Gene: SST

6750
SMST
somatostatin
protein-coding
3q27.3
Ensembl:ENSG00000157005 MIM:182450 Vega:OTTHUMG00000156462 UniprotKB:P61278
NC_000003.12
PubMed
0   ANCO-SNPs
CD|ND|AD
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.248e-1 (AD)  7.651e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRHBP0.883
TAC10.859
CORT0.856
GNG40.84
CRH0.818
GAD20.807
SCG20.79
NNAT0.787
SLC32A10.777
GAD10.776

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDC14A-0.527
TGFBR3-0.523
CDA-0.513
NFE2-0.5
ZIC5-0.498
FCGR3B-0.486
RGL3-0.484
NBPF10-0.479
TNFRSF11B-0.477
HIF3A-0.47

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00847CysteamineSmall Molecule60-23-1Approved|InvestigationalTarget
ID Drug Name Action PubMed
C5309251-(2-(1-adamantyl)ethyl)-1-pentyl-3-(3-(4-pyridyl)propyl)urea1-(2-(1-adamantyl)ethyl)-1-pentyl-3-(3-(4-pyridyl)propyl)urea results in increased expression of SST protein19878665
C5309251-(2-(1-adamantyl)ethyl)-1-pentyl-3-(3-(4-pyridyl)propyl)urea1-(2-(1-adamantyl)ethyl)-1-pentyl-3-(3-(4-pyridyl)propyl)urea results in increased secretion of SST protein18508045
C4887951,2,3,4,4a,5,10,10a-octahydro-6-methoxy-1-methylbenz(g)quinoline-3-carboxylic acid 4-(4-nitrophenyl)piperazine amide"1,2,3,4,4a,5,10,10a-octahydro-6-methoxy-1-methylbenz(g)quinoline-3-carboxylic acid 4-(4-nitrophenyl)piperazine amide results in increased expression of SST protein"20134357
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SST mRNA"22698814
C5822121NMPP1 compound[NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in decreased expression of SST mRNA27417517
C499293(1'S, 2S)-4-amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4''-methyl-1''-naphthalenesulfonylamino)butanamide"(1'S, 2S)-4-amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4''-methyl-1''-naphthalenesulfonylamino)butanamide results in decreased secretion of SST protein"16953190
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of SST mRNA"19327374
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SST mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of SST mRNA"19327374
C0230353,4,5,3',4'-pentachlorobiphenyl"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of SST mRNA"19327374
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SST mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SST mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SST mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SST mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SST mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SST mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SST mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SST mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of SST mRNA17562736
D019342Acetic AcidAcetic Acid results in decreased expression of SST protein21296659
D000242Cyclic AMP[SST protein co-treated with SSTR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]22056254
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SST gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SST mRNA16483693
C015001arsenitearsenite results in increased methylation of SST promoter23974009
D001205Ascorbic AcidAscorbic Acid results in increased expression of SST mRNA15372504
C487081belinostatbelinostat results in increased expression of SST mRNA26272509
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SST mRNA27195522
D018723BethanecholBethanechol affects the secretion of SST protein19296048
D018723BethanecholCALCA protein promotes the reaction [Bethanechol affects the secretion of SST protein]19296048
C006780bisphenol Abisphenol A promotes the reaction [SST binds to SSTR2 protein alternative form]12060835
C006780bisphenol Abisphenol A results in decreased expression of SST mRNA25181051
C006780bisphenol ARo 15-4513 promotes the reaction [bisphenol A promotes the reaction [SST binds to SSTR2 protein alternative form]]12060835
C006780bisphenol Azolpidem promotes the reaction [bisphenol A promotes the reaction [SST binds to SSTR2 protein alternative form]]12060835
C099813bromochloroacetic acidbromochloroacetic acid results in increased expression of SST protein21296659
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of SST mRNA12414654
D002104CadmiumCadmium affects the activity of SST protein9392874
D002211CapsaicinCapsaicin results in increased expression of SST protein19878665
D002211CapsaicinAMN protein inhibits the reaction [Capsaicin results in increased expression of SST protein]16938409
D002211CapsaicinCapsaicin results in decreased expression of SST mRNA8093704
D002211CapsaicinCapsaicin results in increased expression of SST protein16938409
D002211CapsaicinCapsaicin results in increased secretion of SST protein19296048|8093880
D002220CarbamazepineCarbamazepine affects the expression of SST mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SST mRNA17805973
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of SST mRNA18636392
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SST mRNA"27188386
D004390ChlorpyrifosChlorpyrifos results in decreased expression of SST mRNA20682304
D003024ClozapineClozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST mRNA]16567023
D003024ClozapineClozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST protein]16567023
D005576Colforsin[SST protein co-treated with SSTR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]22056254
C042079copper methionatecopper methionate results in decreased expression of SST mRNA21110139
C042079copper methionatecopper methionate results in decreased expression of SST protein21110139
D019327Copper SulfateCopper Sulfate results in decreased expression of SST mRNA19549813
D019327Copper SulfateCopper Sulfate results in decreased expression of SST mRNA21110139
D019327Copper SulfateCopper Sulfate results in decreased expression of SST protein21110139
D003543CysteamineCysteamine results in decreased expression of SST protein15778430
D003634DDTDDT results in decreased expression of SST mRNA19797855
C014347decitabinedecitabine affects the methylation of SST promoter17999418
D003907DexamethasoneDexamethasone results in decreased expression of SST mRNA25047013
D016291Dizocilpine MaleateClozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST mRNA]16567023
D016291Dizocilpine MaleateClozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST protein]16567023
D016291Dizocilpine MaleateDizocilpine Maleate results in decreased expression of SST mRNA16567023
D016291Dizocilpine MaleateDizocilpine Maleate results in decreased expression of SST protein16567023
D004298DopamineSST protein alternative form results in increased abundance of Dopamine16771832
C106246EdotreotideEdotreotide inhibits the reaction [SST protein binds to SSTR2 protein]10353735
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SST mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SST mRNA23550701
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of SST protein16534498
D005472FluorouracilFluorouracil results in increased expression of SST protein21296659
D004397FonofosFonofos results in increased methylation of SST promoter22847954
C039281furanfuran results in increased expression of SST mRNA27387713
D005839GentamicinsSST protein results in decreased susceptibility to Gentamicins19294753
D006632HistamineSST protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]11164953
D006632HistamineSST protein inhibits the reaction [GAST protein results in increased secretion of Histamine]11164953
D012701SerotoninSST protein alternative form results in increased abundance of Serotonin16771832
D006851Hydrochloric AcidHydrochloric Acid results in increased expression of SST protein9530148
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of SST mRNA12414654
D007608Kainic AcidKainic Acid results in decreased expression of SST mRNA17997037
C076948lafutidinelafutidine results in increased expression of SST protein16416222
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SST protein17291600
D008070Lipopolysaccharidesresiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased expression of SST protein]17291600
C042720mercuric bromidemercuric bromide results in increased expression of SST mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SST mRNA"27188386
D008687MetforminMetformin results in increased expression of SST mRNA23457588
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SST mRNA28001369
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of SST mRNA24810058
D009020MorphineMorphine results in increased expression of SST mRNA21178816
D009538NicotineNicotine results in decreased expression of SST mRNA17997037
D015282OctreotideOctreotide results in decreased secretion of SST protein16601281
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of SST mRNA18636392
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SST mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of SST mRNA26272509
D010269ParaquatParaquat affects the expression of SST mRNA15206577
D010278ParathionParathion results in increased methylation of SST promoter22847954
C410127PCB 180"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of SST mRNA"19327374
D010578PetroleumPetroleum affects the expression of SST mRNA25208076
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SST mRNA"27188386
C006253pirinixic acidpirinixic acid results in decreased expression of SST mRNA17426115
D011188PotassiumPotassium results in increased secretion of SST protein16601281
D011374ProgesteroneProgesterone results in decreased expression of SST mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of SST mRNA16376865
D011441PropylthiouracilPropylthiouracil results in increased expression of SST mRNA24780913
C024353resiniferatoxinresiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased expression of SST protein]17291600
C042957Ro 15-4513Ro 15-4513 promotes the reaction [bisphenol A promotes the reaction [SST binds to SSTR2 protein alternative form]]12060835
C042957Ro 15-4513Ro 15-4513 promotes the reaction [SST binds to SSTR2 protein alternative form]12060835
D012715Sesame OilSesame Oil results in decreased expression of SST mRNA29191790
D012834SilverSilver analog results in increased expression of SST mRNA22727896
D013629TamoxifenTamoxifen promotes the reaction [SST protein results in decreased secretion of GH1 protein]1350760
C012568terbufosterbufos results in increased methylation of SST promoter22847954
D013726TerbutalineSST inhibits the reaction [Terbutaline results in increased expression of INS protein]2563217
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SST mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SST mRNA16922920
D013806TheophyllineTheophylline results in increased secretion of SST protein16601281
D014212TretinoinTretinoin results in increased expression of SST mRNA21934132
D014212TretinoinTretinoin results in increased expression of SST protein16473924
C012589trichostatin Atrichostatin A results in increased expression of SST mRNA24935251
C046243tryptanthrinetryptanthrine results in increased expression of SST mRNA23500671
D014635Valproic AcidValproic Acid affects the expression of SST mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SST mRNA23179753
C025643vinclozolinvinclozolin affects the expression of SST mRNA19015723
D014801Vitamin A[Vitamin A co-treated with INHBA protein] results in increased expression of SST mRNA17244017
D014801Vitamin AVitamin A affects the expression of SST protein16757122
D024483Vitamin K 3Vitamin K 3 results in decreased expression of SST mRNA12414654
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of SST mRNA"25208076
D015032ZincZinc deficiency results in decreased expression of SST mRNA18356318
D015032ZincZinc deficiency results in decreased secretion of SST protein11842894
D015032ZincZinc deficiency results in increased expression of SST mRNA11717422
D015034Zinc OxideZinc Oxide analog results in decreased expression of SST mRNA27215404
C049109zolpidemzolpidem promotes the reaction [bisphenol A promotes the reaction [SST binds to SSTR2 protein alternative form]]12060835
C049109zolpidemzolpidem promotes the reaction [SST binds to SSTR2 protein alternative form]12060835
D015054ZymosanSST protein inhibits the reaction [Zymosan results in increased expression of TNF protein]15834315

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005179hormone activity-TAS9886848  
GO ID GO Term Qualifier Evidence PubMed
GO:0006972hyperosmotic response-IEA-  
GO:0007166cell surface receptor signaling pathway-TAS9437026  
GO:0007186G-protein coupled receptor signaling pathway-TAS8405411  
GO:0007267cell-cell signaling-TAS6145156  
GO:0007268chemical synaptic transmission-TAS9437026  
GO:0007584response to nutrient-TAS6145156  
GO:0007586digestion-TAS6145156  
GO:0008285negative regulation of cell proliferation-TAS9886848  
GO:0008628hormone-mediated apoptotic signaling pathway-TAS8961277  
GO:0009408response to heat-IEA-  
GO:0010447response to acidic pH-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0030334regulation of cell migration-IBA21873635  
GO:0042493response to drug-IEA-  
GO:0043200response to amino acid-IEA-  
GO:0048545response to steroid hormone-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-TAS9437026  
GO:0043025neuronal cell body-IEA-  
KEGG ID KEGG Term
hsa04971Gastric acid secretion
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22445419Dimensions of impulsivity among heavy drinkers, smokers, and heavy drinking smokers: singular and combined effects. (2012 Jul)Moallem NRAddict Behav
11116069Contribution of apolipoprotein C-III gene variants to determination of triglyceride levels and interaction with smoking in middle-aged men. (2000 Dec)Waterworth DMArterioscler Thromb Vasc Biol
29426577Common variants at somatostatin are significantly associated with hypertension incidence in smoking and drinking populations. (2018 Mar)Zhu HJ Am Soc Hypertens
20572039Relation between normal rectal methylation, smoking status, and the presence or absence of colorectal adenomas. (2010 Oct 1)Paun BCCancer
20163923Increased error-related thalamic activity during early compared to late cocaine abstinence. (2010 Jun 1)Li CSDrug Alcohol Depend
21692047Association between somatostatin receptor 5 gene polymorphisms and pancreatic cancer risk and survival. (2011 Jul 1)Li DCancer
28261068GABRB1 Single Nucleotide Polymorphism Associated with Altered Brain Responses (but not Performance) during Measures of Impulsivity and Reward Sensitivity in Human Adolescents. (2017)Duka TFront Behav Neurosci
16444185Thyroid associated ophthalmopathy: pediatric and endocrine aspects. (2004 Aug)Wiersinga WMPediatr Endocrinol Rev