Gene: SRY

6736
SRXX1|SRXY1|TDF|TDY
sex determining region Y
protein-coding
Yp11.2
Ensembl:ENSG00000184895 MIM:480000 Vega:OTTHUMG00000036084 UniprotKB:Q05066
NG_011751.1
PubMed
0   ANCO-SNPs
CD|ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EIF1AY0.36
RAX0.351
TMSB4Y0.34
RPS4Y10.34
ZFY0.326
TMEM2020.318
ITK0.316
IL210.315
CCL10.309
LRRC150.305

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AQP12B-0.235
FMOD-0.219
PRR15L-0.216
PRSS55-0.211
MAP2K6-0.209
CPZ-0.209
ACTL8-0.209
PRB3-0.207
SPATA18-0.206
F10-0.205

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SRY mRNA16483693
C015001arsenitearsenite results in increased methylation of SRY promoter23974009
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of SRY protein mutant form27576690
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde[benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of SRY protein mutant form] which results in increased expression of SOX9 mRNA27576690
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SRY protein modified form27576690
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeSRY protein mutant form promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SRY protein modified form]27576690
C006780bisphenol Abisphenol A results in decreased expression of SRY mRNA25181051
C037123cadmium sulfate[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of SRY mRNA18654764
D002330CarmustineCarmustine results in decreased expression of SRY mRNA15980968
D002994ClofibrateClofibrate results in decreased expression of SRY mRNA17585979
C018021cobaltous chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of SRY mRNA18654764
D003300CopperCopper deficiency results in increased expression of SRY mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of SRY mRNA26577399
D003471CuprizoneCuprizone results in increased expression of SRY mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of SRY mRNA25562108
D004041Dietary FatsDietary Fats results in decreased expression of SRY mRNA25016146
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SRY mRNA26219507|2706063
C010176halofuginonehalofuginone results in decreased expression of SRY mRNA17180598
C016517indole-3-carbinolindole-3-carbinol affects the expression of SRY mRNA21396975
C029891lead chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of SRY mRNA18654764
D010795Phthalic AcidsPhthalic Acids results in increased expression of SRY mRNA22112501
D011374ProgesteroneProgesterone results in increased expression of SRY mRNA18037150
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of SRY mRNA20189893
D017974Uranium CompoundsUranium Compounds results in increased expression of SRY mRNA19654044
D014520UrethaneUrethane results in decreased expression of SRY mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0003677DNA binding-IDA1425584  8265659  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IDA21412441  
GO:0005515protein binding-IPI9054412  15527767  16166090  
GO:0005516calmodulin binding-IEA-  
GO:0008134transcription factor binding-IPI16582099  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0007417central nervous system development-IBA21873635  
GO:0007548sex differentiation-IEA-  
GO:0009653anatomical structure morphogenesis-IBA21873635  
GO:0030154cell differentiation-IBA21873635  
GO:0030154cell differentiation-IEA-  
GO:0030182neuron differentiation-IBA21873635  
GO:0030238male sex determination-IBA21873635  
GO:0030238male sex determination-NAS1695712  
GO:0045893positive regulation of transcription, DNA-templated-IDA21412441  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:2000020positive regulation of male gonad development-IDA21412441  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA21412441  28030592  
GO:0005634nucleus-NAS1425584  8265659  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IEA-  
GO:0016607nuclear speck-IEA-  
GO:0044798nuclear transcription factor complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-3769402Deactivation of the beta-catenin transactivating complexTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22712019Forced Abstinence from Cocaine Self-Administration is Associated with DNA Methylation Changes in Myelin Genes in the Corpus Callosum: a Preliminary Study. (2012)Nielsen DAFront Psychiatry
29162857Temporal expression pattern of genes during the period of sex differentiation in human embryonic gonads. (2017 Nov 21)Mamsen LSSci Rep
18055732Maternal smoking: effect on circulating cell-free fetal and total DNA levels in maternal plasma from the second trimester. (2007 Dec)Lapaire OObstet Gynecol
27150062Association of SOX2 and Nestin DNA amplification and protein expression with clinical features and overall survival in non-small cell lung cancer: A systematic review and meta-analysis. (2016 Jun 7)Li QOncotarget