504517	GSK 3987	GSK 3987 results in increased expression of SREBF1 mRNA	16107141
C473027	GW 3965	GW 3965 results in increased expression of SREBF1 mRNA	16107141
C473027	GW 3965	GW 3965 results in increased expression of SREBF1 protein	23651738
C473027	GW 3965	resveratrol inhibits the reaction [GW 3965 results in increased expression of SREBF1 protein]	23651738
C473027	GW 3965	GW 3965 results in increased expression of SREBF1 mRNA	28315714
C412815	GW 4064	GW 4064 results in decreased expression of SREBF1 mRNA	16269825
D066248	High Fructose Corn Syrup	High Fructose Corn Syrup results in increased expression of SREBF1 mRNA	25238689
D066248	High Fructose Corn Syrup	resveratrol inhibits the reaction [High Fructose Corn Syrup results in increased expression of SREBF1 mRNA]	25238689
C070163	homobrassinolide	homobrassinolide results in increased expression of SREBF1 mRNA	21491949
C005499	honokiol	honokiol affects the localization of SREBF1 protein	19371623
C005499	honokiol	honokiol inhibits the reaction [Ethanol affects the localization of SREBF1 protein]	19371623
C005499	honokiol	honokiol inhibits the reaction [Ethanol promotes the reaction [SREBF1 protein binds to FAS promoter]]	19371623
C005499	honokiol	honokiol inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]	19371623
C005499	honokiol	honokiol results in decreased expression of SREBF1 mRNA	19371623
C000594496	hugan qingzhi	"hugan qingzhi inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SREBF1 mRNA]"	24735863
C000594496	hugan qingzhi	"hugan qingzhi inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SREBF1 protein]"	24735863
D006834	Hydrazines	Hydrazines results in decreased expression of SREBF1 mRNA	21647536
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of SREBF1 mRNA	26846883
C082359	imidacloprid	imidacloprid results in increased expression of SREBF1 mRNA	27960282
D007099	Imipramine	Imipramine results in increased cleavage of and results in increased activity of SREBF1 protein	16324787
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of SREBF1 mRNA	21396975
D007213	Indomethacin	Indomethacin results in decreased expression of SREBF1 mRNA	28201806
D007306	Insecticides	Insecticides results in decreased expression of SREBF1 mRNA	23401056
D015056	1-Methyl-3-isobutylxanthine	[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA	26200599
D015056	1-Methyl-3-isobutylxanthine	[1-Methyl-3-isobutylxanthine co-treated with troglitazone co-treated with INS protein] results in increased expression of SREBF1 mRNA	27003841
D015056	1-Methyl-3-isobutylxanthine	Dichlorodiphenyl Dichloroethylene promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]	26200599
D015056	1-Methyl-3-isobutylxanthine	boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of SREBF1 mRNA]	28285642
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SREBF1 protein	18586010
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of SREBF1 mRNA	28285642
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SREBF1 mRNA	16054899
D015056	1-Methyl-3-isobutylxanthine	EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SREBF1 mRNA]	16054899
D015056	1-Methyl-3-isobutylxanthine	[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SREBF1 protein	11101056
D015056	1-Methyl-3-isobutylxanthine	Quercetin inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SREBF1 protein]	18586010
D015056	1-Methyl-3-isobutylxanthine	Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SREBF1 protein]	11101056
D015056	1-Methyl-3-isobutylxanthine	sodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of SREBF1 mRNA]	28285642
D015056	1-Methyl-3-isobutylxanthine	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SREBF1 mRNA]	16054899
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of SREBF1 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of SREBF1 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of SREBF1 mRNA	23086925
C468270	Kangen-karyu	Kangen-karyu results in decreased expression of SREBF1	20363309
C468270	Kangen-karyu	Kangen-karyu results in decreased expression of SREBF1 protein	21155823
C468270	Kangen-karyu	Kangen-karyu affects the expression of SREBF1	17883899
C468270	Kangen-karyu	Kangen-karyu results in decreased expression of SREBF1 protein	17524234
D007649	Ketamine	Ketamine results in increased expression of SREBF1 mRNA	20080153
D007665	Ketotifen	Ketotifen results in increased expression of SREBF1 mRNA	27089845
C096429	L 709049	L 709049 analog inhibits the reaction [Glucose results in increased expression of SREBF1 protein]	23647015
C096429	L 709049	L 709049 analog inhibits the reaction [Glucose results in increased expression of SREBF1 protein]	23647015
C029310	lard	[lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of SREBF1 mRNA	24440342
C029310	lard	[lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of SREBF1 mRNA	24440342
C008261	lead acetate	lead acetate affects the expression of SREBF1 mRNA	21147602
D001556	Lindane	Lindane results in decreased expression of SREBF1 mRNA	17785943
D008070	Lipopolysaccharides	Lipopolysaccharides affects the localization of SREBF1 protein	21689150
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of SREBF1 mRNA	16847310
D008070	Lipopolysaccharides	Melatonin inhibits the reaction [Lipopolysaccharides affects the localization of SREBF1 protein]	21689150
D008095	Lithocholic Acid	Lithocholic Acid results in decreased expression of SREBF1 mRNA	20359477
D008095	Lithocholic Acid	Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of SREBF1 mRNA]	20359477
D019808	Losartan	Losartan inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]	19109942
D019808	Losartan	Losartan inhibits the reaction [AGT protein results in increased phosphorylation of SREBF1 protein]	19109942
C005498	magnolol	magnolol affects the localization of SREBF1 protein	19371623
C013592	mangiferin	mangiferin results in decreased expression of SREBF1 mRNA	22038976
D008383	Margarine	[Margarine co-treated with Dietary Fats] results in increased expression of SREBF1 mRNA	24450870
D008550	Melatonin	Melatonin inhibits the reaction [Lipopolysaccharides affects the localization of SREBF1 protein]	21689150
D008687	Metformin	[Metformin co-treated with caffeic acid] results in decreased expression of SREBF1 protein	28576465
D008715	Methionine	Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]	19593819
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA	19593819\|2897353
D008715	Methionine	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]]	19593819
D008715	Methionine	pirinixic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]	19593819
C002950	methylformamide	methylformamide analog results in decreased expression of SREBF1 mRNA	17040096
C002950	methylformamide	methylformamide results in decreased expression of SREBF1 mRNA	17040096
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of SREBF1 mRNA	23649840
D008777	Methyltestosterone	Methyltestosterone results in increased expression of SREBF1 mRNA	29191790
C012258	mevastatin	EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased cleavage of SREBF1 protein]	16330322
C012258	mevastatin	mevastatin results in increased cleavage of SREBF1 protein	16330322
C012258	mevastatin	mevastatin results in decreased expression of SREBF1 protein	17526932
C035133	mirtazapine	mirtazapine results in increased cleavage of and results in increased activity of SREBF1 protein	16324787
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of SREBF1 mRNA	23118965
C016599	mono-(2-ethylhexyl)phthalate	[Genistein co-treated with mono-(2-ethylhexyl)phthalate] affects the expression of SREBF1 mRNA	27181934
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate affects the expression of SREBF1 mRNA	27181934
C500085	muraglitazar	muraglitazar results in increased expression of SREBF1 mRNA	21515302
C040015	myricetin	myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased expression of SREBF1 protein]	25240712
D009270	Naloxone	Naloxone results in decreased expression of SREBF1 mRNA	17522070
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of SREBF1 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of SREBF1 mRNA"	25620056
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in decreased expression of SREBF1 mRNA	17522070\|2538013
C005274	naringin	naringin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	22198281
C461488	N-benzylpiperazine	N-benzylpiperazine results in increased expression of SREBF1 mRNA	26821219
C066471	NCS 382	NCS 382 results in decreased expression of SREBF1 mRNA	28119166
C051752	nefazodone	nefazodone results in decreased expression of SREBF1 mRNA	24136188
D019888	Nelfinavir	Nelfinavir affects the localization of SREBF1 protein	21355074
D019888	Nelfinavir	Nelfinavir inhibits the reaction [MBTPS2 protein results in increased cleavage of and results in increased activity of SREBF1 protein]	21355074
D019888	Nelfinavir	Nelfinavir results in decreased cleavage of SREBF1 protein	21355074
D019888	Nelfinavir	Nelfinavir results in decreased expression of SREBF1 protein alternative form	21355074
D019888	Nelfinavir	Nelfinavir results in increased expression of SREBF1 protein	16940799
D019888	Nelfinavir	Nelfinavir results in increased stability of SREBF1 protein	21355074
D019829	Nevirapine	Nevirapine results in increased expression of SREBF1 mRNA	21619898
D019829	Nevirapine	Nevirapine metabolite results in decreased expression of SREBF1 mRNA	23947594
C028007	nickel monoxide	nickel monoxide results in increased expression of SREBF1 mRNA	19167457
D009538	Nicotine	Nicotine results in decreased expression of SREBF1 mRNA	18247414
D009538	Nicotine	Nicotine results in increased expression of SREBF1 mRNA	29155039
C012655	nimesulide	nimesulide results in decreased expression of SREBF1 mRNA	24136188
C475771	N-piperidinyl-(8-chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydrobenzo(6,7)cyclohepta(1,2-c)pyrazole-3-carboxamide)	"N-piperidinyl-(8-chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydrobenzo(6,7)cyclohepta(1,2-c)pyrazole-3-carboxamide) inhibits the reaction [bisphenol A results in increased expression of SREBF1 mRNA]"	27014939
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of SREBF1 mRNA	20971185
C464660	obeticholic acid	obeticholic acid inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]	27939985
C464660	obeticholic acid	obeticholic acid results in decreased expression of SREBF1 mRNA	27939613
D019787	Linoleic Acid	Linoleic Acid results in decreased expression of SREBF1 mRNA	14563831
D019301	Oleic Acid	Oleic Acid results in decreased expression of SREBF1 mRNA	15949695\|2360300
D019301	Oleic Acid	Oleic Acid results in decreased expression of SREBF1 protein	23603006
D019301	Oleic Acid	Plant Extracts inhibits the reaction [Oleic Acid results in decreased expression of SREBF1 mRNA]	23603006
D019301	Oleic Acid	Plant Extracts inhibits the reaction [Oleic Acid results in decreased expression of SREBF1 protein]	23603006
D019301	Oleic Acid	[Oleic Acid co-treated with Palmitic Acid co-treated with Ethanol] results in increased expression of SREBF1 protein	26854922
D019301	Oleic Acid	[Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 mRNA	26190035
D019301	Oleic Acid	Oleic Acid results in increased expression of SREBF1 mRNA	23395669
D019301	Oleic Acid	quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 mRNA]	26190035
D019301	Oleic Acid	sophocarpine inhibits the reaction [Oleic Acid results in increased expression of SREBF1 mRNA]	23395669
C076029	olanzapine	olanzapine promotes the reaction [SREBF1 protein results in increased expression of LDLR mRNA]	17651982
C076029	olanzapine	olanzapine results in increased activity of and results in increased expression of SREBF1 protein	17651982
C076029	olanzapine	olanzapine results in increased expression of SREBF1 mRNA	17651982
D009828	Oleanolic Acid	Oleanolic Acid promotes the reaction [NFE2L2 protein results in increased expression of SREBF1 mRNA]	28796629
C108709	oleoyl-estrone	[Corticosterone co-treated with oleoyl-estrone] affects the expression of SREBF1 mRNA	19545626
C108709	oleoyl-estrone	oleoyl-estrone results in decreased expression of SREBF1 mRNA	19326039\|2018472
C108709	oleoyl-estrone	oleoyl-estrone results in increased expression of SREBF1 mRNA	19545626
C002769	oleuropein	"oleuropein inhibits the reaction [Cholesterol, Dietary results in increased expression of SREBF1 protein]"	27019295
D009840	Oligomycins	Oligomycins results in increased expression of SREBF1 mRNA	23227865
D000069463	Olive Oil	[Olive Oil co-treated with Dietary Fats] results in increased expression of SREBF1 mRNA	24450870
D000068557	Olmesartan Medoxomil	Olmesartan Medoxomil results in decreased expression of SREBF1 mRNA	18501344
C016340	o,p'-DDT	"o,p'-DDT affects the expression of SREBF1 mRNA"	18925944
C016340	o,p'-DDT	"o,p'-DDT affects the expression of SREBF1 mRNA"	17984292
D010100	Oxygen	EPAS1 gene mutant form inhibits the reaction [Oxygen deficiency results in decreased expression of SREBF1 protein]	24503013
D010100	Oxygen	HIF1A gene mutant form inhibits the reaction [Oxygen deficiency results in decreased expression of SREBF1 protein]	24503013
D010100	Oxygen	Oxygen deficiency results in decreased expression of SREBF1 protein	24503013
D010126	Ozone	Ozone results in decreased expression of SREBF1 mRNA	25838073
D010168	Palmitates	[Palmitates co-treated with TO-901317] results in increased expression of SREBF1 mRNA	21209018
D010168	Palmitates	SREBF1 protein affects the reaction [Palmitates results in increased abundance of Triglycerides]	21209018
D010168	Palmitates	SREBF1 protein affects the reaction [Palmitates results in increased cleavage of CASP3 protein]	21209018
D010168	Palmitates	SREBF1 protein affects the reaction [Palmitates results in increased cleavage of PARP1 protein]	21209018
D010168	Palmitates	SREBF1 protein affects the reaction [TO-901317 inhibits the reaction [Palmitates results in increased cleavage of CASP3 protein]]	21209018
D010168	Palmitates	SREBF1 protein affects the susceptibility to Palmitates	21209018
D019308	Palmitic Acid	ATG5 protein promotes the reaction [resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]]	25943029
D019308	Palmitic Acid	BECN1 protein promotes the reaction [resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]]	25943029
D019308	Palmitic Acid	Palmitic Acid results in increased expression of SREBF1 protein	25943029
D019308	Palmitic Acid	resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]	25943029
D019308	Palmitic Acid	[Oleic Acid co-treated with Palmitic Acid co-treated with Ethanol] results in increased expression of SREBF1 protein	26854922
D019308	Palmitic Acid	[Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 mRNA	26190035
D019308	Palmitic Acid	quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 mRNA]	26190035
D000073878	Palm Oil	Palm Oil affects the expression of SREBF1 mRNA	19680557
D052638	Particulate Matter	CCR2 gene mutant form inhibits the reaction [Particulate Matter results in increased expression of SREBF1 mRNA]	24149114
D052638	Particulate Matter	Particulate Matter results in increased expression of SREBF1 mRNA	24149114
D010396	Penicillamine	Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of SREBF1 mRNA]	22945834
D010400	Penicillin G	[Penicillin G co-treated with Erythromycin] results in increased expression of SREBF1 mRNA	27503388
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether analog results in decreased expression of SREBF1 mRNA	19095052
C522391	perfluorododecanoic acid	perfluorododecanoic acid results in increased expression of SREBF1 mRNA	23353032
C101816	perfluoro-n-nonanoic acid	perfluoro-n-nonanoic acid results in increased expression of SREBF1 mRNA	22648072
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased cleavage of SREBF1 protein	28288859
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of SREBF1 mRNA	26548598
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of SREBF1 mRNA	19162173
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of SREBF1 mRNA	18692542\|2172336
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of SREBF1 mRNA	21723365
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of SREBF1 mRNA	25092180
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased cleavage of SREBF1 protein	25092180
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of SREBF1 mRNA	25092180
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of SREBF1 mRNA	21723365
D010634	Phenobarbital	Estradiol inhibits the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]	21768169
D010634	Phenobarbital	NR1I3 mutant form inhibits the reaction [Estradiol inhibits the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]]	21768169
D010634	Phenobarbital	NR1I3 mutant form inhibits the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]	21768169
D010634	Phenobarbital	NR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]]	21768169
D010634	Phenobarbital	Phenobarbital results in decreased expression of SREBF1 mRNA	21768169
D010634	Phenobarbital	[Progesterone co-treated with Estradiol] inhibits the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]	21768169
D010634	Phenobarbital	Progesterone inhibits the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]	21768169
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital affects the expression of SREBF1 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased expression of SREBF1 mRNA	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of SREBF1 mRNA	19162173
D010654	Phenylbutyrates	Phenylbutyrates inhibits the reaction [Fructose affects the localization of SREBF1 protein alternative form]	22698815
D010654	Phenylbutyrates	Phenylbutyrates inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]	22698815
C030614	picolinic acid	picolinic acid affects the localization of SREBF1 protein	16870493
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SREBF1 mRNA	19710929
C006253	pirinixic acid	pirinixic acid inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]	18620774
C006253	pirinixic acid	pirinixic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]	19593819
C006253	pirinixic acid	pirinixic acid results in increased cleavage of SREBF1 protein	15777286
C006253	pirinixic acid	pirinixic acid results in increased expression of SREBF1 mRNA	17426115\|1830175
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in increased cleavage of SREBF1 protein]	15777286
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased localization of and results in decreased activity of SREBF1 protein	19248225
C006253	pirinixic acid	[[[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased localization of and results in decreased activity of SREBF1 protein] which results in decreased expression of FASN mRNA] which results in decreased abundance of Triglycerides	19248225
C006253	pirinixic acid	pirinixic acid results in increased expression of SREBF1 mRNA	19162173
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Oleic Acid results in decreased expression of SREBF1 mRNA]	23603006
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Oleic Acid results in decreased expression of SREBF1 protein]	23603006
D010936	Plant Extracts	Plant Extracts results in decreased expression of SREBF1 mRNA modified form	24342243
D010936	Plant Extracts	Plant Extracts affects the expression of SREBF1 mRNA	25086370
D010936	Plant Extracts	Plant Extracts results in decreased expression of SREBF1 mRNA	22445738
D010936	Plant Extracts	Plant Extracts results in decreased expression of SREBF1 protein	22967722\|2684561
D010936	Plant Extracts	Plant Extracts results in decreased expression of SREBF1 protein alternative form	23810795
D010936	Plant Extracts	Plant Extracts results in increased expression of SREBF1 mRNA	18534569
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	23365609
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein]	23026700
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]	27795452
D010936	Plant Extracts	Plant Extracts results in decreased expression of SREBF1 mRNA	23306787
D010936	Plant Extracts	Plant Extracts results in increased expression of SREBF1 protein	23603006
D028321	Plant Preparations	"Plant Preparations inhibits the reaction [Cholesterol, Dietary results in increased expression of SREBF1 protein]"	22579924
C108953	platycodin D	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 mRNA]]"	23319015
C108953	platycodin D	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 protein]]"	23319015
C108953	platycodin D	Niacinamide inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 protein]]	23319015
C108953	platycodin D	platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 mRNA]	23319015
C108953	platycodin D	platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 protein]	23319015
C108953	platycodin D	STO 609 inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 mRNA]]	23319015
D011094	Polyethyleneimine	[Polyethyleneimine binds to Gold] which results in decreased expression of SREBF1 mRNA	28433809
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of SREBF1 mRNA]	20359477
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of SREBF1 mRNA	28903501
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of SREBF1 mRNA	19162173
D011374	Progesterone	Progesterone results in increased expression of SREBF1 mRNA	23012394
D011374	Progesterone	"NR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA]]"	21768169
D011374	Progesterone	NR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]]	21768169
D011374	Progesterone	"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA]"	21768169
D011374	Progesterone	[Progesterone co-treated with Estradiol] inhibits the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]	21768169
D011374	Progesterone	"Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA]"	21768169
D011374	Progesterone	Progesterone inhibits the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]	21768169
D011374	Progesterone	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [[Progesterone co-treated with Estradiol] results in increased expression of SREBF1 mRNA]"	21768169
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in increased expression of SREBF1 mRNA	21768169
D011374	Progesterone	Progesterone results in increased expression of SREBF1 mRNA	20726854
C045950	propiconazole	propiconazole results in decreased expression of SREBF1 mRNA	21278054
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [FGF7 protein results in increased expression of SREBF1 protein]	16162944
D011794	Quercetin	Quercetin inhibits the reaction [[Fatty Acids co-treated with INS protein] results in increased expression of SREBF1 mRNA]	24648896
D011794	Quercetin	Quercetin inhibits the reaction [[Fatty Acids co-treated with INS protein] results in increased expression of SREBF1 protein]	24648896
D011794	Quercetin	Quercetin inhibits the reaction [Glucose results in increased expression of SREBF1 protein]	23647015
D011794	Quercetin	Quercetin results in increased expression of SREBF1 mRNA	21632981
D011794	Quercetin	Quercetin inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SREBF1 protein]	18586010
D011794	Quercetin	Quercetin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of SREBF1 mRNA]	21462320
D011794	Quercetin	Quercetin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	24025686
D011794	Quercetin	Quercetin inhibits the reaction [Glucose results in increased expression of SREBF1 protein]	23647015
D011794	Quercetin	Quercetin inhibits the reaction [Streptozocin results in increased expression of SREBF1 mRNA]	23647015
D011794	Quercetin	Quercetin inhibits the reaction [Streptozocin results in increased expression of SREBF1 protein]	23647015
C443401	quercetin 3-O-glucuronide	quercetin 3-O-glucuronide inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	26190035
C443401	quercetin 3-O-glucuronide	quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 mRNA]	26190035
C502851	quinocetone	quinocetone results in increased expression of SREBF1 mRNA	27046791
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SREBF1 mRNA	19059307
D017382	Reactive Oxygen Species	Reactive Oxygen Species affects the expression of SREBF1 mRNA	25800948
C059514	resveratrol	resveratrol results in decreased expression of SREBF1 mRNA	25866375
C059514	resveratrol	ATG5 protein promotes the reaction [resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]]	25943029
C059514	resveratrol	BECN1 protein promotes the reaction [resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]]	25943029
C059514	resveratrol	resveratrol inhibits the reaction [GW 3965 results in increased expression of SREBF1 protein]	23651738
C059514	resveratrol	resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]	25943029
C059514	resveratrol	resveratrol inhibits the reaction [TO-901317 results in increased expression of SREBF1 mRNA]	23651738
C059514	resveratrol	resveratrol inhibits the reaction [TO-901317 results in increased expression of SREBF1 protein]	23651738
C059514	resveratrol	resveratrol results in increased activity of and results in increased cleavage of SREBF1 protein	22153697
C059514	resveratrol	[resveratrol results in increased activity of and results in increased cleavage of [SREBF1 protein co-treated with SREBF2 protein]] which results in increased expression of LDLR mRNA	22153697
C059514	resveratrol	resveratrol results in increased expression of SREBF1 protein modified form	22153697
C059514	resveratrol	[resveratrol co-treated with Dietary Fats] results in decreased expression of SREBF1 mRNA	24985011
C059514	resveratrol	resveratrol inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]	18755807
C059514	resveratrol	resveratrol inhibits the reaction [Glucose results in increased expression of SREBF1 protein]	23090186
C059514	resveratrol	resveratrol inhibits the reaction [TO-901317 results in increased expression of SREBF1 protein]	23651738
C059514	resveratrol	resveratrol results in decreased expression of SREBF1 mRNA	22659145
C059514	resveratrol	[resveratrol results in decreased expression of SREBF1 mRNA] which results in decreased expression of FASN mRNA	22659145
C059514	resveratrol	resveratrol results in decreased expression of SREBF1 protein	23090186
C059514	resveratrol	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol metabolite inhibits the reaction [TO-901317 results in increased expression of SREBF1 mRNA]]"	24633463
C059514	resveratrol	[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]	26973390
C059514	resveratrol	resveratrol inhibits the reaction [Ethanol results in increased acetylation of and results in increased activity of SREBF1 protein]	18239056
C059514	resveratrol	resveratrol inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]	26973390
C059514	resveratrol	resveratrol inhibits the reaction [High Fructose Corn Syrup results in increased expression of SREBF1 mRNA]	25238689
C059514	resveratrol	resveratrol inhibits the reaction [TO-901317 results in increased metabolism of SREBF1 protein]	24633463
C059514	resveratrol	resveratrol metabolite inhibits the reaction [TO-901317 results in increased expression of SREBF1 mRNA]	24633463
C059514	resveratrol	resveratrol metabolite inhibits the reaction [TO-901317 results in increased metabolism of SREBF1 protein]	24633463
C059514	resveratrol	resveratrol results in decreased expression of SREBF1 mRNA	23209300
D018967	Risperidone	Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 mRNA]	20564506
D018967	Risperidone	Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 protein]	20564506
D018967	Risperidone	Risperidone results in increased expression of SREBF1 mRNA	20564506
D018967	Risperidone	Risperidone results in increased expression of SREBF1 protein	20564506
D019438	Ritonavir	Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SREBF1 protein]	11101056
C089730	rosiglitazone	rosiglitazone promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]	25932594
C089730	rosiglitazone	rosiglitazone results in increased expression of SREBF1 mRNA	16806087
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SREBF1 mRNA	16054899
C089730	rosiglitazone	EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SREBF1 mRNA]	16054899
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Ethanol results in decreased expression of SREBF1 mRNA]	22173916
C089730	rosiglitazone	rosiglitazone results in increased expression of SREBF1 mRNA	18534569\|2332281
C089730	rosiglitazone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SREBF1 mRNA]	16054899
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]	19196556
C089730	rosiglitazone	rosiglitazone results in decreased expression of SREBF1 mRNA	21515302
C089730	rosiglitazone	rosiglitazone results in increased expression of SREBF1 mRNA	19201733
C089730	rosiglitazone	rosiglitazone results in increased expression of SREBF1 protein	22726273
D012402	Rotenone	Rotenone results in increased expression of SREBF1 mRNA	17651460
D012402	Rotenone	Rotenone results in decreased expression of SREBF1 mRNA	19693701
C065299	S-allylcysteine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein]"	23465592
C065299	S-allylcysteine	"S-allylcysteine inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of and affects the localization of SREBF1 protein]"	23465592
C065299	S-allylcysteine	"S-allylcysteine inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SREBF1 mRNA]"	23465592
C065299	S-allylcysteine	S-allylcysteine results in decreased expression of SREBF1 protein	23465592
C065299	S-allylcysteine	sirtinol inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein]	23465592
C065299	S-allylcysteine	STO 609 inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein]	23465592
D012503	Saponins	Saponins inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein]	23319015
D012603	Scopoletin	Scopoletin inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]	26115886
D012643	Selenium	Selenium results in increased expression of SREBF1 mRNA	28810182
D012643	Selenium	Selenium results in increased expression of SREBF1 mRNA	19022953
D012645	Selenomethionine	Selenomethionine results in decreased expression of SREBF1 mRNA	23399444
D012645	Selenomethionine	Selenomethionine results in decreased methylation of SREBF1 exon	28810182
D012645	Selenomethionine	Selenomethionine results in increased expression of SREBF1 mRNA	28810182
D012715	Sesame Oil	Sesame Oil results in decreased expression of SREBF1 mRNA	29191790
D012838	Silymarin	Silymarin inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]	26115886\|2779545
D019821	Simvastatin	Simvastatin results in increased localization of SREBF1 protein	17655842
D019821	Simvastatin	Simvastatin results in decreased expression of SREBF1 mRNA	25055962
D019821	Simvastatin	[Ezetimibe co-treated with Simvastatin] results in increased expression of SREBF1 mRNA	17130282
D020123	Sirolimus	Sirolimus results in decreased expression of SREBF1 mRNA	15358118
C439060	sirtinol	sirtinol inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein]	23465592
C017947	sodium arsenite	sodium arsenite affects the expression of SREBF1 protein	27932253
C017947	sodium arsenite	sodium arsenite results in decreased expression of SREBF1 mRNA	23221991\|2515503
C016104	sodium bichromate	sodium bichromate affects the expression of SREBF1 mRNA	22110744
D020358	Sodium Cholate	"[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased cleavage of SREBF1 protein"	27394961
D020358	Sodium Cholate	"MET gene mutant form promotes the reaction [[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased cleavage of SREBF1 protein]"	27394961
C538809	sodium pentaborate	sodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of SREBF1 mRNA]	28285642
D018038	Sodium Selenite	Sodium Selenite inhibits the reaction [Copper Sulfate results in decreased expression of SREBF1 mRNA]	24854705
D018038	Sodium Selenite	Sodium Selenite results in decreased methylation of SREBF1 exon	28810182
D018038	Sodium Selenite	Sodium Selenite results in increased expression of SREBF1 mRNA	28810182
C035933	sophocarpine	sophocarpine inhibits the reaction [Oleic Acid results in increased expression of SREBF1 mRNA]	23395669
C525422	SRT1720	[SRT1720 results in increased activity of SIRT1 protein] which results in increased expression of SREBF1 mRNA	21212096
D013213	Starch	Starch analog inhibits the reaction [Canola Oil metabolite results in increased expression of SREBF1 mRNA]	27363782
C458525	STO 609	STO 609 inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 mRNA]]	23319015
C458525	STO 609	STO 609 inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein]	23465592
D013311	Streptozocin	Allopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF1 mRNA]	23647015
D013311	Streptozocin	Allopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF1 protein]	23647015
D013311	Streptozocin	myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased expression of SREBF1 protein]	25240712
D013311	Streptozocin	Quercetin inhibits the reaction [Streptozocin results in increased expression of SREBF1 mRNA]	23647015
D013311	Streptozocin	Quercetin inhibits the reaction [Streptozocin results in increased expression of SREBF1 protein]	23647015
D013311	Streptozocin	[Streptozocin co-treated with Cadmium] results in increased expression of SREBF1 protein	25240712
D013311	Streptozocin	Streptozocin results in decreased expression of SREBF1 protein	28822685
D013311	Streptozocin	Streptozocin results in increased expression of SREBF1 mRNA	23647015
D013311	Streptozocin	Streptozocin results in increased expression of SREBF1 protein	23647015
D013395	Sucrose	[lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of SREBF1 mRNA	24440342
D013395	Sucrose	[lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of SREBF1 mRNA	24440342
C016766	sulforafan	sulforafan promotes the reaction [NFE2L2 protein results in increased expression of SREBF1 mRNA]	28796629
C016766	sulforafan	[sulforafan co-treated with Aflatoxin B1] affects the expression of SREBF1 mRNA	25450479
D015085	2,4,5-Trichlorophenoxyacetic Acid	"2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SREBF1 mRNA"	18579281
D014284	Triiodothyronine	SIRT1 protein affects the reaction [Triiodothyronine results in decreased activity of SREBF1 protein]	23209300
D014284	Triiodothyronine	SIRT1 protein affects the reaction [Triiodothyronine results in decreased expression of SREBF1 mRNA]	23209300
D014284	Triiodothyronine	Triiodothyronine results in decreased activity of SREBF1 protein	23209300
D014284	Triiodothyronine	Triiodothyronine results in decreased expression of SREBF1 mRNA	23209300
D014284	Triiodothyronine	SIRT1 protein affects the reaction [Triiodothyronine results in decreased activity of SREBF1 protein]	23209300
D014284	Triiodothyronine	Triiodothyronine results in decreased activity of SREBF1 protein	23209300
C013698	tallow	tallow affects the expression of SREBF1 mRNA	19680557
D013629	Tamoxifen	[Tamoxifen co-treated with ESR2 protein] results in decreased expression of SREBF1 mRNA	19059307
C521767	Tanjin extract	Tanjin extract results in decreased expression of SREBF1 protein	17524234
C030141	taurine-ursodeoxycholate conjugate	taurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of SREBF1 mRNA]	21079772
D013662	Tea	Tea inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]	19193814
D013739	Testosterone	Testosterone results in increased expression of SREBF1 mRNA	16579987
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SREBF1 mRNA	20106945
D013749	Tetrachlorodibenzodioxin	"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of SREBF1 mRNA]"	21851831
D013749	Tetrachlorodibenzodioxin	Dietary Fats promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of SREBF1 mRNA]	27713108
D013749	Tetrachlorodibenzodioxin	NFE2L2 gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SREBF1 mRNA]	21846477
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SREBF1 mRNA	24058054\|2637764
D013749	Tetrachlorodibenzodioxin	"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]"	23756648
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SREBF1 mRNA]	16054899
D013749	Tetrachlorodibenzodioxin	"Tetrachlorodibenzodioxin promotes the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of SREBF1 mRNA]"	21851831
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [Dietary Fats results in decreased expression of SREBF1 mRNA]	27713108
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SREBF1 mRNA	18295293\|2000588
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SREBF1 protein	20181658
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SREBF1 mRNA	21846477
D013749	Tetrachlorodibenzodioxin	TIPARP protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SREBF1 mRNA]	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SREBF1 mRNA	21215274\|2172422
D013752	Tetracycline	Tetracycline results in increased expression of SREBF1 mRNA	27089845
D013752	Tetracycline	Tetracycline results in increased expression of SREBF1 mRNA	16917069
D013752	Tetracycline	Tetracycline results in decreased expression of SREBF1 mRNA	17202758\|1752207
C017953	tetramethylpyrazine	NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]]	27837167
C017953	tetramethylpyrazine	NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]]	27837167
C017953	tetramethylpyrazine	tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]	27837167
C017953	tetramethylpyrazine	tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]	27837167
D019284	Thapsigargin	Thapsigargin promotes the reaction [HNRNPA1 protein binds to SREBF1 5' UTR]	23106379
D013806	Theophylline	Theophylline results in decreased expression of SREBF1 mRNA	17522070
D013853	Thioacetamide	Thioacetamide results in increased expression of SREBF1 mRNA	16456712
D013853	Thioacetamide	Thioacetamide results in decreased expression of SREBF1 mRNA	23411599
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	22464149
D013943	Thymol	Thymol inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein]	26680107
C050504	tianeptine	tianeptine results in increased expression of SREBF1 mRNA	27089845
C423915	TO-901317	atheronal-A inhibits the reaction [TO-901317 results in increased expression of SREBF1 mRNA]	27703007
C423915	TO-901317	resveratrol inhibits the reaction [TO-901317 results in increased expression of SREBF1 mRNA]	23651738
C423915	TO-901317	resveratrol inhibits the reaction [TO-901317 results in increased expression of SREBF1 protein]	23651738
C423915	TO-901317	SESN2 protein inhibits the reaction [TO-901317 results in increased expression of SREBF1 protein]	23651738
C423915	TO-901317	TO-901317 promotes the reaction [[NR1H3 protein binds to NR1H2 protein] which binds to SREBF1 promoter]	15548517
C423915	TO-901317	TO-901317 results in increased expression of SREBF1 mRNA	15548517\|2365173
C423915	TO-901317	TO-901317 results in increased expression of SREBF1 protein	15548517\|2598057
C423915	TO-901317	[Fructose co-treated with Dietary Fats co-treated with TO-901317] results in increased expression of SREBF1 mRNA	19509184
C423915	TO-901317	resveratrol inhibits the reaction [TO-901317 results in increased expression of SREBF1 protein]	23651738
C423915	TO-901317	TO-901317 promotes the reaction [LIPE protein results in increased expression of SREBF1 mRNA]	23362264
C423915	TO-901317	TO-901317 promotes the reaction [PARP1 protein binds to SREBF1 promoter]	27026705
C423915	TO-901317	TO-901317 promotes the reaction [SREBF1 protein binds to ALDH1A1 promoter]	16763553
C423915	TO-901317	TO-901317 promotes the reaction [SREBF1 protein binds to ALDH1A2 promoter]	16763553
C423915	TO-901317	TO-901317 results in increased expression of SREBF1 mRNA	16489205\|1676355
C423915	TO-901317	TO-901317 results in increased expression of SREBF1 protein	16763553\|2365173
C423915	TO-901317	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol metabolite inhibits the reaction [TO-901317 results in increased expression of SREBF1 mRNA]]"	24633463
C423915	TO-901317	[Palmitates co-treated with TO-901317] results in increased expression of SREBF1 mRNA	21209018
C423915	TO-901317	resveratrol inhibits the reaction [TO-901317 results in increased metabolism of SREBF1 protein]	24633463
C423915	TO-901317	resveratrol metabolite inhibits the reaction [TO-901317 results in increased expression of SREBF1 mRNA]	24633463
C423915	TO-901317	resveratrol metabolite inhibits the reaction [TO-901317 results in increased metabolism of SREBF1 protein]	24633463
C423915	TO-901317	SREBF1 protein affects the reaction [TO-901317 inhibits the reaction [Palmitates results in increased cleavage of CASP3 protein]]	21209018
C423915	TO-901317	SREBF1 protein affects the susceptibility to TO-901317	21209018
C423915	TO-901317	TO-901317 results in increased expression of SREBF1 mRNA	16790840\|2463346
C423915	TO-901317	TO-901317 results in increased metabolism of SREBF1 protein	24633463
C052342	topiramate	topiramate results in increased expression of SREBF1 mRNA	16979414
C496197	trans-10,cis-12-conjugated linoleic acid	"trans-10,cis-12-conjugated linoleic acid results in decreased activity of SREBF1 protein"	16988111
C496197	trans-10,cis-12-conjugated linoleic acid	"trans-10,cis-12-conjugated linoleic acid results in decreased expression of SREBF1 mRNA"	16988111
C495469	trans-3-(4'-hydroxyphenyl)-2-propenoic acid	trans-3-(4'-hydroxyphenyl)-2-propenoic acid results in decreased expression of SREBF1 protein alternative form	23810795
D014212	Tretinoin	AGN 193109 inhibits the reaction [Tretinoin results in increased expression of SREBF1 mRNA]	16505366
D014212	Tretinoin	Tretinoin results in increased expression of SREBF1 mRNA	16505366
C011559	tributyltin	tributyltin promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]	25932594
C011559	tributyltin	tributyltin results in increased expression of SREBF1 mRNA	28011154
C011559	tributyltin	tributyltin results in increased expression of SREBF1 mRNA	23322813\|2593259
D014280	Triglycerides	[Bezafibrate results in decreased expression of SREBF1] which results in decreased abundance of Triglycerides	19124612
D014280	Triglycerides	[[[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased localization of and results in decreased activity of SREBF1 protein] which results in decreased expression of FASN mRNA] which results in decreased abundance of Triglycerides	19248225
D014280	Triglycerides	SREBF1 protein affects the reaction [Palmitates results in increased abundance of Triglycerides]	21209018
D014280	Triglycerides	[[[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased localization of and results in decreased activity of SREBF1 protein] which results in decreased expression of FASN mRNA] which results in decreased abundance of Triglycerides	19248225
D014304	Triolein	Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]]	15066988
D014304	Triolein	Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]]	15066988
C005445	triphenyl phosphate	triphenyl phosphate results in increased expression of SREBF1 mRNA	28934090
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SREBF1 mRNA"	26179874
C057693	troglitazone	[1-Methyl-3-isobutylxanthine co-treated with troglitazone co-treated with INS protein] results in increased expression of SREBF1 mRNA	27003841
C057693	troglitazone	troglitazone results in decreased expression of SREBF1 mRNA	19140230
C057693	troglitazone	[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased localization of and results in decreased activity of SREBF1 protein	19248225
C057693	troglitazone	[[[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased localization of and results in decreased activity of SREBF1 protein] which results in decreased expression of FASN mRNA] which results in decreased abundance of Triglycerides	19248225
C057693	troglitazone	troglitazone results in decreased expression of SREBF1 mRNA	10900012
C080163	trovafloxacin	trovafloxacin results in decreased expression of SREBF1 mRNA	24136188
D014415	Tunicamycin	HNRNPA1 mutant form inhibits the reaction [Tunicamycin results in increased expression of SREBF1 protein]	23106379
D014415	Tunicamycin	Tunicamycin promotes the reaction [HNRNPA1 protein binds to SREBF1 5' UTR]	23106379
D014415	Tunicamycin	Tunicamycin results in increased expression of SREBF1 protein	23106379
D014415	Tunicamycin	Tunicamycin results in increased cleavage of SREBF1 protein	22414386
D014415	Tunicamycin	HNRNPA1 mutant form inhibits the reaction [Tunicamycin results in increased expression of SREBF1 protein]	23106379
D014415	Tunicamycin	Tunicamycin results in increased expression of SREBF1 protein	23106379
C112106	UAB 30	UAB 30 analog results in increased expression of SREBF1 mRNA	23292798
C406224	valdecoxib	valdecoxib results in decreased expression of SREBF1 mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of SREBF1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of SREBF1 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of SREBF1 mRNA	25716160\|2708984
D014635	Valproic Acid	Valproic Acid affects the expression of SREBF1 mRNA	17292431\|1796380
D014750	Vincristine	Vincristine results in decreased expression of SREBF1 mRNA	23649840
D014752	Vinyl Chloride	Vinyl Chloride results in increased expression of SREBF1 mRNA	18579281
D009536	Niacinamide	Niacinamide inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 protein]]	23319015
D014994	Xylose	Xylose results in increased expression of SREBF1 mRNA	10913129
C403304	zerumbone	zerumbone inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	24709573
D015032	Zinc	Zinc results in decreased expression of SREBF1 mRNA	26602879
D015034	Zinc Oxide	Zinc Oxide affects the expression of SREBF1 protein	28648595

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	-	IDA	23610160
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	-
GO:0003677	DNA binding	-	ISS	-
GO:0003682	chromatin binding	-	IEA	-
GO:0003700	DNA-binding transcription factor activity	-	IDA	16407292
GO:0004879	nuclear receptor activity	-	IDA	23610160
GO:0005515	protein binding	-	IPI	14701856 23610160
GO:0019901	protein kinase binding	-	IEA	-
GO:0032810	sterol response element binding	-	IDA	16407292
GO:0044877	protein-containing complex binding	-	IEA	-
GO:0046983	protein dimerization activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	-
GO:0003062	regulation of heart rate by chemical signal	-	IEA	-
GO:0006357	regulation of transcription by RNA polymerase II	-	TAS	8156598
GO:0006629	lipid metabolic process	-	TAS	8156598
GO:0007568	aging	-	IEA	-
GO:0007623	circadian rhythm	-	TAS	-
GO:0008203	cholesterol metabolic process	-	IEA	-
GO:0008286	insulin receptor signaling pathway	-	IEA	-
GO:0008610	lipid biosynthetic process	-	ISS	-
GO:0009267	cellular response to starvation	-	ISS	16407292
GO:0009749	response to glucose	-	IEA	-
GO:0010867	positive regulation of triglyceride biosynthetic process	-	ISS	-
GO:0019217	regulation of fatty acid metabolic process	-	IEA	-
GO:0030324	lung development	-	IEA	-
GO:0030522	intracellular receptor signaling pathway	-	IEA	-
GO:0031065	positive regulation of histone deacetylation	-	IEA	-
GO:0031647	regulation of protein stability	-	IMP	24912190
GO:0032094	response to food	-	IEA	-
GO:0032526	response to retinoic acid	-	IEA	-
GO:0032570	response to progesterone	-	IEA	-
GO:0033762	response to glucagon	-	IEA	-
GO:0042789	mRNA transcription by RNA polymerase II	-	IEA	-
GO:0045444	fat cell differentiation	-	IEA	-
GO:0045540	regulation of cholesterol biosynthetic process	-	TAS	-
GO:0045542	positive regulation of cholesterol biosynthetic process	-	IEA	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	26437365
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IGI	23610160
GO:0045944	positive regulation of transcription by RNA polymerase II	-	TAS	23610160
GO:0046676	negative regulation of insulin secretion	-	IEA	-
GO:0051591	response to cAMP	-	IEA	-
GO:0071398	cellular response to fatty acid	-	IEA	-
GO:1903146	regulation of autophagy of mitochondrion	-	IMP	24912190
GO:1903214	regulation of protein targeting to mitochondrion	-	IMP	24912190

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000139	Golgi membrane	-	TAS	-
GO:0005634	nucleus	-	IDA	15358760
GO:0005635	nuclear envelope	-	TAS	8156598
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	ISS	-
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0005829	cytosol	-	TAS	-
GO:0012507	ER to Golgi transport vesicle membrane	-	IEA	-
GO:0016021	integral component of membrane	-	IEA	-
GO:0032991	protein-containing complex	-	IEA	-

KEGG ID	KEGG Term
hsa04910	Insulin signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1368082	RORA activates gene expression	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-1430728	Metabolism	IEA
R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	TAS
R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	IEA
R-HSA-1989781	PPARA activates gene expression	TAS
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	TAS
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	IEA
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	IEA
R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	TAS
R-HSA-400253	Circadian Clock	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-556833	Metabolism of lipids	IEA
R-HSA-8957322	Metabolism of steroids	TAS
R-HSA-8957322	Metabolism of steroids	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28194238	Epigenome-wide association study (EWAS) on lipids: the Rotterdam Study. (2017)	Braun KVE	Clin Epigenetics