Gene: SSTR3

6753
SS-3-R|SS3-R|SS3R|SSR-28
somatostatin receptor 3
protein-coding
22q13.1
Ensembl:ENSG00000278195 MIM:182453 Vega:OTTHUMG00000150537 UniprotKB:P32745
NC_000022.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.276e-1 (AD)  6.694e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRDM80.937
KCNC10.931
SPATS20.922
MICAL20.913
RTN4RL10.91
AACS0.909
KCNK90.908
TNFAIP8L10.907
MAPK130.907
SLC45A40.906

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MBNL3-0.619
REST-0.602
YES1-0.6
HEY2-0.6
COPZ2-0.573
ASB4-0.565
RAI14-0.564
LRAT-0.56
PARD3B-0.55
SEPT10-0.545

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB06663PasireotideSmall Molecule396091-73-9ApprovedTarget
DB13985Lutetium Lu 177 dotatateSmall Molecule437608-50-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SSTR3 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SSTR3 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SSTR3 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SSTR3 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SSTR3 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SSTR3 mRNA"25510870
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of SSTR3 mRNA12958071
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in increased expression of SSTR3 mRNA25716159
D000082AcetaminophenAcetaminophen results in decreased expression of SSTR3 mRNA17088403
D000082AcetaminophenN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Acetaminophen results in decreased expression of SSTR3 mRNA]17088403
D000082AcetaminophenU 0126 inhibits the reaction [Acetaminophen results in decreased expression of SSTR3 mRNA]17088403
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SSTR3 mRNA16483693
D001280AtrazineAtrazine affects the expression of SSTR3 mRNA16221967
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SSTR3 mRNA27195522
C006780bisphenol Abisphenol A affects the expression of SSTR3 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of SSTR3 mRNA16162846
C006780bisphenol Abisphenol A results in increased expression of SSTR3 mRNA16162846
C006780bisphenol ARY 008 inhibits the reaction [bisphenol A results in decreased expression of SSTR3 mRNA]16162846
C006780bisphenol Azolpidem affects the reaction [bisphenol A affects the expression of SSTR3 mRNA]16162846
D001761BleomycinBleomycin results in decreased expression of SSTR3 mRNA15808516
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of SSTR3 mRNA18636392
D003300CopperCopper deficiency results in increased expression of SSTR3 mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of SSTR3 mRNA26577399
D003840Deoxycholic Acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of SSTR3 mRNA16556975
D004026DieldrinDieldrin results in increased expression of SSTR3 mRNA20682304
D019422Dietary SucroseDietary Sucrose results in increased expression of SSTR3 mRNA26033743
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with lanreotide] results in increased expression of SSTR3 mRNA19874807
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of SSTR3 mRNA19874807
D005445FlunitrazepamFlunitrazepam affects the expression of SSTR3 mRNA16162846
D005557FormaldehydeFormaldehyde results in increased expression of SSTR3 mRNA12679049
C030691gluconic acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of SSTR3 mRNA16556975
C429627L796778L796778 binds to and results in increased activity of SSTR3 protein16162846
C060347lanreotide[Diethylnitrosamine co-treated with lanreotide] results in increased expression of SSTR3 mRNA19874807
D008628MercuryMercury results in decreased expression of SSTR3 mRNA19937285
D008731MethoxychlorMethoxychlor results in increased methylation of SSTR3 gene23303685
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SSTR3 mRNA21385734
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SSTR3 mRNA24810058
C500085muraglitazarmuraglitazar results in decreased expression of SSTR3 mRNA21515302
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Acetaminophen results in decreased expression of SSTR3 mRNA]17088403
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SSTR3 mRNA25729387
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of SSTR3 mRNA18636392
C517782pasireotidepasireotide binds to SSTR3 protein16625840
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SSTR3 mRNA"25510870
D010862PilocarpinePilocarpine results in decreased expression of SSTR3 protein18951627
D059808PolyphenolsPolyphenols results in decreased expression of SSTR3 mRNA16293270
C042957Ro 15-4513Ro 15-4513 affects the expression of SSTR3 mRNA16162846
C089730rosiglitazonerosiglitazone results in decreased expression of SSTR3 mRNA21515302
C113975RY 008RY 008 affects the expression of SSTR3 mRNA16162846
C113975RY 008RY 008 inhibits the reaction [bisphenol A results in decreased expression of SSTR3 mRNA]16162846
D018038Sodium SeleniteSodium Selenite results in decreased expression of SSTR3 mRNA18175754
D012999SomanSoman results in decreased expression of SSTR3 mRNA19281266
D013004SomatostatinSomatostatin results in increased expression of SSTR3 mRNA18575731
C501413tesaglitazartesaglitazar results in decreased expression of SSTR3 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SSTR3 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SSTR3 mRNA22298810
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SSTR3 mRNA25729387
C057693troglitazonetroglitazone results in decreased expression of SSTR3 mRNA21515302
C113580U 0126U 0126 inhibits the reaction [Acetaminophen results in decreased expression of SSTR3 mRNA]17088403
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SSTR3 gene25560391
C049109zolpidemzolpidem affects the expression of SSTR3 mRNA16162846
C049109zolpidemzolpidem affects the reaction [bisphenol A affects the expression of SSTR3 mRNA]16162846

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004994somatostatin receptor activity-IEA-  
GO:0005102signaling receptor binding-IEA-  
GO:0005515protein binding-IPI19071123  22651821  
GO:0042277peptide binding-IBA21873635  
GO:0042923neuropeptide binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-IBA21873635  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-TAS8405411  
GO:0007218neuropeptide signaling pathway-IBA21873635  
GO:0007267cell-cell signaling-TAS1337145  
GO:0007283spermatogenesis-IEA-  
GO:0008285negative regulation of cell proliferation-TAS8961277  
GO:0008628hormone-mediated apoptotic signaling pathway-TAS8961277  
GO:0021549cerebellum development-IEA-  
GO:0030900forebrain development-IEA-  
GO:0038170somatostatin signaling pathway-IEA-  
GO:0042594response to starvation-IEA-  
GO:0071385cellular response to glucocorticoid stimulus-IEA-  
GO:0071392cellular response to estradiol stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS1337145  
GO:0043005neuron projection-IBA21873635  
GO:0060170ciliary membrane-TAS-  
GO:0097730non-motile cilium-ISS-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5620920Cargo trafficking to the periciliary membraneTAS
R-HSA-5620922BBSome-mediated cargo-targeting to ciliumTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20570798Influence of cigarette smoking on the level of mRNA of somatostatin receptor 3 (SSTR3) in the gastric mucosa of patients with functional dyspepsia. (2010)Stec-Michalska KAdv Med Sci