Gene: SREBF2

6721
SREBP-2|SREBP2|bHLHd2
sterol regulatory element binding transcription factor 2
protein-coding
22q13.2
Ensembl:ENSG00000198911 MIM:600481 Vega:OTTHUMG00000151261 UniprotKB:Q12772
NC_000022.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.293e-1 (AD)  2.048e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLCN60.955
ABR0.951
FASN0.948
CTIF0.948
RNF440.947
DEF80.946
TNPO20.946
CAMTA20.944
CLSTN10.944
RUSC20.944

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.715
OR4F29-0.658
TFPI2-0.457
IL18RAP-0.422
KCNJ15-0.408
CST7-0.4
PROK2-0.393
CD48-0.39
SLAMF6-0.382
CEACAM4-0.382

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0620781-(carboxymethylthio)tetradecane1-(carboxymethylthio)tetradecane affects the expression of SREBF2 mRNA23226405
C0620781-(carboxymethylthio)tetradecane[olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of SREBF2 mRNA23226405
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased metabolism of and affects the localization of SREBF2 protein]22388943
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of SREBF2 mRNA"20005886|2185183
C0140242,4,5,2',4',5'-hexachlorobiphenyl"Tetrachlorodibenzodioxin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of SREBF2 mRNA]"21851831
C00799725-hydroxycholesterol25-hydroxycholesterol inhibits the reaction [resveratrol results in increased activity of and results in increased cleavage of SREBF2 protein]22153697
C00799725-hydroxycholesterol25-hydroxycholesterol inhibits the reaction [[resveratrol results in increased activity of and results in increased cleavage of SREBF2 protein] which results in increased expression of LDLR mRNA]22153697
C00799725-hydroxycholesterol25-hydroxycholesterol inhibits the reaction [resveratrol results in increased expression of SREBF2 protein modified form]22153697
C00799725-hydroxycholesterol25-hydroxycholesterol results in decreased activity of SREBF2 protein17052361
C00799725-hydroxycholesterolClozapine inhibits the reaction [25-hydroxycholesterol results in decreased activity of SREBF2 protein]17052361
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SREBF2 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SREBF2 mRNA"27188386
C0652504-hydroxy-equilenin4-hydroxy-equilenin results in decreased expression of SREBF2 mRNA15135645
C5732335,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one"5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one inhibits the reaction [Dietary Fats results in increased expression of SREBF2 mRNA]"24646949
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SREBF2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SREBF2 mRNA29067470
D000493AllopurinolAllopurinol inhibits the reaction [Glucose results in increased expression of SREBF2 protein]23647015
D000493AllopurinolAllopurinol inhibits the reaction [Glucose results in increased expression of SREBF2 protein]23647015
D000493AllopurinolAllopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF2 mRNA]23647015
D000493AllopurinolAllopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF2 protein]23647015
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of SREBF2 mRNA16541421
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of SREBF2 mRNA16990341
D000639AmitriptylineAmitriptyline results in increased cleavage of and results in increased activity of SREBF2 protein16324787
D000924Anticholesteremic AgentsAnticholesteremic Agents inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of SREBF2 mRNA]28275691
D000924Anticholesteremic AgentsAnticholesteremic Agents results in increased expression of SREBF2 mRNA28275691
D000924Anticholesteremic AgentsAnticholesteremic Agents results in increased expression of SREBF2 protein28275691
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased localization of SREBF2 protein11728391
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased activity of and results in increased localization of SREBF2 protein12056585
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of SREBF2 mRNA12056585|1206572
D000069059Atorvastatin CalciumMevalonic Acid inhibits the reaction [Atorvastatin Calcium results in increased expression of SREBF2 mRNA]12056585
D001280AtrazineAtrazine results in decreased expression of SREBF2 mRNA25929836
D001280AtrazineAtrazine results in increased expression of SREBF2 mRNA22378314
C547126AZM551248AZM551248 results in increased expression of SREBF2 mRNA22323515
C006680baicaleinbaicalein results in decreased expression of SREBF2 mRNA24560969
D001548Benzalkonium CompoundsBenzalkonium Compounds results in increased expression of SREBF2 mRNA26919959
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SREBF2 mRNA20106945
D004958EstradiolEstradiol results in increased expression of SREBF2 mRNA27014939
D001629BezafibrateBezafibrate results in increased expression of SREBF2 mRNA14685799
C006780bisphenol Abisphenol A results in increased expression of SREBF2 mRNA27014939
C006780bisphenol Abisphenol A results in increased expression of SREBF2 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of SREBF2 protein28057006
C006780bisphenol ASREBF2 promotes the reaction [bisphenol A results in increased expression of NPC1L1 mRNA]28057006
C006780bisphenol ASREBF2 promotes the reaction [bisphenol A results in increased import of Cholesterol]28057006
C006780bisphenol Abisphenol A affects the expression of SREBF2 mRNA21932408
C006780bisphenol Abisphenol A affects the expression of SREBF2 protein21932408
C006780bisphenol Abisphenol A affects the methylation of SREBF2 promoter27334623
C006780bisphenol Abisphenol A results in decreased methylation of SREBF2 promoter27502578
C006780bisphenol Abisphenol A results in increased expression of SREBF225168180
C006780bisphenol Abisphenol A results in increased expression of SREBF2 mRNA27502578
C006780bisphenol ASREBF2 mRNA promotes the reaction [bisphenol A results in increased expression of FASN mRNA]27502578
C006780bisphenol ASREBF2 mRNA results in increased susceptibility to bisphenol A27502578
C006780bisphenol Abisphenol A affects the expression of SREBF2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SREBF2 mRNA25181051
D002104CadmiumCadmium results in increased expression of SREBF2 mRNA17066326
D002104Cadmiummyricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased expression of SREBF2 protein]25240712
D002104Cadmium[Streptozocin co-treated with Cadmium] results in increased expression of SREBF2 protein25240712
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SREBF2 mRNA17066326
D000074262Canola OilCanola Oil results in increased expression of SREBF2 mRNA16631440
D002220CarbamazepineCarbamazepine results in decreased expression of SREBF2 mRNA21123845
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SREBF2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of SREBF2 mRNA26272509
D002746ChlorpromazineChlorpromazine results in increased cleavage of and results in increased activity of SREBF2 protein17052361
D002784CholesterolSREBF2 promotes the reaction [bisphenol A results in increased import of Cholesterol]28057006
D002784Cholesterol[[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 protein] which results in decreased abundance of Cholesterol16946405
D002784Cholesterol[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein20578043
D002784CholesterolCholesterol inhibits the reaction [[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein]20578043
D002784CholesterolSREBF2 protein affects the abundance of Cholesterol16946405
D002791Cholesterol, Dietary"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SREBF2 mRNA"19509184
D002791Cholesterol, Dietary"Cholesterol, Dietary deficiency promotes the reaction [SREBF2 protein binds to PPARGC1A protein]"20926756
D002791Cholesterol, Dietary"Cholesterol, Dietary deficiency results in increased activity of SREBF2 protein"20926756
D002791Cholesterol, Dietary"Cholesterol, Dietary deficiency results in increased expression of SREBF2 mRNA"20926756
D002791Cholesterol, Dietary"Cholesterol, Dietary results in increased expression of SREBF2 mRNA"23900008
D002791Cholesterol, Dietary"Plant Preparations inhibits the reaction [Cholesterol, Dietary results in increased expression of SREBF2 mRNA]"23900008
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with RXRA gene mutant form] results in increased expression of SREBF2 mRNA18952117
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SREBF2 mRNA28472532
D015283CitalopramCitalopram results in increased cleavage of and results in increased activity of SREBF2 protein16324787
D002994ClofibrateClofibrate results in decreased expression of SREBF2 mRNA17126302
D002994ClofibrateClofibrate results in decreased expression of SREBF2 protein17126302
D002997ClomipramineClomipramine results in increased cleavage of and results in increased activity of SREBF2 protein16324787
D003024ClozapineClozapine inhibits the reaction [25-hydroxycholesterol results in decreased activity of SREBF2 protein]17052361
D003024ClozapineClozapine results in increased cleavage of and results in increased activity of SREBF2 protein17052361
D003024ClozapineClozapine results in increased expression of SREBF2 mRNA17052361
C018021cobaltous chloridecobaltous chloride results in decreased expression of SREBF2 mRNA19320972
C551994crizotinibcrizotinib results in increased expression of SREBF2 mRNA23707608
C030973cupric oxidecupric oxide results in increased expression of SREBF2 mRNA22077320
D003474CurcuminCurcumin affects the expression of SREBF2 mRNA27208389
D003474CurcuminCurcumin affects the expression of SREBF2 protein27208389
D003474CurcuminCurcumin results in decreased expression of SREBF2 mRNA27208389
C057862cyanoginosin LRcyanoginosin LR results in increased expression of SREBF2 mRNA25497113
D016572CyclosporineCyclosporine results in increased expression of SREBF2 mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SREBF2 protein21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SREBF2 mRNA27392435
D004008DiclofenacDiclofenac results in increased expression of SREBF2 mRNA26934552
C000944dicrotophosdicrotophos results in increased expression of SREBF2 mRNA28302478
D004041Dietary Fats"5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one inhibits the reaction [Dietary Fats results in increased expression of SREBF2 mRNA]"24646949
D004041Dietary FatsDietary Fats results in increased expression of SREBF2 mRNA24646949|2470957
D004041Dietary Fats"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SREBF2 mRNA"19509184
D004041Dietary Fatszerumbone inhibits the reaction [Dietary Fats results in increased expression of SREBF2 mRNA]24709573
D004041Dietary FatsAnticholesteremic Agents inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of SREBF2 mRNA]28275691
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of SREBF2 mRNA28275691|2843392
D004041Dietary FatsDietary Fats results in increased expression of SREBF2 mRNA25016146|2665595
D004041Dietary Fatsobeticholic acid inhibits the reaction [Dietary Fats results in increased expression of SREBF2 mRNA]26655953
D004041Dietary FatsDietary Fats results in decreased expression of SREBF2 mRNA23524313
D019422Dietary SucroseAnticholesteremic Agents inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of SREBF2 mRNA]28275691
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of SREBF2 mRNA28275691|2843392
C051904dinophysistoxin 1dinophysistoxin 1 results in decreased expression of SREBF2 mRNA28939011
D000069438EzetimibeEzetimibe results in decreased expression of SREBF2 mRNA16177187
D000069438EzetimibeEzetimibe results in increased expression of SREBF2 mRNA17130282
D000069438EzetimibeSimvastatin promotes the reaction [Ezetimibe results in increased expression of SREBF2 mRNA]17130282
C033789fenarimolfenarimol results in increased expression of SREBF2 mRNA28970091
C017875fisetinfisetin results in increased expression of SREBF2 protein alternative form23524313
D005632Fructose"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SREBF2 mRNA"19509184
D005897GlafenineGlafenine results in increased expression of SREBF2 mRNA24136188
D005947GlucoseAllopurinol inhibits the reaction [Glucose results in increased expression of SREBF2 protein]23647015
D005947GlucoseGlucose results in increased expression of SREBF2 protein23647015
D005947GlucoseL 709049 analog inhibits the reaction [Glucose results in increased expression of SREBF2 protein]23647015
D005947GlucoseQuercetin inhibits the reaction [Glucose results in increased expression of SREBF2 protein]23647015
D005947GlucoseAllopurinol inhibits the reaction [Glucose results in increased expression of SREBF2 protein]23647015
D005947GlucoseGlucose results in increased expression of SREBF2 protein23647015
D005947GlucoseL 709049 analog inhibits the reaction [Glucose results in increased expression of SREBF2 protein]23647015
D005947GlucoseQuercetin inhibits the reaction [Glucose results in increased expression of SREBF2 protein]23647015
C010974glyphosateglyphosate results in increased expression of SREBF2 mRNA25636363
C442817GW 707OSM protein promotes the reaction [GW 707 affects the localization of SREBF2 protein]12524230
D006220HaloperidolHaloperidol results in increased cleavage of and results in increased activity of SREBF2 protein17052361
D006861Hydrogen Peroxide[isoquercitrin co-treated with Hydrogen Peroxide] results in increased cleavage of and results in increased activity of SREBF2 protein18032389
D006861Hydrogen Peroxide[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SREBF2 mRNA18032389
D006861Hydrogen PeroxideSREBF2 protein affects the susceptibility to [isoquercitrin co-treated with Hydrogen Peroxide]18032389
D007099ImipramineImipramine results in increased cleavage of and results in increased activity of SREBF2 protein16324787
C016527isoquercitrin[isoquercitrin co-treated with Hydrogen Peroxide] results in increased cleavage of and results in increased activity of SREBF2 protein18032389
C016527isoquercitrin[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SREBF2 mRNA18032389
C016527isoquercitrinSREBF2 protein affects the susceptibility to [isoquercitrin co-treated with Hydrogen Peroxide]18032389
C515747isosteviolisosteviol results in increased expression of SREBF2 mRNA22479612
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SREBF2 mRNA27392435
C544151jinfukangjinfukang results in increased expression of SREBF2 mRNA27392435
C468270Kangen-karyuKangen-karyu results in decreased expression of SREBF2 protein21155823
C468270Kangen-karyuKangen-karyu results in decreased expression of SREBF2 protein17524234
D007654KetoconazoleKetoconazole results in increased expression of SREBF2 mRNA28263823
C096429L 709049L 709049 analog inhibits the reaction [Glucose results in increased expression of SREBF2 protein]23647015
C096429L 709049L 709049 analog inhibits the reaction [Glucose results in increased expression of SREBF2 protein]23647015
C017461lead nitratelead nitrate results in increased expression of SREBF2 mRNA15475176
C018584linaloollinalool inhibits the reaction [SREBF2 protein binds to HMGCR promoter]21944868
C018584linaloollinalool results in decreased expression of SREBF2 mRNA21944868
C018584linaloollinalool results in decreased expression of SREBF2 protein21944868
C018584linaloollinalool results in decreased expression of SREBF2 mRNA21944868
C018584linaloollinalool results in decreased expression of SREBF2 protein21944868
D008148LovastatinLovastatin results in increased localization of SREBF2 protein11728391
D008148Lovastatin[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein20578043
D008148LovastatinCholesterol inhibits the reaction [[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein]20578043
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of SREBF2 mRNA27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with RXRA gene mutant form] results in increased expression of SREBF2 mRNA18952117
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]]14500290
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Atorvastatin Calcium results in increased expression of SREBF2 mRNA]12056585
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in increased expression of SREBF2 mRNA]12056585
C012258mevastatinmevastatin results in increased cleavage of SREBF2 protein16330322
C012258mevastatinmevastatin results in increased expression of SREBF2 protein17526932
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of SREBF2 mRNA23118965
C040015myricetinmyricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased expression of SREBF2 protein]25240712
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of SREBF2 mRNA"29244179
C511794N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide"N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide results in decreased expression of SREBF2 mRNA"22205993
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SREBF2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SREBF2 mRNA"25554681
C464660obeticholic acidobeticholic acid results in decreased expression of SREBF2 mRNA27939613
C464660obeticholic acidobeticholic acid inhibits the reaction [Dietary Fats results in increased expression of SREBF2 mRNA]26655953
D019319Okadaic AcidOkadaic Acid results in decreased expression of SREBF2 mRNA28939011
C076029olanzapineolanzapine results in increased cleavage of and results in increased activity of SREBF2 protein17052361
C076029olanzapine[olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of SREBF2 mRNA23226405
D009840OligomycinsOligomycins results in increased expression of SREBF2 mRNA23227865
D010126OzoneOzone results in decreased expression of SREBF2 mRNA25838073
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SREBF2 mRNA20936131
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SREBF2 mRNA20936131|2509218
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased cleavage of SREBF2 protein25092180
D010665PhenylpropanolaminePhenylpropanolamine results in increased cleavage of and results in increased activity of SREBF2 protein27756839
C006253pirinixic acidpirinixic acid results in decreased expression of SREBF2 mRNA17126302
C006253pirinixic acidpirinixic acid results in decreased expression of SREBF2 protein17126302
D028321Plant Preparations"Plant Preparations inhibits the reaction [Cholesterol, Dietary results in increased expression of SREBF2 mRNA]"23900008
C045950propiconazolepropiconazole results in increased expression of SREBF2 mRNA28970091
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Quercetin results in increased metabolism of and affects the localization of SREBF2 protein]22388943
D011794Quercetin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased metabolism of and affects the localization of SREBF2 protein]22388943
D011794Quercetinpyrazolanthrone inhibits the reaction [Quercetin results in increased metabolism of and affects the localization of SREBF2 protein]22388943
D011794QuercetinQuercetin inhibits the reaction [Glucose results in increased expression of SREBF2 protein]23647015
D011794QuercetinQuercetin promotes the reaction [SREBF2 protein binds to PON1 promoter]20728021
D011794QuercetinQuercetin results in increased metabolism of and affects the localization of SREBF2 protein22388943
D011794QuercetinQuercetin inhibits the reaction [Glucose results in increased expression of SREBF2 protein]23647015
D011794QuercetinQuercetin inhibits the reaction [Streptozocin results in increased expression of SREBF2 mRNA]23647015
D011794QuercetinQuercetin inhibits the reaction [Streptozocin results in increased expression of SREBF2 protein]23647015
C059514resveratrol25-hydroxycholesterol inhibits the reaction [resveratrol results in increased activity of and results in increased cleavage of SREBF2 protein]22153697
C059514resveratrol25-hydroxycholesterol inhibits the reaction [[resveratrol results in increased activity of and results in increased cleavage of SREBF2 protein] which results in increased expression of LDLR mRNA]22153697
C059514resveratrol25-hydroxycholesterol inhibits the reaction [resveratrol results in increased expression of SREBF2 protein modified form]22153697
C059514resveratrol[resveratrol results in increased activity of and results in increased cleavage of [SREBF1 protein co-treated with SREBF2 protein]] which results in increased expression of LDLR mRNA22153697
C059514resveratrolresveratrol results in increased activity of and results in increased cleavage of SREBF2 protein22153697
C059514resveratrolresveratrol results in increased expression of SREBF2 protein modified form22153697
C059514resveratrolresveratrol affects the localization of [SREBF2 protein binds to SCAP protein]22153697
C059514resveratrol[resveratrol affects the localization of [SREBF2 protein binds to SCAP protein]] which results in increased cleavage of SREBF2 protein22153697
D012643SeleniumSelenium results in increased expression of SREBF2 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SREBF2 mRNA25895662
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]]14500290
D019821SimvastatinSimvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]14500290
D019821SimvastatinSimvastatin results in increased expression of SREBF2 protein modified form20018177
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in increased expression of SREBF2 mRNA]12056585
D019821SimvastatinSimvastatin results in increased activity of and results in increased localization of SREBF2 protein12056585
D019821SimvastatinSimvastatin results in increased expression of SREBF2 mRNA12056585
D019821SimvastatinSimvastatin promotes the reaction [Ezetimibe results in increased expression of SREBF2 mRNA]17130282
D012999SomanSoman results in decreased expression of SREBF2 mRNA19281266
D053260SootSoot results in increased expression of SREBF2 mRNA22461453
D013024Soybean OilSoybean Oil results in increased expression of SREBF2 mRNA16631440
D013311StreptozocinAllopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF2 mRNA]23647015
D013311StreptozocinAllopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF2 protein]23647015
D013311Streptozocinmyricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased expression of SREBF2 protein]25240712
D013311StreptozocinQuercetin inhibits the reaction [Streptozocin results in increased expression of SREBF2 mRNA]23647015
D013311StreptozocinQuercetin inhibits the reaction [Streptozocin results in increased expression of SREBF2 protein]23647015
D013311Streptozocin[Streptozocin co-treated with Cadmium] results in increased expression of SREBF2 protein25240712
D013311StreptozocinStreptozocin results in increased expression of SREBF2 mRNA23647015
D013311StreptozocinStreptozocin results in increased expression of SREBF2 protein23647015
C025462sulindac sulfidesulindac sulfide results in decreased expression of SREBF2 mRNA16184548
C521767Tanjin extractTanjin extract results in decreased expression of SREBF2 protein17524234
D013739TestosteroneTestosterone results in increased expression of SREBF2 mRNA16579987
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SREBF2 mRNA21570461|2405805
D013749Tetrachlorodibenzodioxin"Tetrachlorodibenzodioxin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of SREBF2 mRNA]"21851831
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SREBF2 mRNA20005886|2185183
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SREBF2 mRNA21215274
D001371trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride"trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride results in increased expression of SREBF2 mRNA"26919959
D014212TretinoinTretinoin results in decreased expression of SREBF2 mRNA23724009
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SREBF2 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SREBF2 mRNA"26179874
C057693troglitazone[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 mRNA16946405
C057693troglitazone[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 protein16946405
C057693troglitazone[[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 protein] which results in decreased abundance of Cholesterol16946405
C057693troglitazone[[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 protein] which results in decreased expression of HMGCR mRNA16946405
C057693troglitazone[[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 protein] which results in decreased expression of LDLR mRNA16946405
D014415TunicamycinTunicamycin results in decreased expression of SREBF2 mRNA22378314
C406224valdecoxibvaldecoxib results in increased expression of SREBF2 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of SREBF2 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of SREBF2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of SREBF2 mRNA17963808
D014638VanadatesVanadates results in decreased expression of SREBF2 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SREBF2 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of SREBF2 mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of SREBF2 mRNA22570695
C111237vorinostatvorinostat results in decreased expression of SREBF2 mRNA27188386
C403304zerumbonezerumbone inhibits the reaction [Dietary Fats results in increased expression of SREBF2 mRNA]24709573

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000247C-8 sterol isomerase activityNOTIDA12941800  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA15358760  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA15358760  
GO:0005515protein binding-IPI10976766  12855700  15527767  16799563  19706601  20936779  
22265415  
GO:0008022protein C-terminus binding-IPI9242699  
GO:0046983protein dimerization activity-IEA-  
GO:0070888E-box binding-IDA15358760  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA15358760  19098903  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006629lipid metabolic process-TAS7903453  
GO:0008203cholesterol metabolic process-IEA-  
GO:0009267cellular response to starvation-IMP25339898  
GO:0010886positive regulation of cholesterol storage-IDA15358760  
GO:0042632cholesterol homeostasis-IEA-  
GO:0045540regulation of cholesterol biosynthetic process-TAS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA12242332  12446768  
GO:0071404cellular response to low-density lipoprotein particle stimulus-IEP15358760  
GO:0071499cellular response to laminar fluid shear stress-NAS15358760  
GO:0072368regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter-IDA15358760  
GO:0090370negative regulation of cholesterol efflux-IDA15358760  
GO:1903146regulation of autophagy of mitochondrion-HMP24912190  
GO:1903955positive regulation of protein targeting to mitochondrion-HMP24912190  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005634nucleus-IDA12202038  12242332  12941800  15358760  19098903  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA12941800  19098903  
GO:0005739mitochondrion-IDA-  
GO:0005783endoplasmic reticulum-IDA12202038  12941800  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005829cytosol-TAS-  
GO:0012507ER to Golgi transport vesicle membrane-IEA-  
GO:0032937SREBP-SCAP-Insig complex-IDA12202038  12242332  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)TAS
R-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)IEA
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-2426168Activation of gene expression by SREBF (SREBP)TAS
R-HSA-2426168Activation of gene expression by SREBF (SREBP)IEA
R-HSA-381340Transcriptional regulation of white adipocyte differentiationIEA
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-556833Metabolism of lipidsIEA
R-HSA-8957322Metabolism of steroidsTAS
R-HSA-8957322Metabolism of steroidsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24382701Comprehensive analyses of DNA repair pathways, smoking and bladder cancer risk in Los Angeles and Shanghai. (2014 Jul 15)Corral RInt J Cancer