Gene: SRM

6723
PAPT|SPDSY|SPS1|SRML1
spermidine synthase
protein-coding
1p36.22
Ensembl:ENSG00000116649 MIM:182891 Vega:OTTHUMG00000002119 UniprotKB:P19623
NC_000001.11
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.262e-1 (AD)  1.864e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM2220.938
NUTF20.93
EDF10.929
EIF5A0.922
TXN20.921
AURKAIP10.917
MRPS260.915
NDUFB70.915
LSM40.914
GPX40.914

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.847
OR4F29-0.811
HMCN1-0.229
PZP-0.225
PABPC4L-0.209
COL14A1-0.2
CXCR2-0.199
FCGR2C-0.199
VNN2-0.198
VNN1-0.195

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00118AdemetionineSmall Molecule29908-03-0Approved|Investigational|NutraceuticalEnzyme
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SRM mRNA"21354444|2890350
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of SRM mRNA"22101062
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of SRM mRNA"20453058
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SRM mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SRM mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SRM mRNA"23196670
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of SRM mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of SRM mRNA17562736
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of SRM mRNA]21233418
D000638AmiodaroneAmiodarone affects the expression of SRM mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SRM mRNA16483693
C004456beauvericinbeauvericin results in decreased expression of SRM mRNA29203277
D001553BenzbromaroneBenzbromarone affects the expression of SRM mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SRM protein22138271
D001564Benzo(a)pyreneMethionine inhibits the reaction [Benzo(a)pyrene results in increased expression of SRM protein]22138271
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to SRM promoter]19654925
D004958EstradiolEstradiol results in increased expression of SRM mRNA23019147
C006780bisphenol Abisphenol A affects the expression of SRM mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of SRM gene28505145
C006780bisphenol Abisphenol A results in increased methylation of SRM gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SRM mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SRM mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SRM mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SRM gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of SRM mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of SRM mRNA25270620
D002994ClofibrateClofibrate affects the expression of SRM mRNA19483382
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SRM mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of SRM mRNA19320972|2220211
C018021cobaltous chloridezinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of SRM mRNA]22202117
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SRM mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of SRM mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SRM mRNA"19167446
D003375CoumestrolCoumestrol results in increased expression of SRM mRNA19167446
C029892cupric chloridecupric chloride results in increased expression of SRM mRNA24650576
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SRM mRNA]18200517
D003520Cyclophosphamide[Doxorubicin co-treated with Cyclophosphamide] affects the expression of SRM mRNA16322899
D016572CyclosporineCyclosporine results in increased expression of SRM mRNA20106945|2798913
D016572CyclosporineCyclosporine results in increased expression of SRM mRNA19770486
D003703DemecolcineDemecolcine results in decreased expression of SRM mRNA23649840
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SRM mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SRM mRNA17361019
D002945CisplatinCisplatin results in decreased expression of SRM mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of SRM mRNA28302478
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SRM mRNA17602206
D002117CalcitriolCalcitriol results in decreased expression of SRM mRNA12875902
D004317Doxorubicin[Doxorubicin co-treated with Cyclophosphamide] affects the expression of SRM mRNA16322899
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of SRM mRNA]21233418
D004967EstrogensEstrogens results in increased expression of SRM mRNA21233418
D000431EthanolEthanol results in decreased expression of SRM protein20621659
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SRM mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SRM mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SRM mRNA17942748
D005001EthionineEthionine affects the expression of SRM mRNA19483382
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SRM mRNA23649840
D005485FlutamideFlutamide results in increased expression of SRM mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SRM gene20938992
D019833GenisteinGenistein results in increased expression of SRM mRNA23019147
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of SRM gene28505145
D005897GlafenineGlafenine results in increased expression of SRM mRNA24136188
C014026hexamethylene bisacetamidehexamethylene bisacetamide inhibits the reaction [BRD2 protein binds to SRM promoter]26941288
C014026hexamethylene bisacetamidehexamethylene bisacetamide results in decreased expression of SRM mRNA26941288
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SRM mRNA20044591
D007545IsoproterenolIsoproterenol results in increased expression of SRM mRNA21335049
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SRM mRNA21889194
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SRM mRNA25982114
C410337K 7174K 7174 results in decreased expression of SRM mRNA24086573
D008715MethionineMethionine inhibits the reaction [Benzo(a)pyrene results in increased expression of SRM protein]22138271
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SRM gene20938992
D008727MethotrexateMethotrexate results in decreased expression of SRM mRNA17400583
D008727MethotrexateMethotrexate affects the expression of SRM mRNA18502557
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SRM mRNA23649840
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of SRM mRNA20024957
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SRM mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SRM mRNA"25554681|2562005
C051752nefazodonenefazodone results in increased expression of SRM mRNA24136188
D009532NickelNickel results in increased expression of SRM mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in increased expression of SRM mRNA19167457
C012655nimesulidenimesulide results in increased expression of SRM mRNA24136188
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SRM mRNA20971185
D009853OmeprazoleOmeprazole affects the expression of SRM mRNA19483382
D010634PhenobarbitalPhenobarbital affects the expression of SRM mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of SRM mRNA23811191
C006253pirinixic acidpirinixic acid affects the expression of SRM mRNA19483382
D010936Plant ExtractsPlant Extracts results in decreased expression of SRM mRNA24677778
C045950propiconazolepropiconazole results in increased expression of SRM mRNA21278054
D011441PropylthiouracilPropylthiouracil affects the expression of SRM mRNA19483382
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SRM mRNA25895662
D012906SmokeSmoke affects the expression of SRM mRNA23693141
C017947sodium arsenitesodium arsenite results in decreased expression of SRM protein20050688
C016104sodium bichromatesodium bichromate results in increased expression of SRM mRNA25993096
D012999SomanSoman results in increased expression of SRM mRNA19281266
D013629TamoxifenTamoxifen affects the expression of SRM mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SRM mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SRM mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SRM mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of SRM mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SRM promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SRM mRNA17942748
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of SRM mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SRM mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of SRM mRNA28973375
D013853ThioacetamideThioacetamide affects the expression of SRM mRNA19483382
C009495titanium dioxidetitanium dioxide results in increased expression of SRM mRNA27760801
D014212TretinoinTretinoin results in decreased expression of SRM mRNA12875902
D014212TretinoinTretinoin results in decreased expression of SRM mRNA16604517
D014241TrichloroethyleneTrichloroethylene results in increased expression of SRM mRNA19448997
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SRM mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of SRM mRNA18200517
D014303TrinitrotolueneTrinitrotoluene affects the expression of SRM mRNA21346803
C080163trovafloxacintrovafloxacin results in decreased expression of SRM mRNA24136188
D014520UrethaneUrethane results in decreased expression of SRM mRNA28818685
C406224valdecoxibvaldecoxib results in increased expression of SRM mRNA24136188
D014635Valproic AcidValproic Acid results in increased expression of SRM mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of SRM gene29154799
D014635Valproic AcidValproic Acid affects the expression of SRM mRNA17292431|1796380
D014635Valproic AcidValproic Acid results in decreased expression of SRM mRNA19136453|2142705
D014750VincristineVincristine results in decreased expression of SRM mRNA23649840
C016837zinc chloridezinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of SRM mRNA]22202117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004766spermidine synthase activity-IBA21873635  
GO:0004766spermidine synthase activity-IDA17585781  
GO:0004766spermidine synthase activity-TAS-  
GO:0005515protein binding-IPI21044950  
GO:0042802identical protein binding-IPI17585781  
GO:0042803protein homodimerization activity-IDA17585781  
GO ID GO Term Qualifier Evidence PubMed
GO:0006595polyamine metabolic process-TAS-  
GO:0006596polyamine biosynthetic process-IBA21873635  
GO:0008295spermidine biosynthetic process-IBA21873635  
GO:0008295spermidine biosynthetic process-IDA17585781  
GO:0008295spermidine biosynthetic process-IEA-  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00270Cysteine and methionine metabolism
hsa00330Arginine and proline metabolism
hsa00410beta-Alanine metabolism
hsa00480Glutathione metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-351202Metabolism of polyaminesTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21859140Quantitation of 7-ethylguanine in leukocyte DNA from smokers and nonsmokers by liquid chromatography-nanoelectrospray-high resolution tandem mass spectrometry. (2011 Oct 17)Balbo SChem Res Toxicol
29092396Refinement of a Methodology for Untargeted Detection of Serum Albumin Adducts in Human Populations. (2017 Dec 18)Preston GWChem Res Toxicol
19081307Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography-mass spectrometry. (2009 Jan 1)Kim KMJ Chromatogr B Analyt Technol Biomed Life Sci
17559234Quantitation of acrolein-derived (3-hydroxypropyl)mercapturic acid in human urine by liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: effects of cigarette smoking. (2007 Jul)Carmella SGChem Res Toxicol
27344311MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: the KORA F4 study. (2016 Sep)von Toerne CDiabetologia
21193536Profiling Cys34 adducts of human serum albumin by fixed-step selected reaction monitoring. (2011 Mar)Li HMol Cell Proteomics