Gene: SRF

6722
MCM1
serum response factor
protein-coding
6p21.1
Ensembl:ENSG00000112658 MIM:600589 Vega:OTTHUMG00000014722 UniprotKB:P11831
NC_000006.12
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.652e-1 (AD)  6.588e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CARM10.923
STRN40.921
DBN10.909
ERGIC10.907
TRAF70.907
CSNK1D0.907
TESK10.904
MED150.903
RNF400.902
NLGN20.9

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.728
OR4F29-0.674
CTNNA3-0.336
C5orf64-0.287
PDE11A-0.264
C9orf153-0.257
CDNF-0.256
TRDN-0.251
OR6C74-0.251
MYOT-0.25

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of SRF mRNA"23146750
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein co-treated with ARHGEF17 protein] results in increased activity of SRF protein"23195829
C0162768-bromocyclic GMP[8-bromocyclic GMP co-treated with PRKG1 protein co-treated with ARHGEF17 protein] results in increased activity of SRF protein23195829
D000082AcetaminophenAcetaminophen affects the expression of SRF mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of SRF mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SRF gene27153756
D003913Dextroamphetamine[Dextroamphetamine co-treated with Phencyclidine] promotes the reaction [SRF protein binds to FOS promoter]12510024
D003913DextroamphetamineDextroamphetamine promotes the reaction [SRF protein binds to FOS promoter]12510024
D000841AnisomycinAnisomycin results in increased phosphorylation of SRF protein12660819
D000841AnisomycinSB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of SRF protein]12660819
C006632arsenic trioxidearsenic trioxide results in increased expression of SRF protein22889704
C006632arsenic trioxidearsenic trioxide results in decreased expression of SRF mRNA20458559|2391187
D001564Benzo(a)pyreneBenzo(a)pyrene affects the activity of SRF protein20624995
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of SRF mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SRF mRNA19770486|2171566
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SRF mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SRF protein21467743
C044887beta-methylcholinebeta-methylcholine affects the expression of SRF mRNA21179406
C006780bisphenol Abisphenol A affects the methylation of SRF promoter27334623
C006780bisphenol Abisphenol A affects the expression of SRF mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SRF gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of SRF mRNA12419474
C018475butyraldehydebutyraldehyde results in decreased expression of SRF mRNA26079696
C584509C646 compoundC646 compound results in increased expression of SRF mRNA26191083
C037123cadmium sulfate[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of SRF mRNA18654764
C523455CCG 1423CCG 1423 results in decreased activity of SRF protein24706986
D004390ChlorpyrifosChlorpyrifos results in decreased expression of SRF mRNA18668222
D004390ChlorpyrifosChlorpyrifos results in increased expression of SRF mRNA20691718
C018021cobaltous chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of SRF mRNA18654764
D016572CyclosporineCyclosporine results in increased expression of SRF mRNA25562108
D003976DiazinonDiazinon results in increased methylation of SRF gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SRF mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SRF mRNA21266533
D004726EndosulfanEndosulfan results in decreased expression of SRF mRNA28161397
D004726EndosulfanEndosulfan results in decreased expression of SRF protein28161397
D000431EthanolEthanol results in decreased expression of SRF mRNA29018328
D005492Folic AcidFolic Acid results in decreased expression of SRF mRNA25006883
C069837fullerene C60fullerene C60 results in decreased expression of SRF mRNA19167457
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of SRF mRNA12419474
C492448ICG 001ICG 001 results in increased expression of SRF mRNA26191083
D007854LeadLead affects the expression of SRF mRNA28903495
C029891lead chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of SRF mRNA18654764
C045463leflunomideleflunomide results in increased expression of SRF mRNA28988120
C045463leflunomideleflunomide results in decreased expression of SRF mRNA19751817
D058185Magnetite NanoparticlesMagnetite Nanoparticles results in increased expression of SRF mRNA24525745
C013592mangiferinmangiferin results in decreased expression of SRF mRNA15135318
D008628MercuryMercury results in decreased expression of SRF mRNA16823088
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased phosphorylation of SRF protein"27566062
C059539midostaurinmidostaurin results in increased expression of SRF mRNA20980353
D009020MorphineMorphine results in increased expression of SRF mRNA22454534
C017096n-butoxyethanoln-butoxyethanol results in increased expression of SRF mRNA19812364
C028007nickel monoxidenickel monoxide results in decreased expression of SRF mRNA19167457
D052638Particulate MatterParticulate Matter results in increased expression of SRF mRNA17987463
D010622Phencyclidine[Dextroamphetamine co-treated with Phencyclidine] promotes the reaction [SRF protein binds to FOS promoter]12510024
D010622PhencyclidinePhencyclidine promotes the reaction [SRF protein binds to FOS promoter]12510024
D010936Plant ExtractsPlant Extracts results in decreased expression of SRF mRNA23557933
D059808PolyphenolsPolyphenols results in decreased expression of SRF mRNA16293270
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of SRF mRNA"21152443
C059514resveratrolresveratrol results in decreased expression of SRF mRNA22975027
C059514resveratrolresveratrol results in decreased expression of SRF mRNA20797428
C093642SB 203580SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of SRF protein]12660819
C093642SB 203580SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of SRF protein]12660819
C093642SB 203580SB 203580 inhibits the reaction [TGFB1 protein results in increased expression of SRF protein]21712382
D012715Sesame OilSesame Oil results in decreased expression of SRF mRNA29191790
C017947sodium arseniteSB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of SRF protein]12660819
C017947sodium arsenitesodium arsenite results in increased phosphorylation of SRF protein12660819
D012999SomanSoman results in increased expression of SRF mRNA19281266
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of SRF mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SRF mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SRF mRNA22298810
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SRF mRNA28111298
D014241TrichloroethyleneTrichloroethylene results in increased expression of SRF mRNA14565619
C046488trimethyltintrimethyltin results in decreased expression of SRF mRNA21435392
D014635Valproic AcidValproic Acid affects the expression of SRF mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in increased expression of SRF mRNA17987463
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SRF gene25560391
C025643vinclozolinvinclozolin results in decreased expression of SRF mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000976transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-ISS-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0000982transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000983transcription factor activity, RNA polymerase II core promoter sequence-specific DNA bindingcontributes_toIMP18296735  
GO:0001076transcription factor activity, RNA polymerase II transcription factor binding-IEA-  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA20808827  
GO:0001085RNA polymerase II transcription factor binding-IEA-  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-ISS-  
GO:0003700DNA-binding transcription factor activity-IDA3203386  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IEA-  
GO:0005515protein binding-IPI7854423  8617811  8887666  12397177  14565952  18296735  
18497331  19350017  25298399  
GO:0008134transcription factor binding-IBA21873635  
GO:0008134transcription factor binding-IPI16054032  18296735  
GO:0010736serum response element binding-IDA3203386  
GO:0031490chromatin DNA binding-IEA-  
GO:0042803protein homodimerization activity-IPI3203386  
GO:0042826histone deacetylase binding-IEA-  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0044212transcription regulatory region DNA binding-IBA21873635  
GO:0070878primary miRNA binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001569branching involved in blood vessel morphogenesis-IEA-  
GO:0001666response to hypoxia-IEP19098903  
GO:0001707mesoderm formation-IEA-  
GO:0001764neuron migration-IEA-  
GO:0001829trophectodermal cell differentiation-IDA17576768  
GO:0001947heart looping-ISS-  
GO:0002011morphogenesis of an epithelial sheet-IEA-  
GO:0002042cell migration involved in sprouting angiogenesis-IMP15180964  
GO:0003257positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation-IGI19783823  
GO:0006366transcription by RNA polymerase II-IDA3203386  
GO:0007160cell-matrix adhesion-IEA-  
GO:0007275multicellular organism development-IBA21873635  
GO:0007507heart development-ISS-  
GO:0007616long-term memory-IEA-  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0008306associative learning-IEA-  
GO:0009636response to toxic substance-TAS12660819  
GO:0009725response to hormone-IDA17975004  
GO:0010669epithelial structure maintenance-IEA-  
GO:0010735positive regulation of transcription via serum response element binding-IDA3203386  8887666  
GO:0021766hippocampus development-IEA-  
GO:0022028tangential migration from the subventricular zone to the olfactory bulb-IEA-  
GO:0030155regulation of cell adhesion-IEA-  
GO:0030168platelet activation-IEA-  
GO:0030220platelet formation-IEA-  
GO:0030336negative regulation of cell migration-IEA-  
GO:0030878thyroid gland development-IEA-  
GO:0031175neuron projection development-IEA-  
GO:0033561regulation of water loss via skin-IEA-  
GO:0034097response to cytokine-IMP15180964  
GO:0034097response to cytokine-NAS3203386  
GO:0035855megakaryocyte development-IEA-  
GO:0035912dorsal aorta morphogenesis-IEA-  
GO:0042789mRNA transcription by RNA polymerase II-ISS-  
GO:0043149stress fiber assembly-IEA-  
GO:0043589skin morphogenesis-IEA-  
GO:0045059positive thymic T cell selection-IEA-  
GO:0045214sarcomere organization-IEA-  
GO:0045597positive regulation of cell differentiation-IDA17576768  
GO:0045773positive regulation of axon extension-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA17576768  19578358  
GO:0045987positive regulation of smooth muscle contraction-IDA17215356  
GO:0046016positive regulation of transcription by glucose-IEA-  
GO:0046716muscle cell cellular homeostasis-ISS-  
GO:0048538thymus development-IEA-  
GO:0048589developmental growth-IEA-  
GO:0048666neuron development-TAS17200232  
GO:0048821erythrocyte development-IEA-  
GO:0051091positive regulation of DNA-binding transcription factor activity-IDA19098903  
GO:0051150regulation of smooth muscle cell differentiation-TAS17215356  
GO:0051491positive regulation of filopodium assembly-IEA-  
GO:0055003cardiac myofibril assembly-IEA-  
GO:0060055angiogenesis involved in wound healing-TAS15180964  
GO:0060218hematopoietic stem cell differentiation-IEA-  
GO:0060261positive regulation of transcription initiation from RNA polymerase II promoter-IDA8887666  
GO:0060292long term synaptic depression-IEA-  
GO:0060324face development-IEA-  
GO:0060347heart trabecula formation-IEA-  
GO:0060425lung morphogenesis-IEA-  
GO:0060532bronchus cartilage development-IEA-  
GO:0060534trachea cartilage development-IEA-  
GO:0060947cardiac vascular smooth muscle cell differentiation-IEA-  
GO:0061029eyelid development in camera-type eye-IEA-  
GO:0061145lung smooth muscle development-IEA-  
GO:0070830bicellular tight junction assembly-IEA-  
GO:0071333cellular response to glucose stimulus-IEA-  
GO:0090009primitive streak formation-IEA-  
GO:0090136epithelial cell-cell adhesion-IEA-  
GO:0090398cellular senescence-IMP15282327  
GO:1900222negative regulation of amyloid-beta clearance-IMP19098903  
GO:1902894negative regulation of pri-miRNA transcription by RNA polymerase II-ISS-  
GO:1902895positive regulation of pri-miRNA transcription by RNA polymerase II-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IEA-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA2108863  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-TAS15180964  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-5663220RHO GTPases Activate ForminsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27735881Addressing Smoking in Supported Residential Facilities for People with Severe Mental Illness: Has Any Progress Been Achieved? (2016 Oct 10)Lawn SInt J Environ Res Public Health
21998125Downregulation of the serum response factor/miR-1 axis in the quadriceps of patients with COPD. (2012 Jan)Lewis AThorax
29315347Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain. (2018)Osterndorff-Kahanek EAPLoS One
25536428[Prospective follow-up of results of tuberculosis treatment]. (2014 Dec)Moreno-Gomez MRev Esp Quimioter