Gene: SSB

6741
LARP3|La|La/SSB
Sjogren syndrome antigen B
protein-coding
2q31.1
Ensembl:ENSG00000138385 MIM:109090 Vega:OTTHUMG00000132212 UniprotKB:P05455
NG_030640.1
PubMed
0   ANCO-SNPs
ND
16   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.534e-1 (AD)  6.033e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSMC20.956
CDC1230.955
TAF70.954
PSMD140.954
PSMA10.954
DRG10.952
DNAJC70.951
PSMD60.95
EMC40.95
MRPS350.95

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.745
OR4F29-0.708
MTRNR2L9-0.291
MTRNR2L6-0.289
MTRNR2L10-0.277
KLRB1-0.243
P2RY14-0.235
VNN3-0.232
TTLL10-0.23
C8orf74-0.227

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of SSB mRNA"19162173
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SSB mRNA"25614096
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SSB mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SSB mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of SSB mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SSB mRNA19770486
D000616AminoglutethimideAminoglutethimide results in decreased expression of SSB protein26102013
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SSB mRNA16483693
C000228aristolochic acid I[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of SSB mRNA23912714
C042310aristolochic acid II[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of SSB mRNA23912714
C006632arsenic trioxidearsenic trioxide results in decreased expression of SSB protein25419056
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of SSB mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SSB mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SSB mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SSB mRNA27858113
C006780bisphenol Abisphenol A affects the expression of SSB mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SSB mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SSB mRNA28628672
D002104CadmiumCadmium affects the reaction [Tetrachlorodibenzodioxin affects the expression of SSB protein]29107029
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SSB mRNA24982889
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SSB mRNA27858113
D002995Clofibric AcidClofibric Acid affects the expression of SSB mRNA17602206
D003033Coal TarCoal Tar results in decreased expression of SSB mRNA27858113
C018021cobaltous chloridecobaltous chloride results in increased expression of SSB mRNA24612858
D003042CocaineCocaine affects the expression of SSB mRNA20187946
C029892cupric chloridecupric chloride results in decreased expression of SSB protein21641295
D016572CyclosporineCyclosporine results in decreased expression of SSB mRNA19770486
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SSB mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SSB mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of SSB mRNA28302478
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of SSB mRNA27638505
D004221DisulfiramDisulfiram results in decreased expression of SSB mRNA20530235
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SSB protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SSB mRNA17555576
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SSB mRNA23649840
D005485FlutamideFlutamide results in increased expression of SSB mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of SSB mRNA23649840
D005839GentamicinsGentamicins results in increased expression of SSB mRNA22061828
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of SSB mRNA19376150
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SSB mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SSB mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SSB mRNA28628672
C544151jinfukangjinfukang results in decreased expression of SSB mRNA27392435
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SSB mRNA21641980
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SSB mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SSB mRNA23649840
C022838nickel chloridenickel chloride results in increased expression of SSB mRNA24612858
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SSB mRNA27153767
D010634PhenobarbitalPhenobarbital affects the expression of SSB mRNA23091169
D010936Plant ExtractsPlant Extracts results in increased expression of SSB mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SSB mRNA23608068
C017947sodium arsenitesodium arsenite results in decreased expression of SSB mRNA19072884
C016104sodium bichromatesodium bichromate results in increased expression of SSB mRNA24612858
D012969Sodium FluorideSodium Fluoride results in decreased expression of SSB protein28918527
D018038Sodium SeleniteSodium Selenite results in increased expression of SSB mRNA18175754
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SSB mRNA21641980
D013629TamoxifenTamoxifen affects the expression of SSB mRNA17555576
C004648testosterone enanthatetestosterone enanthate affects the expression of SSB mRNA17440010
D013749TetrachlorodibenzodioxinCadmium affects the reaction [Tetrachlorodibenzodioxin affects the expression of SSB protein]29107029
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SSB protein29107029
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SSB mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SSB mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SSB mRNA25613284
D013893ThiramThiram results in decreased expression of SSB mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution analog results in increased expression of SSB mRNA20920546
C025643vinclozolinvinclozolin results in increased expression of SSB mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000049tRNA binding-IMP10983981  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003723RNA binding-IMP3192525  
GO:0003729mRNA binding-TAS9154801  
GO:0005515protein binding-IPI23552417  24965446  25616068  
GO:0008266poly(U) RNA binding-IMP12842046  15004549  16387655  
GO:0042803protein homodimerization activityNOTIMP12842046  
GO:1990825sequence-specific mRNA binding-IMP9154801  
GO ID GO Term Qualifier Evidence PubMed
GO:0001682tRNA 5'-leader removal-IGI10983981  
GO:0006400tRNA modification-TAS10983981  
GO:0006409tRNA export from nucleus-IMP17308035  
GO:0008033tRNA processing-IMP17308035  
GO:0008334histone mRNA metabolic process-TAS9154801  
GO:0042780tRNA 3'-end processing-IGI10983981  
GO:0071045nuclear histone mRNA catabolic process-IMP9154801  
GO:0075522IRES-dependent viral translational initiation-IDA12384597  
GO:1903608protein localization to cytoplasmic stress granule-IDA24965446  
GO ID GO Term Qualifier Evidence PubMed
GO:0000784nuclear chromosome, telomeric region-HDA19135898  
GO:0005634nucleus-IDA17308035  24965446  
GO:0005737cytoplasm-IDA17308035  
GO:1990904ribonucleoprotein complex-IEA-  
KEGG ID KEGG Term
hsa05322Systemic lupus erythematosus
Reactome ID Reactome Term Evidence
R-HSA-73980RNA Polymerase III Transcription TerminationIEA
R-HSA-74158RNA Polymerase III TranscriptionIEA
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-749476RNA Polymerase III Abortive And Retractive InitiationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29211358Chest HRCT findings in patients with primary Sjogren's syndrome. (2017 Oct)Sebastian AAdv Clin Exp Med
19940226Prospective study of pre-gravid sugar-sweetened beverage consumption and the risk of gestational diabetes mellitus. (2009 Dec)Chen LDiabetes Care
16038584Influence of polymorphisms in DNA repair genes XPD, XRCC1 and MGMT on DNA damage induced by gamma radiation and its repair in lymphocytes in vitro. (2005 Aug)Rzeszowska-Wolny JRadiat Res
28951328Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease. (2017 Oct)Shindi RClin Immunol
20823900Risk associations of obesity with sugar-sweetened beverages and lifestyle factors in Chinese: the 'Better Health for Better Hong Kong' health promotion campaign. (2010 Dec)Ko GTEur J Clin Nutr
22194529Coffee, tea, and sugar-sweetened carbonated soft drink intake and pancreatic cancer risk: a pooled analysis of 14 cohort studies. (2012 Feb)Genkinger JMCancer Epidemiol Biomarkers Prev
27465381Sugar-sweetened beverage consumption and genetic predisposition to obesity in 2 Swedish cohorts. (2016 Sep)Brunkwall LAm J Clin Nutr
27998016Elucidating the role of hyposalivation and autoimmunity in oral candidiasis. (2017 Apr)Billings MOral Dis
16510609XRCC1 genotype and breast cancer: functional studies and epidemiologic data show interactions between XRCC1 codon 280 His and smoking. (2006 Mar 1)Pachkowski BFCancer Res
14582242[European multicenter cross-sectional study on exposure to low doses of benzene]. (2003 Jul-Sep)Merlo FG Ital Med Lav Ergon
10627428Lower frequency of focal lip sialadenitis (focus score) in smoking patients. Can tobacco diminish the salivary gland involvement as judged by histological examination and anti-SSA/Ro and anti-SSB/La antibodies in Sjogren's syndrome? (2000 Jan)Manthorpe RAnn Rheum Dis
9739811DNA single-strand breaks and DNA repair in the lymphocytes of wooden furniture workers. (1998 Aug 7)Palus JMutat Res
2030705Biologic markers in ethylene oxide-exposed workers and controls. (1991 May)Mayer JMutat Res
27659405Cystic lung disease in Sjogren's syndrome: An observational study. (2017 May)Lechtman SJoint Bone Spine
7618165Changes in lymphocyte single strand breakage and liver function of workers exposed to vinyl chloride monomer. (1995 May)Du CLToxicol Lett
9473526Effects of tobacco smoke on the gene expression of the Cyp1a, Cyp2b, Cyp2e, and Cyp3a subfamilies in mouse liver and lung: relation to single strand breaks of DNA. (1998 Feb)Villard PHToxicol Appl Pharmacol